KR19990022712A - aPL 면역반응성 펩티드, 그것의 콘주게이트 및 aPL항체-매개병변의 치료방법 - Google Patents
aPL 면역반응성 펩티드, 그것의 콘주게이트 및 aPL항체-매개병변의 치료방법Info
- Publication number
- KR19990022712A KR19990022712A KR1019970709154A KR19970709154A KR19990022712A KR 19990022712 A KR19990022712 A KR 19990022712A KR 1019970709154 A KR1019970709154 A KR 1019970709154A KR 19970709154 A KR19970709154 A KR 19970709154A KR 19990022712 A KR19990022712 A KR 19990022712A
- Authority
- KR
- South Korea
- Prior art keywords
- apl
- phage
- antibody
- peptide
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/482,651 US5874409A (en) | 1995-06-07 | 1995-06-07 | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| US8/482651 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR19990022712A true KR19990022712A (ko) | 1999-03-25 |
Family
ID=23916889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019970709154A Ceased KR19990022712A (ko) | 1995-06-07 | 1996-06-06 | aPL 면역반응성 펩티드, 그것의 콘주게이트 및 aPL항체-매개병변의 치료방법 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5874409A (https=) |
| EP (1) | EP0833648A4 (https=) |
| JP (1) | JPH11507822A (https=) |
| KR (1) | KR19990022712A (https=) |
| CN (1) | CN1326557C (https=) |
| AU (1) | AU711192B2 (https=) |
| CA (1) | CA2223687A1 (https=) |
| WO (1) | WO1996040197A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| US6410775B1 (en) * | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| US5817752A (en) * | 1996-06-06 | 1998-10-06 | La Jolla Pharmaceutical Company | Cyclic polypeptides comprising a thioether linkage and methods for their preparation |
| KR20000016414A (ko) * | 1996-06-06 | 2000-03-25 | 와이즈먼 앤드루 | Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법 |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) * | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| IL126447A (en) * | 1998-10-04 | 2004-09-27 | Vascular Biogenics Ltd | An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis |
| US20050197283A1 (en) * | 1998-10-04 | 2005-09-08 | Vascular Biogenics Ltd. | Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease |
| US6399578B1 (en) * | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| US20010010818A1 (en) * | 1998-12-09 | 2001-08-02 | Engle Steven B. | Methods and formulations for reducing circulating antibodies |
| US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| CN1762990A (zh) * | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
| AUPQ272699A0 (en) * | 1999-09-09 | 1999-09-30 | Unisearch Limited | Use of beta2GPI in diagnostic tests for autoimmune diseases |
| MXPA02005236A (es) * | 1999-11-28 | 2004-03-19 | Jolla Pharma | Metodos de tratamiento de lupus con base en la afinidad de anticuerpos y metodos de separacion por exclusion y composiciones para el uso de los mismos. |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| WO2001093914A2 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
| US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| PT2281843T (pt) * | 2000-06-16 | 2017-01-02 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
| AU2001288301A1 (en) * | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
| AU8506601A (en) * | 2000-08-18 | 2002-03-04 | Dyax Corp | Binding polypeptides for b lymphocyte stimulator protein (blys) |
| US7319012B2 (en) * | 2001-05-30 | 2008-01-15 | Gene Therapy Systems, Inc. | Protein arrays and methods and systems for producing the same |
| EP2423335B1 (en) | 2001-06-21 | 2014-05-14 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
| US20030114405A1 (en) * | 2001-08-13 | 2003-06-19 | Linnik Matthew D. | Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function |
| US7105135B2 (en) * | 2001-10-16 | 2006-09-12 | Lockheed Martin Corporation | System and method for large scale detection of hazardous materials in the mail or in other objects |
| DE60222816T2 (de) * | 2001-12-03 | 2008-07-03 | Amgen Fremont Inc. | Identifizierung hochaffiner moleküle durch screening mit begrenzter verdünnung |
| US7771951B2 (en) * | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| CA2469196A1 (en) * | 2001-12-03 | 2003-06-12 | Abgenix, Inc. | Discovery of therapeutic products |
| AU2003237870A1 (en) * | 2002-06-07 | 2003-12-22 | The Brigham & Women's Hospital, Inc. | Method and composition for inhibing or slowing blood coagulation |
| CN100471486C (zh) | 2002-08-12 | 2009-03-25 | 戴纳伐克斯技术股份有限公司 | 免疫调节组合物,其制备方法和使用方法 |
| WO2004060320A2 (en) * | 2002-12-27 | 2004-07-22 | La Jolla Pharmaceutical Company | Methods of improving health-related quality of life in individuals with systemic lupus erythematosus |
| US20040258683A1 (en) * | 2003-03-30 | 2004-12-23 | Linnik Matthew D. | Methods of treating and monitoring systemic lupus erythematosus in individuals |
| US7771956B2 (en) * | 2003-06-30 | 2010-08-10 | Brigham & Women's Hospital, Inc. | Method for detecting the presence of a phospholipid |
| US9062392B2 (en) * | 2003-12-30 | 2015-06-23 | Intel Corporation | Methods for isolating a peptide methods for identifying a peptide |
| JP2008514187A (ja) | 2004-09-01 | 2008-05-08 | ダイナバックス テクノロジーズ コーポレイション | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| EP1799709B1 (en) * | 2004-09-30 | 2012-04-04 | ORICO Limited | Myostatin isoform |
| CN101146826A (zh) * | 2005-01-24 | 2008-03-19 | 得克萨斯大学体系董事会 | 与磷脂酰丝氨酸结合的fc融合构建体及其治疗用途 |
| EP1874334A4 (en) * | 2005-04-15 | 2011-03-30 | Vascular Biogenics Ltd | COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES |
| WO2007142667A2 (en) * | 2005-10-13 | 2007-12-13 | Human Genome Sciences, Inc. | Treatment of patients with autoantibody positive disease |
| US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| WO2007123765A2 (en) * | 2006-03-31 | 2007-11-01 | Human Genome Sciences Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| CN101522707B (zh) * | 2006-08-03 | 2013-08-28 | 莫约斯汀医疗有限公司 | 肌肉生长抑制素拮抗剂 |
| WO2009052148A1 (en) * | 2007-10-15 | 2009-04-23 | California Institute Of Technology | Functionalized polymers using protected thiols |
| EP2209896B1 (en) | 2007-10-26 | 2017-03-01 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| WO2010093993A2 (en) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
| EP2582398B1 (en) | 2010-06-16 | 2016-04-13 | Dynavax Technologies Corporation | Methods of treatment using tlr7 and/or tlr9 inhibitors |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| CN105353137A (zh) * | 2015-12-10 | 2016-02-24 | 中国农业科学院饲料研究所 | 一种快速检测色素苏丹红的方法 |
| JP7117741B2 (ja) * | 2018-10-10 | 2022-08-15 | 国立大学法人 鹿児島大学 | IgG結合性ペプチドを含む固相担体及びIgGの分離方法 |
| WO2022197295A1 (en) * | 2021-03-17 | 2022-09-22 | Milliken & Company | Polymeric colorants with reduced staining |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191668A (en) | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
| US6022544A (en) | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US5126131A (en) | 1983-01-24 | 1992-06-30 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates. |
| US5370871A (en) | 1983-01-24 | 1994-12-06 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US4650675A (en) | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
| US4751181A (en) | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| JP2524586B2 (ja) | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| DE68925899T2 (de) | 1988-04-04 | 1996-10-02 | Byron E Anderson | Bindung von immunkomplexen durch modifizierte formen von c-reaktiven proteinen |
| WO1991006006A1 (en) * | 1989-10-19 | 1991-05-02 | Yamasa Shoyu Kabushiki Kaisha | Carrier for binding antiphospholipid antibody, immunoassay using the same, and kit therefor |
| US5552391A (en) | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
| US5162515A (en) | 1990-01-16 | 1992-11-10 | La Jolla Pharmaceutical Company | Conjugates of biologically stable polymers and polynucleotides for treating systemic lupus erythematosus |
| JPH04218000A (ja) | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| ATE127925T1 (de) * | 1990-04-06 | 1995-09-15 | Yamasa Shoyu Kk | Verfahren zur bestimmung von antiphospholipid antikörpern. |
| WO1991015722A1 (de) * | 1990-04-10 | 1991-10-17 | Masur, Walter | Verfahren zum betreiben einer kompressionswärmepumpe, sowie kompressionswärmepumpe |
| JPH06503833A (ja) | 1990-12-17 | 1994-04-28 | ザ ジョンズ ホプキンス ユニバーシティ | 制御された化学のオリゴマー形態の抗原での免疫応答抑制 |
| AU666352B2 (en) * | 1992-02-05 | 1996-02-08 | Takao Koike | Solid-phase reagent and assay method for measuring antibodies specific to antiphospholipid syndrome |
| ES2282988T3 (es) * | 1993-09-08 | 2007-10-16 | La Jolla Pharmaceutical Company | Moleculas plataforma de valencia no polimericas,. |
| CA2176007A1 (en) | 1993-11-16 | 1995-05-26 | Eiji Matsuura | Method of assaying antiphospholipid antibody and kit therefor |
| US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| CN1225015A (zh) * | 1996-06-06 | 1999-08-04 | 拉卓拉药物公司 | aPL免疫反应性肽、其缀合物以及aPL抗体介导的疾病的治疗方法 |
| KR20000016414A (ko) | 1996-06-06 | 2000-03-25 | 와이즈먼 앤드루 | Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법 |
-
1995
- 1995-06-07 US US08/482,651 patent/US5874409A/en not_active Expired - Fee Related
-
1996
- 1996-06-06 EP EP96921498A patent/EP0833648A4/en not_active Withdrawn
- 1996-06-06 JP JP9502123A patent/JPH11507822A/ja active Pending
- 1996-06-06 KR KR1019970709154A patent/KR19990022712A/ko not_active Ceased
- 1996-06-06 AU AU62710/96A patent/AU711192B2/en not_active Ceased
- 1996-06-06 WO PCT/US1996/009976 patent/WO1996040197A1/en not_active Ceased
- 1996-06-06 US US08/660,092 patent/US6207160B1/en not_active Expired - Fee Related
- 1996-06-06 CN CNB96196006XA patent/CN1326557C/zh not_active Expired - Fee Related
- 1996-06-06 CA CA002223687A patent/CA2223687A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US5874409A (en) | 1999-02-23 |
| EP0833648A1 (en) | 1998-04-08 |
| AU6271096A (en) | 1996-12-30 |
| JPH11507822A (ja) | 1999-07-13 |
| US6207160B1 (en) | 2001-03-27 |
| CN1192153A (zh) | 1998-09-02 |
| WO1996040197A1 (en) | 1996-12-19 |
| AU711192B2 (en) | 1999-10-07 |
| EP0833648A4 (en) | 1999-10-13 |
| CA2223687A1 (en) | 1996-12-19 |
| CN1326557C (zh) | 2007-07-18 |
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Legal Events
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Patent event date: 19971208 Patent event code: PA01051R01D Comment text: International Patent Application |
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| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20010413 Comment text: Request for Examination of Application |
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| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20030728 Patent event code: PE09021S01D |
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Comment text: Notification of reason for refusal Patent event date: 20040629 Patent event code: PE09021S01D |
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