KR102594051B1 - 단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 - Google Patents
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 Download PDFInfo
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- KR102594051B1 KR102594051B1 KR1020197007806A KR20197007806A KR102594051B1 KR 102594051 B1 KR102594051 B1 KR 102594051B1 KR 1020197007806 A KR1020197007806 A KR 1020197007806A KR 20197007806 A KR20197007806 A KR 20197007806A KR 102594051 B1 KR102594051 B1 KR 102594051B1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020237036111A KR20230155013A (ko) | 2016-08-20 | 2017-08-21 | 단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377586P | 2016-08-20 | 2016-08-20 | |
| US62/377,586 | 2016-08-20 | ||
| US201762462808P | 2017-02-23 | 2017-02-23 | |
| US62/462,808 | 2017-02-23 | ||
| US201762501750P | 2017-05-05 | 2017-05-05 | |
| US62/501,750 | 2017-05-05 | ||
| PCT/US2017/047861 WO2018039145A1 (en) | 2016-08-20 | 2017-08-21 | Single guide rna, crispr/cas9 systems, and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237036111A Division KR20230155013A (ko) | 2016-08-20 | 2017-08-21 | 단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190041499A KR20190041499A (ko) | 2019-04-22 |
| KR102594051B1 true KR102594051B1 (ko) | 2023-10-26 |
Family
ID=61246315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197007806A Active KR102594051B1 (ko) | 2016-08-20 | 2017-08-21 | 단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 |
| KR1020237036111A Ceased KR20230155013A (ko) | 2016-08-20 | 2017-08-21 | 단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237036111A Ceased KR20230155013A (ko) | 2016-08-20 | 2017-08-21 | 단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190185850A1 (https=) |
| EP (1) | EP3500677A4 (https=) |
| JP (3) | JP2019524149A (https=) |
| KR (2) | KR102594051B1 (https=) |
| CN (1) | CN109963945A (https=) |
| WO (1) | WO2018039145A1 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP4036228A1 (en) | 2015-11-13 | 2022-08-03 | Avellino Lab USA, Inc. | Methods for the treatment of corneal dystrophies |
| KR102787119B1 (ko) | 2015-11-30 | 2025-03-27 | 듀크 유니버시티 | 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법 |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Cpf1に基づくゲノム編集の治療適用 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| JP2019524149A (ja) * | 2016-08-20 | 2019-09-05 | アベリノ ラボ ユーエスエー インコーポレイテッドAvellino Lab USA, Inc. | 一本鎖ガイドRNA、CRISPR/Cas9システム、及びそれらの使用方法 |
| WO2020225754A1 (en) * | 2019-05-06 | 2020-11-12 | Mcmullen Tara | Crispr gene editing for autosomal dominant diseases |
| WO2020046861A1 (en) * | 2018-08-27 | 2020-03-05 | Avellino Lab Usa, Inc. | Crispr/cas9 systems, and methods of use thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| WO2018225807A1 (ja) * | 2017-06-07 | 2018-12-13 | 国立大学法人東京大学 | 顆粒状角膜変性症に対する遺伝子治療薬 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3740580A4 (en) | 2018-01-19 | 2021-10-20 | Duke University | GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS |
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- 2017-08-21 KR KR1020197007806A patent/KR102594051B1/ko active Active
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- 2017-08-21 KR KR1020237036111A patent/KR20230155013A/ko not_active Ceased
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| WO2018039145A1 (en) | 2018-03-01 |
| JP2019524149A (ja) | 2019-09-05 |
| KR20190041499A (ko) | 2019-04-22 |
| WO2018039145A9 (en) | 2018-05-03 |
| JP2024041905A (ja) | 2024-03-27 |
| EP3500677A4 (en) | 2020-04-01 |
| KR20230155013A (ko) | 2023-11-09 |
| CN109963945A (zh) | 2019-07-02 |
| US20190185850A1 (en) | 2019-06-20 |
| JP2022046694A (ja) | 2022-03-23 |
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