KR102656181B1 - 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물 - Google Patents
디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물 Download PDFInfo
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- KR102656181B1 KR102656181B1 KR1020227009546A KR20227009546A KR102656181B1 KR 102656181 B1 KR102656181 B1 KR 102656181B1 KR 1020227009546 A KR1020227009546 A KR 1020227009546A KR 20227009546 A KR20227009546 A KR 20227009546A KR 102656181 B1 KR102656181 B1 KR 102656181B1
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- South Korea
- Prior art keywords
- ophthalmic composition
- aqueous ophthalmic
- eye
- polyvinylpyrrolidone
- eye drop
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- 239000000203 mixture Substances 0.000 title claims abstract description 239
- 229950003529 diquafosol Drugs 0.000 title claims abstract description 151
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- 239000001267 polyvinylpyrrolidone Substances 0.000 title claims abstract description 92
- NMLMACJWHPHKGR-NCOIDOBVSA-N P(1),P(4)-bis(uridin-5'-yl) tetraphosphate Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@H]([C@@H](O2)N2C(NC(=O)C=C2)=O)O)O)C=CC(=O)NC1=O NMLMACJWHPHKGR-NCOIDOBVSA-N 0.000 title claims abstract description 60
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
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| KR20250160050A (ko) | 2024-05-03 | 2025-11-11 | 삼천당제약주식회사 | 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117137866A (zh) * | 2018-02-28 | 2023-12-01 | 参天制药株式会社 | 含有地夸磷索及阳离子性聚合物的眼科用组合物 |
| JP6966667B2 (ja) * | 2019-08-27 | 2021-11-17 | 参天製薬株式会社 | ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 |
| CA3215750A1 (en) * | 2021-03-30 | 2022-10-06 | Senju Pharmaceutical Co., Ltd. | Suspension containing heterocyclidene acetamide derivative |
| CN114646705A (zh) * | 2022-03-22 | 2022-06-21 | 武汉绿合医药科技有限公司 | 一种地夸磷索钠滴眼液有关物质含量检测方法 |
| JP7245383B1 (ja) | 2022-09-20 | 2023-03-23 | 参天製薬株式会社 | ジクアホソルまたはその塩を含有する眼科用組成物のｐＨの低下を抑制する方法 |
| CN119970633A (zh) * | 2025-03-26 | 2025-05-13 | 苏州乐珠制药有限公司 | 一种地夸磷索钠滴眼液及其制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0365270A (ja) | 1989-07-31 | 1991-03-20 | Kanzaki Paper Mfg Co Ltd | 塗布シートの製造方法 |
| JPH0365270U (https=) | 1989-10-31 | 1991-06-25 | ||
| US5358706A (en) * | 1992-09-30 | 1994-10-25 | Union Carbide Chemicals & Plastics Technology Corporation | Muco-adhesive polymers |
| CA2125060C (en) * | 1993-07-02 | 1999-03-30 | Henry P. Dabrowski | Ophthalmic solution for artificial tears |
| US5422116A (en) * | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| KR100549904B1 (ko) * | 1996-03-27 | 2006-05-16 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 우리딘트리포스페이트및관련화합물을함유하는섬모운동장해치료용약학조성물 |
| US6274626B1 (en) * | 1998-12-22 | 2001-08-14 | Bausch & Lomb Incorporated | Pheniramine-containing compositions and method for treating allergic responses |
| AU2225701A (en) * | 1999-12-27 | 2001-07-09 | Santen Pharmaceutical Co. Ltd. | System for stabilizing lacrimal fluid layer |
| AU2001260643B9 (en) * | 2000-05-30 | 2006-10-19 | Merck Sharp & Dohme Corp. | Ectocornea extension promoters |
| KR20070114130A (ko) * | 2005-02-14 | 2007-11-29 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 착용감이 편안한 안용 장치 및 이의 제조방법 |
| CN106729718A (zh) * | 2010-09-10 | 2017-05-31 | 参天制药株式会社 | 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂 |
| US20110052678A1 (en) * | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
| UA113839C2 (xx) * | 2010-12-28 | 2017-03-27 | Очний розчин, який містить диквафозол, спосіб його отримання і спосіб інгібування утворення нерозчинного осаду | |
| KR20120077080A (ko) | 2010-12-30 | 2012-07-10 | 동우 화인켐 주식회사 | 광학필름 및 이를 이용한 백라이트 유닛 |
| US20160213708A1 (en) * | 2012-01-08 | 2016-07-28 | Medicure Technologies Ltd. | Ophthalmic composition |
| KR101536885B1 (ko) * | 2012-03-26 | 2015-07-14 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 함유 점안액 |
| JP2015032653A (ja) | 2013-08-01 | 2015-02-16 | 株式会社東芝 | 固体撮像装置 |
| JP6267003B2 (ja) | 2014-02-27 | 2018-01-24 | 参天製薬株式会社 | ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤 |
| EP3139903B1 (en) * | 2014-05-07 | 2019-07-03 | Croma-Pharma Gesellschaft m.b.H. | Aqueous ophthalmic solution and method for treating dry eye syndrome |
| KR102330736B1 (ko) * | 2014-12-25 | 2021-11-23 | 산텐 세이야꾸 가부시키가이샤 | 수성 점안액 |
| CN107635565A (zh) * | 2015-06-05 | 2018-01-26 | 参天制药株式会社 | 以向佩戴有软性隐形眼镜的干眼症患者的眼中滴入的方式使用为特征的干眼症治疗剂 |
| CN107837276A (zh) * | 2016-09-19 | 2018-03-27 | 刘力 | 局部给药的药物组合物 |
| CN117137866A (zh) * | 2018-02-28 | 2023-12-01 | 参天制药株式会社 | 含有地夸磷索及阳离子性聚合物的眼科用组合物 |
| JP6966667B2 (ja) * | 2019-08-27 | 2021-11-17 | 参天製薬株式会社 | ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 |
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2020
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250160050A (ko) | 2024-05-03 | 2025-11-11 | 삼천당제약주식회사 | 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물 |
Also Published As
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| CN114286670B (zh) | 2024-01-16 |
| JP2025031918A (ja) | 2025-03-07 |
| CN117771172A (zh) | 2024-03-29 |
| JP2022003099A (ja) | 2022-01-11 |
| CN114286670A (zh) | 2022-04-05 |
| TWI848171B (zh) | 2024-07-11 |
| KR20220052971A (ko) | 2022-04-28 |
| JP7614069B2 (ja) | 2025-01-15 |
| JPWO2021039748A1 (ja) | 2021-09-30 |
| TW202122094A (zh) | 2021-06-16 |
| PH12022550474A1 (en) | 2023-03-06 |
| KR20240049646A (ko) | 2024-04-16 |
| JP6966667B2 (ja) | 2021-11-17 |
| WO2021039748A1 (ja) | 2021-03-04 |
| MY209059A (en) | 2025-06-18 |
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