KR102720769B1 - FcRn 길항제를 사용하여 Fc-함유된 제제의 혈청 수준을 감소시키는 방법 - Google Patents

FcRn 길항제를 사용하여 Fc-함유된 제제의 혈청 수준을 감소시키는 방법 Download PDF

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KR102720769B1
KR102720769B1 KR1020177027256A KR20177027256A KR102720769B1 KR 102720769 B1 KR102720769 B1 KR 102720769B1 KR 1020177027256 A KR1020177027256 A KR 1020177027256A KR 20177027256 A KR20177027256 A KR 20177027256A KR 102720769 B1 KR102720769 B1 KR 102720769B1
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fcrn
pharmaceutical composition
antagonist
autoimmune
disease
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KR20170131463A (ko
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니콜라스 쥐.에이치. 옹쥬네
토르스텐 드라이어
피터 울리츠
요하네스 데 하드
크리스토프 블란체토트
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아르제넥스 비브이
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/526—CH3 domain
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020177027256A 2015-03-09 2016-03-08 FcRn 길항제를 사용하여 Fc-함유된 제제의 혈청 수준을 감소시키는 방법 Active KR102720769B1 (ko)

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Application Number Priority Date Filing Date Title
US201562130076P 2015-03-09 2015-03-09
US62/130,076 2015-03-09
PCT/IB2016/000398 WO2016142782A1 (en) 2015-03-09 2016-03-08 Methods of reducing serum levels of fc-containing agents using fcrn antagonsits

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KR20170131463A KR20170131463A (ko) 2017-11-29
KR102720769B1 true KR102720769B1 (ko) 2024-10-22

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US (1) US20160264669A1 (https=)
EP (2) EP3268391B1 (https=)
JP (6) JP2018509413A (https=)
KR (1) KR102720769B1 (https=)
AU (2) AU2016230827B2 (https=)
CA (1) CA2978253A1 (https=)
DK (1) DK3268391T3 (https=)
EA (1) EA038178B1 (https=)
ES (1) ES2882999T3 (https=)
HU (1) HUE056775T2 (https=)
IL (2) IL295425A (https=)
LT (1) LT3268391T (https=)
MX (2) MX386491B (https=)
MY (1) MY188761A (https=)
PL (1) PL3268391T3 (https=)
PT (1) PT3268391T (https=)
SG (2) SG10201908259WA (https=)
WO (1) WO2016142782A1 (https=)
ZA (1) ZA202109042B (https=)

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