KR20000065838A - A cosmetic composition comprising canna indica extract - Google Patents

Abstract

PURPOSE: A cosmetic composition containing Canna indica extract is provided, which shows good inhibition effect of 5alpha-reductase activity, so inhibits secretion of sebum, and inhibits production of melanin pigment, so can be used for improvement of freckles or skin whitening. CONSTITUTION: A process for the preparation of Canna indica extract comprises of: pulverizing Canna indica; pouring the pulverized Canna indica 300g to 80% methanol solution 3L, boiling in circulating extractor with refrigerating condenser for 3hrs; filtering with 300mesh filter sheath, and extracting the residue again for 1 time by the same process; adding each extract together, filtering the extract with the Whatman No.2 filter sheath to eliminate non-soluble material; concentrating under decompression by a distillation apparatus with refrigerating condenser at 60°C, and freeze-drying to get dried Canna indica extract 72g. The cosmetic composition or an ointment for external use contains the Canna indica extract 0.0001-10.0wt.%, desirably 0.0005-10.0wt.%(as dried weight).

Description

Cosmetic composition containing a beautiful woman extract {A COSMETIC COMPOSITION COMPRISING CANNA INDICA EXTRACT}

[Industrial use]

The present invention relates to a cosmetic composition comprising a beauty extract, more specifically, to inhibit sebum secretion, effective in the treatment of acne, cosmetics containing a beautiful beauty extract extract that is effective in improving blemishes and freckles or as a skin whitening agent. It relates to a composition.

[Private Technology]

Acne and seborrheic dermatitis are chronic hormone diseases that depend on men (Van Luu-The etc, Characterization, Expression, and Immunohystochemical Localization of 5α-reductase in Human skin, J. Invest. Dermatol, 102, 1994). Acne and seborrheic dermatitis is a sebum-related disease caused by excess sebum produced by male hormones. For the fundamental treatment, it is known that the overproduction of sebum is inhibited through inhibition of male hormone activity.

For the treatment of acne, antibacterial agents have been added, or raw materials for promoting exfoliation have been used. As a raw material for promoting exfoliation, acidic raw materials such as AHA and retinoid (vitamin A) have been used, but only a very limited amount is used because the effect is insignificant or excessive skin irritation occurs. Antimicrobial agents such as tetracycline are used as antimicrobial agents. However, these antimicrobial agents are known to cause side effects such as the appearance of bacteria resistance and photosensitization effects. You can, but you can't expect to prevent or heal the underlying acne. In addition, studies have been reported to inhibit the activity of 5 alpha-reductase (Yasuro Sugimoto etc, Cation inhibit specifically type I 5α-reductase found in human skin, J. Invest. Dermatol, 104, 1995). This is known to require little attention and use.

Human skin color is genetically determined by the concentration and distribution of melanin in the skin, but is also influenced by environmental or physiological conditions such as solar ultraviolet rays, fatigue and stress. Melanin is a type of amino acid tyrosin (tyrosin) enzymes called tyrosinase (tyrosinase) acts to convert to dopa (DOPA), dopaquinone (Dopaquinone) is produced through a non-enzymatic oxidation reaction. However, although the pathways are known, the mechanisms that drive melanin synthesis, the previous stages of tyrosinase action, are still unknown.

Therefore, conventionally, a substance having an inhibitory activity on tyrosinase such as hydroquinone, ascorbic acid, kojic acid, glutathione, and the like is added to the ointment or cosmetics to improve skin whitening, blemish and freckles. Although it has been used for such purposes, the whitening effect of hydroquinone is recognized, but the amount of use is extremely limited due to severe skin irritation. In addition, it is easy to oxidize archolic acid causes a problem such as discoloration, discoloration of the cosmetics containing it, and cosmetics such as glutathione, cysteine has a characteristic unpleasant smell and has a problem in transdermal absorption. In addition, placenta extract has a problem that the whitening effect is insufficient.

An object of the present invention is to suppress sebum secretion and have an effect on acne healing, excellent whitening effect, harmless to the human cosmetic composition.

[Means for solving the problem]

In order to achieve the above object, the present invention provides a cosmetic composition containing the extract of the fine herbaceous acid to inhibit the activity of 5 alpha-reductase or to inhibit the production of melanin pigment.

Preferably it provides a cosmetic composition, characterized in that the content of the extract of the beauty of the beauty extract in the cosmetic composition is 0.0001-10% by weight in dry weight.

In addition, the cosmetic composition provides a cosmetic composition, characterized in that the sebum secretion cosmetic composition, acne healing cosmetic composition, or skin whitening cosmetic composition.

In addition, the cosmetic composition provides a cosmetic composition that is an external skin ointment, cream, supple cosmetics, nourishing cosmetics, pack or essence.

The present invention will be described in detail as follows.

Testosterone, one of the male hormones, is converted to the active male hormone dihydrotestosterone (DHT) by 5 alpha-reductase, and an abnormal excess of this hormone causes a major causative agent to cause the sebum cells to overproduce sebum. to provide. When sebum is excessively produced, sebum-related diseases such as acne and seborrheic dermatitis are caused. Therefore, by inhibiting the activity of 5 alpha-reductase to inhibit the overproduction of dihydrotestosterone, the above diseases can be fundamentally and effectively prevented and treated.

Human acne is known to be caused by excess sebum secretion of sebaceous glands and blockage of the sequela of the sebaceous gland, which is blocked by keratin, or by the growth of Propionibacterium acnes, a dermatological bacterium. These causes vary from person to person and are found to be correlated with each other, especially acne is known to be aggravated during the second stage of growth, when sebum secretion is activated by testosterone, a sex hormone that matures sebaceous glands. Excess of sebum secretion is the main cause.

The herbaceous herb is a perennial herb of the Connaceae family, named Canna indica. It grows in wet grassland, can be harvested year-round, and root or starch is dried or raw. Beauty has traditionally been used for gynecological diseases such as hypertension, bleeding and uterine bleeding, white crab, menstrual irregularity as an undergarment, and for external use, such as Changyang poisoning and traumatic bleeding. It is distinguished from the acne healing effect or skin whitening effect of the invention. Previous studies on the identification of vinegar components indicate that compounds such as beta-cytosterol, palmitic acid, palmitic 1-monoglyceride, and doucinin And others have been reported (Middle Herbal Medicine, vol. 26-2, 1995).

In the present invention, it has been found that the extract of B. herb has a very strong 5 alpha-reductase inhibitory effect, through which the extract of B. herb has sebum secretion inhibitory effect and acne healing effect, and also very strong melanin production inhibitory effect and whitening. It turned out to be effective.

The preparation of the extract of Bellechorea is finely pulverized, and 50-min. In an extractor equipped with a reflux condenser with 5-20 volumes of water or 1-4 anhydrous or hydrous lower alcohol, ethyl acetate or acetone, based on the dry weight of the powder. Extract by heating to 100 ° C. for 1-5 hours. Extraction is not performed below 50 ° C, and other impurities are extracted together at temperatures above 100 ° C. After filtration with filter cloth, the residue is extracted one more time in the same manner. The extracts were combined and concentrated under reduced pressure and then lyophilized or spray dried to obtain a dry extract.

The prepared herbaceous extract showed a strong inhibitory effect against 5 alpha-reductase obtained from female rats. In addition, the results of clinical trials of the cosmetic composition containing the beauty extract extract showed excellent sebum control and acne healing effect without causing any side effects on the human body.

In addition, the prepared beauty extract has a strong melanin production inhibitory effect in the whitening effect experiment using melanoma cells of the mouse, and clinical results by manufacturing a cosmetic composition containing the extract of beauty extract, as a result of any side effects on the human body It was shown that there is an excellent whitening effect without causing.

The cosmetic composition containing the extract of beauty of the herb varies depending on the kind of cosmetics. The cosmetic composition comprising the extract of the beauty of the present invention generally refers to a cosmetic composition comprising the activity of 5 alpha-leaderases or melanin pigment suppression, including the beauty of the extract provided in each cosmetic composition, each other It can be applied to any of the other forms, such as liquid, cream, paste or solid.

The content of the vinegar extract contained in skin external ointment or cosmetic preparation is preferably 0.0001-10.0% by weight, preferably 0.0005-10.0% by weight in dry weight. At a concentration below 0.0001% by weight, no pronounced effect can be expected, and at concentrations above 10% by weight, no apparent increase in effect occurs with increasing content.

EXAMPLE

Hereinafter, the Example of this invention is described. However, the following examples are illustrative of the present invention, and the present invention is not limited only to the examples.

Example 1

300 g of crushed fine grass was added to 3 L of 80% methanol solution, boiled for 3 hours in a reflux extractor equipped with a cooling capacitor, filtered through a 300 mesh filter cloth, and the residue was extracted once more in the same manner. Each extract was combined, filtered at room temperature with Whatman No. 2 filter paper to remove insoluble materials, concentrated under reduced pressure at 60 ° C. in a distillation apparatus equipped with a cooling condenser, and lyophilized to obtain a dry weight of the extract of Mt. .

Example 2

300g of the crushed fine vinegar was put into 3L of purified water, and it carried out by the same method as Example 1, and obtained dry weight 82g.

Example 3

300 g of pulverized fine vinegar was put in 3 L of an 85% ethanol solution, and the same procedure as in Example 1 was carried out to obtain a dry weight of 70 g.

Example 4

300 g of the crushed fine vinegar was put in 3 L of a 70% acetone solution, and the same procedure as in Example 1 was carried out to obtain a dry weight of 61 g.

Example 5

300 g of pulverized fine vinegar was put in 3 L of 50% ethanol solution, and the same procedure as in Example 1 was carried out to obtain a dry weight of 78 g.

Example 6

300 g of the pulverized fine vinegar was put in 3 L of a 60% methanol solution, and then lost in the same manner as in Example 1 to obtain a dry weight of 75 g.

Example 7

300 g of the pulverized finely divided vinegar was put in 3 L of saturated normal butanol solution, and it carried out by the same method as Example 1, and obtained dry weight 51g.

Example 8

300 g of pulverized fine vinegar was put in 3 L of chloroform solution, and the same procedure as in Example 1 was carried out to obtain a dry weight of 42 g.

Example 9

Each of the extracts obtained according to Examples 1-8 was purified from female rat liver and contained 5 alpha-reductase and a labeling substance, (3H-1,2,4,5,6,7) -testosterone. Was added to phosphate buffer (pH 6.6) and reacted at 37 ° C for 15 minutes. After the reaction was stopped, the steroid material was extracted and quantified dihydrotestosterone, a product produced by the action of 5 alpha-reductase by testosterone using HPLC and radioisotope measurement. Dihydrotestosterone, an indicator, is known to promote sebum secretion in sebaceous glands.

Each extract obtained in Example 1-8 was incubated in a solution containing 5 alpha-reductase for 15 minutes at a final concentration of 0.004%, and then the reaction was stopped. The amount of dihydrotestosterone produced was determined by HPLC and radioactivity. Quantification was carried out using an isotope meter.

The 5 alpha-reductase inhibitory activity relative to the control without the sample was calculated as the area of the dihydrotestosterone peak and the results are summarized in Table 1. As can be seen from the results in Table 1, it was found that each of the samples obtained according to Examples 1-8 had a very potent inhibitory activity against 5 alpha-reductase obtained from female rat liver, despite being an unpurified extract. Can be.

sample DHT peak area % Inhibition Control group (no addition) 12051 - Example 1 (final concentration 0.004%) 5423 55% Example 2 (final concentration 0.004%) 7231 40% Example 3 (final concentration 0.004%) 6267 48% Example 4 (final concentration 0.004%) 6508 46% Example 5 (final concentration 0.004%) 5905 51% Example 6 (final concentration 0.004%) 6990 42% Example 7 (final concentration 0.004%) 5664 53% Example 8 (final concentration 0.004%) 4941 59%

* Number of iterations = 3

Example 10

In the same manner as in Example 9, 5alpha-reductase activity inhibitory effect was investigated according to the concentration of the extract of Example 1 with respect to 5alpha-reductase obtained from female rat liver. The results are shown in Table 2.

As can be seen from the results of Table 2, the extract of B. herb has very strong activity inhibitory effect against 5 alpha-reductase obtained from female rat liver, which can inhibit sebum secretion of skin and can be very useful for acne healing. .

sample Application concentration (%) DHT peak area % Inhibition Control group (no addition) - 12051 - Beautiful herb extract content Final concentration (0.0004%) 10122 16% Final concentration (0.004%) 5423 55% Final concentration (0.04%) 0 100% Final concentration (0.4%) 0 100%

* Number of iterations = 3

Example 11

In order to test the skin whitening effect of the extract of B. herb extract, each extract obtained according to Example 1-8 was added to the culture solution of B-16 mouse melanoma cells to test the whitening effect at the cellular level. (Lotan R, Lotan D. Cancer Res. 40: 3345-3350, 1980). Each extract obtained according to Example 1-8 was added to the culture medium of B-16 melanoma cells with a hydroquinone aqueous solution and the final concentration was 0.001%, and then cultured for 3 days, and the cells were trypsinized. Melanin was extracted from the culture vessel by centrifugation.

To this, 1 ml of sodium hydroxide solution (1N concentration) was added, boiled for 10 minutes to dissolve the melanin, and the absorbance was measured at 400 nanometers (nm) using a spectrophotometer to determine the amount of melanin produced per unit cell (10 ⁶ cells). It was carried out by the method showing the, melanin production relative to the control group calculated the inhibition rate (%) and the results are summarized in Table 3.

As can be seen from the results in Table 3, considering that each sample obtained according to Examples 1-8 is an extract that is not purified at all, it is very strong against the melanoma cells of the cultured mice compared to hydroquinone, a known whitening substance. It can be seen that the melanin production inhibitory ability.

sample Melanin production % Inhibition Control group (no addition) 0.044 ± 0.004 - Example 1 (final concentration 0.005%) 0.030 ± 0.002 32% Example 2 (final concentration 0.005%) 0.032 ± 0.003 27% Example 3 (final concentration 0.005%) 0.028 ± 0.002 36% Example 4 (final concentration 0.005%) 0.030 ± 0.001 32% Example 5 (final concentration 0.005%) 0.029 ± 0.003 34% Example 6 (final concentration 0.005%) 0.027 ± 0.002 39% Example 7 (final concentration 0.005%) 0.024 ± 0.004 45% Example 8 (final concentration 0.005%) 0.023 ± 0.001 48% Hydroquinone (final concentration 0.0001%) 0.025 ± 0.002 43%

* Number of iterations = 3

Example 12

Melamine production of rats cultured in the same manner as in Example 11 was investigated for the melanin production inhibitory ability according to the concentration of the extract of Example 1 and the results are shown in Table 4.

sample Application concentration (%) Melanin production % Inhibition Control group (no addition) - 0.044 ± 0.004 - Example 1 Final concentration (0.0005%) 0.037 ± 0.0033 16% Final concentration (0.005%) 0.030 ± 0.002 32% Final concentration (0.05%) 0.024 ± 0.003 45% Final concentration (0.5%) 0.020 ± 0.003 55% Hydroquinone Final concentration (0.0001%) 0.025 ± 0.002 43%

* Number of iterations = 3

As can be seen from the results of Table 4, it is found that the extract of the beauty of the vinegar has a very strong melanin production inhibitory ability against the cultured melanoma cells. Hydroquinone has a strong melanin production inhibitory ability at low concentrations, but the cytotoxicity is severe and can not be tested at 0.0001% or more, whereas the extract of the present invention is the maximum amount of hydro that can be used without showing cytotoxicity at 0.05% or more concentration It has a higher melanin production inhibitory effect than quinone. In addition, since the extract of the beauty of the herb has a very high melanin production inhibitory ability considering that it is not a single substance but a mixture, it can be very useful for improving freckles and freckles or skin whitening.

Preparation of a cosmetic composition comprising the extract of beauty of the beauty

The cosmetic composition containing the extract of beauty of the herb varies depending on the kind of cosmetics. The cosmetic composition comprising the extract of the beauty of the present invention generally refers to a cosmetic composition which inhibits the activity of 5 alpha-reductase or inhibits the production of melanin by including the extract of the beauty of the beauty of the composition provided in each cosmetic.

Example 13 and Comparative Example 1

Examples of prescription external skin ointment containing beauty extract extract are shown in Table 5.

Here, it is said that the extract from the beauty of the plant according to Example 5.

Composition Example 13 (% by weight) Comparative Example 1 -Beautiful Herb Extract 10 - -Diethyl sebacate 8 8 -Payment 5 5 Polyoxyethylene oleyl ether phosphate 6 6 Sodium benzoate Quantity Quantity -vaseline Remaining capacity (up to 100) Remaining capacity (up to 100)

Example 14 and Comparative Example 2

Prescription example of the cream of the cosmetic containing the beauty extract extract is shown in Table 6.

Here, the beauty extract extracts that of Example 5.

Composition Example 14 (% by weight) Comparative Example 2 -Beautiful Herb Extract 1.0 - Stearic acid 15.0 15.0 -ethanol 1.0 1.0 Potassium hydroxide 0.7 0.7 -glycerin 5.0 5.0 Propylene glycol 3.0 3.0 -antiseptic Quantity Quantity -incense Quantity Quantity -Purified water Remaining capacity (up to 100) Remaining capacity (up to 100)

Example 15 and Comparative Example 3

Prescription examples of the flexible cosmetics in cosmetics containing the extract of beauty of the beauty is shown in Table 7.

Here, the beauty extract is according to Example 5.

Composition Example 15 (% by weight) Comparative Example 3 -Beautiful Herb Extract 0.2 - -ethanol 10.0 10.0 Polylauric acid polyoxyethylene sorbitan 1.0 1.0 Paraoxybenzoic acid methyl 0.2 0.2 -glycerin 5.0 5.0 -1,3-butylene glycol 6.0 6.0 -incense Quantity Quantity Pigment Quantity Quantity -Purified water Remaining capacity (up to 100) Remaining capacity (up to 100)

Example 16 and Comparative Example 4

Prescription example of nutritional longevity among cosmetics containing the extract of beauty of the herb is shown in Table 8.

Here, the beauty extract extracts that of Example 5.

Composition Example 16 (% by weight) Comparative Example 4 -Beautiful Herb Extract 0.1 - Waserin 2.0 2.0 Sesquioleate sorbitan 0.8 0.8 Paraoxyethylene oleylethyl 1.2 1.2 Paraoxybenzoic acid methyl Quantity Quantity Propylene glycol 5.0 5.0 -ethanol 3.2 3.2 Carboxy vinyl polymer 18.0 18.0 Potassium hydroxide 0.1 0.1 Pigment Quantity Quantity -incense Quantity Quantity -Purified water Remaining capacity (up to 100) Remaining capacity (up to 100)

Example 17 and Comparative Example 5

Prescription examples of the pack of cosmetics containing the extract of beauty of the beauty is shown in Table 9.

Here, the beauty extract extracts that of Example 5.

Composition Example 15 (% by weight) Comparative Example 5 Beautiful herb extract 0.5 - glycerin 5.0 5.0 Propyl glycol 4.0 4.0 Polyvinyl alcohol 15.0 15.0 ethanol 8.0 8.0 Polyoxyethylene Oleethyl 1.0 1.0 Paraoxybenzoic Acid Methyl 0.2 0.2 incense Quantity Quantity Pigment Quantity Quantity Purified water Remaining capacity (up to 100) Remaining capacity (up to 100)

Example 18 and Comparative Example 6

Formulation examples of the essence of the cosmetic containing the extract of beauty of the beauty is shown in Table 10.

Here, the beauty extract is according to Example 5.

Composition Example 16 (% by weight) Comparative Example 6 -Beautiful Herb Extract 5.0 - Propylene glycol 10.0 10.0 -glycerin 10.0 10.0 Sodium hyaluronate aqueous solution (1%) 5.0 5.0 -ethanol 5.0 5.0 Polyoxyethylene Cured Castor Oil 1.0 1.0 Paraoxybenzoic acid methyl 0.1 0.1 -incense Quantity Quantity -Purified water Remaining capacity (up to 100) Remaining capacity (up to 100)

Example 19

Sebu tape was attached to two foreheads of 10 male test subjects to remove already secreted sebum, and a new sediment tape was removed after 40 minutes to measure sebum secretion in a normal state. The removed tape was measured by the amount of sebum secreted by the image analysis method and calculated the sebum secretion rate (Sebum Excretion Rate; SER, ㎍ / ㎠ / min).

After applying the external skin ointment of Example 13 containing the extract of Bellechorea and Comparative Example 1 without the extract of Bellechorea on the forehead area of the test subject, and attaching a new tape to remove it after 40 minutes, it was applied to the short-term sample application. Sebum secretion was measured by image analysis, and the Sebum Excretion Rate (SER, µg / cm 2 / min) was calculated.

The change in sebum secretion according to the sebum secretion and sample application at steady state is shown in Table 11.

Experimental substance SER % Reduction Example 11 1.05 ㎍ / ㎠ / min 15 Comparative Example 1 1.5 ㎍ / ㎠ / min 0

In addition, in order to measure the long-term effect of the sample, the external skin ointment of Example 13 and Comparative Example 1 was applied twice a day, and after 2 weeks, sebum secreted with savubut tape was taken to calculate SER. The sebum secretion change is calculated as a percentage and is shown in Table 12.

Experimental substance SER % Reduction Example 11 0.825 µg / cm 2 / min 32 Comparative Example 1 1.5 µg / cm 2 / min 0

In addition, the short-term and long-term effects of sebum secretion inhibition were measured by applying the essence of Example 18 and Comparative Example 6, which did not include the extract of S. aureus. Short-term effects are shown in Table 13 and long-term effects are shown in Table 14.

Experimental substance SER % Reduction Example 16 1.15 µg / cm 2 / min 24 Comparative Example 6 1.52 µg / cm 2 / min 0

Experimental substance SER % Reduction Example 16 1.05 µg / cm 2 / min 26 Comparative Example 6 1.42 µg / cm 2 / min 0

As can be seen from the results of Tables 11 to 14 above, the acne healing ointment containing the beauty extract extract according to Example 13 has 15% and 32% inhibitory effects on the sebum secretion of the skin in short and long term application, respectively. It could be confirmed that the essence extract containing the vinegar extract according to Example 18 was found to be 24% and 26%, respectively, in the short and long term application for sebum secretion of the skin. In addition, no side effects occur in the skin during the experiment, it can be seen that beauty extract is a safe and effective sebum secretion inhibitor.

Example 20

Thirty healthy men and women suffering from acne were selected, and the sample containing the beautiful woman's herb extract prepared according to Example 13-18 and Comparative Example 1-6 and the base of the woman's herb extract did not contain each group of five people each. It was applied to the morning and evening twice a day for two months divided into left and right. (In the case of the pack formulations of Example 17 and Comparative Example 5, after the application and peeling off after 15 minutes.) The degree of healing of the acne of the production example and the comparative example was visually determined for each, and the Example improved acne as compared with the comparative example. The degree of evaluation was evaluated in three stages of distinct effects, effects, and no differences, and the results are shown in Table 15.

Experimental substance Distinct Effects (persons) Effective (persons) No difference (persons) Example 13 2 2 One Example 14 2 One 2 Example 15 One 3 2 Example 16 One 2 2 Example 17 One 2 2 Example 18 2 2 One

As can be seen from the results of Table 15 above, acne healing ointment and cosmetics containing the extract of beauty of the herbaceous extract prepared according to Example 13-18 has at least three of the five subjects in each group of acne healing effect In particular, in the experiments of Examples 13 and 18, in which a large amount of B. herb extract was applied, 80% showed acne healing effect, and no side effects occurred in the skin. It can be seen that it is an acne cure

Example 21

Twenty healthy men and women were selected to attach aluminum foil in two rows of six holes with a diameter of 7 mm in the lower part of both arms, and 60 mJ / The amount of light in cm 2 was investigated. The irradiation site was washed well with 70% ethanol aqueous solution before irradiation. Twice a day from 3 days before irradiation to 3 weeks after irradiation, a pair of samples containing the extract of Bellechorea extract prepared according to Example 13-18 and Comparative Example 1-6 and the base containing no Bellechorea extract in pairs Was applied. (In the case of the pack formulations of Example 17 and Comparative Example 5, 15 minutes after application was removed.) The pigmentation degree of the Preparation Example and the Comparative Example was visually determined for each, and the Preparation Example suppressed the pigmentation compared with the Comparative Example. One degree was evaluated in three stages of distinct effects, effects, and no differences, and the results are shown in Table 16.

Experimental substance Distinct Effects (persons) Effective (persons) No difference (persons) Example 11 6 8 6 Example 12 4 8 8 Example 13 2 10 8 Example 14 2 10 8 Example 15 One 9 10 Example 16 6 8 6

As can be seen from the results in Table 16 above, the skin whitening ointment and cosmetics containing the extract of fine herbaceous extract prepared according to Example 13-18 showed a whitening effect for at least 10 or more of 20 subjects. In the comparative experiments of Example 13 and Comparative Example 1 to which a large amount of Bellechorea extract was applied, 70% showed a pigmentation inhibitory effect, and no side effects appeared in the skin. It was found to be a freckle improver or skin lightening agent.

As described above, the cosmetic composition including the extract of the beauty of the herb extract has the effect of inhibiting sebum secretion by inhibiting the activity of 5-alpha-reductase, which converts testosterone to dihydrotestosterone, and cures acne, and melanin pigment. By suppressing the production of blemishes and freckles or skin whitening effect, does not cause any side effects on the human body.

Claims (4)

A cosmetic composition containing the extract of Bellecho chinensis to inhibit the activity of 5 alpha-reductase or to inhibit the production of melanin pigment. The cosmetic composition according to claim 1, wherein the content of the extract of Belle B. in the cosmetic composition is 0.0001-10% by weight in dry weight. The cosmetic composition according to claim 1, wherein the cosmetic composition is a cosmetic composition for sebum secretion, acne healing or skin whitening. The cosmetic composition according to claim 1 or 3, wherein the cosmetic composition is an external skin ointment, cream, softening lotion, nourishing lotion, pack or essence.