KR102515509B1 - 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 - Google Patents

결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 Download PDF

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KR102515509B1
KR102515509B1 KR1020187038115A KR20187038115A KR102515509B1 KR 102515509 B1 KR102515509 B1 KR 102515509B1 KR 1020187038115 A KR1020187038115 A KR 1020187038115A KR 20187038115 A KR20187038115 A KR 20187038115A KR 102515509 B1 KR102515509 B1 KR 102515509B1
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antibody
ctla
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KR20190015406A (ko
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마이클 액셀슨
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187038115A 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 Active KR102515509B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237010151A KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662345662P 2016-06-03 2016-06-03
US62/345,662 2016-06-03
PCT/US2017/035822 WO2017210637A1 (en) 2016-06-03 2017-06-02 Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer

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KR1020237010151A Division KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

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KR20190015406A KR20190015406A (ko) 2019-02-13
KR102515509B1 true KR102515509B1 (ko) 2023-03-28

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KR1020187038115A Active KR102515509B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020237010151A Active KR102702675B1 (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도
KR1020247029228A Pending KR20240134249A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

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KR1020247029228A Pending KR20240134249A (ko) 2016-06-03 2017-06-02 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도

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US (3) US11332529B2 (enExample)
EP (2) EP3988570A1 (enExample)
JP (3) JP2019517512A (enExample)
KR (3) KR102515509B1 (enExample)
CN (1) CN109476754A (enExample)
ES (1) ES2897964T3 (enExample)
WO (1) WO2017210637A1 (enExample)

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SG11201708223QA (en) * 2015-04-17 2017-11-29 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
CN114591433A (zh) 2015-07-13 2022-06-07 西托姆克斯治疗公司 抗pd-1抗体、可活化抗pd-1抗体及其使用方法
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EP3988570A1 (en) 2016-06-03 2022-04-27 Bristol-Myers Squibb Company Use of anti-pd-1 antibody in the treatment of patients with colorectal cancer
KR20200108868A (ko) 2018-01-12 2020-09-21 브리스톨-마이어스 스큅 컴퍼니 암을 치료하기 위한 항-il-8 항체 및 항-pd-1 항체와의 조합 요법
US12398209B2 (en) * 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
BR112020015915A8 (pt) * 2018-02-13 2023-01-31 Merck Sharp & Dohme Usos de um anticorpo anti-pd-1 e um anticorpo anti-ctla4 ou fragmentos de ligação ao antígeno dos mesmos, bem como kit para tratamento de um paciente com câncer
WO2020033283A1 (en) * 2018-08-09 2020-02-13 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer with a combination of programmed death receptor (pd-1) antibodies and vicriviroc
CA3111066A1 (en) * 2018-09-13 2020-03-19 Merck Sharp & Dohme Corp. Combination therapy of a pd-1 antagonist and lag3 antagonist for treating patients with non-microsatellite instability-high or proficient mismatch repair colorectal cancer
CN113677402A (zh) * 2019-03-28 2021-11-19 百时美施贵宝公司 治疗肿瘤的方法
GB201912107D0 (en) * 2019-08-22 2019-10-09 Amazentis Sa Combination
CN110656179A (zh) * 2019-10-29 2020-01-07 至本医疗科技（上海）有限公司 免疫敏感性预测的生物标志组成物及用途、试剂盒设备存储介质
AR122043A1 (es) * 2020-05-12 2022-08-03 Bristol Myers Squibb Co Dosificación y administración del anticuerpo anti-ctla-4 activable
CN115569193B (zh) * 2021-10-09 2024-04-02 施慧达药业集团(吉林)有限公司 戈氏梭菌芽孢联合帕博利珠单抗的应用及治疗结肠癌药物和戈氏梭菌芽孢冻干粉制备方法
JP2026502785A (ja) * 2022-10-31 2026-01-27 アジェナス インコーポレイテッド 抗ｃｔｌａ４抗体を用いて大腸癌を治療する方法
JP2026506594A (ja) * 2023-02-09 2026-02-25 アンボーゲン セラピューティクス インコーポレイテッド 大腸癌の治療のための医薬キット及びその使用

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US20220356254A1 (en) 2022-11-10
JP2025143276A (ja) 2025-10-01
JP2019517512A (ja) 2019-06-24
KR20190015406A (ko) 2019-02-13
KR20230047498A (ko) 2023-04-07
EP3464373B1 (en) 2021-10-27
CN109476754A (zh) 2019-03-15
US11332529B2 (en) 2022-05-17
KR102702675B1 (ko) 2024-09-05
WO2017210637A1 (en) 2017-12-07
EP3988570A1 (en) 2022-04-27
ES2897964T3 (es) 2022-03-03
JP2023002567A (ja) 2023-01-10
EP3464373A1 (en) 2019-04-10
KR20240134249A (ko) 2024-09-06
US20190153100A1 (en) 2019-05-23
US20250026831A1 (en) 2025-01-23
JP7721494B2 (ja) 2025-08-12

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