KR20010000390A - Skin Improvement Composition Including Anti-Aging and Anti-Acne with Kimchi Extract - Google Patents

Abstract

PURPOSE: A mixed composition containing Kimchi extract for skin improvement including aging and comedones is provided, which shows good synergic skin improvement effect even with a small quantity, overcomes appearance change during preservation of products, and does not give irritation on skin. CONSTITUTION: A process for the preparation of Kimchi extract comprises: cutting fresh Kimchi which is ripened fermentatively at 3-5°C for 4weeks into fine pieces, and soaking into 80% acetone(or 80% methanol) solution; extracting for 10days, and concentrating the extract with a decompression-concentrator; filtering with a filter sheath(Whatman No.1) to eliminate precipitates, and drying under decompression to get the objective Kimchi extract. The mixed composition for skin improvement including aging and comedones contains Kimchi extract and fruit acid in the weight % ratio of 1:0.1-10, desirably 1:1-5. The compound of Kimchi extract and fruit acid can be added in a softening lotion, an emotional lotion, a nutrient cream, a massage cream, an essence, or a pack in the content of 0.01-10.0wt.%, desirably 0.1-3.0wt.% based on the total weight of each preparation.

Description

Skin Improvement Composition Including Anti-Aging and Anti-Acne with Kimchi Extract}

The present invention relates to a skin improving agent mixed composition including aging and acne, more specifically, as a main component containing kimchi extract extracted from fermented aged kimchi at 3 ~ 5 ℃ for 4 weeks, and contains fruit acid as an auxiliary component It relates to a skin improver mixed composition comprising aging and acne.

Acne is an inflammatory disease that occurs in the hair follicle sebaceous glands of the skin and is caused by the relationship between male hormones, keratin production, sebum and bacteria.As a result of male hormones, acne production increases in the upper cells of the hair follicles, and at the same time the sebum secretion increases. It is like a stopper, the sebum is difficult to come out, and the pores and sebaceous glands become swollen. This stopper is called a cotton cloth. The color of the cotton cloth is white or black depending on the degree of closure. When the hair is clogged, the growth of bacteria is easy, and the growth of this bacteria is easy, and the sebum is broken down by bacteria. It becomes free fatty acid and free fatty acid irritates the walls of the hair follicles and goes deep into the skin to cause inflammation. Inflammatory acne bulges red around the scalp and destroys the wall of the pores, leaving a final scar. It also increases the activity of the 5-alpha-redactase enzyme, which converts testosterone into dehydrotestosterone, and increases blood levels of toxins absorbed from the intestine. In general, when acne becomes severe, tetracycline or macrolide antibiotics are used a lot. When antibiotics are used for a long time, candida, which is a fungus in the intestine, grows and acne worsens, and various drugs such as stress, corticosteroids, It is worsened by cosmetics.

Therefore, it is noted that by inhibiting the activity of 5-alpha-dactactase enzyme and male hormone, sebum production and its keratin production can be inhibited. Therefore, hydroquinone, trethioin, salicylic acid, hydrogen peroxide, Some methods of using ascorbic acid, fruit acid, topical antibiotics, steroid hormone ointment as inhibitors of sebum secretion activity have been used. However, if the above components are used, there is a problem in safety of the skin, because the increase in the blood lines, the pores are enlarged, itching occurs and the immunity of the skin is lowered. In the case of using a small amount of the active ingredient, there was a disadvantage in that sufficient skin improvement effects could not be obtained.

Therefore, it is necessary to develop a skin improver including aging and acne without using a small amount than the existing skin improver and having an excellent skin improvement effect and no side effects such as irritation to the skin.

The inventors of the present invention solve the problems of the skin improver material including the skin problems such as aging and acne, and to find a better raw material for skin improver, among the various natural products that are effective in preventing skin problems such as aging and acne As a result, Kimchi extract, our unique food, can be used as 5-alpha-dactase enzyme, the activity and sebum production of male hormone and thus keratin production inhibitors among skin improvement raw materials that can be used in cosmetics. I found out.

In addition, the present inventors can not only compensate for the shortcomings of the existing skin improvement ingredients due to the skin improvement effect between the two components when using a combination of the existing skin improver ingredients and kimchi extract, the desired skin improvement with a small amount of the combination It was confirmed that the effect can be obtained and completed the present invention.

Therefore, an object of the present invention is to provide a skin-modifying composition for cosmetics having a skin improvement effect, including excellent acne and anti-aging, and no side effects such as skin irritation while using a smaller amount than the existing skin improver.

The present invention contains a kimchi extract extracted from kimchi as a main component, and provides a mixed skin improver composition, including acne and aging prevention, characterized in that it contains fruit acid as an auxiliary component.

Kimchi used in the present invention is already marketed as an edible food in Korea, etc. of origin, and according to a recent study, kimchi extract has an antioxidant effect, cancer prevention, anticancer effect, immune enhancing effect, intestinal action, cancer cell metastasis effect, autologous It is known for its detoxification, antibacterial and antimutagenic properties.

The skin improver composition according to the present invention can be applied to softening cosmetics (skin), nourishing cosmetics (lotion), nutrition cream, massage cream, essence or pack.

The present invention will be described in more detail as follows.

In order to obtain an extract from kimchi in the present invention, a method of extracting kimchi at least one solvent selected from polar solvents such as water, hydrous or anhydrous lower alcohols having 1 to 4 carbon atoms, ethyl acetate and acetone and drying under reduced pressure Among them, acetone or methanol is preferably used as the extraction solvent.

Hereinafter, the present invention will be described in more detail based on the following extraction examples, experimental examples and examples. However, these examples are only for the understanding of the present invention, but the scope of the present invention in any sense is not limited to these examples.

Extraction Example 1

15 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. for 4 weeks was finely chopped, soaked in 13 L of an aqueous 80% acetone solution, and extracted at room temperature for 10 days. The extract was concentrated with a vacuum concentrator and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 150 g of extract.

Extraction Example 2

7 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. for 4 weeks was finely chopped, soaked in 5 L of 80% methanol aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a vacuum concentrator and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 250 g of extract.

Extraction Example 3

For 4 weeks, 4.2 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. were finely chopped, soaked in 4 L of 80% acetone aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a vacuum concentrator and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 115 g of extract.

Extraction Example 4

For 4 weeks, 2 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. were finely chopped, soaked in 2 L of 80% methanol aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a vacuum concentrator and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 190 g of extract.

Extraction Example 5

2.5 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. for 4 weeks was finely chopped, soaked in 2.5 L of 80% acetone aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a vacuum condenser and then filter paper (Whatman No. 1 Precipitate was removed and dried under reduced pressure to obtain about 120 g of extract.

Extraction Example 6

2.5 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. for 4 weeks was finely chopped, soaked in 2.5 L of 80% aqueous methanol solution, and extracted at room temperature for 10 days. The extract was concentrated under a reduced pressure concentrator, and then the filter paper (Whatman No. 1 ) To remove the precipitate and dried under reduced pressure to obtain about 350 g of extract.

Extraction Example 7

53 kg of fresh kimchi fermented and fermented at 3 to 5 ° C. for 4 weeks was finely chopped, soaked in 50 L of 80% acetone aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a pressure reducer, filtered through a strain of Whatman No. 1 to remove the precipitate, and dried under reduced pressure to obtain about 740 g of extract.

Extraction Example 8

10 kg of fresh kimchi fermented and fermented at 3-5 ° C. for 4 weeks was finely chopped, soaked in 10 L of 80% methanol aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a pressure reducer and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 820 g of the extract.

Extraction Example 9

For 4 weeks, 48.5 kg of fresh kimchi fermented and aged at 3 to 5 ° C. was finely chopped, and then dipped in 50 L of 80% acetone aqueous solution and extracted at room temperature for 10 days. The extract was concentrated with a vacuum concentrator and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 1540 g of extract.

Extraction Example 10

10 kg of fresh kimchi fermented and fermented at 3-5 ° C. for 4 weeks was finely chopped, soaked in 10 L of 80% methanol aqueous solution, and extracted at room temperature for 10 days. The extract was concentrated with a vacuum concentrator and then filtered through a filter paper (Whatman No. 1) to remove the precipitate and dried under reduced pressure to obtain about 310 g of extract.

In the mixed skin improvement composition according to the present invention, the blending ratio of fruit acid as an auxiliary component and kimchi extract as a main component is 1: 0.1 to 10, preferably 1: 1 to 5 by weight.

The blend of fruit acid and kimchi extract mixed in the above-described blending ratio may be added to softened longevity (skin), nutritious longevity (lotion), nourishing cream, massage cream, essence or pack, etc., and the total weight of each body type It may generally contain 0.01 to 10.0% by weight, preferably 0.1 to 3.0% by weight.

The inhibitory effect of 5-alpadocactase of the mixed skin improvement composition according to the present invention can be obtained by the methods described in the literature, for example, by H. S. Mason and T. Nagath. Mason, Biochem. Biophysics. Acta. 111, 134 (1965); T. Nagath, Experimentia, 28 (6), 634 (1972)].

The present invention will be described with reference to the following examples, but the present invention is not limited thereto, and various embodiments and changes can be made without departing from the spirit and scope of the present invention. Kimchi extract of the following example is used as a reference to the extraction example 1.

EXAMPLE

Composition Example 1: Nourishing Cream

Content (% by weight)

Kimchi Extract 2.0

Fruit acid 1.0

Liquid paraffin 6.0

Squalane 4.0

Sorbitan Sesquioleate0.5

Polysorbate 601.5

Beeswax 10.0

Capricic / Capric Triglycerides5.0

Concentrated glycerin6.0

Propylene Glycol 3.0

Butylene Glycol2.0

Triethanolamine 0.2

Preservative traces

A small amount of pigment

A small amount of spices

Purified Water Balance

Using the above ingredients to prepare the desired nutrition cream according to the conventional method in the cosmetic manufacturing field.

Composition Example 2: Nutrients (Lotion)

Content (% by weight)

Kimchi Extract 1.0

Fruit acid 1.0

Cetanol1.0

Stearyl Alcohol 1.0

Glycerin Monostearate 3.0

Sorbitan Monostearate 1.0

Polyoxyethylene sorbitan monooleate 2.0

Vaseline 2.0

Liquid paraffin 6.0

Squalane 5.0

Octyldodecyl Myristate 5.0

Glycerin5.0

1,3-butylene glycol 5.0

Carboxy Vinyl Polymer 0.3

Triethanolamine0.3

Preservative

A small amount of pigment

Trace amount

Purified water balance

Using the above ingredients to prepare the desired nutrient cosmetics according to a conventional method in the cosmetic manufacturing field.

Composition Example 3: Softening Longevity (Skin)

Content (% by weight)

Kimchi Extract 1.0

Fruit acid 1.0

Concentrated glycerin2.0

Propylene Glycol 3.0

Butylene Glycol2.0

Ethanol 10.0

Carboxy Vinyl Polymer 0.1

Triethanolamine 0.1

Preservative

A small amount of pigment

Trace amount

Purified water balance

Using the above ingredients to prepare the desired softening cosmetics according to the conventional method in the cosmetic manufacturing field.

Composition Example 4: Essence

Content (% by weight)

Kimchi Extract 3.0

Fruit acid 1.0

Propylene Glycol5.0

Glycerin10.0

1,3-butylene glycol 10.0

Polyethylene Glycol 15005.0

Carboxy Vinyl Polymer0.5

Hydroxyethyl Cellulose0.5

Triethanolamine0.5

Ethanol 5.0

Polyoxyethylene Nonylphenyl Ether 0.7

Preservative

A small amount of pigment

Trace amount

Purified water balance

The above ingredients were used to prepare the desired essence according to conventional methods in the field of cosmetic manufacture.

Composition Example 5: Massage Cream

Content (% by weight)

Kimchi Extract0.5

Fruit acid0.5

Liquid paraffin 40.0

Souk Alan 5.0

Sorbitan Sesquioleate 0.8

Polysorbate 601.5

Beeswax 10.0

Capric & Capric Triglycerides 4.0

Concentrated glycerin6.0

Propylene Glycol2.0

Butylene Glycol4.0

Triethanolamine 0.2

Preservative

A small amount of pigment

Trace amount

Purified water balance

Using the above ingredients to prepare the desired massage cream according to a conventional method in the cosmetic manufacturing field.

Composition Example 6: Pack

Ingredient Content (wt%)

Kimchi Extract0.5

Fruit acid 1.0

Allantoin0.2

Ethanol 5.0

Nonylphenyl Ether0.3

Sodium Carboxymethyl Cellulose0.2

Polyvinyl Alcohol 13.0

Preservative

A small amount of pigment

Trace amount

Purified water balance

Using the above ingredients, the desired pack was prepared according to a conventional method in the cosmetic manufacturing field.

Performance Evaluation Test

Inhibitory Effects of Kimchi Extracts and Fruit Acids on 5-alpha-dactactase

Inhibition of 5-alpha-dacactase activity of the mixed skin improvement composition of the present invention was carried out according to the method of Mason (H.S. Mason) and Nagas (T. Nagath). As a test skin improver, a combination composition was used in which the concentration of fruit acid was fixed at 0.03% and the concentration of kimchi extract was changed to 0.02, 0.04, 0.10, 0.16 and 0.20%. 0.1 ml of doctase solution (5 mg of 5-alpha-dactactase 3400 unit / solid mg in 10 ml of 1/15 M phosphate buffer solution) and 0.9 ml of 1/15 M phosphate buffer (pH 6.8) The mixture was preheated at 37 ° C. for 10 minutes, and then 1 ml of 0.03% Testosterone solution was added and reacted at 37 ° C. for 10 minutes. In this case, 1 ml of 1 / 15M phosphate buffer (pH 6.8) was added to the control group instead of each skin improvement sample. After the reaction, the absorbance of the reaction mixture was measured at 470 nm using an absorption spectrometer (UVT06856, MICROPLATE READER from MOLECULAR DEVICE). The inhibition rate of 5-alpha-dactactase activity of each skin improver sample was obtained by the following formula.

5-Alpha dactase activity inhibition rate (%) = 100- (response absorbance of each skin improver sample) / (control absorbance of control) * 100

The results are shown in Table 1 below.

TABLE 1

Inhibitory Activity of 5-alpha-dactase According to the Concentration of Kimchi Extract and Fruit Acid

density(%) Inhibition rate of 5-alpha-dactase activity 0.02 30.1 ± 0.5 0.04 50.3 ± 0.8 0.10 69.3 ± 0.7 0.16 83.1 ± 0.6 0.20 88.7 ± 0.8

Twenty males were used as test subjects, and the area of 2 cm × 2 cm acne on the right face was washed well with 70% ethanol solution. Each of the same base as the composition of Examples 1, 4, and 5 was added to one of three lines of acne, except that kimchi extract and fruit acid were not added to the other line. Four times a week was applied. Four weeks later, the degree of skin improvement was visually determined by comparison with the control group (gigi-do). The criterion was evaluated in three stages: significant inhibitory effect, slight inhibitory effect, and no inhibition. The results are shown in Table 2 below.

TABLE 2

Acne Inhibitory Effect (Unit: Persons)

Significant inhibitory effect Slight inhibitory effect No inhibitory effect Example 1 15 4 One Example 4 8 7 5 Example 5 12 5 3

As can be seen from the results of Table 2, in the case of the compositions of Examples 1, 4, and 5 according to the present invention, it was confirmed that at least 16 or more of them were remarkable or had acne inhibitory effects and skin improvement effects.

Claims (6)

A mixed skin improvement composition comprising kimchi extract extracted from kimchi as a main component and containing fruit acid as an auxiliary component. The method of claim 1, wherein the blending ratio of the fruit acid and the kimchi extract is A mixed composition comprising skin problems such as acne and aging, which is 1: 0.1 to 10. The composition according to claim 1, which is obtained by extracting the Jimnem leaf with one or more solvents selected from water, hydrous or anhydrous lower alcohols having 1 to 4 carbon atoms, ethyl acetate, and acetone. The composition of claim 5 wherein the solvent is acetone or methanol. The composition of claim 1 wherein the formulation is an external ointment for skin. The composition of claim 1, wherein the formulation is one selected from softening cream, nutrient cream, nourishing cream, massage cream, essence and pack.