KR102713173B1 - 비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체 - Google Patents

비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체 Download PDF

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KR102713173B1
KR102713173B1 KR1020197036866A KR20197036866A KR102713173B1 KR 102713173 B1 KR102713173 B1 KR 102713173B1 KR 1020197036866 A KR1020197036866 A KR 1020197036866A KR 20197036866 A KR20197036866 A KR 20197036866A KR 102713173 B1 KR102713173 B1 KR 102713173B1
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KR20200008579A (ko
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에이미 한
앤드류 제이. 머피
윌리엄 올슨
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리제너론 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/88—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups further acylated
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020197036866A 2017-05-18 2018-05-09 비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체 Active KR102713173B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247032445A KR20240150809A (ko) 2017-05-18 2018-05-09 비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762508327P 2017-05-18 2017-05-18
US62/508,327 2017-05-18
PCT/US2018/031910 WO2018213082A1 (en) 2017-05-18 2018-05-09 Bis-octahydrophenanthrene carboxamides and protein conjugates thereof

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KR1020247032445A Division KR20240150809A (ko) 2017-05-18 2018-05-09 비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체

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KR20200008579A KR20200008579A (ko) 2020-01-28
KR102713173B1 true KR102713173B1 (ko) 2024-10-07

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KR1020197036866A Active KR102713173B1 (ko) 2017-05-18 2018-05-09 비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체
KR1020247032445A Pending KR20240150809A (ko) 2017-05-18 2018-05-09 비스-옥타하이드로페난트렌 카복스아미드 및 이의 단백질 접합체

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US (3) US20180334426A1 (https=)
EP (1) EP3625209A1 (https=)
JP (2) JP7728636B2 (https=)
KR (2) KR102713173B1 (https=)
CN (1) CN111065622A (https=)
AU (1) AU2018269568B2 (https=)
BR (1) BR112019023990A2 (https=)
CA (2) CA3247217A1 (https=)
CL (2) CL2019003270A1 (https=)
CO (1) CO2019014286A2 (https=)
EA (1) EA201900562A1 (https=)
IL (1) IL270595B2 (https=)
MA (1) MA47392B1 (https=)
MX (1) MX2019013693A (https=)
PH (1) PH12019502576A1 (https=)
WO (1) WO2018213082A1 (https=)
ZA (1) ZA201907599B (https=)

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WO2018213082A1 (en) * 2017-05-18 2018-11-22 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
KR20200007905A (ko) 2017-05-18 2020-01-22 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
MX2020004691A (es) * 2017-11-07 2020-08-20 Regeneron Pharma Enlazadores hidrofilicos para conjugados anticuerpo-farmaco.
SG11202006510XA (en) 2018-01-08 2020-08-28 Regeneron Pharma Steroids and antibody-conjugates thereof
CN118955710A (zh) 2018-05-09 2024-11-15 里珍纳龙药品有限公司 抗msr1抗体及其使用方法
IL283313B2 (en) 2018-11-20 2025-08-01 Regeneron Pharma Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists
BR112021013464A2 (pt) * 2019-01-08 2021-09-21 Regeneron Pharmaceuticals, Inc. Ligantes sem traço e conjugados de proteína dos mesmos
CN115968304A (zh) 2020-04-16 2023-04-14 瑞泽恩制药公司 狄尔斯-阿尔德缀合方法
EP4172141A1 (en) * 2020-06-26 2023-05-03 Synaffix B.V. Methods for the preparation of linker payload constructs
CN116390771A (zh) * 2020-07-13 2023-07-04 瑞泽恩制药公司 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途
US20220143194A1 (en) 2020-11-10 2022-05-12 Regeneron Pharmaceuticals, Inc. Selenium antibody conjugates
CN112661783B (zh) * 2020-12-28 2022-06-07 中国林业科学研究院林产化学工业研究所 一种硅氧烷二元松香基苯并环丁烯单体及其制备方法和应用
CN115006390B (zh) * 2022-06-27 2024-04-19 国药集团动物保健股份有限公司 一种病毒减毒制剂、其制备方法以及应用

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