KR102622245B1 - 근육 성능 개선 화합물 - Google Patents
근육 성능 개선 화합물 Download PDFInfo
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- KR102622245B1 KR102622245B1 KR1020197018624A KR20197018624A KR102622245B1 KR 102622245 B1 KR102622245 B1 KR 102622245B1 KR 1020197018624 A KR1020197018624 A KR 1020197018624A KR 20197018624 A KR20197018624 A KR 20197018624A KR 102622245 B1 KR102622245 B1 KR 102622245B1
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2319/00—Fusion polypeptide
Landscapes
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Applications Claiming Priority (3)
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| GBGB1620119.6A GB201620119D0 (en) | 2016-11-29 | 2016-11-29 | Compounds |
| GB1620119.6 | 2016-11-29 | ||
| PCT/IB2017/057436 WO2018100483A1 (en) | 2016-11-29 | 2017-11-28 | Muscle performance improvement compounds |
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| KR20190085132A KR20190085132A (ko) | 2019-07-17 |
| KR102622245B1 true KR102622245B1 (ko) | 2024-01-05 |
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| KR1020197018624A Active KR102622245B1 (ko) | 2016-11-29 | 2017-11-28 | 근육 성능 개선 화합물 |
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| EP (1) | EP3548509A1 (enExample) |
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| WO (1) | WO2018100483A1 (enExample) |
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| JP7051846B2 (ja) | 2016-11-10 | 2022-04-11 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物 |
| JP7258021B2 (ja) | 2017-11-09 | 2023-04-14 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体を含む医薬組成物 |
| KR20200109330A (ko) | 2018-01-12 | 2020-09-22 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법 |
| CA3098679A1 (en) | 2018-05-09 | 2019-11-14 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| EP4081241A4 (en) | 2019-12-24 | 2024-05-01 | Juvena Therapeutics, Inc. | REGENERATIVE POLYPEPTIDES AND THEIR USES |
| WO2021189006A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| US20230257435A1 (en) * | 2020-07-24 | 2023-08-17 | Agency For Science, Technology And Research | Wound Healing Composition and Uses Thereof |
| CA3211515A1 (en) * | 2021-03-10 | 2022-09-15 | Acceleron Pharma Inc. | Actrii-alk4 antagonists and methods of treating heart failure |
| BR112023018283A2 (pt) * | 2021-03-10 | 2023-10-31 | Acceleron Pharma Inc | Antagonistas de actrii-alk4 e métodos para tratar insuficiência cardíaca |
| IL309562A (en) | 2021-06-21 | 2024-02-01 | Juvena Therapeutics Inc | Regenerative polypeptides and their uses |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006516886A (ja) | 2002-10-25 | 2006-07-13 | ワイエス | Ａｃｔｒｉｉｂ融合ポリペプチドおよびその使用 |
| US20060216279A1 (en) | 2005-03-22 | 2006-09-28 | Glass David J | Myostatin inhibiting fusion polypeptides and therapeutic methods thereof |
| JP2010502633A (ja) | 2006-09-05 | 2010-01-28 | イーライ リリー アンド カンパニー | 抗ミオスタチン抗体 |
| US20110135638A1 (en) | 2009-11-17 | 2011-06-09 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| JP2012525128A (ja) | 2009-04-27 | 2012-10-22 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
| JP2013503825A (ja) * | 2009-09-04 | 2013-02-04 | ニューロチューン・アクチエンゲゼルシャフト | 薬物として用いる、筋力を回復する能力がある改変アグリン断片 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2174098C (en) * | 1993-10-14 | 2011-01-25 | Douglas A. Melton | Method of inducing and maintaining neuronal cells |
| US7355018B2 (en) * | 2003-09-30 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Modified IGF1 polypeptides with increased stability and potency |
| EP2056850A4 (en) | 2006-08-08 | 2011-10-12 | Univ Louisiana State | THERAPEUTIC PROCEDURES FOR NEUROPATHIC PAIN |
| KR20160129095A (ko) | 2007-02-09 | 2016-11-08 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| US9676845B2 (en) * | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
-
2016
- 2016-11-29 GB GBGB1620119.6A patent/GB201620119D0/en not_active Ceased
-
2017
- 2017-11-28 JP JP2019548783A patent/JP7683901B2/ja active Active
- 2017-11-28 WO PCT/IB2017/057436 patent/WO2018100483A1/en not_active Ceased
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006516886A (ja) | 2002-10-25 | 2006-07-13 | ワイエス | Ａｃｔｒｉｉｂ融合ポリペプチドおよびその使用 |
| US20060216279A1 (en) | 2005-03-22 | 2006-09-28 | Glass David J | Myostatin inhibiting fusion polypeptides and therapeutic methods thereof |
| JP2010502633A (ja) | 2006-09-05 | 2010-01-28 | イーライ リリー アンド カンパニー | 抗ミオスタチン抗体 |
| JP2012525128A (ja) | 2009-04-27 | 2012-10-22 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
| JP2013503825A (ja) * | 2009-09-04 | 2013-02-04 | ニューロチューン・アクチエンゲゼルシャフト | 薬物として用いる、筋力を回復する能力がある改変アグリン断片 |
| US20110135638A1 (en) | 2009-11-17 | 2011-06-09 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| JP2013511474A (ja) * | 2009-11-17 | 2013-04-04 | アクセルロン ファーマ， インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用 |
Non-Patent Citations (2)
| Title |
|---|
| Experimental Gerontology 85(8962):1-8(2016.09.12.) |
| Nature Reviews Drug Discovery 14(1):58-74(2014.12.31.) |
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| KR20190085132A (ko) | 2019-07-17 |
| CA3045245A1 (en) | 2018-06-07 |
| EP3548509A1 (en) | 2019-10-09 |
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| AU2017367277A1 (en) | 2019-07-04 |
| JP7683901B2 (ja) | 2025-05-27 |
| CN110036024A (zh) | 2019-07-19 |
| ZA201903261B (en) | 2020-02-26 |
| GB201620119D0 (en) | 2017-01-11 |
| AU2017367277B2 (en) | 2021-04-01 |
| US20210253654A1 (en) | 2021-08-19 |
| JP2019536818A (ja) | 2019-12-19 |
| US11407799B2 (en) | 2022-08-09 |
| JP2023116479A (ja) | 2023-08-22 |
| CN110036024B (zh) | 2024-05-07 |
| NZ754625A (en) | 2023-03-31 |
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