KR102753367B1 - 설포로다민 포스포아미다이트 염료 - Google Patents

설포로다민 포스포아미다이트 염료 Download PDF

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KR102753367B1
KR102753367B1 KR1020207035076A KR20207035076A KR102753367B1 KR 102753367 B1 KR102753367 B1 KR 102753367B1 KR 1020207035076 A KR1020207035076 A KR 1020207035076A KR 20207035076 A KR20207035076 A KR 20207035076A KR 102753367 B1 KR102753367 B1 KR 102753367B1
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KR20210035079A (ko
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케빈 피. 룬드
드미트리 세르귀브
마허 엔. 카바
알렉산더 갈
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세페이드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020207035076A 2018-05-07 2019-05-07 설포로다민 포스포아미다이트 염료 Active KR102753367B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862668109P 2018-05-07 2018-05-07
US62/668,109 2018-05-07
PCT/US2019/031188 WO2019217470A1 (en) 2018-05-07 2019-05-07 Sulforhodamine phosphoramidite dyes

Publications (2)

Publication Number Publication Date
KR20210035079A KR20210035079A (ko) 2021-03-31
KR102753367B1 true KR102753367B1 (ko) 2025-01-10

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US (2) US12071547B2 (cg-RX-API-DMAC7.html)
EP (1) EP3790931B1 (cg-RX-API-DMAC7.html)
JP (1) JP7399882B2 (cg-RX-API-DMAC7.html)
KR (1) KR102753367B1 (cg-RX-API-DMAC7.html)
CN (1) CN112533998B (cg-RX-API-DMAC7.html)
AU (1) AU2019266218B2 (cg-RX-API-DMAC7.html)
CA (1) CA3099701A1 (cg-RX-API-DMAC7.html)
ES (1) ES2967690T3 (cg-RX-API-DMAC7.html)
MX (1) MX2020011378A (cg-RX-API-DMAC7.html)
WO (1) WO2019217470A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA202006485B (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021307437A1 (en) 2020-07-16 2023-03-16 Cepheid Fluorescent dyes
CN117207137A (zh) 2022-06-10 2023-12-12 南京泉峰科技有限公司 动力工具
CN115636843B (zh) * 2022-09-27 2024-12-13 大连理工大学 一类多功能荧光染料及应用
CN115414703B (zh) * 2022-11-03 2023-01-17 百力格生物科技(上海)股份有限公司 染料修饰后的核酸探针纯化方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231191A (en) 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US20050170363A1 (en) 2004-02-03 2005-08-04 Biosearch Technologies, Inc. Xanthene dyes
CN101454315A (zh) 2006-03-31 2009-06-10 应用生物系统有限公司 用于合成罗丹明-标记的寡核苷酸的试剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451463A (en) * 1989-08-28 1995-09-19 Clontech Laboratories, Inc. Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
CN105412945B (zh) * 2010-04-02 2021-02-05 药物影像股份有限公司 罗丹明染料的单一同分异构结合物
WO2014058535A1 (en) 2012-08-19 2014-04-17 Michigan Technological University Lysosomal targeting probes
US9598455B2 (en) 2014-03-30 2017-03-21 Cepheid Modified thymine polynucleotide oligomers and methods
US9598456B2 (en) 2014-03-30 2017-03-21 Cepheid Modified cytosine polynucleotide oligomers and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231191A (en) 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US20050170363A1 (en) 2004-02-03 2005-08-04 Biosearch Technologies, Inc. Xanthene dyes
CN101454315A (zh) 2006-03-31 2009-06-10 应用生物系统有限公司 用于合成罗丹明-标记的寡核苷酸的试剂

Also Published As

Publication number Publication date
KR20210035079A (ko) 2021-03-31
EP3790931B1 (en) 2023-09-27
CN112533998A (zh) 2021-03-19
JP7399882B2 (ja) 2023-12-18
JP2021523268A (ja) 2021-09-02
AU2019266218B2 (en) 2024-08-15
CA3099701A1 (en) 2019-11-14
ES2967690T3 (es) 2024-05-03
US20250051577A1 (en) 2025-02-13
ZA202006485B (en) 2025-07-30
EP3790931A1 (en) 2021-03-17
AU2019266218A1 (en) 2021-01-07
WO2019217470A1 (en) 2019-11-14
US12071547B2 (en) 2024-08-27
CN112533998B (zh) 2023-06-20
US20240067824A1 (en) 2024-02-29
BR112020022684A2 (pt) 2021-02-17
MX2020011378A (es) 2021-02-15

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