KR102847736B1 - 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체 - Google Patents

변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체

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Publication number
KR102847736B1
KR102847736B1 KR1020247019564A KR20247019564A KR102847736B1 KR 102847736 B1 KR102847736 B1 KR 102847736B1 KR 1020247019564 A KR1020247019564 A KR 1020247019564A KR 20247019564 A KR20247019564 A KR 20247019564A KR 102847736 B1 KR102847736 B1 KR 102847736B1
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KR20240095463A (ko
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아론 얌니우크
마리 스트루더스
수잔 제이. 슈샤드
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020247019564A 2017-05-25 2018-05-24 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체 Active KR102847736B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762511245P 2017-05-25 2017-05-25
US62/511,245 2017-05-25
KR1020197037759A KR20200012907A (ko) 2017-05-25 2018-05-24 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체
PCT/US2018/034330 WO2018217988A1 (en) 2017-05-25 2018-05-24 MODIFIED IgG1 Fc DOMAINS AND ANTI-CD40 DOMAIN ANTIBODY FUSIONS THEREWITH

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197037759A Division KR20200012907A (ko) 2017-05-25 2018-05-24 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체

Publications (2)

Publication Number Publication Date
KR20240095463A KR20240095463A (ko) 2024-06-25
KR102847736B1 true KR102847736B1 (ko) 2025-08-18

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Application Number Title Priority Date Filing Date
KR1020247019564A Active KR102847736B1 (ko) 2017-05-25 2018-05-24 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체
KR1020197037759A Ceased KR20200012907A (ko) 2017-05-25 2018-05-24 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197037759A Ceased KR20200012907A (ko) 2017-05-25 2018-05-24 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체

Country Status (6)

Country Link
US (1) US20200148779A1 (enExample)
EP (1) EP3630832A1 (enExample)
JP (2) JP2020521458A (enExample)
KR (2) KR102847736B1 (enExample)
CN (1) CN110637035A (enExample)
WO (1) WO2018217988A1 (enExample)

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TWI711630B (zh) 2014-11-21 2020-12-01 美商必治妥美雅史谷比公司 抗ｃｄ７３抗體及其用途
PT3468997T (pt) 2016-06-08 2023-12-07 Debra Zack Tratamento de doenças relacionadas com igg4 com anticorpos anti-cd19 com ligação cruzada a cd32b
US11220550B2 (en) 2017-05-25 2022-01-11 Bristol-Myers Squibb Company Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity
SG11202009625WA (en) 2018-04-02 2020-10-29 Bristol Myers Squibb Co Anti-trem-1 antibodies and uses thereof
AR117091A1 (es) 2018-11-19 2021-07-07 Bristol Myers Squibb Co Anticuerpos monoclonales antagonistas contra cd40 y sus usos
CN114599389A (zh) * 2019-08-22 2022-06-07 奇达拉治疗公司 变体fc结构域及其用途
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
JP2023516459A (ja) * 2020-03-09 2023-04-19 ブリストル－マイヤーズ スクイブ カンパニー 増強されたアゴニスト活性を有するｃｄ４０に対する抗体
WO2021216372A1 (en) * 2020-04-23 2021-10-28 Eli Lilly And Company Subcutaneous absorption and bioavailability of antibodies
WO2021236546A1 (en) 2020-05-18 2021-11-25 Bristol-Myers Squibb Company Antibody variants with improved pharmacokinetic properties
CN112552389B (zh) * 2020-08-07 2023-06-06 中爱瑞祥(杭州)生物科技有限公司 一种活性肽融合蛋白及其制备方法
US12161692B2 (en) * 2020-11-02 2024-12-10 Attralus, Inc. SAP FC fusion proteins and methods of use
KR20230142831A (ko) 2021-01-13 2023-10-11 비스테라, 인크. 인간화된 보체 5a 수용체 1 항체 및 이의 사용 방법

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US20130209445A1 (en) * 2004-03-26 2013-08-15 Xencor, Inc. Optimized Fc Variants
JP2014513953A (ja) * 2011-04-21 2014-06-19 ブリストル−マイヤーズ スクイブ カンパニー Ｃｄ４０を拮抗する抗体ポリペプチド

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US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
JP2008505174A (ja) * 2004-07-15 2008-02-21 ゼンコー・インコーポレイテッド 最適化Ｆｃ変異体
KR20080073293A (ko) * 2005-10-14 2008-08-08 메디뮨 엘엘씨 항체 라이브러리의 세포 디스플레이
US10053513B2 (en) * 2009-11-30 2018-08-21 Janssen Biotech, Inc. Antibody Fc mutants with ablated effector functions
AR083847A1 (es) * 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
US20140294812A1 (en) * 2013-03-15 2014-10-02 Xencor, Inc. Fc variants that improve fcrn binding and/or increase antibody half-life
EP3113796A1 (en) * 2014-03-07 2017-01-11 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize cd40 to treat ibd
WO2016028810A1 (en) * 2014-08-18 2016-02-25 Biogen Ma Inc. Anti-cd40 antibodies and uses thereof
CN108368510B (zh) * 2015-09-30 2023-09-01 詹森生物科技公司 特异性结合人cd40的激动性抗体和使用方法
US11220550B2 (en) * 2017-05-25 2022-01-11 Bristol-Myers Squibb Company Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20130209445A1 (en) * 2004-03-26 2013-08-15 Xencor, Inc. Optimized Fc Variants
JP2014513953A (ja) * 2011-04-21 2014-06-19 ブリストル−マイヤーズ スクイブ カンパニー Ｃｄ４０を拮抗する抗体ポリペプチド

Also Published As

Publication number Publication date
JP2020521458A (ja) 2020-07-27
WO2018217988A1 (en) 2018-11-29
CN110637035A (zh) 2019-12-31
EP3630832A1 (en) 2020-04-08
JP2023113636A (ja) 2023-08-16
KR20200012907A (ko) 2020-02-05
US20200148779A1 (en) 2020-05-14
WO2018217988A9 (en) 2019-05-02
KR20240095463A (ko) 2024-06-25

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