KR102717601B1 - FcRn 항체 및 이의 사용 방법 - Google Patents

FcRn 항체 및 이의 사용 방법 Download PDF

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KR102717601B1
KR102717601B1 KR1020237006882A KR20237006882A KR102717601B1 KR 102717601 B1 KR102717601 B1 KR 102717601B1 KR 1020237006882 A KR1020237006882 A KR 1020237006882A KR 20237006882 A KR20237006882 A KR 20237006882A KR 102717601 B1 KR102717601 B1 KR 102717601B1
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seq
sequence
cdr
antibody
fcrn
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KR20230035439A (ko
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레오나 이. 링
수카리타 로이
나타니엘 워쉬번
마릴린 케리
데이비드 제이. 킹
제임스 삼세 미도르
안토니 매닝
잔 힐슨
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모멘타 파머슈티컬스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
KR1020237006882A 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법 Active KR102717601B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247033727A KR20240151878A (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662368770P 2016-07-29 2016-07-29
US201662368803P 2016-07-29 2016-07-29
US62/368,803 2016-07-29
US62/368,770 2016-07-29
PCT/US2017/044765 WO2018023136A1 (en) 2016-07-29 2017-07-31 Fcrn antibodies and methods of use thereof
KR1020197006049A KR102505995B1 (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법

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KR20230035439A KR20230035439A (ko) 2023-03-13
KR102717601B1 true KR102717601B1 (ko) 2024-10-16

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KR1020237006882A Active KR102717601B1 (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법
KR1020197006049A Active KR102505995B1 (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법
KR1020247033727A Pending KR20240151878A (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법

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KR1020197006049A Active KR102505995B1 (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법
KR1020247033727A Pending KR20240151878A (ko) 2016-07-29 2017-07-31 FcRn 항체 및 이의 사용 방법

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US (2) US11345751B2 (enExample)
EP (2) EP3491025B1 (enExample)
JP (3) JP7094941B2 (enExample)
KR (3) KR102717601B1 (enExample)
CN (2) CN117679506A (enExample)
AU (1) AU2017301915B2 (enExample)
BR (1) BR112019001806A2 (enExample)
CA (1) CA3032415A1 (enExample)
DK (1) DK3491025T3 (enExample)
ES (1) ES2968439T3 (enExample)
FI (1) FI3491025T3 (enExample)
HR (1) HRP20240048T1 (enExample)
HU (1) HUE065780T2 (enExample)
IL (3) IL302288B2 (enExample)
LT (1) LT3491025T (enExample)
PL (1) PL3491025T3 (enExample)
PT (1) PT3491025T (enExample)
RS (1) RS65070B1 (enExample)
SG (1) SG11201900813RA (enExample)
SI (1) SI3491025T1 (enExample)
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CN118638229A (zh) 2015-01-30 2024-09-13 动量制药公司 Fcrn抗体及其使用方法
WO2018023136A1 (en) * 2016-07-29 2018-02-01 Momenta Pharmaceuticals, Inc. Fcrn antibodies and methods of use thereof
SG10202112298TA (en) * 2017-05-11 2021-12-30 Nat Univ Singapore Targeted prevention of maternal to foetal vertical transmission of infection
JP7422659B2 (ja) 2017-12-08 2024-01-26 アルジェニクス ビーブイ 全身型重症筋無力症治療のためのＦｃＲｎアンタゴニストの使用
JP7420720B2 (ja) * 2017-12-13 2024-01-23 モメンタ ファーマシューティカルズ インコーポレイテッド ＦｃＲｎ抗体およびその使用方法
US12054558B2 (en) 2018-05-23 2024-08-06 The Jackson Laboratory Anti-NGly-1 antibodies and methods of use
MX2020013195A (es) 2018-06-08 2021-02-26 Argenx Bvba Composiciones y metodos para el tratamiento de la trombocitopenia inmunitaria.
MX2021000790A (es) * 2018-07-20 2021-07-21 Momenta Pharmaceuticals Inc Composiciones de anticuerpos del receptor neonatal para fc y metodos de uso de las mismas.
IL280278B2 (en) * 2018-07-20 2025-10-01 Momenta Pharmaceuticals Inc Fcrn antibody preparations
WO2020236695A1 (en) * 2019-05-17 2020-11-26 Alexion Pharmaceuticals, Inc. Use of anti-fcrn antibodies in the treatment of pemphighus and pemphigoid diseases
CA3148826A1 (en) * 2019-08-01 2021-02-04 Janssen Biotech, Inc. Fcrn antibodies and methods of use thereof
TW202132346A (zh) * 2019-11-19 2021-09-01 瑞士商依牧諾萬科學有限公司 使用抗-fcrn抗體治療溫抗體型自體免疫性溶血性貧血之方法
FI4087875T3 (fi) 2020-01-08 2024-10-25 argenx BV Vastasyntyneen ihmisen Fc-reseptorin (FcRn) antagonisteja pemfigus-häiriöiden hoitoon
CN116234827A (zh) * 2021-09-03 2023-06-06 舒泰神（北京）生物制药股份有限公司 特异性识别FcRn的抗体及其应用
CN113912730B (zh) * 2021-12-14 2022-03-04 北京科诺信诚科技有限公司 缓释的抗FcRn抗体或抗原结合片段及其应用
WO2023242372A1 (en) 2022-06-15 2023-12-21 argenx BV Fcrn/hsa binding molecules and methods of use
WO2024147074A1 (en) * 2023-01-06 2024-07-11 argenx BV Methods for treating pots using fcrn antagonists

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