KR102905557B1 - THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도 - Google Patents

THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도

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Publication number
KR102905557B1
KR102905557B1 KR1020217021249A KR20217021249A KR102905557B1 KR 102905557 B1 KR102905557 B1 KR 102905557B1 KR 1020217021249 A KR1020217021249 A KR 1020217021249A KR 20217021249 A KR20217021249 A KR 20217021249A KR 102905557 B1 KR102905557 B1 KR 102905557B1
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compound
alkyl
pharmaceutically acceptable
group
acceptable salt
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KR20210102328A (ko
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상하이 유
벤 리
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테른스, 인크.
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Assigned to 테른스 파마슈티칼스, 인크. reassignment 테른스 파마슈티칼스, 인크. 권리의 전부이전등록 Assignors: 테른스, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
KR1020217021249A 2018-12-13 2019-12-12 THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도 Active KR102905557B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257028884A KR20250133486A (ko) 2018-12-13 2019-12-12 THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811527414.4 2018-12-13
CN201811527414.4A CN111320609A (zh) 2018-12-13 2018-12-13 一种THRβ受体激动剂化合物及其制备方法和用途
PCT/US2019/066013 WO2020123827A1 (en) 2018-12-13 2019-12-12 Thrβ receptor agonist compound and preparation method and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257028884A Division KR20250133486A (ko) 2018-12-13 2019-12-12 THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도

Publications (2)

Publication Number Publication Date
KR20210102328A KR20210102328A (ko) 2021-08-19
KR102905557B1 true KR102905557B1 (ko) 2025-12-31

Family

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Family Applications (2)

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KR1020217021249A Active KR102905557B1 (ko) 2018-12-13 2019-12-12 THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도
KR1020257028884A Pending KR20250133486A (ko) 2018-12-13 2019-12-12 THRβ 수용체 효능제 화합물 및 그의 제조 방법 및 용도

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Country Status (25)

Country Link
US (6) US11084802B2 (https=)
EP (3) EP3893889B8 (https=)
JP (3) JP7532371B2 (https=)
KR (2) KR102905557B1 (https=)
CN (4) CN111320609A (https=)
AR (1) AR117694A1 (https=)
AU (2) AU2019398339C1 (https=)
BR (1) BR112021010871A2 (https=)
CA (1) CA3120880A1 (https=)
CL (1) CL2021001521A1 (https=)
CO (1) CO2021008817A2 (https=)
DK (2) DK4574821T3 (https=)
ES (1) ES3064255T3 (https=)
FI (2) FI4574821T3 (https=)
HR (1) HRP20260358T1 (https=)
IL (3) IL310699B2 (https=)
LT (2) LT4574821T (https=)
MA (1) MA54471A (https=)
MX (2) MX2021006908A (https=)
MY (1) MY207657A (https=)
PE (2) PE20252338A1 (https=)
PT (1) PT3893889T (https=)
SG (1) SG11202106194TA (https=)
TW (3) TW202600541A (https=)
WO (1) WO2020123827A1 (https=)

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CN119013027A (zh) 2021-11-11 2024-11-22 拓臻制药公司 用于治疗肝脏病症的SSAO抑制剂和THR-β激动剂的组合
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