KR102673489B1 - Cxcr2 항체 및 그의 용도 - Google Patents

Cxcr2 항체 및 그의 용도 Download PDF

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Publication number
KR102673489B1
KR102673489B1 KR1020197027809A KR20197027809A KR102673489B1 KR 102673489 B1 KR102673489 B1 KR 102673489B1 KR 1020197027809 A KR1020197027809 A KR 1020197027809A KR 20197027809 A KR20197027809 A KR 20197027809A KR 102673489 B1 KR102673489 B1 KR 102673489B1
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South Korea
Prior art keywords
seq
set forth
antibody
cxcr2
variable region
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KR1020197027809A
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English (en)
Korean (ko)
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KR20190123753A (ko
Inventor
찰스 레이 맥카이
레미 마이클 로버트
Original Assignee
모나쉬 유니버시티
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Priority claimed from AU2017900656A external-priority patent/AU2017900656A0/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020197027809A 2017-02-27 2018-02-27 Cxcr2 항체 및 그의 용도 Active KR102673489B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017900656A AU2017900656A0 (en) 2017-02-27 CXCR2 antibodies
AU2017900656 2017-02-27
PCT/IB2018/000253 WO2018154391A1 (en) 2017-02-27 2018-02-27 Cxcr2 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
KR20190123753A KR20190123753A (ko) 2019-11-01
KR102673489B1 true KR102673489B1 (ko) 2024-06-07

Family

ID=63253562

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197027809A Active KR102673489B1 (ko) 2017-02-27 2018-02-27 Cxcr2 항체 및 그의 용도

Country Status (8)

Country Link
US (1) US11053319B2 (enExample)
EP (1) EP3585816A4 (enExample)
JP (2) JP7562258B2 (enExample)
KR (1) KR102673489B1 (enExample)
CN (1) CN110637034B (enExample)
AU (1) AU2018224391B2 (enExample)
CA (1) CA3054616A1 (enExample)
WO (1) WO2018154391A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018154391A1 (en) 2017-02-27 2018-08-30 Monash University Cxcr2 antibodies and uses thereof
CA3108071A1 (en) 2018-08-01 2020-02-06 Cephalon, Inc. Anti-cxcr2 antibodies and uses thereof
US20220332835A1 (en) * 2019-09-04 2022-10-20 Shanghaitech University Anti-cxcr2 antibodies and uses thereof
TWI825687B (zh) * 2021-04-26 2023-12-11 高雄醫學大學 抗ｃｘｃｒ２抗體及其用途
KR20250001497A (ko) * 2023-06-28 2025-01-07 (재) 스크립스코리아항체연구원 항-cxcr2 항체 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160060347A1 (en) 2013-04-17 2016-03-03 Morphosys Ag Antibodies targeting specifically human cxcr2
JP2016174611A (ja) 2010-11-08 2016-10-06 ノバルティス アーゲー Ｃｘｃｒ２結合ポリペプチド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5440021A (en) * 1991-03-29 1995-08-08 Chuntharapai; Anan Antibodies to human IL-8 type B receptor
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
WO2015169811A2 (en) * 2014-05-06 2015-11-12 Medimmune Limited Anti-cxc chemokine receptor-2 binding molecules and uses thereof
WO2018129261A1 (en) * 2017-01-05 2018-07-12 Brown University Methods and compositions relating to anti-chi3l1 antibody reagents
WO2018154391A1 (en) 2017-02-27 2018-08-30 Monash University Cxcr2 antibodies and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016174611A (ja) 2010-11-08 2016-10-06 ノバルティス アーゲー Ｃｘｃｒ２結合ポリペプチド
US20160060347A1 (en) 2013-04-17 2016-03-03 Morphosys Ag Antibodies targeting specifically human cxcr2

Also Published As

Publication number Publication date
KR20190123753A (ko) 2019-11-01
JP2020508074A (ja) 2020-03-19
CN110637034B (zh) 2023-10-10
CN110637034A (zh) 2019-12-31
CA3054616A1 (en) 2018-08-30
AU2018224391B2 (en) 2025-06-12
US11053319B2 (en) 2021-07-06
EP3585816A4 (en) 2020-12-30
US20190016809A1 (en) 2019-01-17
JP2023052023A (ja) 2023-04-11
AU2018224391A1 (en) 2019-09-19
EP3585816A1 (en) 2020-01-01
WO2018154391A1 (en) 2018-08-30
JP7562258B2 (ja) 2024-10-07

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