KR20000060070A - ToothPaste Which Contains Nephrite Jade Powder And Process For Preparing Thereof - Google Patents

Abstract

PURPOSE: A Nephrite powder contained toothpaste is provided, which eliminates bad breath; inhibits growth of bacteria(antibiotic effect); so prevents parodontitis and dental caries. A preparing process of the toothpaste is also provided. CONSTITUTION: A process for the preparation of Nephrite powder contained toothpaste comprises of: adding gelatin agent powder(e.g., sodium carboxylmethyl cellulose, sodium saccharine) to the moisturizer(e.g., glycerin, sorbitol, polyethylene glycol, or a compound thereof), diluting watery with distilled water, and mixing with a mixer(the primary mixing step); adding a polisher(calcium phosphate, silica), sodium fluorine, and the Nephrite powder, and mixing with a mixer(the secondary mixing step); adding sodium rauryl sulfate(foam-producing agent), perfume, sweetener, and mixing under vacuum(the tertiary mixing step) to get the toothpaste; pouring the toothpaste ingredient into a tube.

Description

Toothpaste Which Contains Nephrite Jade Powder And Process For Preparing Thereof}

The present invention relates to a toothpaste composition containing nephrite powder and a method of manufacturing the same, in particular, the ability to treat diseases of the human body (headache, insomnia, indigestion, hand and foot, etc.), the ability to remove impurities from objects (heavy metal removal) , Etc.), which has fine grained jade powder of finely grained fiber made of hollow fiber, which is a kind of hollow fiber, which has the ability of improving water quality and promoting the growth of animals and plants. A toothpaste and a method of manufacturing the same.

It is well known that toothpaste has been developed for use in the prevention of tooth decay as well as oral hygiene in the past. In particular, in recent years, in order to increase the bactericidal power for the prevention of antibacterial and inflammation in the oral cavity, certain substances such as bamboo salt or anti plasmin and allantoin Toothpastes containing derivatives, vitamin esters, or minerals such as ganbanite, mica, or ceramics have been developed, but they do not have very good effects.

In light of these points, purgatory jade with excellent disease treatment is contained in toothpaste. Generally, jade is roughly divided into jadeite and nephrite, and jadeite is a lead masonry mineral belonging to the pyroxene family. Soda is a monoclinic substance, hardness is a dense mass like crystal, light is black, cyan, green, transparent or translucent, and jade usually refers to jadeite. .

Purgatory is an inosilicates monolithic whiskey mineral, divided into purgatory and serpentine superbasic purgates in high-quality surrogate rocks, and their quality is fine. It is known that the structure, that is, the degree of fineness of the hollow granite-positive stone sperm into fastenings and fibers, and the finer the fiber, the better the quality. The jadeite and purgatory are two different ores, which, like most gemstones, contain silicon and oxygen, as published in the German medical literature (KRAFF der KRISTALLE und der EDELSTEINE) by Mauda Palmer Die Verborgene. However, jadeite is formed of granular crystals, whereas jadeite is composed of countless crystals such as fibers and hair and fine aggregates. Especially, jadeite is beneficial to the human body, unlike the sodium and aluminum components of jadeite. It has been recently announced that it contains three minerals, calcium, iron, and magnesium, which greatly affect the healing of diseases caused by high blood pressure, diabetic circulatory disorders, heart disease and kidney disorders when worn with purgatory. "Die Magie der E" by Hedy Brusisu delsteine).

Also, in Dongbobogam, a classic of oriental medicine, if you put jade in Omiju and Jiyuju, it turns into water and puts it in Honjangsu, which is good to eat. When eaten in the same size as 大, the waste is discharged to the outside of the body, 1 oxol, 1 jijicho (地 楡 草), 1 bream (1 米), and 3 egret (白露) are mixed together and put in a copper bowl. If you build a temple, the oxol is converted into water, which is called oxal (玉液) and is called Shinseonokjang (신 仙 玉 장), and it is based on Sinnonboncho, Dangboncho, and Herbaceous trees. Even if you take jade as a powder to make it enlightenment, it not only has the effect of moistening the five intestines and completely discharging waste products in the body, but also removing the heat in the stomach, which is effective for the digestive system, and bronchial Asthma, fever and heartburn Good and thirst quenching, sesame-like blouse, makes the body lighter and longer to fly, lubricates the lungs, helps the vocal cords nourish, nourish the hair, nourish the hair and function of the intestines In addition, it is effective to relieve stressful neurological disorders.In addition, it is good to eat white jade powder when the muscles are tense and the rat flies. Rubbing and scarring are the main ingredients of purgatory has been known to exert an excellent effect on the human body with little side effects.

However, despite the fact that purgatory is known to have an excellent medical effect on the human body as described above, it is used only as some personal decorative jewelry ornaments such as necklaces, rings, and bracelets due to its scarcity. In particular, processing of purgatory requires a lot of time, effort, and careful attention, and it is impossible to craft it unless it is a skilled person with long experience. Since it is expensive, there is almost no development as a general household goods using purgatory with economical burden. It is true. Therefore, research and development of various household goods or medical supplies and body beauty supplies for urgent use of purgatory is urgently required.

Therefore, the present inventors have found that purgatory has properties that give beneficial effects to humans such as odor removal ability, disease treatment ability (headache, insomnia, indigestion, hand-to-hand, etc.), and object removal ability (heavy metal removal, etc.). It is a result of long research and experiments, and by containing a certain amount of purgatory powder in the toothpaste component, purgatory powder that has maintained oral cleanliness, antibacterial, antiseptic and bactericidal properties, and cell renewal It is to provide a toothpaste and a method of manufacturing the same.

Another object of the present invention is to provide a maximal utilization of the purgatory powder by using the purgatory powder treated with residues or wastes derived from mining or jewelry processing.

Toothpaste containing a purgatory powder of the present invention to achieve the above object is a toothpaste composition containing abrasives, binders, wetting agents, foaming agents, fragrances and sweeteners according to claim 1, containing 3 to 10 parts by weight of jade powder It is characterized by.

The nephrite powder is characterized by having a particle size of 100 to 1000 mesh.

The nephrite powder is characterized in that it is defined as butch δ ¹⁸ O as a diaphragm nephrite in the high quality surrogate rock.

The composition ratio of the purgatory powder is characterized in that it is made as follows.

<Semi QuanTitative Analysis (%)>

Silicon 34

Magnesium 10

Calcium 4.9

Iron 0.23

Aluminum 0.16

Copper 0.17

Cobalt 0.046

Manganese 0.14

Tin 0.024

Beryllium 0.00072

Is 0.0013

Titanium 0.0038

Nickel 0.0028

Chromium 0.0030

Miscellaneous 0

In order to achieve the above object, a method of preparing a toothpaste containing a purgatory powder of the present invention comprises 3 to 10 by weight of a purifying powder during preparation of a toothpaste composition containing an abrasive, a binder, a humectant, a foaming agent, a fragrance and a sweetener according to claim 5. It is characterized by containing a weight part.

The jadeite powder is characterized in that it is defined as butch δ 18 O as a hollowstone jadeite in high-quality surrogate rock.

In general, the particle size of the nephrite powder used in the present invention is preferably 100-350 mesh. However, when the ductility should be increased, it is advantageous to use the finer particles of 350-1000 mesh, which are finer particles. If the grain size of the jade powder is smaller than the above range, the roughness of the product is increased, which is not preferable.

In addition, if the addition amount of the nephrite powder is less than 3 parts by weight, the effect due to the addition of nephrite can not be expected, and the higher the addition amount of the nephrite powder improves the inherent efficacy of the nephrite, but if the addition amount of the nephrite powder is too large, the raw material In addition to lowering the properties, in particular, the ductility of the product to be vulnerable, due to the high price of the purgatory powder, the price of the product is increased, so less than 10 parts by weight of the total weight of the toothpaste composition is preferred.

1 is a crystal structure diagram of a jadeite powder, which is used in the present invention with a scanning electron microscope (SEM),

2 is a scanning electron microscope (SEM) photograph of the jade water untreated silk used in the present invention,

3 is a scanning electron microscope (SEM) photograph of the jade water treated silk used in the present invention,

Figure 4 is a graph showing the change in the test sphere (mouse) activity after drinking drinking water used in the present invention,

5 is a graph showing the results of observing the change in the total volume of the culture medium of digitalis lantana (Digitalis lanata) cells growing in the growth medium,

FIG. 6 is a graph showing changes in the volume of digitalis lantana (Digitalis lanata) cells,

7 is a graph showing changes in the bio weight of cells,

8 is a graph showing the change in dry weight of cells,

9 is a graph showing the pH change of the digitalis lanna (Digitalis lanata) culture medium,

10 is a graph showing the pH change of the production medium after the addition of purgatory powder,

11 is a view showing the result of the state condition of the analyzer;

12 is a diagram showing an output of an analysis result.

Hereinafter, embodiments of the present invention will be described in more detail.

Toothpaste according to the present invention is prepared by adding a gelling agent powder such as sodium carboxymethyl cellulose or sodium saccharin to a humectant such as general glycerin, sorbetol, polyethylene glycol and the mixture thereof, and diluting it with water (purified water). First mixing step, and then after the addition of sodium fluoride and nephrite powder with abrasives such as calcium phosphate, silica, and the like and secondary mixing using a mixer again, sodium lauryl sulfate, fragrance, Toothpaste is prepared by adding a sweetener or the like and tertiary mixing under vacuum, and the toothpaste thus prepared is used in a tube.

The fragrance may be added fragrance oil such as spearmint, peppermint, cinnamon, lemon and orange. The sweeteners include sucrose, lactose, maltose and sodium saccharin. In addition, toothpaste should have a suitable pH, which is generally in the range of 5 to 10, which can be adjusted as a suitable acidic or alkaline substance such as citric acid or sodium hydroxide. The toothpaste can also be used stabilizers such as sodium benzoate.

Hereinafter, the embodiment of the toothpaste containing the purgatory powder according to the present invention manufactured by the above method is as follows, but is not limited to these examples.

<Example 1>

Glycerin 10.0 parts (weight)

Purgatory powder (100 to 1000 mesh) 3.0 parts

0.2 parts of sodium fluoride

Sodium Saccharin 0.20part

Sodium Carboxymethyl Cellulose1.0part

Polyethylene glycol3.00

Titanium Dioxide 0.02part

Sedimented Silica Part 20.00

Dicalcium phosphate dihydrate20.00 parts

0.5 part sodium monofluorophosphate

2.0 parts sodium lauryl sulfate

0.8 parts of air freshener

100.00 parts by adding purified water

<Example 2>

Glycerin 10.0 parts (weight)

Purgatory powder (100 to 1000 mesh) 10.0 parts

0.2 parts of sodium fluoride

Sodium Saccharin 0.20part

Sodium Carboxymethyl Cellulose1.0part

Polyethylene glycol3.00

Titanium Dioxide 0.02part

Sedimented Silica Part 20.00

Dicalcium phosphate dihydrate20.00 parts

0.5 part sodium monofluorophosphate

2.0 parts sodium lauryl sulfate

0.8 parts of air freshener

100.00 parts by adding purified water

<Example 3>: Oral cleaning agent

Purity powder 3 parts (weight)

Glycerin (98%) 15.00

Sodium lauryl sulfate20.0parts

3.00 parts of polyethyl glycol

Zaccarin Sodium 0.2 part

Spices 2.0 parts

100 parts by adding purified water

The results of the tests for removing bad breath, preventing periodontal disease and tooth decay, and skin irritation on the products obtained from the examples were as follows.

<Experimental Example 1>

In this experimental example, to examine the aesthetics of the toothpaste containing the purgatory powder, the male and female toothpaste containing the purgatory powder prepared in the above example and the toothpaste containing no purgatory powder were used. The testers were evaluated according to the taste of each tester so as not to know the taste, the touch, the results are shown in Table 1 below.

Aesthetic and touch characteristics Purgatory powder Toothpaste (the number of the respondents) Control toothpaste (number of respondents) I don't know (number of respondents) Gives a more refreshing feeling. 28 20 2 Feel good 22 21 7 I feel a good fragrance 25 21 4

As shown in the above experimental results, it was proved that the dentifrice or detergent containing the purgatory powder was superior to or comparable to the control toothpaste in terms of consumers' taste.

<Experimental example 2>

50 adult men and women who complained of symptoms such as periodontitis, toothache, bad breath, and tooth decay were diagnosed and used continuously for about 30 days three times a day. . The results are shown in Table 2 below.

Effect Determination Disease No effect Effective Considerable effect Cure effect system toothache 2 6 3 One 12 Periodontitis One 7 5 4 17 Bad breath 3 4 One 4 12 Caries prevention One 4 3 One 9 system 7 (14%) 21 (42%) 12 (24%) 10 (20%) 50 (100%)

As shown in the results of the experiment, if you continuously use the purgatory toothpaste of the present invention, toothache (89%), periodontitis (94%), bad breath (83%), prevention of tooth decay (75%) is effective as a health supplement toothpaste. It can be seen.

<Experiment 3>: skin irritation experiment

50 adult men and women were attached to the inner soft skin of the upper arm and the toothpaste prepared according to the above-described prescription of the present invention after 12 hours, the skin irritation, erythema, itching, allergies and the like. The results were as shown in Table 3 below.

Skin irritation % Of respondents No change in skin 45 (90%) Slight itching after removal 2 (4%) The attachment area is slightly red but disappears after 1-2 hours 3 (6%) Significant irritation 0 (0%)

Test results showed that the toothpaste containing the purgatory powder of the present invention did not irritate the skin. The following experimental examples were conducted on the efficacy of the purgatory powder contained in the cosmetic of the present invention and the effects of the purgatory powder on the living body, and the results are shown in the following tables.

<Lead content test> sample Jade minutes Sample property White powder Job number Federal Institute of F.D.A.American Studies IW 091394-1 Way Atomic absorption analysis result Not detected

<Heavy metal (Pb etc.)> sample Jade powder Sample property White Job number Federal IW 080894-4 Way USP 23 result Not detected

<Inorganic elution test> sample Jade powder Sample property White Job number Federal IW 080894-4 Way As result As

100 g of the sample was extracted with 1 liter of water by autoclave treatment, and the extract liquid was analyzed.

Analyte Results (ppm) Detection limit (ppm) Arsenic (As) ND 0.05 Barium (Ba) ND 0.20 Cadmium (Cd) 0.007 0.005 Chlorine (Cl) ND One Chrome (Cr) ND 0.01 Copper (Cu) ND 0.05 Fe ND 0.10 Pb ND 0.05 Manganese (Mn) ND 0.02 Mercury (Hg) ND 0.0005 Nitrate (NO3) ND 0.1 Selenium (Se) ND 0.05 Silver (Ag) ND 0.01 Sulfate (SO4) 2 One Zinc (Zn) ND 0.01

(ND = concentration is below detection limit or not detected)

As shown in the above experimental results, purgatory powder used in the present invention was proved to be safe when used in, for example, nipples for mammals, because no harmful lead, heavy metals, or other toxic components were detected.

<Experiment 3>

In this experiment, the effects of purgatory used in the present invention on the growth development and the quality of silkworms were examined (see FIGS. 1, 2 and 3).

① Materials and Methods

1. Disclosed silkworm breed: Baekokjam

2. Breeding time: November-December

3. Breeding method: constant temperature and humidity, heraldic mulberry leaf meat

4. Number of Disclosures: Control-150 Repeats 2 Repeats

Treatment-130 Heads 2 Repeat

5. Treatment details: Control-Mulberry feed by distilled water spray

Treatment-Mulberry Feed by Purgatory Spray

Processing Period: From 2nd Stage Sleep

<Breeding results performed by fertilization treatment> division repeat Treated Larvae 5th Infancy Total larvae Chrysalis percentage Work time Work time % Indices Control One 150 7 07 23 07 91.3 100 2 150 7 07 23 07 76.6 Average 150 7 07 23 07 84.0 Treatment group One 130 7 15 23 15 74.1 85 2 130 7 15 23 15 68.2 Average 130 7 15 23 15 71.2

division repeat High yield Cocoon weight Cocoon shell weight Cocoon shell percentage (kg / 10,000) Indices g Indices cg time % Indices Control One 17.9 100 2.08 100 43.0 100 20.7 100 2 15.0 1.96 39.0 19.9 Average 16.5 2.02 41.0 20.3 Treatment group One 16.2 93 2.14 106 44.0 109 20.6 102 2 14.6 2.14 45.0 21.0 Average 15.4 2.14 44.5 20.8

<Threading from Kochi by Oxygen Treatment> division Cocoon filament length (m) Cocoon filament weight (cg) Silk size (d) Specific cutting length (m) Specific Cutting Filament Weight (cg) Thread Pulling Ability (%) Control 1,222 33.7 2.48 3.47 23.4 69 Treatment group 1,283 36.3 2.55 1,005 28.5 78

division Percentage of unprocessed silk (%) Refinement (score) Adhesion (g / d) Elongation (%) Raw silk weight (kg) Control 19.68 95 3.80 3.47 2.75 Treatment group 16.96 96 3.93 1,005 2.61

<Changes in Larva Weight Due to Jade Treatment> division Weight of larvae immediately away from the third slough Weight of larvae immediately away from the fourth slough 5 weights on the 3rd day Mature caterpillars Control 0.46 1.85 20.80 47.4 Treatment group 0.47 1.94 23.03 52.2

<Reduction effect of blood glucose by jade solution> Silkworm extract Blood sugar Reduction effect of blood glucose Injection with maltose '(A) Injection into silkworm extract (B) Reduction amount (C = A-B) efficiency Water treatment mg / 100ml mg / ml mg / ml% 64.0 ± 1.87 27.7 ± 1.70 36.3 56.7 Treated with jade solution 69.6 ± 1.62 20.7 ± 1.62 48.9 70.3

': Injection of Silkworm Extract Previous

result

The weight of larvae was heavier than the control of distilled water in the age of messenger, especially 0.48 g / kg.

2. The rate of fire was 71.2%, which was 15% lower than that of control, and 15.4g of 10,000 head was 7% lower than control.

3. The total weight of the necrosis was 2.14 g, 6% heavier than the control, and 44.5 g, 9% heavier. The silk ratio was 2% higher than the control.

4. Purgatory feeding showed better overall performance than control. Especially silk

The length was long, there were many silks, and the rate was much higher than that of the control by about 9%.

5. In the sands, the nephrophylls showed slightly thicker fine grains, and showed higher ratios of strength, elongation, and yield than those of the control.

6. There was no significant difference in silk surface structure between control and treatment.

7. The crystal structure of the nephrite nephrite had a pointed rod structure.

<Experiment 4>

In this experiment, we observed changes in the activity of mice drinking jade flour drinking water added with jade jade used in the present invention. As shown in FIG. 4, the mice in the positive control group began to stabilize the central nerve from 5 minutes after drinking Ubabitto (Note: Chinese name) in the stabilization experiment, and gradually returned to normal after 30 minutes. Mice in the control group showed ups and downs in activity rates and declined overall. The activity rate of the drinking test group (mouse) of the drinking water of jade powder was similar to that of the normal control group, but the average value of the overall activity rate was not only higher than that of the control group but also significantly different from that of the control group. .

<Experiment 5>

In this experimental example, infrared experiments were performed on purgatory powder.

sample Jade minutes Sample property White method of inspection Perkin elmer 137 result As

<In IR spectrum>

Form: Tetrahydrofran Liquefied Thin Film

It appeared to match the pattern of polycarbonate resin and radiated electromagnetic waves with a wavelength of 6-52μ.

<Experiment 6>

In this experimental example, the experiments were performed as shown in Table 13 and Table 14 below for the chemical and biological oxygen demands for the purgatory powder samples used in the present invention.

sample Jade minutes Sample property White Way Standard method result As

division Water (control) Jade addition 5-day BOD 224 mg / l 223 mg / l COD 115 mg / l 110 mg / l

<Experiment 7>

In this experimental example, the experiment on the effect of the purgatory powder used in the present invention for the experimental sphere (rabbit) was performed as shown in Table 15.

<Primary eye irritation test> sample Jade minutes Sample property Milky powder Way As result As

Method: US Federal Register Vol 43.No 163-1978.8.22 p37359

Experimental procedure: Place 0.1 ml of the extract on the inverted lower eyelid of one eye, and gently hold for 1 second before placing the upper and lower eyelids. The other eye is not treated and observed as a control example. The treated eyes of the six rabbits were left unwashed, and the eyes of the three rabbits were washed with running lukewarm water for one minute immediately after treatment. Prior to treatment with the sample, the eyes were examined in advance by fluorescence and only animals that did not show corneal damage were used for the test. Eye lesions were observed 24 hours, 48 hours, 72 hours, 7 days and 14 days after treatment. The results were shown in Table 16 below.

<Lesion degree of eyes> rabbit time Corneal Opacity Corneal area Iris Price Conjunctival redness Conjunctival Chemosis Conjunctival secretion # 1 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 2 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 3 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 4 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 5 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0)

# 6 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 7wash 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 8wash 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 9wash 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0)

I. Cornea

(A) Opacity-Density (area for detoxification)

Normal-0

Scattered Diffusion Zones-Details of the iris are clearly visible-1

Translucent areas that are easily identified, slightly blurred details of the iris-2

Milky white area, details of the iris are not visible, pupil size is almost indistinguishable

Opaque, no iris visible-4

(B) corneal area

Normal-0

Less than 1/4, but not 0-1

More than 1/4, less than 1/2-2

1/2 or more, 3/4 or less-3

More than 3/4, less than total area-4

Score is A × B × 5, total max = 80

II. Iris

(A) value

Normal-0

Folded above normal, hyperemia, swelling, pericorneal congestion (these symptoms appear in any size, alone or in combination), the iris still responds to light (slow response is pronounced)-1

Not responding to light, bleeding, total destruction (one or both of these symptoms)-2

Score is A × 5, maximum possible total = 10

III. conjunctiva

(A) red tide (only related to the conjunctiva of the eyelid)

Normal-0

Blood vessels are surely reddened above normal-1

More diffuse, deeper magenta, individual vessels not easily distinguished-2

Spread red like beef-2

(B) chemosis

No Snooze-0

Random swelling phenomenon over normal (including eye blink membrane)-1

Clearly swollen with partial inversion of the eyelids-2

Eyelid half closed and swollen-3

Eyelid half to full closed and swollen-4

(C) secretion

Normal-0

Any phenomenon other than normal (not including small amounts observed at the tip of the inner eye of normal animals)-1

Secretions only on the eyelids and eyebrows adjacent to the eyelids-2

Significant area around the eyes-3

Score (A + B + C) × 2, total max = 20

CONCLUSIONS: This sample was determined to be free of eye irritation and, therefore, was found to be suitable for use in eye cosmetic products.

<Primary skin irritation test> sample Jade minutes Sample property White powder Way As result As

Method: US Federal Register Vol. 43, No. 163

CTFA (The Cosmetic, Toiletry and Fragrance Association, Washington, D.C.) Technical Guidelines

Experimental procedure: Patch testing was performed on the skin of the white rabbit and the original skin. The hair was cut short at the back and sides. Two areas, about 10 cm away, were selected as patch locations. One area is made of 4 small epidermal incisions in the patch area to remove the skin (two of which are perpendicular to the other and are "tic-tac-toe"). The patch is attached using a thin rubber band and adhesive tape Samples are introduced in each part in an amount of 0.5 ml (g) under the patch The body of the animal is wrapped with a rubberized cloth for 24 hours of exposure. After the patch was removed, the reaction at each site was evaluated based on the scores described below (see Table 18).

Evaluation of Skin Response

Erythema and crust formation

No erythema-0

Very weak erythema (recognizable barely)-1

Properly identified erythema-2

Moderate to severe erythema-3

Severe erythema (beat red) to slight crust formation (deep damage)-4

Edema

No edema-0

Very mild edema (recognizable barely)-1

Slight edema (it is obvious that the edges of the area are prominent)-2

Moderate edema (approximately 1 mm up)-3

rabbit 24 hours 72 hours Original skin Worn skin Original skin Worn skin ER ED ER ED ER ED ER ED #One 0 0 0 0 0 0 0 0 #2 0 0 0 0 0 0 0 0 # 3 0 0 0 0 0 0 0 0 #4 0 0 0 0 0 0 0 0 # 5 0 0 0 0 0 0 0 0 # 6 0 0 0 0 0 0 0 0

Conclusions: This sample was determined to have no skin irritation. Therefore it appeared to be suitable for use in skin cosmetic products.

<Acute oral toxicity [(0.5 g) / 100 g body weight] experiment> sample Purgatory powder Sample property White powder Way As result Same as Table 24 below

rat gender Initial weight (g) Dosage (ml) Lag weight (g) Toxicity One F 207 1.0 219 none 2 F 211 1.1 226 none 3 F 215 1.1 225 none 4 F 208 1.0 217 none 5 F 200 1.0 213 none 6 M 227 1.1 235 none 7 M 216 1.1 224 none 8 M 205 1.0 218 none 9 M 210 1.1 224 none 10 M 212 1.1 221 none

Preparation of Samples: A portion of the sample was placed in sterile distilled water and boiled for 10 minutes to extract, and the extract was administered by intubation in an amount of 0.5 g per 100 g of body weight.

CONCLUSIONS: The sample meets the criteria for no oral toxicity.

<Experimental example 8>

This experiment example is the process and results of the experiment performed by Inha University bioinformatics system engineering laboratory to investigate the various effects of purgatory powder used in the present invention on the living body. In this experiment, 70% of the constituent elements of the human body are water. Therefore, the impact of water on the water and the impact on the human body are investigated. Experiments on the effects were performed.

A. Hard water change

<Experiment 1>

100 ml of artificially-made hard water was transferred to each of the four flasks by 50 ml, and purgatory was placed on the bottom of two flasks for about 10 minutes.

To determine the change in hardness, a titration method using ethylene diamineacetic acid (hereinafter referred to as "EDTA" titer 2.9412) was used. 1 ml of a buffer solution of pH 10, EBT was used as an indicator.

The change in hardness was measured by the amount of EDTA until the moment when the color of the hard water was changed by EDTA. At this time, the color returned to its original state over time, but in this experiment, the measurement was made based on the changing moment.

<Result 1>

At 100ppm of hard water, it takes 1.70ml of EDTA.

It takes 1.25ml of EDTA after purgatory test, so the hardness of 100.00ppm is lowered to 73.53ppm. That is, the hardness of 100.00 ppm was softened 26.47%.

<Experiment 2>

200 ml of 100ppm hard water made in the same manner as in Experiment 1 was transferred to a beaker to immerse the purgatory. After about 30 minutes, the water in the beaker was divided into three flasks to measure the change in hardness. In this experiment, the hardness was measured by adding EDTA until the color of hard water did not change any more after the color of hard water changed by EDTA.

<Result 2>

Each 100ppm hard water before purgatory experiment

89.62 ppm

91.19ppm

89.62 ppm

Average 90.14ppm, thus 9.9% hardness decrease

<Experiment 3>

This experiment was conducted with tap water. Tap water was placed in a container and transferred to six flasks, and purgatory was placed at the bottom of three flasks, and hardness was measured after about 5 minutes.

<Result 3>

* Tap water without purgatory

97.48 ppm

97.48 ppm

97.48 ppm

Average 97.48 ppm

* Tap water after purgatory experiment

91.19ppm

91.19ppm

91.19ppm

Average 91.19ppm therefore, hardness decrease of 6.5%

I. Effect of Purgatory on the Proliferation of Digital Plant Suspensions of Digitalis lanata

Effects of Purgatory on the Growth of Digitalis lanata Cells in Growth Medium

FIG. 5 is a graph showing changes in culture medium volume of cells grown in growth medium for 11 days, and FIG. 6 is a graph showing changes in cell volume, in proportion to the increase of cells growing over time. As the depletion of and the evaporation of the medium occur, the volume change of the whole culture reflects these factors. In particular, humidity and temperature in the atmosphere are closely related to the evaporation of the medium, and such factors also affect the cell growth rate.

As shown in the figure, the use of purgatory shows that the volume of the total culture solution is slightly decreased compared to the control group which is not used. This is because the use of purgatory rather than the control group has a faster cell growth rate against the evaporation of the medium or the depletion of nutrients, and thus, it is possible to offset the rapid decrease of the depleted medium to some extent. This phenomenon is observed in the case of continuous use of purgatory from day 4 to day 11 after inoculation of cells as shown in Fig. 6 measuring the volume change of the sunk cells only increase the volume of the cell than the unused control group. This fact can be estimated. Therefore, the use of nephrite showed a faster cell growth rate than the control without the nephrite. These results can be said to be the result of delaying the decrease of the total volume than the control by offsetting the decrease in the total culture volume due to nutrient depletion and medium evaporation. In addition, the result of comparing the volume of the increased cell alone is also observed to show a tendency to gradually increase the cell volume after 4 days, it is thought that can support this result.

Cell proliferation and dry weight are the most common measures of cell proliferation. In general, the growth curve of all cells is represented by the S-shaped curve, which can be classified into four stages. Lag phase, which is a period of adaptation to the medium, in which there is no cell proliferation and no mass growth, and an exponential curve showing a steep slope due to a mass increase at a rapid proliferation rate after this period. phase), the stationary phase, which has a maximum growth to some extent, and the Chinese food is slowed down and shows no mass increase, and the cell ruptures due to the depletion of nutrients, the release of toxic components, and the saturation of cell density. It can be divided into a dead phase where the total cell volume or mass decreases due to the tendency to die.

7 and 8 are the results of measuring the cell biomass and dry weight.

7 follows the growth curve of these four stages. In the case of using jade, after 7 days, the growth rate was slightly higher than that of the control without jade, and the growth stopped until 10 days, unlike the control showing the decrease in cell biomass. have. This is remarkable in that cell growth is continued even when the concentration of nutrient is almost depleted and the concentration in the medium becomes zero compared with the change in the concentration of glucose, a nutrient that acts as the main metabolic substrate in the medium. It is common to show a tendency to stop the growth and decrease the growth rate at the point of depletion of the influenced ingredients, like the control without purgatory, but the effect of purgatory on cell growth is different from purgatory It is assumed that there is. This result is also shown in Figure 8 shows the cell growth proliferating at a higher rate than the control after 3 days, and from 9 days after, the same phenomenon as in FIG. As a result, cells grown near nephrite in the growth medium showed better effect on cell growth than the control group that did not. Digitalis lanata plant cells, which have a growth limit of about 10 days, are maintained in a stable state that does not cause necrosis of cells without exchanging with new medium even after 10 days when cultured with purgatory. Rather, it is expected that cell proliferation may be an advantageous method for optimizing cell growth and concentration in the production process for the production of useful substances.

② Effect of Purgatory on Changes in Medium pH

9 is a graph showing the pH change in the cell growth medium, Figure 10 is a graph showing the pH change of the production medium after the addition of purgatory powder.

Figure 9 is a measure of the change in the pH of the medium in the control medium with and without the purgatory in the growth medium. The control group shows a general tendency of pH in the medium applied to the plant cells, which gradually decreases over time and is maintained at a certain level. However, when using purgatory, it showed a similar pattern to the control group until day 7, and gradually increased. This phenomenon is extreme in the result of FIG. . The control group without added jade powder showed a consistent drop in pH, while the addition of jade powder showed a tendency to maintain the value to some extent. It is assumed that it acts as a cause.

③ Results of analysis of water quality for purgatory

FIG. 11 is a view showing the condition of the water analyzer containing the purgatory powder used in the present invention, and FIG.

The data from FIG. 11 and FIG. 12 are summarized in Table 21 to Table 24. Table 21 shows each analysis item for Sample 1 after 48 hours of injecting 20 g of nephrite lump in solution. In Table 21, there is little change in each measurement item, and the effect of purgatory is hardly seen.

Table 22 shows the measured values for each analysis item in Sample 2 after 48 hours of placing 20g of jade purgatory blocks outside the solution.

Table 24 also shows the measured values for each analysis item in Sample 4 after 48 hours of purifying powder outside the solution. However, in the case of Sample 3, the data measured for each analysis item of the sample 48 hours passed after adding 20 g of purgatory powder in the solution is shown in Table 23. This change is as follows.

Cr, Pb, Ni, and Co, which are harmful to the human body, changed significantly after 48 hours. Cr is

In the absence of purgatory powder, that is, 45.30 mg before the reaction was removed to 0 after 48 hours of purifying powder, and Pb was also completely removed from 13.76 mg to 0. Ni decreased from 51.8 mg to 1.733 mg and Co also decreased from 52.69 mg to 11.94 mg. Mg, one of the necessary elements in the human body, increased from 48.36mg to 55.74mg.

The hydrogen ion concentration of distilled water was acidic at pH 3.5, but after the reaction, it became neutral at pH 6.8, and the conductivity was also rapidly decreased. to be.

Analytical results before and after the reaction in solution Purgatory lumps (purg of jade in solution) (Sample 1): Purgatory lumps in solution (20 g) Item Before the reaction After reaction (48hr) Change pH 3.5 3.82 - Ni 51.8 mg 51.75mg - Co 52.69mg 52.54mg - Cr 45.30mg 43.88mg - Mg 48.36mg 48.59 mg - Pb 13.76 mg 13.90mg -

Results of analysis of purgatory lumps outside the solution. (Sample 2): lump of purgatory jade (20g) Item Before the reaction After reaction (48hr) Change pH 3.5 3.65 - Ni 51.8 mg 48.92mg - Co 52.69mg 49.83mg - Cr 45.30mg 41.23mg - Mg 48.36mg 47.97mg - Pb 13.76 mg 15.1mg -

Analysis result when adding purgatory powder to solution. (Sample 3): Purgatory powder in solution (20g) Item Before the reaction After reaction (48hr) Change pH 3.5 6.8 +3.3 Ni 51.8 mg 1.733 mg -50.06mg Co 52.69mg 11.94mg -40.75mg Cr 45.30mg 0mg -45.30mg Mg 48.36mg 55.74mg + 7.38mg Pb 13.76 mg 0mg -13.76 mg

Analysis result when purgatory powder was placed outside solution (Sample 4): Purgatory powder outside solution (20g) Item Before the reaction After reaction (48hr) Change pH 3.5 3.7 - Ni 51.8 mg 51.53 mg - Co 52.69mg 52.55mg - Cr 45.30mg 43.0mg - Mg 48.36mg 48.39mg - Pb 13.76 mg 14.29 g -

As described above, in the case of Digitalis lanata plant suspension cells cultured for one week with nephrite close, proliferation of more than about 30% was observed. This is a rare proliferative result even in the various experiments performed for the proliferation effect on conventional Digigitalis lanata plant cells for high concentration culture. In addition, experiments on how purgatory water affects hard water showed that soft water softened hard water without contact with water. Particularly, in the component analysis experiments on water using distilled water, precipitation of nephrite was carried out. After 48 hours, in the component analysis, the pH was increased, the Ni and Co components were reduced, the Cr and Pb were removed, and the heavy metals were removed. An unusual phenomenon was observed that led to the phenomenon of.

As such, purgatory powder according to the present invention has not yet been clearly identified theoretically, but also changes the hardness of water without contact with water, and also proliferates more than 30% of the digitalis lanna plant (Digitalis lanata) plant suspension cells, The elimination of heavy metals harmful to the human body, such as the reduction of Ni and Co components, and the removal of Cr and Pb, is believed to be due to the radiation effect of the electromagnetic wave wavelengths of the purgatory powder and the ionic reaction by the mineral components contained in the nephrite. These facts will be proved by the efficacy shown in the above-described products of the present invention, and the experimental results in particular, dental and oral hygiene due to the effects of purgatory powder and purgatory when using the toothpaste containing the purgatory powder of the present invention. It will be proved that it will have a useful effect.

As described above, according to the present invention, when using a toothpaste product made with the addition of purgatory powder, antibacterial agents such as removing bad breath, inhibiting bacterial propagation, and periodontitis due to medical effects such as cell function activation, blood circulation and metabolism promotion due to purgatory It has the effect of having prevention and caries prevention function.

Claims (6)

A dentifrice composition comprising an abrasive, a binder, a humectant, a foaming agent, a fragrance, and a sweetener, wherein the dentifrice contains 3 to 10 parts by weight of jadeite. The toothpaste of claim 1, wherein the nephrite powder has a particle size of 100 to 1000 mesh. The dentifrice containing jadeite powder according to claim 1, wherein the jadeite powder is defined as butch δ ¹⁸ O as a hollow-trillite gemstone in high-quality surrogate rock. According to any one of claims 1 to 3, wherein the composition ratio of the purgatory powder used in the above is made as follows. <Semi QuanTitative Analysis (%)> Silicon 34 Magnesium 10 Calcium 4.9 Iron 0.23 Aluminum 0.16 Copper 0.17 Cobalt 0.046 Manganese 0.14 Tin 0.024 Beryllium 0.00072 Is 0.0013 Titanium 0.0038 Nickel 0.0028 Chromium 0.0030 Miscellaneous 0 A method for producing a dentifrice-containing toothpaste, comprising 3 to 10 parts by weight of jadeite during the preparation of a dentifrice composition comprising an abrasive, a binder, a humectant, a foaming agent, a fragrance, and a sweetener. The method of manufacturing a toothpaste containing jadeite powder according to claim 1, wherein the jadeite powder is defined as butch δ ¹⁸ O as a hollowstone jadeite in high-quality surrogate rock.