AU2018303175B2 - Agents, uses and methods for treatment - Google Patents

Agents, uses and methods for treatment Download PDF

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Publication number
AU2018303175B2
AU2018303175B2 AU2018303175A AU2018303175A AU2018303175B2 AU 2018303175 B2 AU2018303175 B2 AU 2018303175B2 AU 2018303175 A AU2018303175 A AU 2018303175A AU 2018303175 A AU2018303175 A AU 2018303175A AU 2018303175 B2 AU2018303175 B2 AU 2018303175B2
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AU
Australia
Prior art keywords
ser
seq
gly
chain variable
variable domain
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AU2018303175A
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English (en)
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AU2018303175A1 (en
Inventor
Lars Christian Biilmann Rønn
Søren CHRISTENSEN
Jan Egebjerg
Arnout Gerritsen
Ibrahim John Malik
Paul Parren
Kasper Dyrberg RAND
Jeffrey B. Stavenhagen
Tina STUMMANN
Esben TRABJERG
Edward Van Den Brink
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H Lundbeck AS
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H Lundbeck AS
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Publication of AU2018303175A1 publication Critical patent/AU2018303175A1/en
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Publication of AU2018303175B2 publication Critical patent/AU2018303175B2/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2018303175A 2017-07-20 2018-07-18 Agents, uses and methods for treatment Active AU2018303175B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201700419 2017-07-20
DKPA201700419 2017-07-20
PCT/EP2018/069460 WO2019016247A2 (en) 2017-07-20 2018-07-18 AGENTS, USES AND METHODS OF TREATMENT

Publications (2)

Publication Number Publication Date
AU2018303175A1 AU2018303175A1 (en) 2020-01-16
AU2018303175B2 true AU2018303175B2 (en) 2025-01-23

Family

ID=63113476

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018303175A Active AU2018303175B2 (en) 2017-07-20 2018-07-18 Agents, uses and methods for treatment

Country Status (25)

Country Link
US (2) US10894833B2 (enExample)
EP (1) EP3655438A2 (enExample)
JP (2) JP7563975B2 (enExample)
KR (1) KR102800556B1 (enExample)
CN (3) CN119161481A (enExample)
AR (1) AR112563A1 (enExample)
AU (1) AU2018303175B2 (enExample)
BR (1) BR112019005428A2 (enExample)
CA (1) CA3069391A1 (enExample)
CL (1) CL2020000070A1 (enExample)
CO (1) CO2019014090A2 (enExample)
CR (1) CR20200027A (enExample)
DO (1) DOP2020000006A (enExample)
EA (1) EA201992688A1 (enExample)
EC (1) ECSP20002935A (enExample)
IL (1) IL271728B2 (enExample)
JO (1) JOP20200007A1 (enExample)
MA (1) MA49633A (enExample)
NI (1) NI202000005A (enExample)
PE (1) PE20210467A1 (enExample)
PH (1) PH12019502869A1 (enExample)
RU (1) RU2019140933A (enExample)
SG (1) SG11201912228WA (enExample)
TW (1) TW201908342A (enExample)
WO (1) WO2019016247A2 (enExample)

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GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
PE20210186A1 (es) 2018-07-13 2021-02-02 Alector Llc Anticuerpos anti-sortilina y metodos para su uso
US11407828B2 (en) 2019-02-01 2022-08-09 Novarock Biotherapeutics, Ltd. Anti-CLauDiN 18 antibodies and methods of use thereof
TWI877170B (zh) * 2019-06-11 2025-03-21 美商阿列克特有限責任公司 抗揀選蛋白抗體之使用方法
CA3183994A1 (en) * 2020-06-24 2021-12-30 Philip James Dolan Iii Antibodies recognizing sortilin
CN119403786A (zh) 2022-06-23 2025-02-07 德罗普尼尔生物有限公司 选择性诱导细胞外靶标在溶酶体中降解的双功能分子

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Also Published As

Publication number Publication date
PH12019502869A1 (en) 2020-09-28
BR112019005428A2 (pt) 2019-07-16
US20190023788A1 (en) 2019-01-24
CN119161480A (zh) 2024-12-20
US20210292414A1 (en) 2021-09-23
ECSP20002935A (es) 2020-02-28
RU2019140933A (ru) 2021-08-20
DOP2020000006A (es) 2020-07-15
JOP20200007A1 (ar) 2020-01-15
RU2019140933A3 (enExample) 2021-10-28
IL271728B2 (en) 2024-05-01
CA3069391A1 (en) 2019-01-24
EA201992688A1 (ru) 2020-05-20
IL271728A (en) 2020-02-27
JP7563975B2 (ja) 2024-10-08
CN110945029B (zh) 2024-10-01
IL271728B1 (en) 2024-01-01
CR20200027A (es) 2020-04-17
EP3655438A2 (en) 2020-05-27
CN119161481A (zh) 2024-12-20
CO2019014090A2 (es) 2020-01-17
JP2020527152A (ja) 2020-09-03
WO2019016247A2 (en) 2019-01-24
US10894833B2 (en) 2021-01-19
NI202000005A (es) 2020-05-20
KR102800556B1 (ko) 2025-04-24
AU2018303175A1 (en) 2020-01-16
PE20210467A1 (es) 2021-03-08
CL2020000070A1 (es) 2020-06-12
SG11201912228WA (en) 2020-01-30
AR112563A1 (es) 2019-11-13
TW201908342A (zh) 2019-03-01
MA49633A (fr) 2020-05-27
KR20200031610A (ko) 2020-03-24
CN110945029A (zh) 2020-03-31
JP2024119866A (ja) 2024-09-03
WO2019016247A3 (en) 2019-06-20

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