KR100441308B1 - A diet ginseng drink and the preparing method thereof - Google Patents

Abstract

The present invention relates to the development of functional diet products of the anti-obesity to therapeutic level using ginseng and herbal medicine. More specifically, 12 kinds of herbal medicines used in oriental prescriptions were selected from ginseng and body fat, which are effective in maintaining stamina when body strength was reduced by promoting metabolism. Formulation ingredients and ratios were selected. As a result, the formulated product has been confirmed by animal and clinical experiments to reduce the body weight by the mechanism of fat loss, which is involved in metabolism, which promotes divergence and consumption rather than absorbed energy. A feature of the present invention relates to a diet-specialized functional ginseng complex drink minimized side effects of the therapeutic level for relieving obesity and a method of manufacturing the same.

Description

A diet ginseng drink and the preparing method

The present invention relates to a ginseng complex drink for the diet and a method of manufacturing the same, and more specifically, 12 kinds of herbal medicines that were frequently used among over 40 herbal prescriptions of obesity-relieving herbal medicines used in herbal prescriptions to suppress appetite , Herbal medicines known to have diuretic, body fat reduction and stabilizing effects, and especially ginseng and larvae, which promote the release of absorbed energy while compensating for the loss of energy from weight loss. After mixing ginseng products to produce ginseng products to confirm the weight loss effect by animal experiments and to check the weight loss effect clinically in a professional medical institution and to develop a convenient drink product.

The development of civilization for convenience brought the lack of exercise to the human body, and the development of high-calorie instant foods made from Western meats has made the human body obese and high cholesterol. Obesity has become a serious health problem in Korea as well as in the West, where meat is a staple food, and methods for preventing and treating obesity are being studied in various aspects of the world, and the method is a calorie-restricted diet that limits calorie intake. , Exercise therapy, surgical therapy and drug therapy using appetite suppressants or energy metabolism accelerators have been proposed, but they are not used as effectively as expected for various reasons.

In the case of calorie-restricted diets, it is difficult to overcome the temptations of food and the urge to habitual food intake in modern life where a wide variety of foods are readily available everywhere in daily life. In the case of exercise therapy, the obese person has not gained a great effect from the obese person because it is difficult to continue the exercise for a sufficient amount of time due to the excessive weight. Even if the weight is lost by diet or exercise therapy, diet and exercise therapy should be carried out steadily in order to maintain the weight loss. Otherwise, there is a problem such as the yo-yo phenomenon of weight gain. Even by the methods, a great effect is difficult to expect. Various appetite suppressants or energy metabolic accelerators have been proposed, but most of these drugs have serious side effects, and in some cases, the efficacy of these drugs is not clearly identified. Currently, studies are being actively conducted in the West to compensate for the shortcomings of the methods described above for the treatment of obesity. In particular, the energy metabolic accelerators have been actively studied in this field because of the advantage that weight gain effect can be obtained without limiting caloric intake. However, all of the energy metabolic accelerators developed to date suffer from serious side effects. If such a drug is put to practical use, it is highly prone to long-term dependence on the drug, so the side effects of drug use are recognized as serious problems. In this respect, it is urgent to develop drugs that can significantly increase energy metabolism without accompanying side effects, and the prospect is very opaque at present.

Obesity is a metabolic disease caused by an imbalance between calorie intake and consumption, which can be defined as an increased state of adipose tissue. Recently, in Korea, the calorie intake is increasing due to the improvement of diet and the westernization of food due to the rapid economic development. Obesity is not only psychologically and socially atrophy of the individual, but also known to be an important factor to increase the risk of hypertension, arteriosclerosis, diabetes.

In the body, in order to prevent the development and progression of obesity, the center of gravity, which detects the increase and decrease of body weight, is present in the hypothalamus, and by the powerful feedback action, the body maintains a constant weight of fat tissue. However, the specific mechanism of this physiological control mechanism is not yet known.

The sympathetic nervous system promotes fat metabolism and glucose metabolism in the brown adipose tissue, an energy consuming organ, to increase metabolic heat production capacity. The action of the sympathetic nerve to increase energy consumption is known to be expressed mainly via betatriadrenaline ( β ₃ adrenaline) receptors present in these tissues. The effect of catecholamine through the important betatriadrenaline ( β ₃ adrenaline) receptor in brown adipose tissue is to promote lipolysis. As a result, triglycerides stored in brown and white adipose tissue are mobilized as fatty acids and oxidized in the de-conjugated proteins of mitochondria of white adipose tissue and consumed by heat production. Eventually, catecholamines are thought to act to regulate the consumption of stored triglycerides, consuming excess energy in the body through heat production. Therefore, if the function of the sympathetic nervous system or the beta-triadrenaline ( β ₃ adrenaline) receptor is abnormal, the energy consumption in the body is expected to cause obesity. Therefore, the possibility that agents that stimulate beta-adrenergic tree (β ₃ adrenaline) receptors of the sympathetic used as a new treatment of obesity and is being conducted extensive research on the metabolic heat accelerator in Western countries. However, the synthetic drugs currently being studied do not act purely on adipose tissue, but can act on cardiovascular system and cause tachycardia and blood pressure increase.

Most domestically marketed products for weight loss are indigestible polysaccharides, which are made from some herbal medicines that are dependent on imported materials or have effects such as appetite suppression and diuresis, but reported that they resulted in substantial weight loss without side effects. Is not yet.

The present invention is to solve the problems of the conventional obesity treatment, to develop an obesity treatment that can effectively reduce the body fat without side effects on the heart and circulatory system effective in the treatment of obesity difficult to control only diet and exercise therapy Relates to food manufacturing.

The cause of obesity is due to the imbalance of nutrients ingested and the amount of calories that are not consumed accumulate in the body. It is known that body fat accumulates according to defects of adrenaline receptors and innate qualities and constitutions. Among Korean traditional medicines that have been used traditionally in Korea, drugs that have sympathetic nerve activity regulating mechanisms are known, and in applying their effective prescriptions for the treatment of obesity, total saponin among ginseng components is the absorption of sugar and cholesterol from the stomach. It has the function of promoting the dissipation of absorbed energy and at the same time, it has indirect obesity prevention effect and also ginseng is used to prevent energy loss when losing weight in oriental medicine, which is based on ginseng and has anti-obesity effect It is an object of the present invention to develop an anti-obesity composite product exhibiting a synergistic effect by the addition.

In order to achieve this purpose, in the selection and use of herbal medicines that can be used to treat obesity without side effects, Korea has been developing oriental medicine and folk medicine considerably while belonging to Oriental medicine. Recently, herbal medicine used in oriental medicine and folk medicine As they show excellent physiological activity and have no side effects, they are increasingly interested in oriental medicine and folk medicine, and efforts to scientificize them are urgently required.

However, as far as substances related to the prevention and treatment of obesity in oriental medicine and folk medicine are known, many are known by oral rather than the literature, and there are not many studies reported using them for the prevention and treatment of obesity.

Therefore, in the present invention, the anti-obesity effect on the subjects anticipated to have an anti-obesity effect based on all the information in the literature and oral textbooks, and based on this, a combination preparation of several substances to increase the anti-obesity effect of the substances The body fat accumulated in the normal dietary process is considered in consideration of the negative perception of consumers due to excessive dietary restrictions and diuretics such as diuresis, and the yo-yo phenomenon that increases weight when the product is stopped. The basic concept is to develop obesity prevention or therapeutic products that can reduce weight by promoting consumption as a caloric metabolism.

The 12 kinds of herbal medicines selected primarily for the treatment of obesity are known to have high frequency of use, and their functions are mainly used to suppress appetite, diuresis, body fat reduction and stamina. Especially, in the case of ginseng It promotes the dissipation of absorbed energy and complements the stamina consumption from weight loss, and it has been found to have a sensation effect in Angelica, Ogapi, Sukjiwang, and green tea, including tofu, so that these medicinal herbs are freeze-dried and added to dietary feed. As a herbal medicine that is recognized as a weight-lowering effect by administering to the experimental animals (Sprague dawley: 200 ± 5g♂), added the water-soluble extracts of the leaves of the leaves of lettuce, worms, Angelica, sorghum, green tea, and green tea, which are expected to have a synergistic effect, After preparing a complex prescription product by adding vitamins which are expected to be tested, the effect was confirmed by animal experiments and clinical There are features of the present invention for the production of the actually a haptic effect in humans confirmed ginseng composite beverage product to test.

1 is a ginseng composite beverage manufacturing process of the present invention

Figure 2 is a ginseng saponin pattern for each beverage, capsule, tablet products of the ginseng composite product of the present invention

As a preferred method for expressing the efficacy of anti-obesity products, low-calorie diet, energy metabolism accelerator, and nutritional absorption inhibitor are used as basic directions, and the effect of reducing ginseng fat on body fat It is to select herbal medicines and functional ingredients to search for their efficacy and to develop ginseng and anti-obesity products at the level of fat containing the body fat resolution of each of these herbal medicines.

Dietary fiber functional materials and obesity-relieving herbal medicines in the selection of raw materials Six herbal medicines that were found to be effective in eliminating obesity among 12 herbal medicines frequently used among 44 herbal prescriptions. Was added to ginseng and the formulation of the product, the direction of manufacture and the optimum formulation conditions of the contents were set.

Functional materials include materials such as polydextrose, an indigestible polysaccharide, to promote digestive tract movement, to provide satiety and to suppress appetite, to reduce nutrient absorption, to promote intestinal contents, and to provide nutrients for intestinal microflora. It was intended to promote the dressing action.

For herbal medicines, the first experiment was conducted on the physicochemical components of herbal medicines by the Ginseng and Tobacco Research Institute. School of Medicine).

In the experiments on anti-obesity by herbal medicines, the old prescription, bodily sensation of bodily sensation, bodily sensation dehumidification bath, bodily sensation qitang, bodily sensation Botang, bodily sensation guktangtang, bodily sensation defense Tongseong-san, Banggi Hwanggi-tang, Kamibanha-tang, etc. The experimental herbal materials used were ginseng, tree barrel, yellow ginseng, safflower, joiner, donkey, cheongung, baekboknyeong, licorice, ogapi, tofu, and chason water-soluble extract dry powder. dawley, ♂, weight 200 ± 5g) were used to investigate the changes in triglyceride (TG) and cholesterol contents, including body weight, body fat content and energy consumption for 14 days.

Herbal medicines that have been found to have anti-obesity effects through animal experiments include ginseng extract, ogapi, tofu, Angelica, sage, and green tea. The ginseng complex of each of them was selected as a medicinal herb in ginseng complex for 14 days at the Gunsan University Department of Food and Nutrition, and the body fat reduction effect was confirmed. Clinical trials were carried out in this study to confirm that the herbal medicine selected herein has a body fat reducing effect and no side effects on the human body was used as a raw material of the ginseng composite beverage of the present invention.

In the properties of the herbal medicines and subsidiary ingredients added to the ginseng composite beverage of the present invention, ginseng and herbal medicines Angelica, Tofu, Ogapi, Sukjihwang, green tea as described above, the anti-obesity effect was confirmed by animal and clinical experiments, the upper leaf fat It has the effect of enhancing energy activity of cells and lowering cholesterol in blood (Anti-obesity effect was also confirmed in Kyung Hee University Medical School with upper leaf as a component of ginseng complex). It is especially effective in activating lipid metabolism and reducing body fat. (Japan Agricultural Research and Development Institute, 393rd Conference of the 3rd Conference of the Society of Agricultural Science, 1995) Silk peptide is used as a diabetic food as a water-soluble powder. It lowers cholesterol and supplies natural amino acids. Citric acid is a glycogen under the action of phosphoprokinase. It inhibits degradation and increases the synthesis efficiency of glycogen (J. Nutr. Sci. Vitaminol 32: 343-353, 1986), and maltitol is stable to heat, acid and alkali, has a soft and mild sweetness and is indigestible It has the effect of non-cavity, so it was used as a raw material of ginseng compound drink.

The formulation of the present invention was made into a ginseng composite beverage product in consideration of the convenience of taking and carrying by the consumer based on the scientific research results and the literature as described above.

Ginseng complex beverage products are water-soluble extracts of ginseng extract (products of Korea Ginseng Corp.) and herbal medicines that have been proven to have an obesity effect, upper leaf extract, poly-dextrose, silk peptide, vitamin, The first prototypes were prepared using sweeteners, flavors, etc., and then the sensory tests were conducted several times to select the ingredients and ratios of the final products.

Table 1. Compounded Components and Ratio of Ginseng Complex Drink

Raw material Ginseng A Ginseng B Remarks g % g % Ginseng Ext.Ogapi Ext.Tobacco Ext.Dangguk Ext.Suji Sulfur Ext.Green Tea Ext.Upper Leaf Ext.Hydrochlorinated Hydrochlorinate Na-P B) Fragrance (C) 0.3 to 0.61 to 51 to 50.2 to 1.00.2 to 0.81 to 50.3 to 10.001 to 0.0040.001 to 0.0040.008 to 0.0120.06 to 0.13 to 10-1 to 2.50.05 to 0.2 0.3 to 0.61 to 51 to 50.2 to 1.00.2 to 0.81 to 50.3 to 10.001 to 0.0040.001 to 0.0040.008 to 0.0120.06 to 0.13 to 10-1 to 2.50.05 to 0.2-- 0.3 to 0.61 to 51 to 50.2 to 1.00.2 to 0.81 to 50.3 to 10.001 to 0.0040.001 to 0.0040.008 to 0.0120.06 to 0.1-0.2 to 1.01 to 2.5-0.03 to 0.090.01 to 0.08 0.3 ~ 0.61 ~ 51 ~ 50.2 ~ 1.00.2 ~ 0.81 ~ 50.3 ~ 10.001 ~ 0.0040.001 ~ 0.0040.008 ~ 0.0120.06 ~ 0.1-0.2 ~ 1.01 ~ 2.5-0.03 ~ 0.090.01 ~ 0.08 Solid content 64% Solid content 64% Solid content 64% Solid content 64% Solid content 64% Solid content 64% Solid content 64 %% by weight Ginseng Ext. Is manufactured by Korea Ginseng Corporation Fruit mixLemonRaspberry system 100 g 100% 100 g 100%

The ginseng composite beverage manufacturing process is the same as FIG. 1 and the manufacturing method thereof is as follows.

The ginseng compound beverage is prepared by extracting and concentrating each raw material of herbal medicines, and the extract extract consists of 1 ~ 5% of Ogapi extract, 1 ~ 5% of Tofu extract, 0.2 ~ 1.0% of Angelica extract, and 0.2 ~ 0.8% of Sukji sulfur extract. Weigh and mix each herbal ingredient so that green tea extract 1 ~ 5%, upper leaf extract 0.3 ~ 1%, add 7 ~ 15 times purified water, extract twice at 60 ~ 90 ℃ for 5 hours, and collect the extracts at 5 ~ 10 ℃, Centrifuged at 8,000 rpm for 20 minutes, the supernatant was concentrated under reduced pressure up to 36% of water content at 60 ° C. or lower to produce a crude drug extract (64% solids), and ginseng extract (Ext solids 64%) in the proportion of the ingredients shown in Table 1 below. After weighing and mixing the herbal extract (64% solids) with functional supplements and fragrances, the filtrate is sterilized at 93 ° C for 15 seconds and then filled into a container, sterilized at 80 ° C for 20 minutes, and then packaged to produce a product.

On the other hand, instead of adding 3-10% of polydextrose (Type A beverage), 0.2-1.0% of silk peptide (Type B beverage) can be added and mixed in fragrance. Instead of adding 0.05 to 0.2% of fruit mix (type A beverage), you can add lemon (0.03 to 0.09%) and raspberry (0.01%) to 0.08% (type B beverage).

Ginseng extract, herbal medicine, anti-obesity functional material, and other supplementary ingredients that have been confirmed to reduce weight are shown in Table 2.

Table 2. Characteristics of Ginseng Complex Drink

division Characteristics Flavor Ginseng, herbal medicine, vitamin and bitter, sour, fruit flavor shape Brown drink Ginseng Extract 0.47 g PH (pH) 3.76 (A), 4.15 (B) Sugar (° Bx) 16.8 (A), 13.5 (B) dosage 1 bottle / 1 time, 3 times / 1 day Packing unit 100 ml / bottle

The pattern of ginseng saponin (Total Ginseng Saponin Pattern) of the ginseng composite beverage according to the present invention is as shown in FIG.

Ginseng extract increased appetite, but body fat did not change when ginseng extract powder was added to high-fat diet prepared separately in primary experimental animals. It was found that the amount of calories consumed is not accumulated as body fat, but the calorie consumption is increased by ginseng extract, so there is no change in body fat accumulation. This result indicates that ginseng extract has an effect of reducing body fat, and when the appetite suppression by ginseng extract is artificially reduced, substantial body fat accumulation due to calorie consumption decreases. In addition, in order to confirm the anti-obesity effect of the 12 kinds of selected herbal medicines, the water-soluble extracts were added to the high fat diet by 1% each, and when administered to the experimental animals, there were statistically significant effects on the neck, head, and green tea. It was also confirmed that there was some anti-obesity effect in Dongguk, Hwanggi, and Paekbokyeong.

In this experiment, the raw herbal medicine with body fat reduction effect was used as a ginseng compound, and the animal experiment was conducted at the Department of Food and Nutrition, Kunsan National University, and the clinical experiment was performed on the human body at the College of Medicine, Kyung Hee University. The effect was elucidated.

According to the study on the anti-obesity natural product search and body fat reduction effect of ginseng complex product of the present invention, which was conducted at Kunsan National University (Professor Ju Jong-jae, Department of Food and Nutrition), Ginseng complex prescription increased body fat. Two weeks of anti-obesity effects of ginseng complexes in animals (sprague-dawley male rats) were found. In general, complex prescriptions did not significantly reduce body fat accumulation. However, the combination prescription increased energy intake through food intake, but the increase in energy intake did not lead to an increase in body fat accumulation. In addition, the anti-obesity effect of ginseng complex products is suppressed when the increase of energy intake is suppressed. (Pair-feeding: two dogs are fed free and one ginseng is restricted to normal levels) Experimental results show that the multi-prescription drug reduces body fat by reducing body weight by 23% and body fat accumulation by 45%, which is achieved by increasing the consumption up to the accumulated energy rather than the energy consumed. The increase of is thought to be closely related to the increase of activity of the sympathetic nervous system by the complex prescription. In conclusion, the ginseng complex prescription developed in this study has a strong anti-obesity effect. It is found to be very effective if used in combination with proper diet control in practical terms.

On the other hand, an experiment on the effect of ginseng complex products on body fat reduction in obesity, conducted by Kyung Hee University College of Medicine (Dr. Obese patients with over 30% body fat were administered to observe the effect of reducing body fat, and the safety of the drug was investigated. For 20 obese patients, 4 weeks of diet, 4 weeks of diet and ginseng combination therapy were administered. The result was a 3.7% reduction from 70.04kg to 67.43kg, a 4.1% decrease in body mass index (BMI) from 27.12 to 26.01, a 1.47% decrease in waist / hip circumference ratio 0.8855 to 0.8758, and body fat from 35.16% to 31.68%. There was a significant decrease of 9.9%. In addition, no significant changes were found in the biochemical tests before and after the administration to see if there were serious adverse effects on the medications. A few patients complained of sympathetic and gastrointestinal symptoms. The amount was slight. Plasma epinephrine (hormone secreted by the adrenal cortex) increased to 0.27 dl / ml in the endocrinological examination, and the weight loss caused by ginseng complex products is thought to be caused by the sympathetic nervous system rather than the adrenal gland.

In conclusion, administration of ginseng complex in obese patients showed a significant weight loss effect when combined with diet, and there were few side effects.

In conclusion, the ginseng complex of the present invention acts on the sympathetic nervous system without side effects, increases energy consumption and reduces weight loss, especially in combination with diet. If you can lose weight effectively.

Claims (2)

Extract and concentrate the raw materials of each medicinal herb, and the extract extract (solid content 64%) consists of 1 ~ 5% of Ogapi Extract, 1 ~ 5% of Tortilla Extract, 0.2 ~ 1.0% of Angelica Extract, 0.2 ~ 0.8% of Sukji Hwang Extract. , Weigh and mix each herbal medicine to make green tea extract 1 ~ 5%, upper leaf extract 0.3 ~ 1%, add 7 ~ 15 times purified water, extract twice at 60 ~ 90 ℃ for 5 hours, and collect the extracts at 5 ~ 10 ℃, The supernatant centrifuged at 8,000 rpm for 20 minutes was concentrated under reduced pressure at 60 ℃ or lower, and the herbal extract (solid content 64%), ginseng extract (solid content 64%) 0.3-0.6%, and hydrochloric acid amine 0.001-0.004%. Riboflavin Na-P 0.001-0.004%, pyridoxine hydrochloride 0.008-0.012%, citric acid 0.06-0.1%, polydextrose 3-10%, functional aid maltitol 1-2.5 Method for producing a diet ginseng complex beverage, characterized in that to fill the container so that the final amount is 100% after weighing and mixing 0.05% to 0.2% of the fruit flavor mixed fruit (Fruit mix). Herb extract (1-5%), duvet extract (1-5%), Angelica extract (0.2-1.0%), Sukji sulfur extract (0.2-0.8%), green tea extract (1-5%), leaf extract (0.3-1%), herbal extract (64% solids) Ginseng extract (solid content 64%) 0.3-0.6%, and hydrochloric acid amine 0.001-0.004%. Riboflavin Soda-P 0.001 to 0.004%, pyridoxine hydrochloride 0.008 to 0.012%, citric acid 0.06 to 0.1%, polydextrose 3 to 10%, functional aid maltitol 1 to 2.5 Diet ginseng complex drink characterized in that the mixture of the fruit and fruit (Fruit mix) flavoring 0.05% to 0.2% and then purified water in a container so that the final amount is 100%.