KR19980066566A - Hair cosmetic composition having anti-dandruff effect - Google Patents

Abstract

The present invention relates to a hair cosmetic composition having an anti-dandruff effect, and more particularly, to a hair cosmetic composition having iodopropynyl butylcabamate having sterilization and antibacterial action against dandruff, and hydroxypropyl trimonium chloride, 7, polyquaternium-10, urea, and EDTA at the same time to provide a hair cosmetic composition having dandruff reduction, itching prevention, and bactericidal action.

Description

Hair cosmetic composition having anti-dandruff effect

The present invention relates to a hair cosmetic composition having an anti-dandruff effect, and more particularly, to a hair cosmetic composition having iodopropynyl butylcabamate having sterilization and antibacterial action against dandruff, and hydroxypropyl trimonium chloride, 7, polyquaternium-10, urea, and EDTA at the same time to provide a hair cosmetic composition having dandruff reduction, itching prevention, and bactericidal action.

Dandruff generally refers to a keratinous mass formed by the dead or peeled cells of the scalp caused by the vigorous metabolism of the human body, which are dried together with the secretions of the scalp sebaceous glands. Dandruff gradually has a clear boundary with the normal skin, and becomes reddish to increase the scar on the scalp, and it usually goes to the dermatitis with itching and inflammation.

Although the underlying cause of such severe dandruff is still unclear, it is generally considered to be caused by imbalance of endocrine hormone, imbalance of nutritional metabolism, neurological factors such as stress, biochemical changes of epithelial tissue due to excessive proliferation of scalp cells, It is known that the complex effect of various factors such as growth and activity of scalp microorganisms and inflammation due to air pollution is known.

In particular, the growth and activity of microorganisms called Pityrosporum Ovale, which is present in the unclean scalp, has been recognized as a major factor for aggravating dandruff and itching for a long time and has been widely accepted in recent years.

Accordingly, hair cosmetic compositions having a dandruff-preventing effect for the treatment and prevention of dandruff and itching effectively inhibit the proliferation and activity of the microorganism pitilox formovalle, which is a major cause of dandruff occurrence, and inhibit the abnormal metabolism activity And a component capable of normalizing the composition of the present invention.

An example of a hair cosmetic composition intended to inhibit dandruff and itching is a hair cosmetic composition containing zinc pyricion (zinc-2-pyridinethiol-1-oxide) as an active ingredient U.S. Patent No. 2,809,971, U.S. Patent No. 4,323,683, U.S. Patent No. 4,345,080, U.S. Patent No. 4,470,982, European Patent No. 285,388). However, zinc pyrithione is a water-insoluble solid particle having a spherical morphology of about 1 탆 and having a very low solubility, which is soluble only at 15 ppm in water at 25 캜. It is a hair cosmetic composition mainly comprising a water- It is limited in its usability due to sedimentation by sedimentation, and its content is regulated by Korean FDA (Food and Drug Adminstration) due to problems of stimulation and safety in human body.

Therefore, the present inventors have studied anti-dandruff agents having excellent dandruff prevention effect than known anti-dandruff agents such as zinc pyrithione, and applicants have found that dandruff occurrence among the substances used as general preservatives due to their sterilizing power against bacteria or yeast the leading cause of error correcting capability of Ross form while trying Ovalle review the material having the antimicrobial and antibacterial effect for a, iodo-propynyl butyl-carbazol of boehmite (Iodopropynyl Butylcabamate) finds that the sterilization and antimicrobial effects to the error correcting capability of Ross form Ovalle And a hair cosmetic composition containing iodopropynyl butylcarbamate as an anti-dandruff agent.

On the other hand, the present inventors have repeatedly researched to provide a hair cosmetic composition having an excellent dandruff-preventing effect in a hair cosmetic composition containing iodopropynyl butylcarbamate, When at least one member selected from propyl butylcarbamate and hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, urea and EDTA is contained at the same time, an increase in dandruff reduction, itching prevention, And the present invention has been completed.

It is therefore an object of the present invention to provide a hair cosmetic composition which can provide dandruff reduction, itching prevention and sterilizing effect.

In order to achieve the above-mentioned object, the hair cosmetic composition according to the present invention is a hair cosmetic composition comprising iodopropynyl butylcarbamate, 1-hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, And more than one species.

Other objects and applications of the present invention will become apparent from the following detailed description of the invention.

Hereinafter, the present invention will be described in more detail.

The iodopropynyl butylcarbamate used as an active ingredient in the hair cosmetic composition showing the anti-dandruff effect of the present invention is a substance represented by the following formula (1), and its production process and production process are described in U.S. Patent No. 4,259,350, No. 4,841,088, U.S. Patent No. 5,321,151, and U.S. Patent No. 5,326,899.

Iodopropionylbutylcarbamate is a substance having antibacterial activity against bacteria and yeast. It is insoluble in water but soluble in ionic and nonionic surfactants and exhibits good solubility in alcohol and glycol derivatives. Therefore, Product is easy to prescribe. In addition, in the safety and toxicity data, the known anti-dandruff zinc Pyrithione Acute Oral LD ₅₀ (rats) is 354 mg / kg, which is stable at 70 ~ 80 ℃ and pH 4 ~ as compared to so-iodo-propynyl butyl-carbazol of boehmite of Acute Oral LD ₅₀ (rats) is 1470 mg / kg is superior to the zinc-rich blood-one.

The hair cosmetic composition of the present invention is used in an amount of 0.001 to 20% by weight, preferably 0.001 to 10% by weight, based on the total weight of the composition, of iodopropynyl butylcarbamide having the above-mentioned characteristics.

In addition, the hair cosmetic composition according to the present invention is intended to enhance the effect of iodopropynyl butylcarbamide, which is an effective ingredient, and is useful as a hair cosmetic composition which contains at least one selected from the group consisting of guar hydroxypropyltrimonium chloride (cationized guar gum), polyquaternium- 10, urea, and EDTA in an amount of 0.001 to 10 wt% based on the total weight of the composition. When the content of the ascender is less than 0.001% by weight, an increased dandruff preventing effect can not be obtained.

Among the ascending agents, urea is an adsorption promoter, which enhances the scalp permeability of iodopropynyl butylcarbamide to enhance dandruff prevention effect. In addition, EDTA is widely used as a metal ion sequestering agent as a substance having a structure of the following formula (2), and recently has a synergistic effect when it is used in combination with a germ-negative bacteria, a yeast, and a fungicide effective against fungi (Cosmetic and drug Preservation, pp. 323-337, 1984).

The hair cosmetic composition of the present invention may have conventional formulations and may be formulated into, for example, shampoos, rinses, hair conditioners, hair tonics, hair treatments and the like. The composition of each of these formulations may contain various kinds of bases and additives necessary for formulation of the formulation, and the kinds and amounts of these ingredients can be easily selected by those skilled in the art. Hereinafter, typical shampoo compositions of a hair cosmetic composition will be described, for example, representative base ingredients and additives.

The hair cosmetic composition according to the present invention, in particular, the shampoo composition, can be prepared by mixing the active ingredient iodopropynyl butylcarbamate and a conventional cosmetic agent such as cationizing guar gum, polyquaternium-7, polyquaternium-10, A shampoo composition.

[Surfactants]

The synthetic surfactant used in the present invention may be any one selected from anionic, amphoteric, nonionic, and cationic surfactants, and the surfactant may be present in an amount of 10 to 70 wt%, preferably 10 to 30 wt% % ≪ / RTI > On the other hand, the cationic surfactant is used in an amount of 0.01 to 10% by weight, preferably 0.1 to 5% by weight based on the total weight of the composition.

Synthetic anionic surfactants usable in the present invention are alkyl and alkyl ether sulfates represented by the following general formula (3).

RO (C ₂ H ₄ O) _n SO ₃ M

Wherein R is an alkyl group having 10 to 22 carbon atoms, n is an integer of 0 to 4, and M is a water-soluble cation such as ammonium, sodium or triethanolamine. Preferably, alkyl sulfates and alkyl ether sulfates having 12 to 16 carbon atoms are preferred. Alcohols may be derived from, or synthesized from, fats, for example palm oil or tallow. In the present invention, lauryl alcohol and straight chain alcohol derived from palm oil are preferred. These alcohols are reacted with about 1 to 4 mol, in particular 3 mol, of ethylene oxide, for example, the resulting mixture in molecules having an average of 3 moles of ethylene oxide per mole of alcohol is sulfated and neutralized. Specific examples thereof include sodium laurylsulfate, ammonium laurylsulfate, triethanolamine laurylsulfate, sodium polyoxyethylene laurylsulfate, and ammonium polyoxyethylene laurylsulfate.

Synthetic amphoteric surfactants are alkyl betaines and alkyl amidopropyl betaines, represented by formulas (4) and (5).

In the above formulas, R ₁ is an alkyl group having 8 to 18 carbon atoms, and R ₂ CO is an alkoxy group having 8 to 18 carbon atoms. Specific examples include coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α-carboxyethyl betaine, cetyl dimethyl carboxymethyl, and cocoamidopropyl betaine.

Synthetic nonionic surfactants are alkanolamides and alkylamine oxides represented by the general formulas (6) and (7).

R _One R ₂ R ₃ N → O

Wherein R ₁ is an alkyl group having 8 to 18 carbon atoms, R ₂ and R ₃ are an alkyl group having 1 to ₃ carbon atoms, R ₄ CO is an alkoxy group having 8 to 16 carbon atoms, and n is 0 or 1. Specific examples thereof include lauryldiethylamine oxide, palm oil alkyldimethylamine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide and palm oil fatty acid monoethanolamide.

The above-mentioned surfactants can be used alone or in combination in the hair cosmetic composition of the present invention.

[Optional ingredients]

The optional ingredients used in the compositions of the present invention are well known to those skilled in the art as conventional optional ingredients to maintain basic properties and quality. Specific examples include pearl wood supplements, preservatives, thickeners, viscosity modifiers, pH adjusting agents, perfumes, dyes, hair conditioning agents, and water.

For example, a pearl liquor aid such as ethylene glycol, monostearate, ethylene glycol distearate; Preservatives such as methyl p-hydroxybenzoate, methyl chloroisothiazolinone and methyl isothiazolinone compounds; Viscosity modifiers such as sodium chloride, ammonium chloride, propylene glycol; PH adjusting agents such as citric acid, phosphoric acid, sodium hydroxide and potassium hydroxide; Hair conditioning agents such as methyl polysiloxane, dimethyl cone polyol, hydrolyzed animal protein; Dyes such as water-soluble tar are used, and flavoring agents can be used.

The hair cosmetic composition according to the present invention may be used according to a conventional method of use, and may be used in a different number of times depending on a user's scalp condition or taste.

Hereinafter, the hair cosmetic composition of the present invention will be described in detail with reference to examples of the present invention, but the present invention is not limited to these examples.

[Examples 1 to 5 and Comparative Examples 1 to 5]

Raw material name Example Comparative Example One 2 3 4 5 One 2 3 4 5 1. Polyoxyethylene lauryl ether Sodium sulfate 30% 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 2. Sodium lauryl sulfate 28% 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 3. Lauryl diethanolamide 4.5 4.5 4.5 4.5 4.5 4.5 4.5 4.5 4.5 4.5 4. Propylene glycol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 5. Methyl para-hydroxybenzoate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 6. Pigment Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 7. Incense Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 8. Citric acid Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 9. Iodopropynyl butylcarbamate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 10. Condensation of guar hydroxypropyl trimonium chloride 0.5 - 11. Polyquaternium 6 - - 0.5 12. Polyquaternium 7 - 0.5 - - 13. Polyquaternium 10 0.5 14. Polyquaternium 11 0.5 15. Element 0.5 16. Azone 0.5 17. Ethanol 0.5 18. EDTA 0.5 19. Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100

[Test Example 1] Comparison test of antibacterial activity

Staphylococcus aureus was streaked on an agar plate containing the shampoos of the above-mentioned Comparative Examples and Examples in concentration, and the dandruff causative bacteria were cultured for 2 days under aerobic conditions. Thereafter, the presence or absence of growth of the bacteria was observed, and the lowest inhibition The concentration (MIC) was measured to confirm the antimicrobial action against the dandruff causative bacteria.

1. Test bacteria

Dandruff causing bacteria: Pityrosporum ovale ATCC 12087

2. Usage badge

Blood agar medium (blood agar base + 5% final concentration, blood), BHI agar

Minimum inhibitory concentration (MIC) Sample test bacteria Example Comparative Example One 2 3 4 5 One 2 3 4 5 Pythio Formo Valle 0.58 0.89 0.75 0.39 0.05 1.34 1.33 1.34 1.33 1.32

As can be seen from Table 1, compared to Comparative Example 1 containing iodopropynyl butylcarbamate alone as an anti-dandruff agent, iodopropynyl butylcarbamate, guar hydroxypropyltrimonium chloride, polyquaternium- 7, polyquaternium-10, urea, and EDTA, the effect of reducing the MIC for the dandruff was greatly increased. On the other hand, it can be seen that the comparative examples containing other cationic polymers and adsorption promoters polyquaternium-6, azone and ethanol show no synergistic effect as compared with Comparative Example 1.

Therefore, the composition of the present invention can be effectively used for preventing dandruff formation, treating and alleviating dandruff.

[Test Example 2] Anti-stamch effect test

The anti-stamen effect is measured by the Skin Disc Diffusion Method. First, the test bacteria were streaked on agar plates, and cultured for 2 days dandruff causative organism of Pitti Los form Ovalle to 37 ℃ under aerobic conditions. After the skin disk was sterilized with 70% ethanol, the shampoo of the above Comparative Example and each Example was diluted by 10 times, and then washed with purified water. The treated skin disk was placed on an agar plate, and inhibition zones were measured after 48 hours at 37 ° C, and the results were averaged three times and the results are shown in Table 2. This inhibition area is the size of the radius (mm) excluding the size of the skin disk.

Inhibition Zones (mm) Sample test bacteria Example Comparative Example One 2 3 4 5 One 2 3 4 5 Inhibition zone (mm) 22.58 20.63 20.52 23.54 27.83 18.55 18.56 18.59 18.59 18.62

As can be seen in Table 2, the most excellent dandruff in the examples containing iodopropynyl butylcarbamate and guar hydroxypropyl trimonium chloride, polyquaternium-7, polyquaternium-10, urea and EDTA Respectively. In particular, it can be seen that the dandruff-preventing effect is most excellent when EDTA is used as a synergist with the same content (Example 5).

[Test Example 3] Dandruff reduction test

A total of 56 men aged 19 to 35 years with a relatively large number of dandruff were selected and tested for seven months in a group of 8 persons for each of the shampoos of the Examples and Comparative Examples. The results are shown in Table 3.

Before the start of the test, the hair was smeared with ordinary shampoo, and the dandruff accumulated during 3 days after shaking was sampled. The dandruff weight was sampled every 3 days with the hair cosmetic compositions of the examples and the comparative examples. The dandruff weight was compared and evaluated. At this time, accumulated dandruff was collected directly from the scalp with a vacuum suction device, and the dandruff reduction rate was calculated according to the following formula.

Dandruff reduction rate (%) =

Weight of dandruff before start of test (mg) - Weight of dandruff after 1 month of test start (mg)

────────────────────────── × 100

Weight of dandruff before start of test (mg)

Comparison of effects of dandruff reduction rate Sample test bacteria Example Comparative Example One 2 3 4 5 One 2 3 4 5 Dandruff reduction rate (%) 78.8 65.3 67.5 75.6 86.7 59.8 59.9 60.0 59.7 59.8

As can be seen in Table 3, in the examples containing iodopropynyl butylcarbamate and guar hydroxypropyl trimonium chloride, polyquaternium-7, polyquaternium-10, urea and EDTA, the average damping reduction rate Was higher than that of Comparative Example 1 containing iodopropynyl butylcarbamate alone.

As can be seen from the above description, the present applicant found by the bideumgyun is iodo which are capable of inhibiting the proliferation and activity of the error correcting capability of Ross form Ovalle FIG propynyl butyl cover boehmite and, guar hydroxypropyl trimonium chloride, Polyquaternium 7, polyquaternium-10, urea, and EDTA are used together, they exhibit excellent dandruff and itching-suppressing effects by mutual synergism.

Claims (3)

In the hair cosmetic composition, Characterized in that it contains at least one selected from iodopropynyl butylcabamate and hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, urea and EDTA at the same time Hair cosmetic composition. The hair cosmetic composition according to claim 1, wherein the iodopropynyl butylcarbamate is contained in an amount of 0.001 to 20 wt% based on the total weight of the composition. The composition according to claim 1, wherein at least one selected from the group consisting of hydroxypropyltrimonium chloride, polyquaternium-7, polyquaternium-10, urea and EDTA is contained in an amount of 0.001 to 10 wt% Wherein the composition has a dandruff-preventing effect.