KR20000038283A - Silicone rubber containing nephrite powder and method for preparing thereof - Google Patents

Abstract

PURPOSE: A silicone rubber containing nephrite powder which has an improved physical strength and mechanical strength and a method for preparing thereof are provided. CONSTITUTION: A silicone rubber containing the nephrite powder is prepared by mixing 10-30 wt. parts of nephrite powder having 100-1,000 mesh with silicone compound and then extruding the mixture, wherein the nephrite powder consists of 35% of Si, 10% of Mg, 4.9% of Ca, 0.23% of Fe, 0.16% of Al, 0.17% of Cu, 0.046% of Co. 0.14% of Mn, 0.024% of Sn, 0.00072% of Be, 0.00135 of Ag, 0.0038% of Ti, 0.0028% of Ni and 0.003% of Cr according to the Semy Quantitative Analysis and the silicone compound is prepared by mixing filler, vulcanizing agent and accelerating agent with at least one silicone selected from the group consisting of dimethylsilicone, methylphenylsilicone, methylvinylsilicone, methylphenylsilicone and methyltetramersilicone.

Description

Silicon rubber containing jade powder and its manufacturing method

The present invention relates to a silicone rubber containing nephrite powder and a method for manufacturing the same, and in particular, a hollow fiber of brown fiber having a very fine fiber of cationic granules in the raw material of the silicone rubber. The fine powder of nephrite with a microstructure is used to manufacture articles such as medical devices, household goods, industrial goods, daily necessities, leisure goods, sporting goods and personal goods, electronic devices, precision machine goods, or the like. By making it contained during the manufacture of the article, the physical and mechanical strength of the product itself is improved, and the components (Ca, Fe, and Mg) contained in the purgatory can be used to treat diseases of the human body (headache, insomnia, indigestion, hand and foot, etc.) The present invention relates to a silicone rubber containing jade powder, which has been shown to exhibit the ability to remove impurities (such as heavy metals), improve water quality, and promote growth of animals and plants, and a method of manufacturing the same.

In general, jade is roughly divided into jadeite and nephrite, and jadeite is a lead masonry mineral belonging to the pyroxene family. Soda is a monoclinic substance, hardness is a dense mass like crystal, light is black, cyan, green, transparent or translucent, and jade usually refers to jadeite. .

Purgatory is an inosilicates monolithic whiskey mineral, divided into purgatory and serpentine superbasic purgates in high-quality surrogate rocks, whose quality is fine. It is known that the structure, that is, the granules of caterpillar-positive stone sperm, is made of fastening and fiber, and the finer the fiber, the better the quality.

The jadeite and jadeite are two different ores, which, like most gemstones, contain silicon and oxygen, as published in the German medical literature ("KRAFF der KRISTALLE und der EDELSTEINE") by Mauda Palmer Die Verborgene. While jadeite is formed of granular crystals, jadeite is composed of countless crystals such as fibers and hair and fine aggregates. Especially, jadeite is beneficial to human body, unlike sodium and aluminum in jadeite. It has been recently announced that it has a major effect on the healing of diseases caused by hypertension, diabetic circulatory disorders, heart disease and kidney disorders. "Die Magie der Edels" by Hedy Brusisu teine ".

On the other hand, in Dongbobogam, a classic of oriental medicine, if you put jade into Omiju and Jiyuju, it turns into water, and if you put it in Honjangsu, it's good to eat. When eaten in the same size as 大, the waste is discharged to the outside of the body, 1 oxol, 1 jijicho (地 楡 草), 1 bream (1 米), and 3 egret (白露) are mixed together and put in a copper bowl. If you build a temple, the oxol is converted into water, which is called oxal (玉液) and is called Shinseonokjang (신 仙 玉 장), and it is based on Sinnonboncho, Dangboncho, and Herbaceous trees. Even if you take jade as a powder to make it enlightenment, it not only has the effect of moistening the five intestines and completely discharging waste products in the body, but also removing the heat in the stomach, which is effective for the digestive system, and bronchial Asthma, fever and heartburn Good and thirst quenching, sesame-like blouse, makes the body lighter and longer to fly, lubricates the lungs, helps the vocal cords nourish, nourish the hair, nourish the hair and function of the intestines In addition, it is effective to relieve stressful neurological disorders.In addition, it is good to eat white jade powder when the muscles are tense and the rat flies. Rubbing and scarring are the main ingredients of purgatory has been known to exert an excellent effect on the human body with little side effects.

However, despite the fact that purgatory is known to have excellent medical effects on the human body, due to its scarcity, it is produced and used only as some jewelry for jewelry, such as necklaces, rings, and bracelets. It is hard to develop it as a skilled person with long experience because it requires hard work and careful attention, and because it is expensive, there is almost no development as a general household goods using purgatory due to economic burden. Therefore, research and development on various household goods or medical supplies are urgently needed for the people to use purgatory more profitably.

Therefore, the present inventors have the characteristic that purgatory gives a beneficial effect to humans such as the ability to treat such diseases (headache, insomnia, indigestion, hand-to-hand, etc.), odor removal ability, the ability to remove impurities of the object (heavy metal removal, etc.) Taking note of the fact that it has been developed for a long time, it has been developed from the purgatory by adding a certain amount of purgatory powder to the raw material of silicone rubber, kneading and extruding it or molding it into a household or medical product. Among the wavelengths, the purgatory powder that enables far-infrared rays absorbed by the human body to exhibit medical characteristics such as metabolism promoting ability, blood circulation activation ability, cell activation ability and odor removal ability, as well as physical and mechanical strength characteristics are improved. It is to provide a silicone rubber contained and a method of manufacturing the same.

Another object of the present invention is to provide a maximal utilization of the purgatory powder by using the purgatory powder treated with residues or wastes derived from mining or jewelry processing.

In order to achieve the above object, the silicone rubber containing the purgatory powder of the present invention is characterized by extruding after kneading by putting 10 to 30 parts by weight of the purifying powder into the silicone compound in preparing the silicone rubber material using the silicone compound.

The nephrite powder is preferably made to achieve a particle size of 100 to 1000 mesh.

The silicone compound is characterized by mixing dimethylsilicone, methylphenylsilicone, methylvinylsilicone, methylphenylvinylsilicone, methyltetramersilicone, filler, vulcanizing agent and accelerator.

The composition ratio of the nephrite powder used above is made as follows.

`` Semy QuanTitative Analysis (%)>

Silicon 34

Magnesium 10

Calcium 4.9

Iron 0.23

Aluminum 0.16

Copper 0.17

Cobalt 0.046

Manganese 0.14

Tin 0.024

Beryllium 0.00072

Is 0.0013

Titanium 0.0038

Nickel 0.0028

Chromium 0.0030

Miscellaneous 0

In addition, in order to achieve the above object, the manufacturing method of the silicone rubber containing the purgatory powder of the present invention is a method of manufacturing the silicone rubber using the silicone compound, the particle size of 100 to 1000 mesh in the silicone compound during the manufacturing process of the silicone rubber Put 10 to 30 parts by weight of the purgatory powder having a characterized in that the extrusion after kneading.

The process is characterized in that it further comprises the step of making household goods, medical supplies and personal care products by the silicon rubber containing jade powder.

In general, the particle size of the nephrite powder used in the present invention is preferably 100-350 mesh. However, when the ductility should be increased, it is advantageous to use the finer particles of 350-1000 mesh, which are finer particles. If the grain size of the purgatory powder is larger than the above range, the surface roughness of the product becomes severe, which is not preferable.

In addition, if the addition amount of the nephrite powder is less than 10% by weight, the effect due to the addition of nephrite can not be expected, and the higher the addition amount of the nephrite powder improves the inherent efficacy of the nephrite, but when the addition amount is excessive, the properties of the raw material, in particular In addition to lowering the ductility, the product may be vulnerable, and due to the high price of the jadeite powder, the unit price is increased.

In addition, the silicone rubber containing the purifying powder according to the present invention is used for industrial products such as coating, packing, oil seal, O-ring, bushing, gaskets, various dustproof rubbers, rubber tapes, rubber rollers, tubes, rubber coating crosses, and the like. Electronic parts, medical supplies such as blood transfusion tubes, condoms, gauze, catheters, wax bottle caps, household goods such as nipples of baby bottles, kitchen utensils such as rubber gloves, slippers, boots It is used to manufacture various personal goods such as.

In addition, the nephrite powder used in the manufacture of silicone rubber is mainly made of gemstones such as jewelry, bowls, sculptures, etc., and the remaining residues are crushed and used, which is economically advantageous in terms of cost reduction. It is possible to obtain products of various practical items having inherent properties of purgatory at low cost.

1 is a crystal structure diagram of a purgatory powder which shows the purgatory powder used in the present invention by a scanning electron microscope (SEM),

2 is a scanning electron microscope (SEM) photograph of the jade water untreated silk used in the present invention,

3 is a scanning electron microscope (SEM) photograph of the jade water treated silk used in the present invention,

Figure 4 is a graph showing the change in the test sphere (mouse) activity after drinking drinking water used in the present invention,

5 is a graph showing the results of observing the change in the total volume of the culture medium of digitalis lantana (Digitalis lanata) cells growing in the growth medium,

FIG. 6 is a graph showing changes in the volume of digitalis lantana (Digitalis lanata) cells,

7 is a graph showing changes in the bio weight of cells,

8 is a graph showing the change in dry weight of cells,

9 is a graph showing the pH change of the digitalis lanna (Digitalis lanata) culture medium,

10 is a graph showing the pH change of the production medium after the addition of purgatory powder,

11 is a view showing the result of the state condition of the analyzer;

12 is a diagram showing an output of an analysis result.

The preferred embodiment of the silicone rubber containing the purgatory powder according to the present invention and a method of manufacturing the same will be described in detail.

Purifying the silicone rubber containing the purgatory according to the present invention is kneaded with 10 to 30 parts by weight of the purifying powder having a particle size of 100 to 1000 mesh, and then kneaded with the silicone compound as the raw material of the silicone rubber. It is also possible to obtain a desired product by a general forming process after extrusion.

In the above, the extrusion pressure is suitable to extrude at a pressure of 30 ~ 80kg / ㎠ at 100 ~ 200 ℃.

The silicone compound is a mixture of a filler, a vulcanizing agent, and an accelerator in any one silicon material selected from dimethylsilicone, methylphenylsilicone, methylvinylsilicone, methylphenylvinylsilicone and methyltetramersilicone.

The vulcanization conditions are generally performed at a high temperature, and any one selected from benzoyl peroxide and bis 2,4-dichloro benzoyl, which are organic peroxides, is preferably used at about 1 to 5 phr. In addition, the filler is a mixture of 20 to 30 parts by weight of any one selected from high purity fumed silica (130 ~ 380㎡ / g), zinc oxide, titanium oxide, etc. in order to enhance the strength due to the increase in bonding strength between silicon. In addition, an accelerator for promoting the mixing of the compound with the purgatory powder is mixed with approximately 0.1 to 2.0 parts by weight of an organic acid ester and hydroxysilane.

<Example 1>

10 parts by weight of a jade powder having a mesh size of 100 mesh is added to a silicon compound containing dimethyl silicone, benzoyl peroxide, high purity fumed silica (150 m2 / g), and an organic acid ester, and then mixed uniformly. Silicone rubber was obtained while extruding at a pressure of 70 kg / cm 2 at.

<Example 2>

Only the ratio of the particle size (350 mesh) of the nephrite powder to the silicon compound and the ratio of the nephrite powder (30% by weight) was changed, except that the silicone rubber was obtained in the same manner as in Example 1 above.

As a result of testing the physical properties of the products obtained from the above examples, it can be seen that the heat resistance and physical strength is improved compared to the conventional silicone rubber, as confirmed from Tables 1 and 2 below, In the case of using a silicone product, as shown by the following experimental example, it was found that there is a medical effect due to the influence of far-infrared rays (about 10 microns or so) absorbed in vivo in the wavelength.

Item Name Invention Product Comparative product (1) (KE 650) Comparative product (2) (KE 660) Shore A 250 ° C 24hr 80 45 60 Tensile Strength (kg / ㎠) 250 ℃ 24hr 120 86 70 Elongation (%) 250 ℃ 24hr 350 340 200

Item Name Invention Product Comparative product (1) (KE 650) Comparative product (2) (KE 660) % Heat change at 250 ° C for 72hr The tensile strength -1.1 -9.2 -8.2 Height -1.0 -4.0 70 Hardness +1.7 +10.0 +15.0

<Experimental Example 1>

In order to find out how beneficial the product made of the silicone rubber containing the purgatory powder prepared by the above embodiment has a beneficial effect on the human body, it was carried out by requesting the Oriental Medical Hospital of Daejeon University, and the experimental method contained the purifying powder of the present invention. The inner body (panties) in which the silicone rubber was used as a waist band and the inner underwear in which the general silicone rubber band was worn were worn by adult men and women over 45 years for about 2 hours, and then the change of the human body was measured. The results were as shown in Tables 3 to 5 below.

<Test object: 45-year-old adult man> division In the inner which general silicon rubber was adopted In the inside which the product of this invention was employ | adopted Heart rate HR (SaO ₂ ) 81 BPM 76 BPM Blood pressure NIBP SYS 127 mmHg 128 mmHg MEAN (average) 107 mmHg 104 mmHg DIAS 80 mmHg 76 mmHg Oxygen Concentration (SaO ₂ ) 91% 93% Pulse rate 81 BPM 76 BPM

<Inspection object: 55-year-old adult man> division In the inner which general silicon rubber was adopted In the inside which the product of this invention was employ | adopted Heart rate HR (SaO ₂ ) 81 BPM 85 BPM Blood pressure NIBP SYS 181mmHg 173 mmHg Average (MEAN) 142 mmHg 127 mmHg DIAS 111mmHg 110 mmHg Oxygen Concentration (SaO ₂ ) 95% 95% Pulse rate 83 BPM 85 BPM

<Inspection object: 64 years old adult woman> division In the inner which general silicon rubber was adopted In the inside which the product of this invention was employ | adopted Heart rate HR (SaO ₂ ) 68 BPM 68 BPM Blood pressure NIBP SYS 185 mmHg 176 mmHg Average (MEAN) 117 mmHg 125 mmHg DIAS 104 mmHg 105 mmHg Oxygen Concentration (SaO ₂ ) 74% 96% Pulse rate 68 BPM 68 BPM

As shown in the above Tables 3 to 5, as a result of wearing a soft-core inner silicone rubber product containing the purgatory powder of the present invention, the oxygen concentration, that is, the amount of oxygen is generally It can be seen that it has an excellent effect of promoting the metabolism of the human body and smoothing blood circulation.

<Experimental Example 2>

As a result of clinical trials in which patients (products in the stomach, slippers, etc.) made using the silicone rubber containing the purgatory powder according to the present invention were worn by the patients, approximately 88% of the trial subjects were found to be effective.

◎ The selection criteria and selection method of the examinee

Twenty-five patients were selected as clinical trial subjects who were diagnosed or diagnosed with symptoms such as headache, insomnia, Hyun-hoon, anxiety, chest pain, and numbness of hands and feet.

◎ Observation Event and Inspection Method

The patient's condition and physical changes were observed after a certain period of time (approximately 10 days or more) in the patient undergoing inpatient treatment for headache, insomnia, vertigo, anxiety, chest pain, and numbness of the hands and feet.

◎ Evaluation criteria and evaluation methods

end. Evaluation Criteria: Based on the initial status of observational items.

I. Evaluation method: was evaluated in the same manner as Table 6, the results were as shown in Table 7.

order division evaluation(%) One If the effect is small or no Less than 70% 2 When it works More than 70% 3 When there is a significant effect 80% or more 4 When the effect is close to cure over 90

Effect Determination Disease No effect Effective Considerable effect Cure effect system Less than 70% More than 70% 80% or more over 90 headache. Hyun Hoon 2 3 5 One 11 Blows 0 2 One One 4 Anxiety. One One One 2 5 Hogtied 0 One One One 3 Indigestion 0 0 2 0 2 system 3 (12%) 7 (28%) 10 (40%) 5 (20%) 25 (100%)

As can be seen from the results of the clinical trials in Table 7, most of the clinical trials showed improvement in symptoms such as alleviation of headache and dizziness, recovery of insomnia and anxiety, improvement of numbness of hands and feet, indigestion, etc. From these results, the medical efficacy of purgatory has been fully demonstrated. The following experimental examples were conducted on the efficacy of the purgatory powder contained in the silicone rubber of the present invention and the effects of the purgatory powder on the living body, and the results are shown in the following tables.

<Lead content test> sample Jade minutes Sample property White powder Job number Federal Institute of F.D.A.American Studies IW 091394-1 Way Atomic absorption analysis result Not detected

<Heavy metal (Pb etc.)> sample Jade powder Sample property White Job number Federal IW 080894-4 Way USP 23 result Not detected

<Inorganic elution test> sample Jade powder Sample property White Job number Federal IW 080894-4 Way As result As

100 g of the sample was extracted with 1 liter of water by autoclave treatment, and the extract liquid was analyzed.

Analyte Results (ppm) Detection limit (ppm) Arsenic (As) ND 0.05 Barium (Ba) ND 0.20 Cadmium (Cd) 0.007 0.005 Chlorine (Cl) ND One Chrome (Cr) ND 0.01 Copper (Cu) ND 0.05 Fe ND 0.10 Pb ND 0.05 Manganese (Mn) ND 0.02 Mercury (Hg) ND 0.0005 Nitrate (NO ₃ ) ND 0.1 Selenium (Se) ND 0.05 Silver (Ag) ND 0.01 Sulfate (SO ₄ ) 2 One Zinc (Zn) ND 0.01

(ND = concentration is below detection limit or not detected)

As shown in the above experimental results, purgatory powder used in the present invention was proved to be safe when used in, for example, nipples for mammals, because no harmful lead, heavy metals, or other toxic components were detected.

<Experimental Example 3>

In this experiment, the effect of purgatory used in the present invention on the growth development and the quality of silkworms was examined (see FIGS.

① Materials and Methods

1. Disclosed silkworm breed: Baekokjam

2. Breeding time: November-December

3. Breeding method: constant temperature and humidity, heraldic mulberry leaf meat

4. Number of Disclosures: Control-150 Repeats 2 Repeats

Treatment-130 Heads 2 Repeat

5. Treatment details: Control-Mulberry feed by distilled water spray

Treatment-Mulberry feed by spraying purgatory

Processing Period: From 2nd Stage Sleep

<Breeding results performed by fertilization treatment> division repeat Treated Larvae 5th Infancy Total larvae Chrysalis percentage Work time Work time % Indices Control One 150 7 7 23 7 91.3 100 2 150 7 7 23 7 76.6 Average 150 7 7 23 7 84.0 Treatment group One 130 7 15 23 15 74.1 85 2 130 7 15 23 15 68.2 Average 130 7 15 23 15 71.2

division repeat High yield Cocoon weight Cocoon shell weight Cocoon shell percentage (kg / 10,000) Indices g Indices cg time % Indices Control One 17.9 100 2.08 100 43.0 100 20.7 100 2 15.0 1.96 39.0 19.9 Average 16.5 2.02 41.0 20.3 Treatment group One 16.2 93 2.14 106 44.0 109 20.6 102 2 14.6 2.14 45.0 21.0 Average 15.4 2.14 44.5 20.8

<Threading from Kochi by Oxygen Treatment> division Cocoon filament length (m) Cocoon filament weight (cg) Silk size (d) Specific cutting length (m) Specific Cutting Filament Weight (cg) Thread Pulling Ability (%) Control 1,222 33.7 2.48 3.47 23.4 69 Treatment group 1,283 36.3 2.55 1,005 28.5 78

division Percentage of unprocessed silk (%) Refinement (score) Adhesion (g / d) Elongation (%) Raw silk weight (kg) Control 19.68 95 3.80 3.47 2.75 Treatment group 16.96 96 3.93 1,005 2.61

<Changes in Larva Weight Due to Jade Treatment> division Weight of larvae immediately away from the third slough Weight of larvae immediately away from the fourth slough 5 weights on the 3rd day Mature caterpillars Control 0.46 1.85 20.80 47.4 Treatment group 0.47 1.94 23.03 52.2

<Reduction effect of blood glucose by jade solution> Silkworm extract Blood sugar Reduction effect of blood glucose Injection with maltose '(A) Injection into silkworm extract (B) Reduction amount (C = A-B) efficiency Water treatment mg / 100ml mg / ml mg / ml% 64.0 ± 1.87 27.7 ± 1.70 36.3 56.7 Treated with jade solution 69.6 ± 1.62 20.7 ± 1.62 48.9 70.3

': Injection of Silkworm Extract Previous

result

The weight of larvae was heavier than the control of distilled water in the age of messenger, especially 0.48 g / kg.

2. The rate of fire was 71.2%, which was 15% lower than that of control, and 15.4g of 10,000 head was 7% lower than control.

3. The total weight of the necrosis was 2.14 g, 6% heavier than the control, and 44.5 g, 9% heavier. The silk ratio was 2% higher than the control.

4. Purgatory feeding showed better overall performance than control. In particular, the length of silk thread was long, the amount of silk was high, and the rate of hatchery was much higher than that of the control by about 9%.

5. In the sands, the nephrophylls showed slightly thicker fine grains, and showed higher ratios of strength, elongation, and yield than those of the control.

6. There was no significant difference in silk surface structure between control and treatment.

7. The crystal structure of the nephrite nephrite had a pointed rod structure.

<Experiment 4>

In this experiment, we observed changes in the activity of mice drinking jade flour drinking water added with jade jade used in the present invention. As shown in FIG. 4, the mice in the positive control group began to stabilize the central nerve from 5 minutes after drinking Ubabitto (Note: Chinese name) in the stabilization experiment, and gradually returned to normal after 30 minutes. Mice in the control group showed ups and downs in activity rates and declined overall. The activity rate of the drinking test group (mouse) of the drinking water of jade powder was similar to that of the normal control group, but the average value of the overall activity rate was not only higher than that of the control group but also significantly different from that of the control group. .

<Experiment 5>

In this experimental example, infrared experiments were performed on purgatory powder.

sample Jade minutes Sample property White method of inspection Perkin elmer 137 result As

<In IR spectrum>

Form: Tetrahydrofran Liquefied Thin Film

It appeared to match the pattern of polycarbonate resin and radiated electromagnetic waves with a wavelength of 6-52μ.

<Experiment 6>

In this Experimental Example, the chemical and biological oxygen requirements for the purgatory powder samples used in the present invention were performed as shown in Tables 17 and 18 below.

sample Jade minutes Sample property White Way Standard method result As

division Water (control) Jade addition 5-day BOD 224 mg / l 223 mg / l COD 115 mg / l 110 mg / l

<Experiment 7>

In this experimental example, the experiment on the effect of the purgatory powder used in the present invention for the experimental sphere (rabbit) was performed as shown in Table 19.

<Primary eye irritation test> sample Jade minutes Sample property Milky powder Way As result As

Method: US Federal Register Vol 43.No 163-1978.8.22 p37359

Experimental procedure: Place 0.1 ml of the extract on the inverted lower eyelid of one eye, and gently hold for 1 second before placing the upper and lower eyelids. The other eye is not treated and observed as a control example. The treated eyes of the six rabbits were left unwashed, and the eyes of the three rabbits were washed with running lukewarm water for one minute immediately after treatment. Prior to treatment with the sample, the eyes were examined in advance by fluorescence and only animals that did not show corneal damage were used for the test. Eye lesions were observed 24 hours, 48 hours, 72 hours, 7 days and 14 days after treatment. The results were shown in Table 20 below.

<Lesion degree of eyes> rabbit time Corneal Opacity Corneal area Iris Price Conjunctival redness Conjunctival Chemosis Conjunctival secretion # 1 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 2 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 3 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 4 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 5 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0)

# 6 fine 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 7wash 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 8wash 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0) # 9wash 24H 0 0 0 0 0 0 48H 0 0 0 0 0 0 72H 0 0 0 0 0 0 7D 0 0 0 0 0 0 score Corneal (0) Iris (0) Conjunctiva (0)

I. Cornea

(A) Opacity-Density (area for detoxification)

Normal-0

Scattered Diffusion Zones-Details of the iris are clearly visible-1

Translucent areas that are easily identified, slightly blurred details of the iris-2

Milky white area, details of the iris are not visible, pupil size is almost indistinguishable

Opaque, no iris visible-4

(B) corneal area

Normal-0

Less than 1/4, but not 0-1

More than 1/4, less than 1/2-2

1/2 or more, 3/4 or less-3

More than 3/4, less than total area-4

Score is A × B × 5, total max = 80

II. Iris

(A) value

Normal-0

Folded above normal, hyperemia, swelling, pericorneal congestion (these symptoms appear in any size, alone or in combination), the iris still responds to light (slow response is pronounced)-1

Not responding to light, bleeding, total destruction (one or both of these symptoms)-2

Score is A × 5, maximum possible total = 10

III. conjunctiva

(A) red tide (only related to the conjunctiva of the eyelid)

Normal-0

Blood vessels are surely reddened above normal-1

More diffuse, deeper magenta, individual vessels not easily distinguished-2

Spread red like beef-2

(B) chemosis

No Snooze-0

Random swelling phenomenon over normal (including eye blink membrane)-1

Clearly swollen with partial inversion of the eyelids-2

Eyelid half closed and swollen-3

Eyelid half to full closed and swollen-4

(C) secretion

Normal-0

Any phenomenon other than normal (not including small amounts observed at the tip of the inner eye of normal animals)-1

Secretions only on the eyelids and eyebrows adjacent to the eyelids-2

Significant area around the eyes-3

Score (A + B + C) × 2, total max = 20

CONCLUSIONS: This sample was determined to be free of eye irritation and, therefore, was found to be suitable for use in eye cosmetic products.

<Primary skin irritation test> sample Jade minutes Sample property White powder Way As result As

Method: US Federal Register Vol. 43, No. 163

CTFA (The Cosmetic, Toiletry and Fragrance Association, Washington, D.C.) Technical Guidelines

Experimental procedure: Patch testing was performed on the skin of the white rabbit and the original skin. The hair was cut short at the back and sides. Two areas, about 10 cm away, were selected as patch locations. One area is made of four small epidermal incisions in the patch area to remove the skin (two of which are "tic-tac-toe" perpendicular to the other). The patch is attached using a thin rubber band and adhesive tape Samples are introduced in each part in an amount of 0.5 ml (g) under the patch The body of the animal is wrapped with a rubberized cloth for 24 hours of exposure. After the patch was removed, the reaction at each site was evaluated based on the scores described below (see Table 22).

Evaluation of Skin Response

Erythema and crust formation

No erythema-0

Very weak erythema (recognizable barely)-1

Properly identified erythema-2

Moderate to severe erythema-3

Severe erythema (beat red) to slight crust formation (deep damage)-4

Edema

No edema-0

Very mild edema (recognizable barely)-1

Slight edema (it is obvious that the edges of the area are prominent)-2

Moderate edema (approximately 1 mm up)-3

rabbit 24 hours 72 hours Original skin Worn skin Original skin Worn skin ER ED ER ED ER ED ER ED #One 0 0 0 0 0 0 0 0 #2 0 0 0 0 0 0 0 0 # 3 0 0 0 0 0 0 0 0 #4 0 0 0 0 0 0 0 0 # 5 0 0 0 0 0 0 0 0 # 6 0 0 0 0 0 0 0 0

Conclusions: This sample was determined to have no skin irritation. Therefore it appeared to be suitable for use in skin cosmetic products.

<Acute oral toxicity [(0.5 g) / 100 g body weight] experiment> sample Purgatory powder Sample property White powder Way As result Same as Table 24 below

rat gender Initial weight (g) Dosage (ml) Lag weight (g) Toxicity One F 207 1.0 219 none 2 F 211 1.1 226 none 3 F 215 1.1 225 none 4 F 208 1.0 217 none 5 F 200 1.0 213 none 6 M 227 1.1 235 none 7 M 216 1.1 224 none 8 M 205 1.0 218 none 9 M 210 1.1 224 none 10 M 212 1.1 221 none

Preparation of Samples: A portion of the sample was placed in sterile distilled water and boiled for 10 minutes to extract, and the extract was administered by intubation in an amount of 0.5 g per 100 g of body weight.

CONCLUSIONS: The sample meets the criteria for no oral toxicity.

<Experimental example 8>

This experiment example is the process and results of the experiment performed by Inha University bioinformatics system engineering laboratory to investigate the various effects of purgatory powder used in the present invention on the living body. In this experiment, 70% of the constituent elements of the human body are water. Therefore, the impact of water on the water and the impact on the human body are investigated. Experiments on the effects were performed.

A. Hard water change

<Experiment 1>

100 ml of artificially-made hard water was transferred to each of the four flasks by 50 ml, and purgatory was placed on the bottom of two flasks for about 10 minutes.

To determine the change in hardness, a titration method using ethylene diamineacetic acid (hereinafter referred to as "EDTA" titer 2.9412) was used. 1 ml of a buffer solution of pH 10, EBT was used as an indicator.

The change in hardness was measured by the amount of EDTA until the moment when the color of the hard water was changed by EDTA. At this time, the color returned to its original state over time, but in this experiment, the measurement was made based on the changing moment.

<Result 1>

At 100ppm of hard water, it takes 1.70ml of EDTA.

It takes 1.25ml of EDTA after purgatory test, so the hardness of 100.00ppm is lowered to 73.53ppm. That is, the hardness of 100.00 ppm was softened 26.47%.

<Experiment 2>

200 ml of 100ppm hard water made in the same manner as in Experiment 1 was transferred to a beaker to immerse the purgatory.

After about 30 minutes, the water in the beaker was divided into three flasks to measure the change in hardness. In this experiment, the hardness was measured by adding EDTA until the color of hard water did not change any more after the color of hard water changed by EDTA.

<Result 2>

Each 100ppm hard water before purgatory experiment

89.62 ppm

91.19ppm

89.62 ppm

Average 90.14ppm, thus 9.9% hardness decrease

<Experiment 3>

This experiment was conducted with tap water. Tap water was placed in a container and transferred to six flasks, and purgatory was placed at the bottom of three flasks, and hardness was measured after about 5 minutes.

<Result 3>

* Tap water without purgatory

97.48 ppm

97.48 ppm

97.48 ppm

Average 97.48 ppm

* Tap water after purgatory experiment

91.19ppm

91.19ppm

91.19ppm

Average 91.19ppm therefore, hardness decrease of 6.5%

I. Effect of Purgatory on the Proliferation of Digital Plant Suspensions of Digitalis lanata

Effects of Purgatory on the Growth of Digitalis lanata Cells in Growth Medium

FIG. 5 is a graph showing changes in culture medium volume of cells grown in growth medium for 11 days, and FIG. 6 is a graph showing changes in cell volume, in proportion to the increase of cells growing over time. As the depletion of and the evaporation of the medium occur, the volume change of the whole culture reflects these factors. In particular, humidity and temperature in the atmosphere are closely related to the evaporation of the medium, and such factors also affect the cell growth rate.

As shown in the figure, the use of purgatory shows that the volume of the total culture solution is slightly decreased compared to the control group which is not used. This is because the use of purgatory rather than the control group has a faster cell growth rate against the evaporation of the medium or the depletion of nutrients, and thus, it is possible to offset the rapid decrease of the depleted medium to some extent. This phenomenon is observed in the case of continuous use of purgatory from day 4 to day 11 after inoculation of cells as shown in Fig. 6 measuring the volume change of the sunk cells only increase the volume of the cell than the unused control group. This fact can be estimated. Therefore, the use of nephrite showed a faster cell growth rate than the control without the nephrite. These results can be said to be the result of delaying the decrease of the total volume than the control by offsetting the decrease in the total culture volume due to nutrient depletion and medium evaporation. In addition, the result of comparing the volume of the increased cell alone is also observed to show a tendency to gradually increase the cell volume after 4 days, it is thought that can support this result.

Cell proliferation and dry weight are the most common measures of cell proliferation. In general, the growth curve of all cells is represented by the S-shaped curve, which can be classified into four stages. Lag phase, which is a period of adaptation to the medium, in which there is no cell proliferation and no mass growth, and an exponential curve showing a steep slope due to a mass increase at a rapid proliferation rate after this period. phase), the stationary phase, which has a maximum growth to some extent, and the Chinese food is slowed down and shows no mass increase, and the cell ruptures due to the depletion of nutrients, the release of toxic components, and the saturation of cell density. It can be divided into a dead phase where the total cell volume or mass decreases due to the tendency to die.

7 and 8 are the results of measuring the cell biomass and dry weight.

7 follows the growth curve of these four stages. In the case of using jade, after 7 days, the growth rate was slightly higher than that of the control without jade, and the growth stopped until 10 days, unlike the control showing the decrease in cell biomass. have. This is remarkable in that cell growth is continued even when the concentration of nutrient is almost depleted and the concentration in the medium becomes zero compared with the change in the concentration of glucose, a nutrient that acts as the main metabolic substrate in the medium. It is common to show a tendency to stop the growth and decrease the growth rate at the point of depletion of the influenced ingredients, like the control without purgatory, but the effect of purgatory on cell growth is different from purgatory It is assumed that there is. This result is also shown in Figure 8 shows the cell growth proliferating at a higher rate than the control after 3 days, and from 9 days after, the same phenomenon as in FIG. As a result, cells grown near nephrite in the growth medium showed better effect on cell growth than the control group that did not. Digitalis lanata plant cells, which have a growth limit of about 10 days, are maintained in a stable state that does not cause necrosis of cells without exchanging with new medium even after 10 days when cultured with purgatory. Rather, it is expected that cell proliferation may be an advantageous method for optimizing cell growth and concentration in the production process for the production of useful substances.

② Effect of Purgatory on Changes in Medium pH

9 is a graph showing the pH change in the cell growth medium, Figure 10 is a graph showing the pH change of the production medium after the addition of purgatory powder.

Figure 9 is a measure of the change in the pH of the medium in the control medium with and without the purgatory in the growth medium. The control group shows a general tendency of pH in the medium applied to the plant cells, which gradually decreases over time and is maintained at a certain level. However, when using purgatory, it showed a similar pattern to the control group until day 7, and gradually increased. This phenomenon is extreme in the result of FIG. . The control group without added jade powder showed a consistent drop in pH, while the addition of jade powder showed a tendency to maintain the value to some extent. It is assumed that it acts as a cause.

③ Results of analysis of water quality for purgatory

FIG. 11 is a view showing the condition of the water analyzer containing the purgatory powder used in the present invention, and FIG.

The data from FIG. 11 and FIG. 12 is summarized in Table 25 to Table 28 for the respective samples. Table 25 shows the measurement of each analysis item for Sample 1 after 48 hours in which 20 g of nephrite lump was added to the solution. In Table 25, there is almost no change in each measurement item, and the effect of purgatory is hardly seen.

Table 26 shows the measurement values for each analysis item in Sample 2 after 48 hours of putting 20g of purgatory lumps outside the solution.

Table 28 also shows the measured values for each analysis item in Sample 4 after 48 hours after purifying the purge powder outside the solution. However, in the case of Sample 3, the data measured for each analysis item of the sample 48 hours passed after adding 20 g of purgatory powder in the solution is shown in Table 27. This change is as follows.

Cr, Pb, Ni, and Co, which are harmful to the human body, changed significantly after 48 hours. Cr was removed in the absence of purgatory powder, that is, 45.30 mg before the reaction was removed to 0 after 48 hours in the purifying powder, and Pb was also completely removed from 13.76 mg to zero. Ni decreased from 51.8 mg to 1.733 mg and Co also decreased from 52.69 mg to 11.94 mg. Mg, one of the necessary elements in the human body, increased from 48.36mg to 55.74mg.

The hydrogen ion concentration of distilled water was acidic to pH 3.5, but after the reaction, it was neutral to pH6.8, and the conductivity rapidly decreased. The adsorption force is physically large, about 3-4 mmol.q (equivalent) per gram.

Analytical results before and after the reaction in solution Purgatory lumps in the solution. (Sample 1): Purgall lump in solution (20 g) Item Before the reaction After reaction (48hr) Change pH 3.5 3.82 - Ni 51.8 mg 51.75mg - Co 52.69mg 52.54mg - Cr 45.30mg 43.88mg - Mg 48.36mg 48.59 mg - Pb 13.76 mg 13.90mg -

Results of analysis of purgatory lumps outside the solution. (Sample 2): lump of purgatory jade (20g) Item Before the reaction After reaction (48hr) Change pH 3.5 3.65 - Ni 51.8 mg 48.92mg - Co 52.69mg 49.83mg - Cr 45.30mg 41.23mg - Mg 48.36mg 47.97mg - Pb 13.76 mg 15.1mg -

Analysis result when adding purgatory powder to solution. (Sample 3): Purgatory powder in solution (20g) Item Before the reaction After reaction (48hr) Change pH 3.5 6.8 +3.3 Ni 51.8 mg 1.733 mg -50.06mg Co 52.69mg 11.94mg -40.75mg Cr 45.30mg 0mg -45.30mg Mg 48.36mg 55.74mg + 7.38mg Pb 13.76 mg 0mg -13.76 mg

Analysis result when purgatory powder was placed outside solution (Sample 4): Purgatory powder outside solution (20g) Item Before the reaction After reaction (48hr) Change pH 3.5 3.7 - Ni 51.8 mg 51.53 mg - Co 52.69mg 52.55mg - Cr 45.30mg 43.0mg - Mg 48.36mg 48.39mg - Pb 13.76 mg 14.29 g -

As described above, the digitalis lanata plant suspension cells cultured for one week with nephrite close showed proliferation of about 30% or more in the absence of purgatory. This is a rare proliferative result even in the various experiments performed for the proliferation effect on conventional Digigitalis lanata plant cells for high concentration culture. In addition, experiments on how purgatory water affects hard water showed that soft water softened hard water without contact with water. Particularly, in the component analysis experiments on water using distilled water, precipitation of nephrite was carried out. After 48 hours, in the component analysis, the pH was increased, the Ni and Co components were reduced, the Cr and Pb were removed, and the heavy metals were removed. An unusual phenomenon was observed that led to the phenomenon of.

As such, purgatory powder according to the present invention has not yet been clearly identified theoretically, but also changes the hardness of water without contact with water, and also proliferates more than 30% of the digitalis lanna plant (Digitalis lanata) plant suspension cells, The elimination of heavy metals harmful to the human body, such as the reduction of Ni and Co components, and the removal of Cr and Pb, is believed to be due to the radiation effect of the electromagnetic wave wavelengths of the purgatory powder and the ionic reaction by the mineral components contained in the nephrite. These facts will be proved by the efficacy shown in the product of the present invention described above, and the experimental results in particular, the characteristics of the purgatory powder and the effect of purgatory when wearing or using a product made of the silicone rubber containing the purgatory powder of the present invention Due to the useful effects on human health will be proved enough.

As described above, according to the present invention, by adding a nephrite powder to produce a silicone rubber, the physical and mechanical strength of the silicone rubber has an improved effect, in particular to wear a product made using the body Or, when used, the components generated from purgatory are effective to exert excellent medical functions such as cell function activation, blood circulation promotion and metabolism promotion.

Claims (8)

In manufacturing a silicone rubber material using a silicone compound, A silicone rubber containing 10-30 parts by weight of jade powder in a silicon compound and containing jade powder which has been extruded after kneading. 2. The silicone rubber according to claim 1, wherein the nephrite powder has a particle size of 100 to 1000 mesh. According to claim 1, wherein the silicone compound is any one selected from dimethylsilicone, methylphenylsilicone, methylvinylsilicone, methylphenylvinylsilicon, methyltetramersilicone, a filler, a vulcanizing agent and an accelerator, characterized in that the mixture Silicone rubber containing purgatory powder. 4. The silicone rubber according to claim 3, wherein 10 to 30 parts by weight of the nephrite powder is added to and mixed with the silicon. 5. The silicone rubber according to any one of claims 1 to 4, wherein the nephrite powder has a composition ratio as follows. `` Semy QuanTitative Analysis (%)> Silicon 34 Magnesium 10 Calcium 4.9 Iron 0.23 Aluminum 0.16 Copper 0.17 Cobalt 0.046 Manganese 0.14 Tin 0.024 Beryllium 0.00072 Is 0.0013 Titanium 0.0038 Nickel 0.0028 Chromium 0.0030 Miscellaneous 0 In the method of manufacturing a silicone rubber using a silicone compound, The method for producing a silicone rubber containing a jade powder which is extruded after kneading into the silicone compound 10 to 30 parts by weight of the nephrite powder having a particle size of 100 to 1000 mesh. The method of claim 6, wherein the silicone compound is any one selected from dimethylsilicone, methylphenylsilicone, methylvinylsilicone, methylphenylvinylsilicon, methyltetramersilicone, a filler, a vulcanizing agent and an accelerator, characterized in that the mixture A method for producing a silicone rubber containing jade powder. The method of claim 6, further comprising the step of making household goods, medical supplies, and personal care products by using the silicon rubber containing the nephrite powder.