ES2925115T3 - Compuestos tricíclicos para uso en el tratamiento de trastornos proliferativos - Google Patents
Compuestos tricíclicos para uso en el tratamiento de trastornos proliferativos Download PDFInfo
- Publication number
- ES2925115T3 ES2925115T3 ES18711927T ES18711927T ES2925115T3 ES 2925115 T3 ES2925115 T3 ES 2925115T3 ES 18711927 T ES18711927 T ES 18711927T ES 18711927 T ES18711927 T ES 18711927T ES 2925115 T3 ES2925115 T3 ES 2925115T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- cycloalkyl
- optionally substituted
- phenyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1704325.8A GB201704325D0 (en) | 2017-03-17 | 2017-03-17 | Compounds |
| PCT/EP2018/056675 WO2018167276A1 (en) | 2017-03-17 | 2018-03-16 | Tricyclic compounds for use in treatment of proliferative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2925115T3 true ES2925115T3 (es) | 2022-10-13 |
Family
ID=58688220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18711927T Active ES2925115T3 (es) | 2017-03-17 | 2018-03-16 | Compuestos tricíclicos para uso en el tratamiento de trastornos proliferativos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11274098B2 (https=) |
| EP (1) | EP3596073B1 (https=) |
| JP (1) | JP7308765B2 (https=) |
| KR (1) | KR102604942B1 (https=) |
| CN (1) | CN110621675B (https=) |
| CA (1) | CA3056726A1 (https=) |
| ES (1) | ES2925115T3 (https=) |
| GB (1) | GB201704325D0 (https=) |
| WO (1) | WO2018167276A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201905780D0 (en) | 2019-04-25 | 2019-06-05 | La Thangue Nicholas | Cancer therapy |
| KR102278691B1 (ko) * | 2019-08-09 | 2021-07-16 | 한국화학연구원 | 신규한 피리미딘 설폰아마이드 유도체 |
| KR102282712B1 (ko) * | 2019-08-09 | 2021-07-27 | 한국화학연구원 | 신규한 피리미딘 설폰아마이드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물 |
| WO2021029450A1 (ko) * | 2019-08-09 | 2021-02-18 | 한국화학연구원 | 신규한 피리미딘 설폰아마이드 유도체 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물 |
| JP7609857B2 (ja) | 2019-10-02 | 2025-01-07 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 二環式化合物及びその使用 |
| CN111454260B (zh) * | 2020-05-25 | 2023-02-28 | 贵州大学 | 一类含异丙醇胺亚结构的1，2，3，4-四氢-β-咔啉类化合物及其制备方法和应用 |
| CN111892593B (zh) * | 2020-08-19 | 2021-11-16 | 南通大学 | 一种8-甲氧基-5H-吡啶并[4,3-b]吲哚及其合成方法 |
| JP2024508235A (ja) * | 2021-02-04 | 2024-02-26 | アムジエン・インコーポレーテツド | 三環－アミド－二環ｐｒｍｔ５阻害剤 |
| CN113105517B (zh) * | 2021-04-10 | 2022-03-01 | 台州仙琚药业有限公司 | 雄甾-1,4,9-三烯-3,17-二酮的合成方法 |
| GB202108383D0 (en) * | 2021-06-11 | 2021-07-28 | Argonaut Therapeutics Ltd | Compounds useful in the treatment or prevention of a prmt5-mediated disorder |
| GB202117230D0 (en) | 2021-11-29 | 2022-01-12 | Argonaut Therapeutics Ltd | Peptide vaccine |
| GB202203588D0 (en) | 2022-03-15 | 2022-04-27 | Argonaut Therapeutics Ltd | Cancer diagnostic |
| CN115521306B (zh) * | 2022-09-26 | 2024-03-26 | 贵州大学 | 一种1,2,3,4-四氢-β-咔啉衍生物及其制备方法和应用 |
| CN117088891A (zh) * | 2023-07-13 | 2023-11-21 | 浙江大学 | 含四氢苯并[4,5]呋喃[2,3-c]吡啶类羟肟酸化合物及其制备方法和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3317524A (en) * | 1965-02-04 | 1967-05-02 | American Home Prod | Substituted 1, 2, 3, 4-tetrahydro-pyrazino[1, 2-a]indoles |
| US3687961A (en) * | 1971-05-03 | 1972-08-29 | Abbott Lab | 8-fluoro-2-{8 3-(4-fluorophenylanilinopropyl{9 -gamma-carboline |
| US4001263A (en) | 1974-04-01 | 1977-01-04 | Pfizer Inc. | 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines |
| DE2854014A1 (de) * | 1978-12-14 | 1980-07-03 | Troponwerke Gmbh & Co Kg | 7,8,9,10-tetrahydrothieno eckige klammer auf 3,2-e eckige klammer zu pyrido eckige klammer auf 4,3-b eckige klammer zu indole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4719211A (en) | 1984-05-01 | 1988-01-12 | American Home Products Corporation | 2,3,4,9-tetrahydro-2-heteroarylalkyl-1H-pyrido(3,4-B)indoles having antihypertensive properties |
| SU1248223A1 (ru) * | 1985-01-07 | 1995-09-20 | Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений | ДИГИДРОХЛОРИД 2-(3-ИЗОПРОПИЛАМИНО-2-ГИДРОКСИПРОПИЛ)-1,2,3,4-ТЕТРАГИДРО- β -КАРБОЛИНА, ОБЛАДАЮЩИЙ АНТИАЛКОГОЛЬНЫМ И ПСИХОТРОПНЫМ ДЕЙСТВИЕМ |
| US4663456A (en) * | 1985-09-16 | 1987-05-05 | American Home Products Corporation | 2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| UA52681C2 (uk) | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| EP0905136A1 (en) | 1997-09-08 | 1999-03-31 | Janssen Pharmaceutica N.V. | Tetrahydro gamma-carbolines |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| SK288365B6 (sk) | 1999-02-10 | 2016-07-01 | Astrazeneca Ab | Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| CN1255392C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管生成抑制剂的秋水仙醇衍生物 |
| AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| CA2593266A1 (en) | 2005-01-03 | 2006-07-13 | Universita Degli Studi Di Siena | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
| WO2007079239A2 (en) | 2005-12-30 | 2007-07-12 | Acadia Pharmaceuticals Inc. | Bicyclic nitrogen compounds as modulators of ghrelin receptor and uses thereof |
| WO2010080253A1 (en) | 2008-12-18 | 2010-07-15 | Merck Patent Gmbh | Tricyclic azaindoles |
| EP3406607A1 (en) | 2012-12-21 | 2018-11-28 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| CA2898040A1 (en) | 2013-01-14 | 2014-07-17 | Ent Associates Of Los Alamos, Llc | Honey nasal rinse |
| ES2786052T3 (es) | 2013-04-23 | 2020-10-08 | Esteve Pharmaceuticals Sa | Compuestos de pirazino[1,2-a]indol, su preparación y su uso en medicamentos |
| EP3013824B8 (en) | 2013-06-28 | 2018-11-21 | Alzprotect | Carboline compounds usable in the treatment of neurodegenerative diseases |
| WO2015110263A1 (en) * | 2014-01-21 | 2015-07-30 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins |
| JP2017519737A (ja) | 2014-05-26 | 2017-07-20 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換テトラヒドロピリドチエノピリミジン |
| EP3160466A4 (en) * | 2014-06-25 | 2017-12-27 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3177288A4 (en) | 2014-08-04 | 2018-04-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
-
2017
- 2017-03-17 GB GBGB1704325.8A patent/GB201704325D0/en not_active Ceased
-
2018
- 2018-03-16 ES ES18711927T patent/ES2925115T3/es active Active
- 2018-03-16 KR KR1020197029438A patent/KR102604942B1/ko active Active
- 2018-03-16 US US16/494,570 patent/US11274098B2/en active Active
- 2018-03-16 JP JP2019571789A patent/JP7308765B2/ja active Active
- 2018-03-16 WO PCT/EP2018/056675 patent/WO2018167276A1/en not_active Ceased
- 2018-03-16 EP EP18711927.6A patent/EP3596073B1/en active Active
- 2018-03-16 CA CA3056726A patent/CA3056726A1/en active Pending
- 2018-03-16 CN CN201880031972.3A patent/CN110621675B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3596073A1 (en) | 2020-01-22 |
| CN110621675B (zh) | 2023-09-19 |
| CA3056726A1 (en) | 2018-09-20 |
| CN110621675A (zh) | 2019-12-27 |
| KR102604942B1 (ko) | 2023-11-21 |
| WO2018167276A1 (en) | 2018-09-20 |
| JP2020510092A (ja) | 2020-04-02 |
| GB201704325D0 (en) | 2017-05-03 |
| US20200325132A1 (en) | 2020-10-15 |
| EP3596073B1 (en) | 2022-05-11 |
| US11274098B2 (en) | 2022-03-15 |
| KR20190129071A (ko) | 2019-11-19 |
| JP7308765B2 (ja) | 2023-07-14 |
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