KR102991654B1 - 종양 조직 표지를 위한 새로운 형광 화합물 - Google Patents

종양 조직 표지를 위한 새로운 형광 화합물

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Publication number
KR102991654B1
KR102991654B1 KR1020227043701A KR20227043701A KR102991654B1 KR 102991654 B1 KR102991654 B1 KR 102991654B1 KR 1020227043701 A KR1020227043701 A KR 1020227043701A KR 20227043701 A KR20227043701 A KR 20227043701A KR 102991654 B1 KR102991654 B1 KR 102991654B1
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South Korea
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chemical formula
tumor
compound
present
alkyl
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English (en)
Korean (ko)
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KR20230010713A (ko
Inventor
조앤 트란기용
빈센트 기용
프랑수아 셰르닌스키
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프로이미징
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1029—Heterocyclic compounds characterised by ligands containing one nitrogen atom as the heteroatom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020227043701A 2020-05-15 2021-05-12 종양 조직 표지를 위한 새로운 형광 화합물 Active KR102991654B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR2004868A FR3110165B1 (fr) 2020-05-15 2020-05-15 Nouveaux composés fluorescents pour le marquage de tissu tumoral
FRFR2004868 2020-05-15
PCT/FR2021/050832 WO2021229188A1 (fr) 2020-05-15 2021-05-12 Nouveaux composés fluorescents pour le marquage de tissu tumoral

Publications (2)

Publication Number Publication Date
KR20230010713A KR20230010713A (ko) 2023-01-19
KR102991654B1 true KR102991654B1 (ko) 2026-07-15

Family

ID=72644317

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227043701A Active KR102991654B1 (ko) 2020-05-15 2021-05-12 종양 조직 표지를 위한 새로운 형광 화합물

Country Status (9)

Country Link
US (1) US20230203014A1 (enExample)
EP (1) EP4149925A1 (enExample)
JP (2) JP7864694B2 (enExample)
KR (1) KR102991654B1 (enExample)
CN (2) CN121471129A (enExample)
BR (1) BR112022023154A2 (enExample)
CA (1) CA3178232A1 (enExample)
FR (1) FR3110165B1 (enExample)
WO (1) WO2021229188A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3248903A1 (en) * 2022-02-02 2023-08-10 Vergent Bioscience, Inc. METHODS FOR LOCALIZING CANCER TISSUE USING A FLUORESCENT MOLECULAR IMAGING AGENT FOR DIAGNOSIS OR TREATMENT
CN114751907A (zh) * 2022-03-17 2022-07-15 南京诺源医疗器械有限公司 一种主动靶向叶酸受体近红外荧光分子及其制备方法和用途
CN116947829B (zh) * 2023-07-05 2025-09-23 上海内瑟汐医疗科技有限公司 一种基于新吲哚菁绿ir820的荧光化合物及其制备和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009112488A2 (en) 2008-03-10 2009-09-17 Mivenion Gmbh Polyether polyol dendron conjugates with effector molecules for biological targeting
WO2011109216A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06145539A (ja) * 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
JPH07287346A (ja) * 1994-04-08 1995-10-31 E I Du Pont De Nemours & Co 近赤外ハレーション防止用の新規なエーテル色素を有する写真エレメント
GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
CN102268191B (zh) * 2010-06-06 2013-08-14 史春梦 七甲川吲哚花菁染料及其合成方法和应用
CN103911017B (zh) * 2012-12-28 2017-09-15 浙江海正药业股份有限公司 菁染料化合物及其制备方法、用于光动力学疗法的双重功能剂及其制备方法
CN105693590B (zh) * 2016-01-15 2019-01-15 复旦大学 一种pH控制识别肿瘤细胞的光热试剂及其制备方法和应用
KR101980292B1 (ko) * 2017-08-03 2019-05-20 (주)바이오액츠 형광 화합물 및 이의 제조방법
EP3517146A1 (en) * 2018-01-26 2019-07-31 Université de Strasbourg Fluorescent polymeric coating film for medical devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009112488A2 (en) 2008-03-10 2009-09-17 Mivenion Gmbh Polyether polyol dendron conjugates with effector molecules for biological targeting
WO2011109216A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications

Also Published As

Publication number Publication date
BR112022023154A2 (pt) 2023-02-07
EP4149925A1 (fr) 2023-03-22
JP7864694B2 (ja) 2026-05-25
CA3178232A1 (fr) 2021-11-18
CN115605459A (zh) 2023-01-13
FR3110165A1 (fr) 2021-11-19
KR20230010713A (ko) 2023-01-19
WO2021229188A1 (fr) 2021-11-18
FR3110165B1 (fr) 2022-10-28
CN121471129A (zh) 2026-02-06
JP2023525601A (ja) 2023-06-16
US20230203014A1 (en) 2023-06-29
JP2026042845A (ja) 2026-03-11

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