KR102900157B1 - 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법 - Google Patents

5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법

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KR102900157B1
KR102900157B1 KR1020237034770A KR20237034770A KR102900157B1 KR 102900157 B1 KR102900157 B1 KR 102900157B1 KR 1020237034770 A KR1020237034770 A KR 1020237034770A KR 20237034770 A KR20237034770 A KR 20237034770A KR 102900157 B1 KR102900157 B1 KR 102900157B1
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phenyl
disorder
delete delete
cycloalkyl
alkyl
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KR20230148384A (ko
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다니엘 제이. 캐니
벤자민 이. 블라스
케빈 엠. 블래트너
더글라스 에이. 피핀
Original Assignee
템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션
프라이벤틱스 엘엘씨
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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KR1020237034770A 2016-11-15 2017-11-15 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법 Active KR102900157B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662422344P 2016-11-15 2016-11-15
US62/422,344 2016-11-15
KR1020197016744A KR102590403B1 (ko) 2016-11-15 2017-11-15 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법
PCT/US2017/061677 WO2018093818A1 (en) 2016-11-15 2017-11-15 Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use

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Related Child Applications (1)

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KR1020257041103A Division KR20260053219A (ko) 2016-11-15 2017-11-15 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법

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KR20230148384A KR20230148384A (ko) 2023-10-24
KR102900157B1 true KR102900157B1 (ko) 2025-12-12

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KR1020197016744A Active KR102590403B1 (ko) 2016-11-15 2017-11-15 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법

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US (4) US10858368B2 (https=)
EP (2) EP4684837A1 (https=)
JP (3) JP7107955B2 (https=)
KR (2) KR102900157B1 (https=)
CN (2) CN119977980A (https=)
AU (3) AU2017361078B2 (https=)
CA (1) CA3043319A1 (https=)
CL (1) CL2019001329A1 (https=)
EA (1) EA201990915A1 (https=)
ES (1) ES3050660T3 (https=)
IL (3) IL291029B2 (https=)
MX (2) MX394746B (https=)
UA (1) UA125631C2 (https=)
WO (1) WO2018093818A1 (https=)
ZA (1) ZA202105774B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970223B1 (en) 2013-03-11 2020-04-15 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
US10544117B2 (en) 2014-09-10 2020-01-28 Temple University—Of the Commonwealth System of Higher Education 5-hydroxytryptamine receptor 7 activity modulators and their method of use
AU2017361078B2 (en) 2016-11-15 2022-01-06 Praeventix, Llc Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
MA49019A (fr) * 2017-03-21 2020-02-05 Univ Temple Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation
MA49017A (fr) * 2017-03-21 2020-02-05 Univ Temple Modulateurs du récepteur 7 de la 5-hydroxytryptamine et utilisation de ces derniers en tant qu'agents thérapeutiques
EA202092328A1 (ru) 2018-05-11 2021-04-08 Темпл Юниверсити-Оф Зэ Коммонвелс Систем Оф Хаер Эдьюкейшн Новые функционализированные лактамы в качестве модуляторов 5-гидрокситриптаминового рецептора 7 и способ их применения
WO2021097117A2 (en) * 2019-11-13 2021-05-20 Temple University-Of The Commonwealth System Of Higher Education Novel functionalized lactones as modulators of the 5-hydroxytryptamine receptor 7 and their method of use
JP7730811B2 (ja) * 2019-11-13 2025-08-28 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法
TW202328148A (zh) * 2021-09-22 2023-07-16 日商塩野義製藥股份有限公司 具有血清素受體結合活性之螺雜環衍生物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160016941A1 (en) 2013-03-11 2016-01-21 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2016040554A1 (en) * 2014-09-10 2016-03-17 Temple University-Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
KR102590403B1 (ko) * 2016-11-15 2023-10-16 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040064499A1 (en) 2002-09-26 2004-04-01 Kasra Kasravi Method and system for active knowledge management
MXPA05008137A (es) 2003-01-31 2005-09-30 Pfizer Prod Inc Antagonistas y agonistas de 5ht7.
BRPI0506909A (pt) * 2004-01-16 2007-05-29 Hoffmann La Roche derivados de 1-benzil-5piperazin-1-il-3,4 diidro-1h-quinazolin-2-ona e os respectivos derivados de 1h-benzo (1,2,6) tiadiazina-2,2-dióxido e 1,4-diidro-benzo (d) (1,3)oxazin-2-ona como moduladores do receptor de 5-hidroxitriptamina (5-ht) para o tratamento de doenças do sistema nervoso central
CN101277700B (zh) * 2005-08-04 2013-02-20 詹森药业有限公司 作为5-羟色胺受体调节剂的嘧啶化合物
EP1875899A1 (en) 2006-06-29 2008-01-09 Laboratorios Del Dr. Esteve, S.A. Use of 5HT7 receptor agonists for the treatment of pain
CA2699674C (en) 2007-10-12 2013-07-16 Eli Lilly And Company 5-ht7 receptor antagonists
US7902091B2 (en) 2008-08-13 2011-03-08 Varian Semiconductor Equipment Associates, Inc. Cleaving of substrates
EP2341912B1 (en) 2008-09-05 2014-01-22 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (adhd)
WO2010069390A1 (en) 2008-12-19 2010-06-24 Nokia Siemens Networks Oy Method and device for data processing in an udwdm network and communication system comprising such device
US8637263B1 (en) * 2010-10-14 2014-01-28 Epiomed Therapeutics, Inc. Assay for determination of compounds having anti-emetic activity
US20130287705A1 (en) 2010-11-03 2013-10-31 Mcmaster University Method of treating mucosal inflammation
WO2013154513A1 (en) * 2012-04-04 2013-10-17 Mi̇lli̇ Savunma Bakanliği The use of 5-ht7 receptor antagonists including some atypical antipsychotics as antipruritic agents
WO2014085413A1 (en) 2012-11-28 2014-06-05 Temple University - Of The Commonwealth System Of Higher Education Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2b activity modulators
US20180221365A1 (en) 2015-05-12 2018-08-09 Temple University-Of The Commonwealth System Of Higher Education Novel sigma-2 receptor binders and their method of use
MA49017A (fr) 2017-03-21 2020-02-05 Univ Temple Modulateurs du récepteur 7 de la 5-hydroxytryptamine et utilisation de ces derniers en tant qu'agents thérapeutiques
MA49019A (fr) 2017-03-21 2020-02-05 Univ Temple Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation
EA202092328A1 (ru) 2018-05-11 2021-04-08 Темпл Юниверсити-Оф Зэ Коммонвелс Систем Оф Хаер Эдьюкейшн Новые функционализированные лактамы в качестве модуляторов 5-гидрокситриптаминового рецептора 7 и способ их применения
WO2021097117A2 (en) * 2019-11-13 2021-05-20 Temple University-Of The Commonwealth System Of Higher Education Novel functionalized lactones as modulators of the 5-hydroxytryptamine receptor 7 and their method of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160016941A1 (en) 2013-03-11 2016-01-21 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2016040554A1 (en) * 2014-09-10 2016-03-17 Temple University-Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
KR102590403B1 (ko) * 2016-11-15 2023-10-16 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 5-히드록시트립타민 수용체 7의 신규 조절제 및 이의 사용 방법

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