KR102704583B1 - 신규한 스트렙토코커스 프로테아제 - Google Patents

신규한 스트렙토코커스 프로테아제 Download PDF

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KR102704583B1
KR102704583B1 KR1020187025476A KR20187025476A KR102704583B1 KR 102704583 B1 KR102704583 B1 KR 102704583B1 KR 1020187025476 A KR1020187025476 A KR 1020187025476A KR 20187025476 A KR20187025476 A KR 20187025476A KR 102704583 B1 KR102704583 B1 KR 102704583B1
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KR20180124857A (ko
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울리치 본 파웰-라밍겐
크리스티안 스포에리
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게노비스 에이비
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641Cysteine endopeptidases (3.4.22)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187025476A 2016-02-04 2017-02-03 신규한 스트렙토코커스 프로테아제 Active KR102704583B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1630021 2016-02-04
SE1630021-2 2016-02-04
PCT/EP2017/052463 WO2017134274A1 (en) 2016-02-04 2017-02-03 New streptococcal proteases

Publications (2)

Publication Number Publication Date
KR20180124857A KR20180124857A (ko) 2018-11-21
KR102704583B1 true KR102704583B1 (ko) 2024-09-06

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ID=57995190

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KR1020187025476A Active KR102704583B1 (ko) 2016-02-04 2017-02-03 신규한 스트렙토코커스 프로테아제

Country Status (13)

Country Link
US (1) US12006530B2 (https=)
EP (1) EP3411389B1 (https=)
JP (2) JP7123801B2 (https=)
KR (1) KR102704583B1 (https=)
CN (1) CN109311951B (https=)
AU (1) AU2017214441B2 (https=)
CA (1) CA3013527C (https=)
DK (1) DK3411389T3 (https=)
ES (1) ES2877754T3 (https=)
PL (1) PL3411389T3 (https=)
PT (1) PT3411389T (https=)
SG (1) SG11201806639VA (https=)
WO (1) WO2017134274A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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US12546782B2 (en) 2013-03-15 2026-02-10 Mayo Foundation For Medical Education And Research Identification and monitoring of monoclonal immunoglobulins related to monoclonal gammopathy by molecular mass with mass spectrometry
CA2944767C (en) 2014-04-04 2022-07-12 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
EP3353200A4 (en) 2015-09-24 2019-06-26 Mayo Foundation for Medical Education and Research IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY
AU2017214441B2 (en) 2016-02-04 2021-08-19 Genovis Ab New Streptococcal proteases
AU2017325022B2 (en) 2016-09-07 2022-10-13 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
CN111183220B (zh) 2017-05-26 2024-03-22 杰诺维斯公司 用于聚糖分析的工具
US20210228738A1 (en) 2017-07-17 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
US12153052B2 (en) 2017-09-13 2024-11-26 Mayo Foundation For Medical Education And Research Identification and monitoring of immunoglobulin J chains
US11946937B2 (en) 2017-09-13 2024-04-02 Mayo Foundation For Medical Education And Research Identification and monitoring of apoptosis inhibitor of macrophage
EP3723794A1 (en) * 2017-12-15 2020-10-21 Intervet International B.V. A vaccine for protection against streptococcus suis
WO2021067598A1 (en) 2019-10-04 2021-04-08 Ultragenyx Pharmaceutical Inc. Methods for improved therapeutic use of recombinant aav
JP2023514204A (ja) 2020-02-14 2023-04-05 ウルトラジェニックス ファーマシューティカル インコーポレイテッド Cdkl5欠損障害を処置するための遺伝子治療
GB202002072D0 (en) * 2020-02-14 2020-04-01 Hansa Biopharma AB immunoglobulin detection and associated therapies
WO2021254479A1 (zh) * 2020-06-18 2021-12-23 上海宝济药业有限公司 一种免疫球蛋白降解酶IdeE的突变体
CA3195177A1 (en) 2020-10-07 2022-04-14 Asklepios Biopharmaceutical, Inc. Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy disorders including limb girdle 2i (lgmd2i)
WO2022221529A1 (en) 2021-04-16 2022-10-20 Asklepios Biopharmaceutical, Inc. Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
EP4079848A1 (en) 2021-04-22 2022-10-26 Genovis Ab Immunoglobulin cleaving enzyme
US20240271115A1 (en) * 2021-06-15 2024-08-15 The University Of North Carolina At Chapel Hill Methods and compositions for depleting antibodies
US20250019721A1 (en) 2021-08-11 2025-01-16 Ultragenyx Pharmaceutical Inc. Compositions and methods for treating a muscular dystrophy
US20240424077A1 (en) * 2021-11-18 2024-12-26 Intervet Inc. A method to produce a vaccine against streptococcus suis and the said vaccine
JPWO2024111657A1 (https=) * 2022-11-25 2024-05-30
JPWO2025047641A1 (https=) * 2023-08-25 2025-03-06
WO2025256977A1 (en) 2024-06-13 2025-12-18 Bayer Aktiengesellschaft Novel igm and igg cleaving enzymes
WO2025256978A1 (en) 2024-06-13 2025-12-18 Bayer Aktiengesellschaft Variants of igm and igg cleaving enzymes
GB202413764D0 (en) 2024-09-18 2024-10-30 Genovis Ab Immunoglobulin proteases and their uses

Citations (2)

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WO2015040125A1 (en) 2013-09-20 2015-03-26 Genovis Ab A method for analysing a sample of immunoglobulin molecules
EP2949749A1 (en) 2001-12-18 2015-12-02 Hansa Medical AB Ides, an igg-degrading enzyme of streptococcus pyogenes

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FR2824074A1 (fr) * 2001-04-26 2002-10-31 Pasteur Institut Sequence du genome streptococcus agalactiae, application au developpement de vaccins, d'outils de diagnostic, et a l'identification de cibles therapeutiques
JP2008525033A (ja) 2004-12-22 2008-07-17 ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド B群連鎖球菌
PL1901773T3 (pl) 2005-06-09 2012-09-28 Hansa Medical Ab Zastosowanie proteinazy IDES (Z S. Pyogenes) do leczenia chorób autoimmunologicznych oraz odrzutów przeszczepu
DK2190984T3 (da) 2007-09-14 2013-12-02 Genovis Ab Fremgangsmåder og kits til oprensning og påvisning af glycosyleret IgG
GB201115841D0 (en) * 2011-09-13 2011-10-26 Genovis Ab Protein and method
AU2017214441B2 (en) 2016-02-04 2021-08-19 Genovis Ab New Streptococcal proteases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2949749A1 (en) 2001-12-18 2015-12-02 Hansa Medical AB Ides, an igg-degrading enzyme of streptococcus pyogenes
WO2015040125A1 (en) 2013-09-20 2015-03-26 Genovis Ab A method for analysing a sample of immunoglobulin molecules

Non-Patent Citations (3)

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Title
GenBank: EFV98161.1, (2013.06.07.)
GenBank: EPU21342.1(2013.07.30.)
JENNIFER L. HESS et al., Journal of Microbiological Methods, Vol.70, pp.284-291 (2007)

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Publication number Publication date
JP2022115853A (ja) 2022-08-09
PT3411389T (pt) 2021-06-28
CN109311951A (zh) 2019-02-05
CA3013527C (en) 2023-09-05
JP2019506866A (ja) 2019-03-14
US20190345533A1 (en) 2019-11-14
DK3411389T3 (da) 2021-06-21
AU2017214441B2 (en) 2021-08-19
ES2877754T3 (es) 2021-11-17
US12006530B2 (en) 2024-06-11
EP3411389A1 (en) 2018-12-12
JP7123801B2 (ja) 2022-08-23
CN109311951B (zh) 2022-10-11
KR20180124857A (ko) 2018-11-21
EP3411389B1 (en) 2021-03-24
WO2017134274A1 (en) 2017-08-10
CA3013527A1 (en) 2017-08-10
AU2017214441A1 (en) 2018-08-16
SG11201806639VA (en) 2018-09-27
PL3411389T3 (pl) 2021-10-25

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