KR102612882B1 - 이관능성 킬레이트 및 그의 용도의 약동학적 증진 - Google Patents

이관능성 킬레이트 및 그의 용도의 약동학적 증진 Download PDF

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KR102612882B1
KR102612882B1 KR1020197036026A KR20197036026A KR102612882B1 KR 102612882 B1 KR102612882 B1 KR 102612882B1 KR 1020197036026 A KR1020197036026 A KR 1020197036026A KR 20197036026 A KR20197036026 A KR 20197036026A KR 102612882 B1 KR102612882 B1 KR 102612882B1
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alkyl
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KR20200006087A (ko
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에릭 스티븐 부락
스튜어트 제임스 마호니
라이언 웨인 심스
존 피츠모리스 밸리언트
알라 다위시
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센터 포 프로브 디벨롭먼트 앤드 커머셜리제이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020197036026A 2017-05-05 2018-05-04 이관능성 킬레이트 및 그의 용도의 약동학적 증진 Active KR102612882B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762502260P 2017-05-05 2017-05-05
US62/502,260 2017-05-05
PCT/US2018/031228 WO2018204869A1 (en) 2017-05-05 2018-05-04 Pharmacokinetic enhancements of bifunctional chelates and uses thereof

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KR20200006087A KR20200006087A (ko) 2020-01-17
KR102612882B1 true KR102612882B1 (ko) 2023-12-11

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US (2) US11191854B2 (https=)
EP (1) EP3619191A4 (https=)
JP (2) JP7693317B2 (https=)
KR (1) KR102612882B1 (https=)
CN (2) CN111263747B (https=)
AU (3) AU2018261888B2 (https=)
BR (1) BR112019023246B1 (https=)
CA (1) CA3062553C (https=)
CL (1) CL2019003168A1 (https=)
EA (1) EA201992595A1 (https=)
IL (1) IL270453B2 (https=)
MA (1) MA48861A (https=)
RU (1) RU2019139432A (https=)
WO (1) WO2018204869A1 (https=)
ZA (1) ZA201908071B (https=)

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CA3062538A1 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
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ES3034597T3 (en) * 2018-04-27 2025-08-20 Univ Iowa Res Found Compositions for chelating metals at low temperatures
EA202191556A1 (ru) * 2018-12-03 2021-10-14 Фьюжн Фармасьютикалз Инк. Комбинированная терапия радиоиммуноконъюгатами и ингибиторами контрольных точек
WO2020186328A1 (en) * 2019-03-20 2020-09-24 The University Of British Columbia Chelators and methods of making and using same
WO2021142231A1 (en) * 2020-01-10 2021-07-15 Fusion Pharmaceuticals Inc. Sustained immunotherapy
BR112022013678A2 (pt) * 2020-01-10 2022-11-16 Fusion Pharmaceuticals Inc Quelatos macrocíclicos e seus usos
IL295999A (en) * 2020-03-23 2022-10-01 Fusion Pharmaceuticals Inc Radioimmunoconjugates designed for 3fgfr and their use
KR102362962B1 (ko) * 2020-06-12 2022-02-16 (주)미래바이오팜 신규한 화합물 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물
JPWO2022025184A1 (https=) * 2020-07-29 2022-02-03
WO2022198319A1 (en) * 2021-03-23 2022-09-29 Fusion Pharmaceuticals Inc. Use of a cold fgfr3-targeting molecule and a fgfr3 targeting radioimmunoconjugate for treating cancer
KR20240022616A (ko) * 2021-06-17 2024-02-20 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 복수의 킬레이트제와 생물학적 제제를 조합하기 위한 방법 및 재료
WO2023164777A1 (en) * 2022-03-04 2023-09-07 Fusion Pharmaceuticals Inc. Gucy2c-targeted radiopharmaceuticals and use thereof
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