KR102638253B1 - C5a 억제제로서의 6-5 융합 고리 - Google Patents
C5a 억제제로서의 6-5 융합 고리 Download PDFInfo
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- KR102638253B1 KR102638253B1 KR1020197038669A KR20197038669A KR102638253B1 KR 102638253 B1 KR102638253 B1 KR 102638253B1 KR 1020197038669 A KR1020197038669 A KR 1020197038669A KR 20197038669 A KR20197038669 A KR 20197038669A KR 102638253 B1 KR102638253 B1 KR 102638253B1
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- mmol
- alkyl
- diethylphenyl
- pharmaceutically acceptable
- pyrazolo
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- 125000001424 substituent group Chemical group 0.000 claims description 25
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- 229910052736 halogen Inorganic materials 0.000 claims description 22
- 150000002367 halogens Chemical class 0.000 claims description 22
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- 125000003545 alkoxy group Chemical group 0.000 claims description 20
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- A61K31/33—Heterocyclic compounds
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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| US20040116425A1 (en) | 2002-08-14 | 2004-06-17 | Li Francine Feirong | Prenylation inhibitors and methods of their synthesis and use |
| US20040147546A1 (en) | 2001-04-26 | 2004-07-29 | Yasuhiro Tanaka | Heterocyclic compounds |
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| US20130184253A1 (en) | 2011-07-22 | 2013-07-18 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as c5a receptor modulators |
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| DK27383A (da) | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
| GB8613591D0 (en) | 1986-06-04 | 1986-07-09 | Roussel Lab Ltd | Chemical compounds |
| FR2761266B1 (fr) | 1997-03-28 | 1999-07-02 | Sanofi Sa | Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates |
| ES2349762T3 (es) | 2000-08-10 | 2011-01-11 | Pfizer Italia S.R.L. | Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden. |
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| US10562896B2 (en) | 2020-02-18 |
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| CN110997674B (zh) | 2022-12-20 |
| BR112019025049A2 (pt) | 2020-06-16 |
| IL270828B (en) | 2022-12-01 |
| EP3630775A4 (en) | 2020-10-07 |
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