KR20000068415A - 매트릭스 메탈로프로테이나제 억제용 화합물 및 방법 - Google Patents

Info

Publication number

KR20000068415A

KR20000068415A KR1019997001757A KR19997001757A KR20000068415A KR 20000068415 A KR20000068415 A KR 20000068415A KR 1019997001757 A KR1019997001757 A KR 1019997001757A KR 19997001757 A KR19997001757 A KR 19997001757A KR 20000068415 A KR20000068415 A KR 20000068415A

Authority

KR

South Korea

Prior art keywords

dibenzofuran

sulfonylamino

acid

phenyl

hexanoic acid

Prior art date

1996-09-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 title claims abstract description 115
• 238000000034 method Methods 0.000 title claims abstract description 52
• 102000002274 Matrix Metalloproteinases Human genes 0.000 title claims abstract description 38
• 108010000684 Matrix Metalloproteinases Proteins 0.000 title claims abstract description 38
• 230000002401 inhibitory effect Effects 0.000 title claims abstract description 5
• 150000001413 amino acids Chemical class 0.000 claims abstract description 18
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 15
• 201000011510 cancer Diseases 0.000 claims abstract description 14
• 208000037260 Atherosclerotic Plaque Diseases 0.000 claims abstract description 12
• 206010019280 Heart failures Diseases 0.000 claims abstract description 12
• 206010052428 Wound Diseases 0.000 claims abstract description 10
• 208000027418 Wounds and injury Diseases 0.000 claims abstract description 10
• 206010003246 arthritis Diseases 0.000 claims abstract description 10
• 230000001684 chronic effect Effects 0.000 claims abstract description 10
• 208000025865 Ulcer Diseases 0.000 claims abstract description 9
• 208000007474 aortic aneurysm Diseases 0.000 claims abstract description 9
• 208000027866 inflammatory disease Diseases 0.000 claims abstract description 9
• 210000000265 leukocyte Anatomy 0.000 claims abstract description 9
• 230000005747 tumor angiogenesis Effects 0.000 claims abstract description 9
• 231100000397 ulcer Toxicity 0.000 claims abstract description 9
• 208000023275 Autoimmune disease Diseases 0.000 claims abstract description 8
• 206010027476 Metastases Diseases 0.000 claims abstract description 8
• 208000004210 Pressure Ulcer Diseases 0.000 claims abstract description 8
• 230000001363 autoimmune Effects 0.000 claims abstract description 8
• 201000007717 corneal ulcer Diseases 0.000 claims abstract description 8
• 230000009545 invasion Effects 0.000 claims abstract description 8
• 230000009401 metastasis Effects 0.000 claims abstract description 8
• 201000006417 multiple sclerosis Diseases 0.000 claims abstract description 8
• 208000028169 periodontal disease Diseases 0.000 claims abstract description 8
• 208000037803 restenosis Diseases 0.000 claims abstract description 8
• 206010064996 Ulcerative keratitis Diseases 0.000 claims abstract description 6
• 206010011985 Decubitus ulcer Diseases 0.000 claims abstract description 4
• -1 6- (2-cyclopent-1-enyl-acetylamino) -2- (dibenzofuran-2-sulfonylamino) -hexanoic acid Chemical compound 0.000 claims description 40
• 229910052739 hydrogen Inorganic materials 0.000 claims description 27
• 239000001257 hydrogen Substances 0.000 claims description 27
• 239000000203 mixture Substances 0.000 claims description 23
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
• 229940024606 amino acid Drugs 0.000 claims description 17
• 150000003839 salts Chemical class 0.000 claims description 13
• 150000001408 amides Chemical class 0.000 claims description 12
• 229910052736 halogen Inorganic materials 0.000 claims description 12
• 150000002367 halogens Chemical class 0.000 claims description 12
• 150000002148 esters Chemical class 0.000 claims description 11
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 9
• 229940002612 prodrug Drugs 0.000 claims description 9
• 239000000651 prodrug Substances 0.000 claims description 9
• 125000001072 heteroaryl group Chemical group 0.000 claims description 8
• 150000002431 hydrogen Chemical class 0.000 claims description 8
• 229910052717 sulfur Inorganic materials 0.000 claims description 8
• 125000003118 aryl group Chemical group 0.000 claims description 7
• 230000005764 inhibitory process Effects 0.000 claims description 6
• 125000001624 naphthyl group Chemical group 0.000 claims description 4
• 229910052760 oxygen Inorganic materials 0.000 claims description 4
• YPOJAHGDLHWILP-IBGZPJMESA-N (2s)-2-(dibenzofuran-2-ylsulfonylamino)-4-phenylbutanoic acid Chemical compound C([C@@H](C(=O)O)NS(=O)(=O)C=1C=C2C3=CC=CC=C3OC2=CC=1)CC1=CC=CC=C1 YPOJAHGDLHWILP-IBGZPJMESA-N 0.000 claims description 3
• XDLSSXYTUMNOHY-AWEZNQCLSA-N (3s)-3-[(dibenzofuran-2-ylsulfonylamino)methyl]-5-methylhexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC[C@@H](CC(C)C)CC(O)=O)=CC=C3OC2=C1 XDLSSXYTUMNOHY-AWEZNQCLSA-N 0.000 claims description 3
• JENZVHXFRQGOFL-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-2-phenylacetic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)C1=CC=CC=C1 JENZVHXFRQGOFL-UHFFFAOYSA-N 0.000 claims description 3
• SJPXJSANXSAHSU-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-3-(4-fluorophenyl)propanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CC1=CC=C(F)C=C1 SJPXJSANXSAHSU-UHFFFAOYSA-N 0.000 claims description 3
• COJSFTGHLOFDLF-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid Chemical compound C1=CC(OC(C)(C)C)=CC=C1CC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 COJSFTGHLOFDLF-UHFFFAOYSA-N 0.000 claims description 3
• SDUOASNEYVEUJP-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-3-phenylmethoxypropanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)COCC1=CC=CC=C1 SDUOASNEYVEUJP-UHFFFAOYSA-N 0.000 claims description 3
• CHJPBQOZZLPRAI-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-oxo-4-(4-propylphenyl)butanoic acid Chemical compound C1=CC(CCC)=CC=C1C(=O)CC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 CHJPBQOZZLPRAI-UHFFFAOYSA-N 0.000 claims description 3
• YPOJAHGDLHWILP-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-phenylbutanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC1=CC=CC=C1 YPOJAHGDLHWILP-UHFFFAOYSA-N 0.000 claims description 3
• SRZSAFSUWTXQMW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(2,2-diphenylethylamino)-5-oxopentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCC(C=1C=CC=CC=1)C1=CC=CC=C1 SRZSAFSUWTXQMW-UHFFFAOYSA-N 0.000 claims description 3
• LRTMILMJYXVICS-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(2-hydroxypropylamino)-5-oxopentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCC(=O)NCC(O)C)C(O)=O)=CC=C3OC2=C1 LRTMILMJYXVICS-UHFFFAOYSA-N 0.000 claims description 3
• AKGOCXPAZXSPOW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(2-methylbutylamino)-5-oxopentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCC(=O)NCC(C)CC)C(O)=O)=CC=C3OC2=C1 AKGOCXPAZXSPOW-UHFFFAOYSA-N 0.000 claims description 3
• MTRHSROQRITLBQ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(4-methylpentan-2-ylamino)-5-oxopentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCC(=O)NC(C)CC(C)C)C(O)=O)=CC=C3OC2=C1 MTRHSROQRITLBQ-UHFFFAOYSA-N 0.000 claims description 3
• DMQDCKWVHYQISX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(phenylmethoxycarbonylamino)pentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCNC(=O)OCC1=CC=CC=C1 DMQDCKWVHYQISX-UHFFFAOYSA-N 0.000 claims description 3
• WGWURNSXKJRMJU-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-[(2-methoxyphenyl)methylamino]-5-oxopentanoic acid Chemical compound COC1=CC=CC=C1CNC(=O)CCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 WGWURNSXKJRMJU-UHFFFAOYSA-N 0.000 claims description 3
• PUWFHONXMCBSPN-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-[(4-methylphenyl)sulfonylamino]pentanoic acid Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 PUWFHONXMCBSPN-UHFFFAOYSA-N 0.000 claims description 3
• RKWQDCZIHNOUDQ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-[2-(1-methylpyrrol-2-yl)ethylamino]-5-oxopentanoic acid Chemical compound CN1C=CC=C1CCNC(=O)CCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 RKWQDCZIHNOUDQ-UHFFFAOYSA-N 0.000 claims description 3
• HDXHPZRRHOAZES-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-[2-(dimethylamino)ethylamino]-5-oxopentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCC(=O)NCCN(C)C)C(O)=O)=CC=C3OC2=C1 HDXHPZRRHOAZES-UHFFFAOYSA-N 0.000 claims description 3
• HDHGKKSSTJLVPS-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-oxo-5-(2-phenylethylamino)pentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCCC1=CC=CC=C1 HDHGKKSSTJLVPS-UHFFFAOYSA-N 0.000 claims description 3
• OGJYDFVQYYKOEE-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-oxo-5-(2-pyridin-4-ylethylamino)pentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCCC1=CC=NC=C1 OGJYDFVQYYKOEE-UHFFFAOYSA-N 0.000 claims description 3
• ZLNOARBTWFZMLC-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-oxo-5-(2-thiophen-2-ylethylamino)pentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCCC1=CC=CS1 ZLNOARBTWFZMLC-UHFFFAOYSA-N 0.000 claims description 3
• ZWEPYHCGARNIDW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-oxo-5-(4-phenylbutylamino)pentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCCCCC1=CC=CC=C1 ZWEPYHCGARNIDW-UHFFFAOYSA-N 0.000 claims description 3
• CQOICWRPIYBULF-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-oxo-5-(4-propylanilino)pentanoic acid Chemical compound C1=CC(CCC)=CC=C1NC(=O)CCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 CQOICWRPIYBULF-UHFFFAOYSA-N 0.000 claims description 3
• IEZZTTCMBWIYEC-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-oxo-5-(thiophen-2-ylmethylamino)pentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCC1=CC=CS1 IEZZTTCMBWIYEC-UHFFFAOYSA-N 0.000 claims description 3
• KTBUWUJBOXSXNR-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(2-methylpropoxycarbonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)OCC(C)C)C(O)=O)=CC=C3OC2=C1 KTBUWUJBOXSXNR-UHFFFAOYSA-N 0.000 claims description 3
• YEPAWRGTEBVAEZ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(2-phenoxybutanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(O)=O)CCCCNC(=O)C(CC)OC1=CC=CC=C1 YEPAWRGTEBVAEZ-UHFFFAOYSA-N 0.000 claims description 3
• NRXAXCZPWVAPDR-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(2-phenylbutanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(O)=O)CCCCNC(=O)C(CC)C1=CC=CC=C1 NRXAXCZPWVAPDR-UHFFFAOYSA-N 0.000 claims description 3
• KJFFSAMWNSAFLX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(2-phenylethenylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNS(=O)(=O)C=CC1=CC=CC=C1 KJFFSAMWNSAFLX-UHFFFAOYSA-N 0.000 claims description 3
• VMMQXFIQQBCZEK-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(3,3,3-triphenylpropanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 VMMQXFIQQBCZEK-UHFFFAOYSA-N 0.000 claims description 3
• YXCUPVJSRBXQQZ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(3-phenylprop-2-enoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)C=CC1=CC=CC=C1 YXCUPVJSRBXQQZ-UHFFFAOYSA-N 0.000 claims description 3
• GPSMOFOMKBFFPD-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(3-phenylpropanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCC1=CC=CC=C1 GPSMOFOMKBFFPD-UHFFFAOYSA-N 0.000 claims description 3
• OOWMSOXRLQBHJU-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(3-pyridin-4-ylpropanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCC1=CC=NC=C1 OOWMSOXRLQBHJU-UHFFFAOYSA-N 0.000 claims description 3
• UUJPYVXIRFHAFR-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(4-thiophen-2-ylbutanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCCC1=CC=CS1 UUJPYVXIRFHAFR-UHFFFAOYSA-N 0.000 claims description 3
• WMSIPIBCOFPIEL-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(6-phenylhexanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCCCCC1=CC=CC=C1 WMSIPIBCOFPIEL-UHFFFAOYSA-N 0.000 claims description 3
• MKGITNAOWOTDLE-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(9h-fluoren-9-ylmethoxycarbonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)OCC4C5=CC=CC=C5C5=CC=CC=C54)C(=O)O)=CC=C3OC2=C1 MKGITNAOWOTDLE-UHFFFAOYSA-N 0.000 claims description 3
• LUGWBOODZQKESV-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(naphthalen-1-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNS(=O)(=O)C=4C5=CC=CC=C5C=CC=4)C(=O)O)=CC=C3OC2=C1 LUGWBOODZQKESV-UHFFFAOYSA-N 0.000 claims description 3
• JQMYQNYDESVNOP-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(naphthalen-2-ylcarbamothioylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=S)NC=4C=C5C=CC=CC5=CC=4)C(=O)O)=CC=C3OC2=C1 JQMYQNYDESVNOP-UHFFFAOYSA-N 0.000 claims description 3
• RNSICHYXRFBCKS-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(naphthalen-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNS(=O)(=O)C=4C=C5C=CC=CC5=CC=4)C(=O)O)=CC=C3OC2=C1 RNSICHYXRFBCKS-UHFFFAOYSA-N 0.000 claims description 3
• MVDDWKMEAQHMRK-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(phenylcarbamoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)NC1=CC=CC=C1 MVDDWKMEAQHMRK-UHFFFAOYSA-N 0.000 claims description 3
• CPAXWZYVQBSDOD-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(phenylmethoxycarbonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)OCC1=CC=CC=C1 CPAXWZYVQBSDOD-UHFFFAOYSA-N 0.000 claims description 3
• ALMQENWFOJJCQE-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(pyridin-3-ylcarbamothioylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=S)NC1=CC=CN=C1 ALMQENWFOJJCQE-UHFFFAOYSA-N 0.000 claims description 3
• IKAUYSNMEWLNGX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(1-phenylcyclopropanecarbonyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)C1(C=2C=CC=CC=2)CC1 IKAUYSNMEWLNGX-UHFFFAOYSA-N 0.000 claims description 3
• FZOUYLLHFHPZDI-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-naphthalen-1-yloxyacetyl)amino]hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)COC=4C5=CC=CC=C5C=CC=4)C(=O)O)=CC=C3OC2=C1 FZOUYLLHFHPZDI-UHFFFAOYSA-N 0.000 claims description 3
• HOSXXBOASBEGAM-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-phenoxyacetyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)COC1=CC=CC=C1 HOSXXBOASBEGAM-UHFFFAOYSA-N 0.000 claims description 3
• HMHKHUNQFYTFFA-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-phenylacetyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC1=CC=CC=C1 HMHKHUNQFYTFFA-UHFFFAOYSA-N 0.000 claims description 3
• SNDIGWWLXHMQSH-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-pyridin-2-ylacetyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC1=CC=CC=N1 SNDIGWWLXHMQSH-UHFFFAOYSA-N 0.000 claims description 3
• ATAVAGZOGOKAAC-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-pyridin-3-ylacetyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC1=CC=CN=C1 ATAVAGZOGOKAAC-UHFFFAOYSA-N 0.000 claims description 3
• JKSGPZSPMJSVPL-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-pyridin-4-ylsulfanylacetyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CSC1=CC=NC=C1 JKSGPZSPMJSVPL-UHFFFAOYSA-N 0.000 claims description 3
• NRJXEHVDVCJWFL-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(3,4-dichlorophenyl)carbamoylamino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)NC1=CC=C(Cl)C(Cl)=C1 NRJXEHVDVCJWFL-UHFFFAOYSA-N 0.000 claims description 3
• RXOISJMDLIMNAM-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(4-fluorophenyl)sulfonylamino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNS(=O)(=O)C1=CC=C(F)C=C1 RXOISJMDLIMNAM-UHFFFAOYSA-N 0.000 claims description 3
• CLAMRBVWUQQDAY-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(4-methoxyphenyl)carbamoylamino]hexanoic acid Chemical compound C1=CC(OC)=CC=C1NC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 CLAMRBVWUQQDAY-UHFFFAOYSA-N 0.000 claims description 3
• NNIRCQIXFDXRIO-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(4-methoxyphenyl)sulfonylamino]hexanoic acid Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 NNIRCQIXFDXRIO-UHFFFAOYSA-N 0.000 claims description 3
• DWHWANYQSULZPQ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[3-(2-methoxyphenyl)propanoylamino]hexanoic acid Chemical compound COC1=CC=CC=C1CCC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 DWHWANYQSULZPQ-UHFFFAOYSA-N 0.000 claims description 3
• JAVKOMHYDZLWAO-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[3-(3,4-dimethoxyphenyl)propanoylamino]hexanoic acid Chemical compound C1=C(OC)C(OC)=CC=C1CCC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 JAVKOMHYDZLWAO-UHFFFAOYSA-N 0.000 claims description 3
• GINOMQNFRZQUEU-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[3-(4-methylphenyl)propanoylamino]hexanoic acid Chemical compound C1=CC(C)=CC=C1CCC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 GINOMQNFRZQUEU-UHFFFAOYSA-N 0.000 claims description 3
• GRBGXVIGTSHJNK-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[3-(diethylamino)propanoylamino]hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)CCN(CC)CC)C(O)=O)=CC=C3OC2=C1 GRBGXVIGTSHJNK-UHFFFAOYSA-N 0.000 claims description 3
• ISYGRERUFBRMRI-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[4-(4-nitrophenyl)butanoylamino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCCC1=CC=C([N+]([O-])=O)C=C1 ISYGRERUFBRMRI-UHFFFAOYSA-N 0.000 claims description 3
• RMYMVHKEXNIPSV-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-(2,4-dichlorophenoxy)acetyl]amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)COC1=CC=C(Cl)C=C1Cl RMYMVHKEXNIPSV-UHFFFAOYSA-N 0.000 claims description 3
• CQPZMQSGTMCLLW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-(2-phenylmethoxyphenyl)acetyl]amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC1=CC=CC=C1OCC1=CC=CC=C1 CQPZMQSGTMCLLW-UHFFFAOYSA-N 0.000 claims description 3
• OIRSIUQPVKOKCW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-(3,4-dimethoxyphenyl)acetyl]amino]hexanoic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 OIRSIUQPVKOKCW-UHFFFAOYSA-N 0.000 claims description 3
• NMDJIHJMEJGDIX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-(4-methoxyphenoxy)acetyl]amino]hexanoic acid Chemical compound C1=CC(OC)=CC=C1OCC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 NMDJIHJMEJGDIX-UHFFFAOYSA-N 0.000 claims description 3
• HEBZFDIZQHFSJO-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-(4-nitrophenoxy)acetyl]amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)COC1=CC=C([N+]([O-])=O)C=C1 HEBZFDIZQHFSJO-UHFFFAOYSA-N 0.000 claims description 3
• IQPDWXHYSLYWSL-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]amino]hexanoic acid Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1CC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 IQPDWXHYSLYWSL-UHFFFAOYSA-N 0.000 claims description 3
• BNMRYRLUFBNYFI-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[[2-[2-(trifluoromethyl)phenyl]acetyl]amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC1=CC=CC=C1C(F)(F)F BNMRYRLUFBNYFI-UHFFFAOYSA-N 0.000 claims description 3
• VGLXBFPXVGHONM-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)butanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CC)C(O)=O)=CC=C3OC2=C1 VGLXBFPXVGHONM-UHFFFAOYSA-N 0.000 claims description 3
• NDLHMLCMEBBXKC-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)pentanedioic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCC(=O)O)C(O)=O)=CC=C3OC2=C1 NDLHMLCMEBBXKC-UHFFFAOYSA-N 0.000 claims description 3
• GTMQOIKCXIIFNC-UHFFFAOYSA-N 5-(4-chloroanilino)-2-(dibenzofuran-2-ylsulfonylamino)-5-oxopentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NC1=CC=C(Cl)C=C1 GTMQOIKCXIIFNC-UHFFFAOYSA-N 0.000 claims description 3
• IQUQANKEWZGZNK-UHFFFAOYSA-N 5-(benzylamino)-2-(dibenzofuran-2-ylsulfonylamino)-5-oxopentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NCC1=CC=CC=C1 IQUQANKEWZGZNK-UHFFFAOYSA-N 0.000 claims description 3
• DTIKAPURNLOPGK-UHFFFAOYSA-N 5-(cyclopropylamino)-2-(dibenzofuran-2-ylsulfonylamino)-5-oxopentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC(=O)NC1CC1 DTIKAPURNLOPGK-UHFFFAOYSA-N 0.000 claims description 3
• REZRGUCAGQKDSR-UHFFFAOYSA-N 6-(1-adamantylcarbamothioylamino)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=S)NC45CC6CC(CC(C6)C4)C5)C(=O)O)=CC=C3OC2=C1 REZRGUCAGQKDSR-UHFFFAOYSA-N 0.000 claims description 3
• UQLLZBYSCGRCRT-UHFFFAOYSA-N 6-(1-adamantyloxycarbonylamino)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)OC45CC6CC(CC(C6)C4)C5)C(=O)O)=CC=C3OC2=C1 UQLLZBYSCGRCRT-UHFFFAOYSA-N 0.000 claims description 3
• XOMJTCOZOGDWGA-UHFFFAOYSA-N 6-(benzenesulfonamido)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNS(=O)(=O)C1=CC=CC=C1 XOMJTCOZOGDWGA-UHFFFAOYSA-N 0.000 claims description 3
• ISPZLYXOBXILKM-UHFFFAOYSA-N 6-(benzhydrylcarbamothioylamino)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=S)NC(C=1C=CC=CC=1)C1=CC=CC=C1 ISPZLYXOBXILKM-UHFFFAOYSA-N 0.000 claims description 3
• JPGQZYDJVNHPMF-UHFFFAOYSA-N 6-(benzylcarbamothioylamino)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=S)NCC1=CC=CC=C1 JPGQZYDJVNHPMF-UHFFFAOYSA-N 0.000 claims description 3
• WVLFDMGQKDSLDH-UHFFFAOYSA-N 6-(benzylcarbamoylamino)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)NCC1=CC=CC=C1 WVLFDMGQKDSLDH-UHFFFAOYSA-N 0.000 claims description 3
• CQWOOXHKYRGLPC-UHFFFAOYSA-N 6-(butylsulfonylamino)-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNS(=O)(=O)CCCC)C(O)=O)=CC=C3OC2=C1 CQWOOXHKYRGLPC-UHFFFAOYSA-N 0.000 claims description 3
• IVWZIOYXHUIFCT-UHFFFAOYSA-N 6-[(2-acetamido-1,3-thiazol-5-yl)sulfonylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound S1C(NC(=O)C)=NC=C1S(=O)(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 IVWZIOYXHUIFCT-UHFFFAOYSA-N 0.000 claims description 3
• XASCCVVJRAFIEI-UHFFFAOYSA-N 6-[(2-anilinoacetyl)amino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CNC1=CC=CC=C1 XASCCVVJRAFIEI-UHFFFAOYSA-N 0.000 claims description 3
• KXPAZEANIKKBQX-UHFFFAOYSA-N 6-[(2-cyclopentyl-2-phenylacetyl)amino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)C(C=1C=CC=CC=1)C1CCCC1 KXPAZEANIKKBQX-UHFFFAOYSA-N 0.000 claims description 3
• BNAPSLZTYMVXRW-UHFFFAOYSA-N 6-[(4-acetamidophenyl)sulfonylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC(NC(=O)C)=CC=C1S(=O)(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 BNAPSLZTYMVXRW-UHFFFAOYSA-N 0.000 claims description 3
• HYWHALSAWYQPTB-UHFFFAOYSA-N 6-[(4-bromophenyl)sulfonylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNS(=O)(=O)C1=CC=C(Br)C=C1 HYWHALSAWYQPTB-UHFFFAOYSA-N 0.000 claims description 3
• GUOCOXCFQUQHTC-UHFFFAOYSA-N 6-[3-(1,3-benzodioxol-5-yl)propanoylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)CCC=4C=C5OCOC5=CC=4)C(=O)O)=CC=C3OC2=C1 GUOCOXCFQUQHTC-UHFFFAOYSA-N 0.000 claims description 3
• SFNMSDQISATWSG-UHFFFAOYSA-N 6-[3-(4-chlorophenoxy)propanoylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCOC1=CC=C(Cl)C=C1 SFNMSDQISATWSG-UHFFFAOYSA-N 0.000 claims description 3
• YRIGNTNVSFVIHE-UHFFFAOYSA-N 6-[3-(4-chlorophenyl)propanoylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCC1=CC=C(Cl)C=C1 YRIGNTNVSFVIHE-UHFFFAOYSA-N 0.000 claims description 3
• UEQKRBIWHTZDKU-UHFFFAOYSA-N 6-[4-(4-chloro-3-methylphenoxy)butanoylamino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=C(Cl)C(C)=CC(OCCCC(=O)NCCCCC(NS(=O)(=O)C=2C=C3C4=CC=CC=C4OC3=CC=2)C(O)=O)=C1 UEQKRBIWHTZDKU-UHFFFAOYSA-N 0.000 claims description 3
• SHCLWHWBMRSRKK-UHFFFAOYSA-N 6-[[2-(1,3-benzodioxol-5-yl)acetyl]amino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)CC=4C=C5OCOC5=CC=4)C(=O)O)=CC=C3OC2=C1 SHCLWHWBMRSRKK-UHFFFAOYSA-N 0.000 claims description 3
• DCUJUMYXAUIEAA-UHFFFAOYSA-N 6-[[2-(4-chlorophenoxy)-2-methylpropanoyl]amino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(O)=O)CCCCNC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 DCUJUMYXAUIEAA-UHFFFAOYSA-N 0.000 claims description 3
• YOBDKRDCOOCWQP-UHFFFAOYSA-N 6-[[2-(4-chlorophenoxy)acetyl]amino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)COC1=CC=C(Cl)C=C1 YOBDKRDCOOCWQP-UHFFFAOYSA-N 0.000 claims description 3
• OAFXXCOTPKUDEM-UHFFFAOYSA-N 6-[[2-(4-tert-butylphenoxy)acetyl]amino]-2-(dibenzofuran-2-ylsulfonylamino)hexanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1OCC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 OAFXXCOTPKUDEM-UHFFFAOYSA-N 0.000 claims description 3
• OPOAKKGPPSNINL-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-3-(4-hydroxyphenyl)sulfanylpropanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CSC1=CC=C(O)C=C1 OPOAKKGPPSNINL-UHFFFAOYSA-N 0.000 claims description 2
• XGRQKCULXVSIPX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-(1,3-dioxobenzo[f]isoindol-2-yl)butanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCN4C(C5=CC6=CC=CC=C6C=C5C4=O)=O)C(=O)O)=CC=C3OC2=C1 XGRQKCULXVSIPX-UHFFFAOYSA-N 0.000 claims description 2
• HADFOIXLELOUCE-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-(1,3-dioxoisoindol-2-yl)butanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCN4C(C5=CC=CC=C5C4=O)=O)C(=O)O)=CC=C3OC2=C1 HADFOIXLELOUCE-UHFFFAOYSA-N 0.000 claims description 2
• XUBNWLNTKGEZDX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-(3-oxo-1h-isoindol-2-yl)butanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCN4C(C5=CC=CC=C5C4)=O)C(=O)O)=CC=C3OC2=C1 XUBNWLNTKGEZDX-UHFFFAOYSA-N 0.000 claims description 2
• ISOSRAWGMUBUMK-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-methoxy-4-oxobutanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CC(=O)OC)C(O)=O)=CC=C3OC2=C1 ISOSRAWGMUBUMK-UHFFFAOYSA-N 0.000 claims description 2
• SJNIHFRNNSGCOI-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-4-pyridin-3-ylbutanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCC1=CC=CN=C1 SJNIHFRNNSGCOI-UHFFFAOYSA-N 0.000 claims description 2
• FQXXJRIYXSNUIZ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(1,3-dioxobenzo[f]isoindol-2-yl)pentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCN4C(C5=CC6=CC=CC=C6C=C5C4=O)=O)C(=O)O)=CC=C3OC2=C1 FQXXJRIYXSNUIZ-UHFFFAOYSA-N 0.000 claims description 2
• ROCYKAXXYZPTDJ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(1,3-dioxoisoindol-2-yl)pentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCN4C(C5=CC=CC=C5C4=O)=O)C(=O)O)=CC=C3OC2=C1 ROCYKAXXYZPTDJ-UHFFFAOYSA-N 0.000 claims description 2
• MGVBRGIBDNQMJT-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(3-oxo-1h-isoindol-2-yl)pentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCN4C(C5=CC=CC=C5C4)=O)C(=O)O)=CC=C3OC2=C1 MGVBRGIBDNQMJT-UHFFFAOYSA-N 0.000 claims description 2
• RYZILWLNJLGPOW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-(4-propylphenyl)pentanoic acid Chemical compound C1=CC(CCC)=CC=C1CCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 RYZILWLNJLGPOW-UHFFFAOYSA-N 0.000 claims description 2
• YQAMZTIBCLFSLQ-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-methoxy-5-oxopentanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCC(=O)OC)C(O)=O)=CC=C3OC2=C1 YQAMZTIBCLFSLQ-UHFFFAOYSA-N 0.000 claims description 2
• RGNKVAABSWEEKX-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-phenylpentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCC1=CC=CC=C1 RGNKVAABSWEEKX-UHFFFAOYSA-N 0.000 claims description 2
• SPMXDDSXZOVALA-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-5-pyridin-3-ylpentanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCC1=CC=CN=C1 SPMXDDSXZOVALA-UHFFFAOYSA-N 0.000 claims description 2
• POIFIXHHWSWDIC-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-(4-phenylbutanoylamino)hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CCCC1=CC=CC=C1 POIFIXHHWSWDIC-UHFFFAOYSA-N 0.000 claims description 2
• IFDYIIOZRLLFKE-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-indol-1-ylacetyl)amino]hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)CN4C5=CC=CC=C5C=C4)C(=O)O)=CC=C3OC2=C1 IFDYIIOZRLLFKE-UHFFFAOYSA-N 0.000 claims description 2
• QVAFZGJGISCWOW-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-naphthalen-1-ylacetyl)amino]hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)CC=4C5=CC=CC=C5C=CC=4)C(=O)O)=CC=C3OC2=C1 QVAFZGJGISCWOW-UHFFFAOYSA-N 0.000 claims description 2
• WGQVBWGGZAEWDN-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[(2-thiophen-2-ylacetyl)amino]hexanoic acid Chemical compound C=1C=C2OC3=CC=CC=C3C2=CC=1S(=O)(=O)NC(C(=O)O)CCCCNC(=O)CC1=CC=CS1 WGQVBWGGZAEWDN-UHFFFAOYSA-N 0.000 claims description 2
• CUFKDYVIEIYECR-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[3-(4-methoxyphenyl)propanoylamino]hexanoic acid Chemical compound C1=CC(OC)=CC=C1CCC(=O)NCCCCC(C(O)=O)NS(=O)(=O)C1=CC=C(OC=2C3=CC=CC=2)C3=C1 CUFKDYVIEIYECR-UHFFFAOYSA-N 0.000 claims description 2
• KPBBBCKEUARNPU-UHFFFAOYSA-N 2-(dibenzofuran-2-ylsulfonylamino)-6-[4-(1h-indol-3-yl)butanoylamino]hexanoic acid Chemical compound C1=CC=C2C3=CC(S(=O)(=O)NC(CCCCNC(=O)CCCC=4C5=CC=CC=C5NC=4)C(=O)O)=CC=C3OC2=C1 KPBBBCKEUARNPU-UHFFFAOYSA-N 0.000 claims description 2
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