CN106536498A - 作为hsp90抑制剂和hsp70诱导剂的具有经修饰醚基的联苯酰胺 - Google Patents

作为hsp90抑制剂和hsp70诱导剂的具有经修饰醚基的联苯酰胺 Download PDF

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CN106536498A
CN106536498A CN201580033560.XA CN201580033560A CN106536498A CN 106536498 A CN106536498 A CN 106536498A CN 201580033560 A CN201580033560 A CN 201580033560A CN 106536498 A CN106536498 A CN 106536498A
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compound according
compound
substituted
alkyl
hydrogen
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B·S·J·布莱格
R·T·多巴罗斯凯
M·安卡
M·安一卡
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University of Kansas
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University of Kansas
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
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    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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CN201580033560.XA 2014-06-24 2015-06-24 作为hsp90抑制剂和hsp70诱导剂的具有经修饰醚基的联苯酰胺 Pending CN106536498A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462016473P 2014-06-24 2014-06-24
US62/016,473 2014-06-24
PCT/US2015/037478 WO2015200514A2 (en) 2014-06-24 2015-06-24 Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers

Publications (1)

Publication Number Publication Date
CN106536498A true CN106536498A (zh) 2017-03-22

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US (3) US10590065B2 (https=)
EP (2) EP4494702A3 (https=)
JP (2) JP6793640B2 (https=)
KR (1) KR102536408B1 (https=)
CN (1) CN106536498A (https=)
AU (2) AU2015279926B2 (https=)
CA (2) CA3289739A1 (https=)
CL (2) CL2016003276A1 (https=)
CO (1) CO2017000552A2 (https=)
EA (1) EA201790070A1 (https=)
IL (1) IL249712B (https=)
MX (2) MX388516B (https=)
NZ (1) NZ728482A (https=)
SG (2) SG10201811574YA (https=)
WO (1) WO2015200514A2 (https=)

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CN112513058A (zh) * 2018-05-14 2021-03-16 里亚塔医药公司 治疗与热休克蛋白通路有关的疾病的具有修饰糖基团的联芳基酰胺类
US11401294B2 (en) 2018-02-07 2022-08-02 Reata Pharmaceuticals, Inc. Co-crystal forms of a novobiocin analog and proline
TWI915111B (zh) 2018-02-07 2026-02-11 美商瑞塔醫藥有限責任公司 新生黴素（ｎｏｖｏｂｉｏｃｉｎ）類似物及脯胺酸之共晶型

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SMT201900660T1 (it) 2012-02-09 2020-01-14 Univ Kansas Inibitori c-terminali di hsp90
CA2951270C (en) 2014-06-13 2023-07-04 The University Of Kansas Triazole modified coumarin and biphenyl amide-based hsp90 inhibitors
MX388516B (es) 2014-06-24 2025-03-20 Univ Kansas Bifenil amidas con grupos éter modificados como inhibidores de hsp90 e inductores de hsp70.
CN108478568B (zh) * 2018-02-01 2020-08-28 华中农业大学 一种香豆素类化合物在制备单胺氧化酶抑制剂中的用途
KR102175125B1 (ko) * 2018-12-28 2020-11-05 울산과학기술원 미토콘드리아 표적 Hsp90 억제제 기반 화합물 및 이를 포함하는 광역학 치료를 위한 약학적 조성물
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
US11401294B2 (en) 2018-02-07 2022-08-02 Reata Pharmaceuticals, Inc. Co-crystal forms of a novobiocin analog and proline
TWI797249B (zh) * 2018-02-07 2023-04-01 美商瑞塔醫藥有限責任公司 新生黴素（ｎｏｖｏｂｉｏｃｉｎ）類似物及脯胺酸之共晶型、其製造方法及用途
TWI868593B (zh) * 2018-02-07 2025-01-01 美商瑞塔醫藥有限責任公司 新生黴素（novobiocin）類似物及脯胺酸之共晶型及其用途
TWI915111B (zh) 2018-02-07 2026-02-11 美商瑞塔醫藥有限責任公司 新生黴素（ｎｏｖｏｂｉｏｃｉｎ）類似物及脯胺酸之共晶型
CN112513058A (zh) * 2018-05-14 2021-03-16 里亚塔医药公司 治疗与热休克蛋白通路有关的疾病的具有修饰糖基团的联芳基酰胺类
CN112513058B (zh) * 2018-05-14 2024-08-20 里亚塔医药公司 治疗与热休克蛋白通路有关的疾病的具有修饰糖基团的联芳基酰胺类

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CO2017000552A2 (es) 2017-04-28
SG10201811574YA (en) 2019-01-30
MX388516B (es) 2025-03-20
JP6793640B2 (ja) 2020-12-02
EP4494702A3 (en) 2025-02-26
CL2018002367A1 (es) 2018-10-12
US20180057446A1 (en) 2018-03-01
AU2015279926A1 (en) 2017-02-16
IL249712A0 (en) 2017-02-28
JP2021042217A (ja) 2021-03-18
WO2015200514A3 (en) 2016-02-25
KR20170035911A (ko) 2017-03-31
US20220041543A1 (en) 2022-02-10
CA3289739A1 (en) 2025-11-29
JP2017521496A (ja) 2017-08-03
AU2015279926B2 (en) 2020-12-24
MX2016017133A (es) 2018-01-12
US11098008B2 (en) 2021-08-24
IL249712B (en) 2021-04-29
CL2016003276A1 (es) 2017-05-26
NZ728482A (en) 2022-11-25
WO2015200514A2 (en) 2015-12-30
US20200270201A1 (en) 2020-08-27
US11708319B2 (en) 2023-07-25
KR102536408B1 (ko) 2023-05-23
BR112016029672A2 (pt) 2017-08-22
MX388515B (es) 2025-03-20
AU2021200969B2 (en) 2022-08-04
JP7105851B2 (ja) 2022-07-25
EP4494702A2 (en) 2025-01-22
SG11201610677XA (en) 2017-01-27
AU2021200969A1 (en) 2021-03-11
CA2952029C (en) 2026-04-07
US10590065B2 (en) 2020-03-17
EP3160977A2 (en) 2017-05-03
EA201790070A1 (ru) 2017-10-31
CA2952029A1 (en) 2015-12-30
MX2019015888A (es) 2020-02-07

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