KR102702675B1 - 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 - Google Patents

결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 Download PDF

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KR102702675B1
KR102702675B1 KR1020237010151A KR20237010151A KR102702675B1 KR 102702675 B1 KR102702675 B1 KR 102702675B1 KR 1020237010151 A KR1020237010151 A KR 1020237010151A KR 20237010151 A KR20237010151 A KR 20237010151A KR 102702675 B1 KR102702675 B1 KR 102702675B1
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antibody
ctla
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nivolumab
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KR20230047498A (ko
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마이클 액셀슨
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020237010151A 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 Active KR102702675B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247029228A KR20240134249A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662345662P 2016-06-03 2016-06-03
US62/345,662 2016-06-03
PCT/US2017/035822 WO2017210637A1 (en) 2016-06-03 2017-06-02 Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer
KR1020187038115A KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

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KR1020187038115A Division KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Related Child Applications (1)

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KR1020247029228A Division KR20240134249A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Publications (2)

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KR20230047498A KR20230047498A (ko) 2023-04-07
KR102702675B1 true KR102702675B1 (ko) 2024-09-05

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KR1020237010151A Active KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020187038115A Active KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020247029228A Pending KR20240134249A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

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KR1020187038115A Active KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020247029228A Pending KR20240134249A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Country Status (7)

Country Link
US (3) US11332529B2 (https=)
EP (2) EP3988570A1 (https=)
JP (3) JP2019517512A (https=)
KR (3) KR102702675B1 (https=)
CN (1) CN109476754A (https=)
ES (1) ES2897964T3 (https=)
WO (1) WO2017210637A1 (https=)

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KR20250004095A (ko) * 2015-04-17 2025-01-07 브리스톨-마이어스 스큅 컴퍼니 항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물
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AR122043A1 (es) * 2020-05-12 2022-08-03 Bristol Myers Squibb Co Dosificación y administración del anticuerpo anti-ctla-4 activable
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CN120731227A (zh) * 2022-10-31 2025-09-30 艾吉纳斯公司 使用抗ctla4抗体治疗结直肠癌的方法
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Also Published As

Publication number Publication date
ES2897964T3 (es) 2022-03-03
JP2025143276A (ja) 2025-10-01
KR20240134249A (ko) 2024-09-06
US20250026831A1 (en) 2025-01-23
JP7721494B2 (ja) 2025-08-12
US20220356254A1 (en) 2022-11-10
KR102515509B1 (ko) 2023-03-28
EP3464373B1 (en) 2021-10-27
JP2023002567A (ja) 2023-01-10
KR20190015406A (ko) 2019-02-13
US20190153100A1 (en) 2019-05-23
CN109476754A (zh) 2019-03-15
EP3464373A1 (en) 2019-04-10
JP2019517512A (ja) 2019-06-24
WO2017210637A1 (en) 2017-12-07
KR20230047498A (ko) 2023-04-07
EP3988570A1 (en) 2022-04-27
US11332529B2 (en) 2022-05-17

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