KR102755545B1 - 프로모터 - Google Patents

프로모터 Download PDF

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Publication number
KR102755545B1
KR102755545B1 KR1020187024944A KR20187024944A KR102755545B1 KR 102755545 B1 KR102755545 B1 KR 102755545B1 KR 1020187024944 A KR1020187024944 A KR 1020187024944A KR 20187024944 A KR20187024944 A KR 20187024944A KR 102755545 B1 KR102755545 B1 KR 102755545B1
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South Korea
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seq
nucleic acid
polynucleotide
acid molecule
nucleotide sequence
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Korean (ko)
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KR20180132045A (ko
Inventor
리안 카우드
리차드 파커-마누엘
웨이헝 수
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옥스포드 제네틱스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020187024944A 2016-03-01 2017-02-28 프로모터 Active KR102755545B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1603577.6A GB201603577D0 (en) 2016-03-01 2016-03-01 Promoter
GB1603577.6 2016-03-01
PCT/GB2017/050537 WO2017149292A1 (en) 2016-03-01 2017-02-28 Promoter

Publications (2)

Publication Number Publication Date
KR20180132045A KR20180132045A (ko) 2018-12-11
KR102755545B1 true KR102755545B1 (ko) 2025-01-17

Family

ID=55807149

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187024944A Active KR102755545B1 (ko) 2016-03-01 2017-02-28 프로모터

Country Status (8)

Country Link
US (1) US10647999B2 (enExample)
EP (2) EP3686282B1 (enExample)
JP (1) JP6960409B2 (enExample)
KR (1) KR102755545B1 (enExample)
AU (1) AU2017225350B2 (enExample)
GB (3) GB201603577D0 (enExample)
SG (1) SG11201806782QA (enExample)
WO (1) WO2017149292A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110892064A (zh) 2017-07-25 2020-03-17 牛津遗传学有限公司 腺病毒载体
CN107630035A (zh) * 2017-09-28 2018-01-26 兰州大学 一种大鼠防御素真核表达载体及其构建方法
GB201800903D0 (en) 2018-01-19 2018-03-07 Oxford Genetics Ltd Vectors
AU2019215152A1 (en) * 2018-02-01 2020-08-20 Homology Medicines, Inc. Adeno-associated virus compositions for restoring PAH gene function and methods of use thereof
GB201901571D0 (en) 2019-02-05 2019-03-27 Oxford Genetics Ltd Inducible AAV sysyem
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
JP2024537896A (ja) 2021-10-18 2024-10-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド アデノウイルス随伴ウイルスポリヌクレオチドを含む真核細胞
AR127674A1 (es) 2021-10-18 2024-02-21 Regeneron Pharma Células de mamífero que comprenden genes cas9 integrados para producir sitios de integración estables, y células de mamífero que comprenden sitios de integración estables y otros sitios

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081336A1 (en) 2006-01-13 2007-07-19 Five Prime Therapeutics, Inc. Mammalian vectors for high-level expression of recombinant proteins
WO2012112603A1 (en) 2011-02-14 2012-08-23 University Of Utah Research Foundations Constructs and methods for generating induced pluri potent stem ( ips) cells
WO2016022075A1 (en) 2014-08-08 2016-02-11 Agency For Science, Technology And Research Mutants of the bacteriophage lambda integrase

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
PT1996238T (pt) * 2006-02-28 2016-07-11 Vaxart Inc Vetores adenovíricos quiméricos e arncd como agonista de tlr3
WO2008051854A2 (en) * 2006-10-20 2008-05-02 Trustees Of Boston University A tunable genetic switch for regulating gene expression
EP2097538A4 (en) 2006-12-07 2011-11-30 Switchgear Genomics TRANSCRIPTION REAGULATION ELEMENTS OF BIOLOGICAL PATHS, TOOLS AND METHODS
WO2011034950A1 (en) * 2009-09-16 2011-03-24 Vaxart, Inc. Immunization strategy to prevent h1n1 infection
BR112013025819A2 (pt) 2011-04-07 2016-12-20 Bayer Crospscience N V promotor específico para semente em algodão
EP2771465A1 (en) * 2011-10-28 2014-09-03 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Genetic element that enhances protein translation
HUE026516T2 (en) * 2012-09-24 2016-06-28 Lonza Biologics Plc Expression vectors containing chimeric cytomegalovirus promoter and enhancer sequences
EP3770263A1 (en) 2013-03-12 2021-01-27 AGC Biologics, Inc. Improved recombinant protein expression using a hybrid chef1 promoter
CN104630267B (zh) * 2014-07-17 2017-10-31 清华大学 利用tale转录抑制子在哺乳动物细胞中模块化构建合成基因线路的试剂盒

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081336A1 (en) 2006-01-13 2007-07-19 Five Prime Therapeutics, Inc. Mammalian vectors for high-level expression of recombinant proteins
WO2012112603A1 (en) 2011-02-14 2012-08-23 University Of Utah Research Foundations Constructs and methods for generating induced pluri potent stem ( ips) cells
WO2016022075A1 (en) 2014-08-08 2016-02-11 Agency For Science, Technology And Research Mutants of the bacteriophage lambda integrase

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Gene Med.,11:941-950(2009.)
NCBI GenBank: LM652706.1(2015.8.24.)*

Also Published As

Publication number Publication date
GB201703224D0 (en) 2017-04-12
KR20180132045A (ko) 2018-12-11
AU2017225350B2 (en) 2023-07-20
GB2553170A (en) 2018-02-28
CN109072251A (zh) 2018-12-21
GB2553170B (en) 2020-05-06
GB202002193D0 (en) 2020-04-01
JP2019506882A (ja) 2019-03-14
WO2017149292A1 (en) 2017-09-08
EP3686282A1 (en) 2020-07-29
GB2578859A (en) 2020-05-27
GB2578859B (en) 2020-10-28
EP3423583B1 (en) 2023-05-24
US20190071692A1 (en) 2019-03-07
EP3423583A1 (en) 2019-01-09
GB201603577D0 (en) 2016-04-13
SG11201806782QA (en) 2018-09-27
JP6960409B2 (ja) 2021-11-05
US10647999B2 (en) 2020-05-12
EP3686282B1 (en) 2024-12-04
AU2017225350A1 (en) 2018-09-06

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