KR102604942B1 - 증식성 장애의 치료에 사용하기 위한 트리사이클릭 화합물 - Google Patents

증식성 장애의 치료에 사용하기 위한 트리사이클릭 화합물 Download PDF

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KR102604942B1
KR102604942B1 KR1020197029438A KR20197029438A KR102604942B1 KR 102604942 B1 KR102604942 B1 KR 102604942B1 KR 1020197029438 A KR1020197029438 A KR 1020197029438A KR 20197029438 A KR20197029438 A KR 20197029438A KR 102604942 B1 KR102604942 B1 KR 102604942B1
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alkyl
propyl
pyrido
solvate
optionally substituted
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KR20190129071A (ko
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앤드류 몰레이
레베카 밀러
니콜라스 라 생
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아르고너트 테라퓨틱스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020197029438A 2017-03-17 2018-03-16 증식성 장애의 치료에 사용하기 위한 트리사이클릭 화합물 Active KR102604942B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1704325.8A GB201704325D0 (en) 2017-03-17 2017-03-17 Compounds
GB1704325.8 2017-03-17
PCT/EP2018/056675 WO2018167276A1 (en) 2017-03-17 2018-03-16 Tricyclic compounds for use in treatment of proliferative disorders

Publications (2)

Publication Number Publication Date
KR20190129071A KR20190129071A (ko) 2019-11-19
KR102604942B1 true KR102604942B1 (ko) 2023-11-21

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KR1020197029438A Active KR102604942B1 (ko) 2017-03-17 2018-03-16 증식성 장애의 치료에 사용하기 위한 트리사이클릭 화합물

Country Status (9)

Country Link
US (1) US11274098B2 (https=)
EP (1) EP3596073B1 (https=)
JP (1) JP7308765B2 (https=)
KR (1) KR102604942B1 (https=)
CN (1) CN110621675B (https=)
CA (1) CA3056726A1 (https=)
ES (1) ES2925115T3 (https=)
GB (1) GB201704325D0 (https=)
WO (1) WO2018167276A1 (https=)

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GB201905780D0 (en) 2019-04-25 2019-06-05 La Thangue Nicholas Cancer therapy
KR102278691B1 (ko) * 2019-08-09 2021-07-16 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체
KR102282712B1 (ko) * 2019-08-09 2021-07-27 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물
WO2021029450A1 (ko) * 2019-08-09 2021-02-18 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물
JP7609857B2 (ja) 2019-10-02 2025-01-07 エスケー バイオファーマスティカルズ カンパニー リミテッド 二環式化合物及びその使用
CN111454260B (zh) * 2020-05-25 2023-02-28 贵州大学 一类含异丙醇胺亚结构的1，2，3，4-四氢-β-咔啉类化合物及其制备方法和应用
CN111892593B (zh) * 2020-08-19 2021-11-16 南通大学 一种8-甲氧基-5H-吡啶并[4,3-b]吲哚及其合成方法
JP2024508235A (ja) * 2021-02-04 2024-02-26 アムジエン・インコーポレーテツド 三環－アミド－二環ｐｒｍｔ５阻害剤
CN113105517B (zh) * 2021-04-10 2022-03-01 台州仙琚药业有限公司 雄甾-1,4,9-三烯-3,17-二酮的合成方法
GB202108383D0 (en) * 2021-06-11 2021-07-28 Argonaut Therapeutics Ltd Compounds useful in the treatment or prevention of a prmt5-mediated disorder
GB202117230D0 (en) 2021-11-29 2022-01-12 Argonaut Therapeutics Ltd Peptide vaccine
GB202203588D0 (en) 2022-03-15 2022-04-27 Argonaut Therapeutics Ltd Cancer diagnostic
CN115521306B (zh) * 2022-09-26 2024-03-26 贵州大学 一种1,2,3,4-四氢-β-咔啉衍生物及其制备方法和应用
CN117088891A (zh) * 2023-07-13 2023-11-21 浙江大学 含四氢苯并[4,5]呋喃[2,3-c]吡啶类羟肟酸化合物及其制备方法和应用

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Also Published As

Publication number Publication date
EP3596073A1 (en) 2020-01-22
CN110621675B (zh) 2023-09-19
CA3056726A1 (en) 2018-09-20
CN110621675A (zh) 2019-12-27
WO2018167276A1 (en) 2018-09-20
JP2020510092A (ja) 2020-04-02
GB201704325D0 (en) 2017-05-03
US20200325132A1 (en) 2020-10-15
EP3596073B1 (en) 2022-05-11
US11274098B2 (en) 2022-03-15
KR20190129071A (ko) 2019-11-19
ES2925115T3 (es) 2022-10-13
JP7308765B2 (ja) 2023-07-14

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