KR102781208B1 - 결합제 - Google Patents

결합제 Download PDF

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Publication number
KR102781208B1
KR102781208B1 KR1020207007972A KR20207007972A KR102781208B1 KR 102781208 B1 KR102781208 B1 KR 102781208B1 KR 1020207007972 A KR1020207007972 A KR 1020207007972A KR 20207007972 A KR20207007972 A KR 20207007972A KR 102781208 B1 KR102781208 B1 KR 102781208B1
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South Korea
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seq
sequence
antigen
binding portion
ser
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English (en)
Korean (ko)
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KR20200038533A (ko
Inventor
윌리엄 제임스 조나단 핀레이
Original Assignee
센테사 파마슈티칼스 (유케이) 리미티드
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Priority claimed from GBGB1713298.6A external-priority patent/GB201713298D0/en
Priority claimed from GBGB1802595.7A external-priority patent/GB201802595D0/en
Priority claimed from GBGB1808570.4A external-priority patent/GB201808570D0/en
Application filed by 센테사 파마슈티칼스 (유케이) 리미티드 filed Critical 센테사 파마슈티칼스 (유케이) 리미티드
Publication of KR20200038533A publication Critical patent/KR20200038533A/ko
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Publication of KR102781208B1 publication Critical patent/KR102781208B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020207007972A 2017-08-18 2018-08-17 결합제 Active KR102781208B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1713298.6 2017-08-18
GBGB1713298.6A GB201713298D0 (en) 2017-08-18 2017-08-18 Binding agents
GBGB1802595.7A GB201802595D0 (en) 2018-02-16 2018-02-16 Binding agents
GB1802595.7 2018-02-16
GBGB1808570.4A GB201808570D0 (en) 2018-05-24 2018-05-24 Binding agents
GB1808570.4 2018-05-24
PCT/GB2018/052347 WO2019034895A1 (en) 2017-08-18 2018-08-17 LIAISON AGENTS

Publications (2)

Publication Number Publication Date
KR20200038533A KR20200038533A (ko) 2020-04-13
KR102781208B1 true KR102781208B1 (ko) 2025-03-17

Family

ID=63371721

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207007972A Active KR102781208B1 (ko) 2017-08-18 2018-08-17 결합제

Country Status (14)

Country Link
US (4) US10683350B2 (https=)
EP (2) EP3668897B1 (https=)
JP (3) JP7256580B2 (https=)
KR (1) KR102781208B1 (https=)
CN (1) CN111212852A (https=)
AU (2) AU2018316742B2 (https=)
BR (1) BR112020003306A2 (https=)
CA (1) CA3072998A1 (https=)
ES (1) ES2983651T3 (https=)
IL (1) IL272643A (https=)
MX (1) MX2020001873A (https=)
RU (1) RU2020109544A (https=)
SG (1) SG11202001425TA (https=)
WO (1) WO2019034895A1 (https=)

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CN114761041A (zh) 2019-07-16 2022-07-15 吉利德科学公司 Hiv疫苗及其制备和使用方法
EP4034171A1 (en) * 2019-09-23 2022-08-03 Cytomx Therapeutics Inc. Anti-cd47 antibodies, activatable anti-cd47 antibodies, and methods of use thereof
CN114555123B (zh) 2019-10-18 2024-04-02 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
KR20220091576A (ko) 2019-10-31 2022-06-30 포티 세븐, 인코포레이티드 혈액암의 항-cd47 및 항-cd20 기반 치료
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WO2021142269A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with muscle atrophy
WO2021142331A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with cardiac muscle disease
KR20260017503A (ko) 2020-02-14 2026-02-05 길리애드 사이언시즈, 인코포레이티드 Ccr8에 결합하는 항체 및 융합 단백질, 및 이의 용도
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
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CN111733162A (zh) * 2020-07-01 2020-10-02 江苏莱森生物科技研究院有限公司 一种经基因修饰的cd47蛋白及其单克隆抗体和应用
WO2022007947A1 (zh) * 2020-07-10 2022-01-13 信达生物制药(苏州)有限公司 抗cd47抗体或其抗原结合片段和dna甲基化转移酶抑制剂的组合及其用途
KR102757518B1 (ko) * 2020-12-07 2025-01-21 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
US12071481B2 (en) 2020-12-23 2024-08-27 D-10 Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
KR20230157388A (ko) 2021-03-12 2023-11-16 멘두스 비.브이. 백신접종의 방법 및 cd47 차단의 용도
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
CN112794903B (zh) * 2021-04-14 2021-06-25 广州市雷德生物科技有限公司 一种特异性结合IFN-γ的抗体及其应用
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
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WO2023277281A1 (ko) * 2021-06-30 2023-01-05 (주)이노베이션바이오 Cd47에 특이적인 인간화 항체 및 이를 포함하는 cd47 관련 질환의 예방 또는 치료용 약학적 조성물
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CN118488946A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
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Also Published As

Publication number Publication date
JP7256580B2 (ja) 2023-04-12
ES2983651T3 (es) 2024-10-24
IL272643A (en) 2020-03-31
AU2025204808A1 (en) 2025-07-17
JP2025000787A (ja) 2025-01-07
KR20200038533A (ko) 2020-04-13
BR112020003306A2 (pt) 2020-08-25
AU2018316742A1 (en) 2020-03-19
JP7825015B2 (ja) 2026-03-05
JP2023073339A (ja) 2023-05-25
AU2018316742B2 (en) 2025-04-10
US20190375840A1 (en) 2019-12-12
US11370840B2 (en) 2022-06-28
JP2020531048A (ja) 2020-11-05
US20250109202A1 (en) 2025-04-03
SG11202001425TA (en) 2020-03-30
WO2019034895A1 (en) 2019-02-21
EP3668897B1 (en) 2024-06-05
CN111212852A (zh) 2020-05-29
RU2020109544A (ru) 2021-09-20
MX2020001873A (es) 2020-10-22
EP4435008A2 (en) 2024-09-25
US20220332819A1 (en) 2022-10-20
CA3072998A1 (en) 2019-02-21
US20200277375A1 (en) 2020-09-03
JP7564274B2 (ja) 2024-10-08
EP3668897A1 (en) 2020-06-24
US10683350B2 (en) 2020-06-16

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