KR102651946B1 - 항암제로서의 시클릭 디뉴클레오티드 - Google Patents

항암제로서의 시클릭 디뉴클레오티드 Download PDF

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KR102651946B1
KR102651946B1 KR1020207008757A KR20207008757A KR102651946B1 KR 102651946 B1 KR102651946 B1 KR 102651946B1 KR 1020207008757 A KR1020207008757 A KR 1020207008757A KR 20207008757 A KR20207008757 A KR 20207008757A KR 102651946 B1 KR102651946 B1 KR 102651946B1
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cancer
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KR20200042939A (ko
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란-잉 친
제밍 루안
리빙 첸
스콧 헌터 워터슨
브라이언 이. 핑크
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020207008757A 2017-08-31 2018-08-30 항암제로서의 시클릭 디뉴클레오티드 Active KR102651946B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762552689P 2017-08-31 2017-08-31
US62/552,689 2017-08-31
PCT/US2018/048662 WO2019046498A1 (en) 2017-08-31 2018-08-30 CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS

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KR20200042939A KR20200042939A (ko) 2020-04-24
KR102651946B1 true KR102651946B1 (ko) 2024-03-26

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US (1) US10947263B2 (https=)
EP (1) EP3676278B1 (https=)
JP (1) JP7209697B2 (https=)
KR (1) KR102651946B1 (https=)
CN (1) CN111051327B (https=)
ES (1) ES2945140T3 (https=)
WO (1) WO2019046498A1 (https=)

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TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
SG11202008827XA (en) * 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds
BR112020024605A2 (pt) 2018-06-01 2021-04-06 Eisai R&D Management Co., Ltd. Métodos para o tratamento de câncer de bexiga
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WO2020212600A1 (en) 2019-04-18 2020-10-22 Nuseed Global Innovation Ltd. Meal fraction of brassica carinata oilseed
WO2020227421A1 (en) 2019-05-09 2020-11-12 Aligos Therapeutics, Inc. Modified cyclic dinucleoside compounds as sting modulators
US12435104B2 (en) 2019-07-25 2025-10-07 Beigene, Ltd. Cyclic dinucleotides as sting agonists
MX2022008123A (es) 2020-01-16 2022-07-21 Bristol Myers Squibb Co Reactivos y su uso para modular la sintesis enantiodivergente de enlaces c-p.
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法

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WO2017123657A1 (en) 2016-01-11 2017-07-20 Gary Glick Cyclic dinucleotides for treating conditions associated with sting activity such as cancer

Also Published As

Publication number Publication date
US20200223883A1 (en) 2020-07-16
US10947263B2 (en) 2021-03-16
JP2020532542A (ja) 2020-11-12
JP7209697B2 (ja) 2023-01-20
EP3676278A1 (en) 2020-07-08
ES2945140T3 (es) 2023-06-28
KR20200042939A (ko) 2020-04-24
CN111051327A (zh) 2020-04-21
WO2019046498A1 (en) 2019-03-07
EP3676278B1 (en) 2023-04-12
CN111051327B (zh) 2023-11-03

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