KR20000068329A - 약물내성 연쇄상구균 폐렴 치료용 약제 제조시의 아목시실린 및클라불라네이트의 조합물의 용도 - Google Patents
약물내성 연쇄상구균 폐렴 치료용 약제 제조시의 아목시실린 및클라불라네이트의 조합물의 용도 Download PDFInfo
- Publication number
- KR20000068329A KR20000068329A KR1019997001492A KR19997001492A KR20000068329A KR 20000068329 A KR20000068329 A KR 20000068329A KR 1019997001492 A KR1019997001492 A KR 1019997001492A KR 19997001492 A KR19997001492 A KR 19997001492A KR 20000068329 A KR20000068329 A KR 20000068329A
- Authority
- KR
- South Korea
- Prior art keywords
- clavulanate
- amoxicillin
- patients
- drug
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 title claims abstract description 54
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title claims abstract description 43
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title claims abstract description 43
- 229940090805 clavulanate Drugs 0.000 title claims abstract description 42
- 239000003814 drug Substances 0.000 title claims abstract description 18
- 238000011282 treatment Methods 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 241000193998 Streptococcus pneumoniae Species 0.000 title description 2
- 201000005010 Streptococcus pneumonia Diseases 0.000 title 1
- 229960003022 amoxicillin Drugs 0.000 claims abstract description 47
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims abstract description 47
- 229940079593 drug Drugs 0.000 claims abstract description 15
- 230000037396 body weight Effects 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 239000003937 drug carrier Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 23
- 238000009472 formulation Methods 0.000 claims description 19
- 239000000725 suspension Substances 0.000 claims description 13
- ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 claims description 11
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 7
- 229960004920 amoxicillin trihydrate Drugs 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 206010035664 Pneumonia Diseases 0.000 claims description 4
- 241000194017 Streptococcus Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 9
- 239000006188 syrup Substances 0.000 description 9
- 235000020357 syrup Nutrition 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 108090000204 Dipeptidase 1 Proteins 0.000 description 4
- 102000006635 beta-lactamase Human genes 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 239000002274 desiccant Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 230000008261 resistance mechanism Effects 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 206010033078 Otitis media Diseases 0.000 description 2
- 230000009798 acute exacerbation Effects 0.000 description 2
- BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 229940038649 clavulanate potassium Drugs 0.000 description 2
- 239000008119 colloidal silica Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000004836 empirical method Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 201000009890 sinusitis Diseases 0.000 description 2
- 239000007909 solid dosage form Substances 0.000 description 2
- 239000001384 succinic acid Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000007916 tablet composition Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000002132 β-lactam antibiotic Substances 0.000 description 2
- 229940124586 β-lactam antibiotics Drugs 0.000 description 2
- QJVHTELASVOWBE-AGNWQMPPSA-N (2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2r,3z,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 QJVHTELASVOWBE-AGNWQMPPSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 208000009362 Pneumococcal Pneumonia Diseases 0.000 description 1
- 206010035728 Pneumonia pneumococcal Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940038195 amoxicillin / clavulanate Drugs 0.000 description 1
- 229940068203 amoxicillin 875 mg Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- 239000003781 beta lactamase inhibitor Substances 0.000 description 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940016109 clavulanate 125 mg Drugs 0.000 description 1
- 229960003324 clavulanic acid Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 235000021013 raspberries Nutrition 0.000 description 1
- 238000009490 roller compaction Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000009491 slugging Methods 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007892 solid unit dosage form Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000022218 streptococcal pneumonia Diseases 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9617780.3A GB9617780D0 (en) | 1996-08-24 | 1996-08-24 | Method of treatment |
| GB9617780.3 | 1996-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20000068329A true KR20000068329A (ko) | 2000-11-25 |
Family
ID=10798919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997001492A Withdrawn KR20000068329A (ko) | 1996-08-24 | 1997-08-19 | 약물내성 연쇄상구균 폐렴 치료용 약제 제조시의 아목시실린 및클라불라네이트의 조합물의 용도 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6214359B1 (cs) |
| EP (1) | EP0938312A1 (cs) |
| JP (1) | JP2000516243A (cs) |
| KR (1) | KR20000068329A (cs) |
| CN (1) | CN1233958A (cs) |
| AR (1) | AR008306A1 (cs) |
| AU (1) | AU722657B2 (cs) |
| BR (1) | BR9711642A (cs) |
| CA (1) | CA2264074A1 (cs) |
| CO (1) | CO5021201A1 (cs) |
| CZ (1) | CZ59299A3 (cs) |
| GB (1) | GB9617780D0 (cs) |
| HU (1) | HUP0201440A3 (cs) |
| IL (1) | IL128644A0 (cs) |
| NO (1) | NO990845L (cs) |
| NZ (1) | NZ334345A (cs) |
| PL (1) | PL331764A1 (cs) |
| TR (1) | TR199900413T2 (cs) |
| WO (1) | WO1998007424A1 (cs) |
| ZA (1) | ZA977564B (cs) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109503A1 (en) * | 1995-06-06 | 2003-06-12 | Smithkline Beecham P.L.C. | Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
| US6294199B1 (en) * | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
| US6878386B1 (en) | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
| US7250176B1 (en) * | 1999-04-13 | 2007-07-31 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection |
| US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6756057B2 (en) | 2000-10-12 | 2004-06-29 | Beecham Pharmaceuticals (Pte) Limited | Amoxicillin and potassium clavulanate dosage form |
| WO2002030392A2 (en) | 2000-10-12 | 2002-04-18 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| KR100456833B1 (ko) * | 2002-08-01 | 2004-11-10 | 주식회사 대웅 | 아목시실린 및 클라불라네이트를 함유하는 유핵정 |
| US8313776B2 (en) | 2003-07-21 | 2012-11-20 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| CA2533292C (en) * | 2003-07-21 | 2013-12-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8425936B2 (en) * | 2003-07-21 | 2013-04-23 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| JP2007502296A (ja) * | 2003-08-11 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | ロバストペレット |
| EP1653924A4 (en) | 2003-08-12 | 2009-09-09 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, USE AND FORMULATION ASSOCIATED |
| JP5686494B2 (ja) | 2003-08-29 | 2015-03-18 | シオノギ インコーポレイテッド | 抗生物質製剤、その使用法及び作成方法 |
| EP1663169A4 (en) * | 2003-09-15 | 2010-11-24 | Middlebrook Pharmaceuticals In | ANTIBIOTICS, ITS USE AND FORMULATION |
| EP1701705A4 (en) * | 2003-12-24 | 2007-08-08 | Advancis Pharmaceutical Corp | IMPROVED ABSORPTION OF DOSAGE FORMS WITH MODIFIED RELEASE |
| CA2572292A1 (en) * | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| US9034410B2 (en) * | 2011-08-22 | 2015-05-19 | Thomas J. Vella | Whole green coffee bean products and methods of production and use |
| WO2013173803A2 (en) * | 2012-05-17 | 2013-11-21 | Michael Spector | Formulations of amoxicillin and clavulanate potassium and methods for using same |
| WO2013173808A2 (en) * | 2012-05-17 | 2013-11-21 | Michael Spector | Methods for use of lower dose compositions of amoxicillin and clavulanate potassium and devices for use |
| JP7629693B2 (ja) | 2020-04-28 | 2025-02-14 | 小林製薬株式会社 | 抗菌剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ198241A (en) * | 1980-09-27 | 1983-12-16 | Beecham Group Ltd | Tablet containing amoxycillin and potassium clavulanate |
| GB9408117D0 (en) * | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
| US5753434A (en) | 1995-02-10 | 1998-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for altering sexual behavior |
| DZ2028A1 (fr) * | 1995-05-03 | 2002-10-23 | Smithkline Beecham Plc | Médicaments destinés au traitement d'infections bactériennes en pédiatrie. |
| WO1997009042A1 (en) * | 1995-09-07 | 1997-03-13 | Smithkline Beecham Corporation | Pharmaceutical formulation |
-
1996
- 1996-08-24 GB GBGB9617780.3A patent/GB9617780D0/en active Pending
-
1997
- 1997-08-19 CN CN97198977A patent/CN1233958A/zh active Pending
- 1997-08-19 IL IL12864497A patent/IL128644A0/xx unknown
- 1997-08-19 CZ CZ99592A patent/CZ59299A3/cs unknown
- 1997-08-19 HU HU0201440A patent/HUP0201440A3/hu unknown
- 1997-08-19 WO PCT/GB1997/002235 patent/WO1998007424A1/en not_active Ceased
- 1997-08-19 CA CA002264074A patent/CA2264074A1/en not_active Abandoned
- 1997-08-19 BR BR9711642-4A patent/BR9711642A/pt not_active Application Discontinuation
- 1997-08-19 KR KR1019997001492A patent/KR20000068329A/ko not_active Withdrawn
- 1997-08-19 EP EP97937682A patent/EP0938312A1/en not_active Ceased
- 1997-08-19 NZ NZ334345A patent/NZ334345A/xx unknown
- 1997-08-19 US US09/242,862 patent/US6214359B1/en not_active Expired - Lifetime
- 1997-08-19 JP JP10510512A patent/JP2000516243A/ja active Pending
- 1997-08-19 TR TR1999/00413T patent/TR199900413T2/xx unknown
- 1997-08-19 PL PL97331764A patent/PL331764A1/xx unknown
- 1997-08-19 AU AU40226/97A patent/AU722657B2/en not_active Withdrawn - After Issue
- 1997-08-21 AR ARP970103808A patent/AR008306A1/es not_active Application Discontinuation
- 1997-08-22 CO CO97048491A patent/CO5021201A1/es unknown
- 1997-08-22 ZA ZA977564A patent/ZA977564B/xx unknown
-
1999
- 1999-02-23 NO NO990845A patent/NO990845L/no not_active Application Discontinuation
-
2001
- 2001-10-19 US US10/036,346 patent/US20020114842A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL128644A0 (en) | 2000-01-31 |
| AU722657B2 (en) | 2000-08-10 |
| US6214359B1 (en) | 2001-04-10 |
| NO990845L (no) | 1999-04-19 |
| HUP0201440A3 (en) | 2003-04-28 |
| NZ334345A (en) | 2000-10-27 |
| AU4022697A (en) | 1998-03-06 |
| BR9711642A (pt) | 2000-10-24 |
| AR008306A1 (es) | 1999-12-29 |
| EP0938312A1 (en) | 1999-09-01 |
| TR199900413T2 (xx) | 1999-06-21 |
| ZA977564B (en) | 1999-02-22 |
| US20020114842A1 (en) | 2002-08-22 |
| CN1233958A (zh) | 1999-11-03 |
| HUP0201440A2 (en) | 2002-09-28 |
| CZ59299A3 (cs) | 1999-08-11 |
| NO990845D0 (no) | 1999-02-23 |
| PL331764A1 (en) | 1999-08-02 |
| CO5021201A1 (es) | 2001-03-27 |
| JP2000516243A (ja) | 2000-12-05 |
| GB9617780D0 (en) | 1996-10-02 |
| WO1998007424A1 (en) | 1998-02-26 |
| CA2264074A1 (en) | 1998-02-26 |
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