KR102664829B1 - 항체 제작 동안 핑크색의 형성을 제어하는 방법 - Google Patents
항체 제작 동안 핑크색의 형성을 제어하는 방법 Download PDFInfo
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- KR102664829B1 KR102664829B1 KR1020197035852A KR20197035852A KR102664829B1 KR 102664829 B1 KR102664829 B1 KR 102664829B1 KR 1020197035852 A KR1020197035852 A KR 1020197035852A KR 20197035852 A KR20197035852 A KR 20197035852A KR 102664829 B1 KR102664829 B1 KR 102664829B1
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- antibody
- cbl
- mab
- hydrogen peroxide
- reduction
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Classifications
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
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- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US62/503,615 | 2017-05-09 | ||
| PCT/US2018/031542 WO2018208743A1 (en) | 2017-05-09 | 2018-05-08 | Method of controlling the formation of pink color during antibody manufacturing |
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| KR20200004355A KR20200004355A (ko) | 2020-01-13 |
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| BR112022012467A2 (pt) | 2020-01-31 | 2022-09-06 | Chugai Pharmaceutical Co Ltd | Método para produção de composição contendo polipeptídeo com coloração suprimida |
| JP2025529484A (ja) * | 2022-09-15 | 2025-09-04 | サノフイ | タンパク質の還元感受性の決定方法 |
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| JP2689458B2 (ja) * | 1988-02-09 | 1997-12-10 | 武田薬品工業株式会社 | 粒状ないし粉末状のビタミンｂ▲下１▼▲下２▼類含有組成物 |
| JP2734709B2 (ja) * | 1990-01-05 | 1998-04-02 | 東レ株式会社 | インクジェット染色用布帛およびそれを用いてなるインクジェット染色法 |
| SE525083C2 (sv) * | 2003-04-23 | 2004-11-23 | Kemira Kemi Ab | Sätt att behandla rötslam |
| WO2006060083A1 (en) * | 2004-10-22 | 2006-06-08 | Amgen Inc. | Methods for refolding polypeptides |
| EP1971488A2 (en) * | 2005-12-05 | 2008-09-24 | Lifeline Cell Technology | Cell culture medium container assembly |
| WO2009009523A2 (en) | 2007-07-09 | 2009-01-15 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
| EP2453874A2 (en) | 2009-07-14 | 2012-05-23 | Biogen Idec MA Inc. | Methods for inhibiting yellow color and peroxide formation in a composition |
| US20170002393A1 (en) * | 2013-12-04 | 2017-01-05 | Immunogen, Inc. | Compositions and methods for antibody production |
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2018
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- 2018-05-08 JP JP2019561819A patent/JP7453788B2/ja active Active
- 2018-05-08 CN CN201880031241.9A patent/CN110831964A/zh active Pending
- 2018-05-08 KR KR1020197035852A patent/KR102664829B1/ko active Active
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2023
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Non-Patent Citations (3)
| Title |
|---|
| Journal of Pharmaceutical Sciences, 제94권, 제304-316면 (2005년)* |
| mAbs, 제5권, 제6호, 제974-981면 (2013년)* |
| mAbs, 제6권, 제3호, 제679-688면 (2014년)* |
Also Published As
| Publication number | Publication date |
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| EP3621989A1 (en) | 2020-03-18 |
| EP3621989B1 (en) | 2023-06-28 |
| JP7453788B2 (ja) | 2024-03-21 |
| JP2020519265A (ja) | 2020-07-02 |
| US20230103511A1 (en) | 2023-04-06 |
| CN110831964A (zh) | 2020-02-21 |
| JP2023182593A (ja) | 2023-12-26 |
| WO2018208743A9 (en) | 2019-12-05 |
| KR20200004355A (ko) | 2020-01-13 |
| US12241107B2 (en) | 2025-03-04 |
| ES2951287T3 (es) | 2023-10-19 |
| WO2018208743A1 (en) | 2018-11-15 |
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