KR102800556B1 - 치료를 위한 제제, 용도 및 방법 - Google Patents

치료를 위한 제제, 용도 및 방법 Download PDF

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Publication number
KR102800556B1
KR102800556B1 KR1020207001250A KR20207001250A KR102800556B1 KR 102800556 B1 KR102800556 B1 KR 102800556B1 KR 1020207001250 A KR1020207001250 A KR 1020207001250A KR 20207001250 A KR20207001250 A KR 20207001250A KR 102800556 B1 KR102800556 B1 KR 102800556B1
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ser
gly
seq
variable domain
chain variable
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KR20200031610A (ko
Inventor
뢴 라르스 크리스티안 빌만
이브라임 욘 말릭
제프리 비 스타벤하겐
쇠렌 크리스텐센
얀 에게베르
티나 스툼만
아르나우트 헤리첸
던 브린크 에드바르트 판
파울 파렌
에스벤 트라베르
카스페르 뒤르베르 란
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하. 룬드벡 아크티에셀스카브
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020207001250A 2017-07-20 2018-07-18 치료를 위한 제제, 용도 및 방법 Active KR102800556B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201700419 2017-07-20
DKPA201700419 2017-07-20
PCT/EP2018/069460 WO2019016247A2 (en) 2017-07-20 2018-07-18 AGENTS, USES AND METHODS OF TREATMENT

Publications (2)

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KR20200031610A KR20200031610A (ko) 2020-03-24
KR102800556B1 true KR102800556B1 (ko) 2025-04-24

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US (2) US10894833B2 (enExample)
EP (1) EP3655438A2 (enExample)
JP (2) JP7563975B2 (enExample)
KR (1) KR102800556B1 (enExample)
CN (3) CN119161480A (enExample)
AR (1) AR112563A1 (enExample)
AU (1) AU2018303175B2 (enExample)
BR (1) BR112019005428A2 (enExample)
CA (1) CA3069391A1 (enExample)
CL (1) CL2020000070A1 (enExample)
CO (1) CO2019014090A2 (enExample)
CR (1) CR20200027A (enExample)
DO (1) DOP2020000006A (enExample)
EA (1) EA201992688A1 (enExample)
EC (1) ECSP20002935A (enExample)
IL (1) IL271728B2 (enExample)
JO (1) JOP20200007A1 (enExample)
MA (1) MA49633A (enExample)
NI (1) NI202000005A (enExample)
PE (1) PE20210467A1 (enExample)
PH (1) PH12019502869A1 (enExample)
RU (1) RU2019140933A (enExample)
SG (1) SG11201912228WA (enExample)
TW (1) TW201908342A (enExample)
WO (1) WO2019016247A2 (enExample)

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PL3280441T3 (pl) 2015-04-07 2022-02-21 Alector Llc Przeciwciała przeciwko sortilinie i sposoby ich stosowania
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US11396546B2 (en) 2018-07-13 2022-07-26 Alector Llc Anti-Sortilin antibodies and methods of use thereof
US11407828B2 (en) 2019-02-01 2022-08-09 Novarock Biotherapeutics, Ltd. Anti-CLauDiN 18 antibodies and methods of use thereof
WO2020252066A1 (en) * 2019-06-11 2020-12-17 Alector Llc Anti-sortilin antibodies for use in therapy
KR20230026489A (ko) * 2020-06-24 2023-02-24 프로테나 바이오사이언시즈 리미티드 소르틸린을 인지하는 항체
JP2025530891A (ja) 2022-06-23 2025-09-18 ドラウプニル バイオ エーピーエス リソソーム内の細胞外標的の分解を選択的に誘導する二機能性分子

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Also Published As

Publication number Publication date
AR112563A1 (es) 2019-11-13
PE20210467A1 (es) 2021-03-08
ECSP20002935A (es) 2020-02-28
CA3069391A1 (en) 2019-01-24
US20190023788A1 (en) 2019-01-24
EP3655438A2 (en) 2020-05-27
IL271728B1 (en) 2024-01-01
AU2018303175A1 (en) 2020-01-16
RU2019140933A3 (enExample) 2021-10-28
JP2020527152A (ja) 2020-09-03
TW201908342A (zh) 2019-03-01
CR20200027A (es) 2020-04-17
US20210292414A1 (en) 2021-09-23
PH12019502869A1 (en) 2020-09-28
WO2019016247A2 (en) 2019-01-24
SG11201912228WA (en) 2020-01-30
NI202000005A (es) 2020-05-20
KR20200031610A (ko) 2020-03-24
AU2018303175B2 (en) 2025-01-23
CN119161480A (zh) 2024-12-20
CN110945029B (zh) 2024-10-01
RU2019140933A (ru) 2021-08-20
US10894833B2 (en) 2021-01-19
JP7563975B2 (ja) 2024-10-08
CL2020000070A1 (es) 2020-06-12
CN110945029A (zh) 2020-03-31
CN119161481A (zh) 2024-12-20
DOP2020000006A (es) 2020-07-15
BR112019005428A2 (pt) 2019-07-16
JOP20200007A1 (ar) 2020-01-15
MA49633A (fr) 2020-05-27
IL271728B2 (en) 2024-05-01
WO2019016247A3 (en) 2019-06-20
CO2019014090A2 (es) 2020-01-17
JP2024119866A (ja) 2024-09-03
EA201992688A1 (ru) 2020-05-20
IL271728A (en) 2020-02-27

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