KR102536408B1 - Hsp90 저해제 및 hsp70 유도제로서의 개질된 에터기를 가진 바이페닐 아마이드 - Google Patents

Hsp90 저해제 및 hsp70 유도제로서의 개질된 에터기를 가진 바이페닐 아마이드 Download PDF

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KR102536408B1
KR102536408B1 KR1020177001978A KR20177001978A KR102536408B1 KR 102536408 B1 KR102536408 B1 KR 102536408B1 KR 1020177001978 A KR1020177001978 A KR 1020177001978A KR 20177001978 A KR20177001978 A KR 20177001978A KR 102536408 B1 KR102536408 B1 KR 102536408B1
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브라이언 에스.제이. 블라그
릭 티. 도브로브스키
머시 아니카
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더 유니버시티 오브 캔사스
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KR1020177001978A 2014-06-24 2015-06-24 Hsp90 저해제 및 hsp70 유도제로서의 개질된 에터기를 가진 바이페닐 아마이드 Active KR102536408B1 (ko)

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US201462016473P 2014-06-24 2014-06-24
US62/016,473 2014-06-24
PCT/US2015/037478 WO2015200514A2 (en) 2014-06-24 2015-06-24 Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers

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KR102536408B1 true KR102536408B1 (ko) 2023-05-23

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013119985A1 (en) 2012-02-09 2013-08-15 University Of Kansas C-terminal hsp90 inhibitors
AU2015274265B2 (en) 2014-06-13 2020-05-21 The University Of Kansas Triazole modified coumarin and biphenyl amide-based Hsp90 inhibitors
CN106536498A (zh) 2014-06-24 2017-03-22 堪萨斯大学 作为hsp90抑制剂和hsp70诱导剂的具有经修饰醚基的联苯酰胺
CN108478568B (zh) * 2018-02-01 2020-08-28 华中农业大学 一种香豆素类化合物在制备单胺氧化酶抑制剂中的用途
IL276583B2 (en) * 2018-02-07 2025-03-01 Reata Pharmaceuticals Inc Crystal structures of proline and a novobiocin analog
KR20210021457A (ko) * 2018-05-14 2021-02-26 리아타 파마슈티컬즈, 아이엔씨. 열충격 단백질 경로와 연관된 질환의 치료를 위한 변형된 당기를 가진 바이아릴 아마이드
KR102175125B1 (ko) * 2018-12-28 2020-11-05 울산과학기술원 미토콘드리아 표적 Hsp90 억제제 기반 화합물 및 이를 포함하는 광역학 치료를 위한 약학적 조성물
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013119985A1 (en) * 2012-02-09 2013-08-15 University Of Kansas C-terminal hsp90 inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1344780A4 (en) 2000-11-30 2004-01-28 Kissei Pharmaceutical GLUCOPYRANOSYLOXYBENZYLBENZOLE DERIVATIVES, MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION
US7622451B2 (en) 2004-11-03 2009-11-24 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
US8212011B2 (en) 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
US8212012B2 (en) 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
WO2010096650A1 (en) 2009-02-20 2010-08-26 University Of Kansas Novobiocin analogues having modified sugar moieties
WO2006050501A2 (en) 2004-11-03 2006-05-11 University Of Kansas Novobiocin analogues as anticancer agents
WO2007025943A2 (en) 2005-08-30 2007-03-08 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
CA2669687C (en) 2006-11-15 2013-09-10 Forest Laboratories Holdings Limited Phthalazine derivatives
KR101313804B1 (ko) 2007-03-20 2013-10-01 쿠리스 인코퍼레이션 Ｈｓｐ９０ 억제제로서의 융합된 아미노 피리딘
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
WO2011041593A1 (en) 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
US20130116227A1 (en) 2010-07-13 2013-05-09 Dainippon Sumitomo Pharma Co., Ltd. Biaryl amide derivative or pharmaceutically acceptable salt thereof
CN103596955B (zh) 2011-04-05 2016-11-16 索隆-基特林癌症研究协会 Hsp90抑制剂
WO2012162054A1 (en) 2011-05-20 2012-11-29 The University Of Kansas Dynamic inhibitors of heat shock protein 90
CN102511153B (zh) 2011-11-16 2014-09-03 华为技术有限公司 一种微波预失真信号生成方法和装置
CN106536498A (zh) 2014-06-24 2017-03-22 堪萨斯大学 作为hsp90抑制剂和hsp70诱导剂的具有经修饰醚基的联苯酰胺

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013119985A1 (en) * 2012-02-09 2013-08-15 University Of Kansas C-terminal hsp90 inhibitors

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BR112016029672A2 (pt) 2017-08-22
EP4494702A3 (en) 2025-02-26
IL249712A0 (en) 2017-02-28
NZ728482A (en) 2022-11-25
US20200270201A1 (en) 2020-08-27
IL249712B (en) 2021-04-29
US20180057446A1 (en) 2018-03-01
WO2015200514A2 (en) 2015-12-30
JP2017521496A (ja) 2017-08-03
CL2016003276A1 (es) 2017-05-26
EP3160977A2 (en) 2017-05-03
AU2021200969A1 (en) 2021-03-11
AU2021200969B2 (en) 2022-08-04
US11098008B2 (en) 2021-08-24
CA2952029A1 (en) 2015-12-30
JP2021042217A (ja) 2021-03-18
CO2017000552A2 (es) 2017-04-28
MX388516B (es) 2025-03-20
KR20170035911A (ko) 2017-03-31
CA3289739A1 (en) 2025-11-29
CL2018002367A1 (es) 2018-10-12
AU2015279926A1 (en) 2017-02-16
US20220041543A1 (en) 2022-02-10
MX388515B (es) 2025-03-20
JP6793640B2 (ja) 2020-12-02
US11708319B2 (en) 2023-07-25
MX2019015888A (es) 2020-02-07
EP4494702A2 (en) 2025-01-22
EA201790070A1 (ru) 2017-10-31
JP7105851B2 (ja) 2022-07-25
WO2015200514A3 (en) 2016-02-25
US10590065B2 (en) 2020-03-17
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