KR102697663B1 - 혈액학적 장애를 치료하기 위한 화합물 및 조성물 - Google Patents

혈액학적 장애를 치료하기 위한 화합물 및 조성물 Download PDF

Info

Publication number
KR102697663B1
KR102697663B1 KR1020207013352A KR20207013352A KR102697663B1 KR 102697663 B1 KR102697663 B1 KR 102697663B1 KR 1020207013352 A KR1020207013352 A KR 1020207013352A KR 20207013352 A KR20207013352 A KR 20207013352A KR 102697663 B1 KR102697663 B1 KR 102697663B1
Authority
KR
South Korea
Prior art keywords
delete delete
cancer
compound
pharmaceutical composition
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020207013352A
Other languages
English (en)
Korean (ko)
Other versions
KR20200080254A (ko
Inventor
로버트 부어
Original Assignee
쿠리스 인코퍼레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쿠리스 인코퍼레이션 filed Critical 쿠리스 인코퍼레이션
Priority to KR1020247027492A priority Critical patent/KR20240130818A/ko
Publication of KR20200080254A publication Critical patent/KR20200080254A/ko
Application granted granted Critical
Publication of KR102697663B1 publication Critical patent/KR102697663B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020207013352A 2017-10-31 2018-10-30 혈액학적 장애를 치료하기 위한 화합물 및 조성물 Active KR102697663B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247027492A KR20240130818A (ko) 2017-10-31 2018-10-30 혈액학적 장애를 치료하기 위한 화합물 및 조성물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762579502P 2017-10-31 2017-10-31
US62/579,502 2017-10-31
PCT/US2018/058194 WO2019089580A1 (en) 2017-10-31 2018-10-30 Compounds and compositions for treating hematological disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247027492A Division KR20240130818A (ko) 2017-10-31 2018-10-30 혈액학적 장애를 치료하기 위한 화합물 및 조성물

Publications (2)

Publication Number Publication Date
KR20200080254A KR20200080254A (ko) 2020-07-06
KR102697663B1 true KR102697663B1 (ko) 2024-08-21

Family

ID=66328095

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247027492A Pending KR20240130818A (ko) 2017-10-31 2018-10-30 혈액학적 장애를 치료하기 위한 화합물 및 조성물
KR1020207013352A Active KR102697663B1 (ko) 2017-10-31 2018-10-30 혈액학적 장애를 치료하기 위한 화합물 및 조성물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020247027492A Pending KR20240130818A (ko) 2017-10-31 2018-10-30 혈액학적 장애를 치료하기 위한 화합물 및 조성물

Country Status (27)

Country Link
US (3) US10758518B2 (enExample)
EP (2) EP4410377A3 (enExample)
JP (3) JP7241747B2 (enExample)
KR (2) KR20240130818A (enExample)
CN (2) CN111225911B (enExample)
AU (3) AU2018359248B2 (enExample)
BR (1) BR112020008214A2 (enExample)
CA (1) CA3079628A1 (enExample)
DK (1) DK3704108T3 (enExample)
EA (1) EA202090497A1 (enExample)
ES (1) ES2979273T3 (enExample)
FI (1) FI3704108T3 (enExample)
HR (1) HRP20240700T1 (enExample)
HU (1) HUE067356T2 (enExample)
IL (3) IL274248B2 (enExample)
LT (1) LT3704108T (enExample)
MX (2) MX2020003666A (enExample)
MY (1) MY203827A (enExample)
NZ (1) NZ762393A (enExample)
PH (1) PH12020550457A1 (enExample)
PL (1) PL3704108T3 (enExample)
PT (1) PT3704108T (enExample)
RS (1) RS65572B1 (enExample)
SG (1) SG11202002386WA (enExample)
SI (1) SI3704108T1 (enExample)
SM (1) SMT202400216T1 (enExample)
WO (1) WO2019089580A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL311677B2 (en) 2014-01-13 2025-06-01 Aurigene Oncology Ltd Bicyclic heterocyclyl derivatives as irak4 inhibitors
WO2018178947A2 (en) 2017-03-31 2018-10-04 Aurigene Discovery Technologies Limited Compounds and compositions for treating hematological disorders
MY203827A (en) * 2017-10-31 2024-07-19 Curis Inc Compounds and compositions for treating hematological disorders
MX2022003504A (es) * 2019-09-24 2022-07-19 Shanghai Meiyue Biotech Dev Co Ltd Inhibidor de irak y metodo de preparacion para el mismo y uso del mismo.
BR112022019987A2 (pt) 2020-04-07 2022-11-22 Bayer Ag Tiazolpiridinas substituídas, seus sais e uso dos mesmos como substâncias herbicidamente ativas
IL300310A (en) * 2020-08-03 2023-04-01 Curis Inc Preparations and methods for treating diseases and disorders
JP2023550739A (ja) * 2020-11-18 2023-12-05 キュリス，インコーポレイテッド 疾患及び障害を治療する方法
EP4269409A4 (en) * 2020-12-25 2024-12-11 Medshine Discovery Inc. AMIDE-OXAZOLE COMPOUND
AU2022254933A1 (en) * 2021-04-08 2023-11-09 Curis, Inc. Combination therapies for the treatment of cancer
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
CN117177965B (zh) 2021-12-23 2024-04-30 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用
WO2025090844A1 (en) * 2023-10-27 2025-05-01 Curis, Inc. Methods of treating cancer associated with reduced interleukin 1 beta expression

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014190163A2 (en) * 2013-05-22 2014-11-27 Children's Hospital Medical Center Combination therapy for mds

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
RU2142937C1 (ru) 1990-05-18 1999-12-20 Хехст АГ Амиды органических кислот, способ их получения и фармацевтическая композиция
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US6403609B1 (en) 1997-07-29 2002-06-11 Alcon Manufacturing, Ltd. Ophthalmic compositions containing galactomannan polymers and borate
CA2318920A1 (en) 1998-01-29 1999-08-05 James W. Young Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
DE10023486C1 (de) 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
DE602004029242D1 (en) 2003-05-01 2010-11-04 Bristol Myers Squibb Co Pyrazolamidverbindungen
CA2526361C (en) 2003-05-20 2012-05-15 Ajinomoto Co., Inc. Amide derivative
EP1628661A2 (en) 2003-06-05 2006-03-01 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20050197364A1 (en) 2003-10-07 2005-09-08 Kelly Michael G. Amide compounds as ion channel ligands and uses thereof
CA2563941C (en) 2004-04-22 2014-10-07 Bayer Cropscience Lp Method and composition for controlling weeds with a combination of a preemergent, a post emergent and a three-way broadleaf herbicidal compositions
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
EP1655297A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
JP2008519850A (ja) 2004-11-10 2008-06-12 シンタ ファーマシューティカルズ コーポレーション Ｉｌ−１２調節化合物
CA2589695A1 (en) 2004-12-17 2006-06-22 Eli Lilly And Company Thiazolopyridinone derivates as mch receptor antagonists
DE602005009021D1 (de) 2004-12-17 2008-09-25 Lilly Co Eli Neue mch-rezeptorantagonisten
EP1674467A1 (en) 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
JP5188988B2 (ja) 2006-02-10 2013-04-24 トランステック ファーマ，インコーポレイティド ベンゾアゾール誘導体、組成物、及びオーロラキナーゼ阻害剤としての使用方法
GB0606429D0 (en) 2006-03-30 2006-05-10 Novartis Ag Organic compounds
US8008481B2 (en) 2006-03-31 2011-08-30 Ericsson Anna M Indazole compounds
WO2007121154A2 (en) 2006-04-11 2007-10-25 Janssen Pharmaceutica, N.V. Substituted benzothiazole kinase inhibitors
CA2663091A1 (en) 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Modulators of interleukin-1 receptor-associated kinase
CN101616910A (zh) 2006-09-07 2009-12-30 比奥根艾迪克Ma公司 作为白细胞介素-1受体相关激酶调节剂的吲唑衍生物
US20080153810A1 (en) 2006-11-15 2008-06-26 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
CA2690619A1 (en) 2007-07-16 2009-01-22 Abbott Laboratories Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
US8399448B2 (en) 2007-08-08 2013-03-19 Merck Serono Sa 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
NZ587039A (en) 2008-02-13 2013-01-25 Gilead Connecticut Inc 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof
CA2743609A1 (en) 2008-11-19 2010-05-27 Schering Corporation Inhibitors of diacylglycerol acyltransferase
US8283360B2 (en) 2008-12-19 2012-10-09 Merck Sharp & Dohme Corp. Bicyclic heterocyclic derivatives and methods of use thereof
JP2012513435A (ja) 2008-12-23 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ７調節薬としてのジヒドロピリドンアミド
WO2011046954A1 (en) 2009-10-13 2011-04-21 Ligand Pharmaceuticals Inc. Hematopoietic growth factor mimetic small molecule compounds and their uses
CN102939283B (zh) 2010-04-22 2015-06-03 詹森药业有限公司 可用作己酮糖激酶抑制剂的吲唑化合物
CA2793697A1 (en) 2010-04-30 2011-11-03 Merck Sharp & Dohme Corp. Inhibitors of phosphoinositide dependent kinase 1 (pdk1)
HRP20171176T1 (hr) 2010-06-24 2017-10-06 Chemocentryx, Inc. C5ar antagonisti
MX340490B (es) 2010-07-13 2016-07-11 F Hoffmann-La Roche Ag * Derivados de pirazolo [1, 5a] pirimidina y de tieno [3, 2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
KR20180099933A (ko) 2010-11-19 2018-09-05 리간드 파마슈티칼스 인코포레이티드 복소환 아민 및 이의 용도
MX2013007149A (es) 2010-12-20 2013-10-30 Merck Serono Sa Derivados de indazoliltriazol como inhibidores de cinasas asociadas con el receptor de interleucinas-1 (irak).
WO2012142125A2 (en) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
BR112014009531A8 (pt) 2011-10-20 2018-01-16 Glaxosmithkline Llc aza-heterociclos bicíclicos substituídos e análogos como moduladores de sirtuína
GB201119401D0 (en) 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
KR101385603B1 (ko) 2012-05-17 2014-04-21 한국원자력의학원 벤조티아졸 유도체 및 암 치료를 위한 그의 용도
WO2014003483A1 (en) 2012-06-29 2014-01-03 Hanmi Pharm. Co., Ltd. Fused pyrimidine derivatives having inhibitory activity on fms kinases
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2014070979A1 (en) 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
SG11201605408RA (en) * 2014-01-10 2016-07-28 Aurigene Discovery Tech Ltd Indazole compounds as irak4 inhibitors
IL311677B2 (en) 2014-01-13 2025-06-01 Aurigene Oncology Ltd Bicyclic heterocyclyl derivatives as irak4 inhibitors
KR20160118345A (ko) 2014-02-06 2016-10-11 애브비 인코포레이티드 6-헤테로아릴옥시- 및 6-아릴옥시-퀴놀린-2-카복사미드 및 이의 용도
US20170152263A1 (en) * 2014-06-20 2017-06-01 Aurigene Discovery Technologies Limited Substituted Indazole Compounds as IRAK4 Inhibitors
US20180201609A1 (en) 2015-07-15 2018-07-19 Aurigene Discovery Technologies Limited Indazole and azaindazole compounds as irak-4 inhibitors
EP3322409A4 (en) 2015-07-15 2019-07-24 Aurigene Discovery Technologies Limited SUBSTITUTED AZA COMPOUNDS AS IRAQ-4 INHIBITORS
EP3331879B1 (en) * 2015-08-04 2020-05-20 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
US20210292843A1 (en) 2016-10-28 2021-09-23 Children's Hospital Medical Center Treatment of diseases associated with activated irak
MY203827A (en) * 2017-10-31 2024-07-19 Curis Inc Compounds and compositions for treating hematological disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014190163A2 (en) * 2013-05-22 2014-11-27 Children's Hospital Medical Center Combination therapy for mds

Also Published As

Publication number Publication date
PH12020550457A1 (en) 2021-03-22
HUE067356T2 (hu) 2024-10-28
CN111225911A (zh) 2020-06-02
US10758518B2 (en) 2020-09-01
RS65572B1 (sr) 2024-06-28
BR112020008214A2 (pt) 2020-10-27
MY203827A (en) 2024-07-19
DK3704108T3 (da) 2024-06-10
SG11202002386WA (en) 2020-04-29
PL3704108T3 (pl) 2024-07-22
EA202090497A1 (ru) 2020-11-23
EP4410377A3 (en) 2024-11-13
CA3079628A1 (en) 2019-05-09
US20200345704A1 (en) 2020-11-05
LT3704108T (lt) 2024-06-25
IL274248B1 (en) 2024-02-01
CN111225911B (zh) 2023-09-01
IL308364B1 (en) 2024-10-01
JP2024096919A (ja) 2024-07-17
IL315025A (en) 2024-10-01
US20220370422A1 (en) 2022-11-24
ES2979273T3 (es) 2024-09-25
EP3704108A1 (en) 2020-09-09
SMT202400216T1 (it) 2024-07-09
HRP20240700T1 (hr) 2024-08-16
EP4410377A2 (en) 2024-08-07
AU2023222890B2 (en) 2025-04-17
EP3704108A4 (en) 2021-08-25
JP2021501145A (ja) 2021-01-14
AU2023222890A1 (en) 2023-09-14
JP2023071915A (ja) 2023-05-23
JP7476380B2 (ja) 2024-04-30
MX2023010882A (es) 2023-09-27
KR20200080254A (ko) 2020-07-06
SI3704108T1 (sl) 2024-07-31
EP3704108B1 (en) 2024-04-24
US20190134010A1 (en) 2019-05-09
KR20240130818A (ko) 2024-08-29
MX2020003666A (es) 2020-08-03
FI3704108T3 (fi) 2024-05-23
AU2018359248A1 (en) 2020-03-26
CN117064897A (zh) 2023-11-17
NZ762393A (en) 2025-07-25
PT3704108T (pt) 2024-06-11
IL274248A (en) 2020-06-30
IL274248B2 (en) 2024-06-01
AU2018359248B2 (en) 2023-06-01
AU2025205341A1 (en) 2025-07-31
JP7241747B2 (ja) 2023-03-17
IL308364A (en) 2024-01-01
WO2019089580A1 (en) 2019-05-09
IL308364B2 (en) 2025-02-01

Similar Documents

Publication Publication Date Title
KR102697663B1 (ko) 혈액학적 장애를 치료하기 위한 화합물 및 조성물
ES2950764T3 (es) Compuestos y composiciones para tratar trastornos hematológicos
CA2990192A1 (en) Compositions and methods for inhibiting arginase activity
CN110730664A (zh) 含谷氨酰胺酶抑制剂的组合疗法
US20240277722A1 (en) Cancer therapy using a combination of cdk7 inhibitor with an anti-cancer agent
HK40031549A (en) Compounds and compositions for treating hematological disorders
WO2019176985A1 (ja) 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット
HK40031549B (zh) 用於治疗血液病的化合物和组合物

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20200508

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20211029

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20240315

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20240520

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20240819

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20240819

End annual number: 3

Start annual number: 1

PG1601 Publication of registration