KR102499737B1 - 종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법 - Google Patents

종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법 Download PDF

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KR102499737B1
KR102499737B1 KR1020167030977A KR20167030977A KR102499737B1 KR 102499737 B1 KR102499737 B1 KR 102499737B1 KR 1020167030977 A KR1020167030977 A KR 1020167030977A KR 20167030977 A KR20167030977 A KR 20167030977A KR 102499737 B1 KR102499737 B1 KR 102499737B1
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immune checkpoint
antagonist
mva
cancer
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KR20170003556A (ko
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수잔 포이
스테파니 만들
라이언 라운트리
알렉스 프란즈소프
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버베리안 노딕 에이/에스
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020167030977A 2014-05-13 2015-05-08 종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법 Active KR102499737B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461992788P 2014-05-13 2014-05-13
US61/992,788 2014-05-13
PCT/US2015/029855 WO2015175334A2 (en) 2014-05-13 2015-05-08 Combination therapy for treating cancer with a recombinant poxvirus expressing a tumor antigen and an immune checkpoint molecule antagonist or agonist

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KR20170003556A KR20170003556A (ko) 2017-01-09
KR102499737B1 true KR102499737B1 (ko) 2023-02-13

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US (1) US20170266270A1 (https=)
EP (1) EP3142690B1 (https=)
JP (1) JP6747981B2 (https=)
KR (1) KR102499737B1 (https=)
CN (1) CN106456747A (https=)
AU (1) AU2015259510B2 (https=)
CA (1) CA2946418C (https=)
DK (1) DK3142690T3 (https=)
ES (1) ES2913236T3 (https=)
IL (1) IL248507B (https=)
NZ (1) NZ725459A (https=)
RU (1) RU2724433C2 (https=)
WO (1) WO2015175334A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
AU2015289081B2 (en) * 2014-07-16 2020-02-06 Transgene Sa Combination of oncolytic virus with immune checkpoint modulators
ES3011733T3 (en) 2015-02-13 2025-04-08 Transgene Immunotherapeutic vaccine and antibody combination therapy
EP4122492A1 (en) 2015-02-25 2023-01-25 Memorial Sloan Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
KR20180006916A (ko) * 2015-04-17 2018-01-19 메모리얼 슬로안-케터링 캔서 센터 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도
CN114591433A (zh) 2015-07-13 2022-06-07 西托姆克斯治疗公司 抗pd-1抗体、可活化抗pd-1抗体及其使用方法
JP7025339B2 (ja) 2016-02-25 2022-02-24 メモリアル スローン ケタリング キャンサー センター 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトｆｌｔ３ｌまたはｇｍ－ｃｓｆの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス
CN109152827B (zh) 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
US20210198689A1 (en) * 2016-03-18 2021-07-01 Nant Holdings Ip, Llc Multimodal Vector for Dendritic Cell Infection
EP3225253A1 (en) * 2016-04-01 2017-10-04 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor
CN107281474A (zh) * 2016-04-11 2017-10-24 中国科学院上海巴斯德研究所 增强抗肿瘤免疫反应的新型免疫策略和免疫组合物
WO2017207814A1 (en) 2016-06-02 2017-12-07 Ultimovacs As A vaccine in combination with an immune checkpoint inhibitor for use in treating cancer
HUE057559T2 (hu) * 2016-11-02 2022-06-28 Jounce Therapeutics Inc PD-1 elleni antitestek és alkalmazásaik
KR200486872Y1 (ko) 2016-11-16 2018-07-10 김영선 가변형 조립식 책상
EP3621646A4 (en) 2017-05-12 2021-06-02 Memorial Sloan Kettering Cancer Center VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY
KR20240113607A (ko) 2017-06-21 2024-07-22 트랜스진 개인 맞춤형 백신
KR102754876B1 (ko) * 2017-08-24 2025-01-13 버베리안 노딕 에이/에스 재조합 mva 및 항체의 정맥내 투여에 의한 암 치료를 위한 병용 요법
WO2019090343A1 (en) * 2017-11-06 2019-05-09 Memorial Sloan Kettering Cancer Center Heat-inactivated vaccinia virus as a vaccine immune adjuvant
WO2019152922A1 (en) * 2018-02-05 2019-08-08 Nant Holdings Ip, Llc Calreticulin and fusion proteins
TWI905535B (zh) * 2018-04-23 2025-11-21 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法
US11564980B2 (en) 2018-04-23 2023-01-31 Nantcell, Inc. Tumor treatment method with an individualized peptide vaccine
BR112021004692A2 (pt) 2018-09-15 2021-06-08 Memorial Sloan Kettering Cancer Center poxvírus recombinantes para imunoterapia de câncer
MX2021005560A (es) 2018-11-20 2021-06-23 Bavarian Nordic As Terapia para el tratamiento del cancer con administracion intratumoral y/o intravenosa de un virus vaccinia ankara (mva) recombinante que codifica ligando 4-1bbl (cd137l) y/o ligando del cumulo o grupo de diferenciacion 40 (cd40l).
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
EP3941514A4 (en) * 2019-03-20 2023-08-30 Turnstone Biologics Inc. ONCOLYTIC VIROTHERAPY BY HETEROLOGY SEQUENTIAL BOOSTER
JP7732977B2 (ja) 2019-09-20 2025-09-02 トランスジーン Ｈｐｖポリペプチドおよびｉｌ－２をコードするポックスウイルスと抗ｐｄ－ｌ１抗体の組合せ
KR20220115569A (ko) 2019-11-18 2022-08-17 얀센 바이오테크 인코포레이티드 돌연변이 calr 및 jak2에 기반한 백신 및 이의 용도
CN114929268A (zh) * 2019-11-20 2022-08-19 巴法里安诺迪克有限公司 4-1bbl辅助的重组修饰的安卡拉痘苗病毒(mva)的医疗用途
CN114867491B (zh) * 2019-11-20 2025-08-15 巴法里安诺迪克有限公司 用于肿瘤内和/或静脉内施用以治疗癌症的重组mva病毒
US12295997B2 (en) 2020-07-06 2025-05-13 Janssen Biotech, Inc. Prostate neoantigens and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006121168A1 (en) * 2005-05-09 2006-11-16 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1119354A (en) * 1914-01-05 1914-12-01 Adelbert Armstrong Broom-holder.
US1391972A (en) * 1920-08-05 1921-09-27 American Cotton Oil Company Method and apparatus for molding soap

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006121168A1 (en) * 2005-05-09 2006-11-16 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer Immunol Immunother, 제61권, 19-29면(published online: 2011.8.7.)*
Lancet Oncol, 제13권, 제5호, 501-508면(published online: 2012.2.10.)*

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EP3142690B1 (en) 2022-02-23
NZ725459A (en) 2023-04-28
RU2016148311A (ru) 2018-06-18
WO2015175334A3 (en) 2016-02-04
RU2016148311A3 (https=) 2018-12-26
JP2017515837A (ja) 2017-06-15
IL248507A0 (en) 2016-12-29
JP6747981B2 (ja) 2020-08-26
AU2015259510A1 (en) 2016-11-10
CA2946418C (en) 2023-07-04
WO2015175334A2 (en) 2015-11-19
CN106456747A (zh) 2017-02-22
ES2913236T3 (es) 2022-06-01
EP3142690A2 (en) 2017-03-22
DK3142690T3 (da) 2022-05-09
AU2015259510B2 (en) 2020-10-01
IL248507B (en) 2022-07-01
RU2724433C2 (ru) 2020-06-23
KR20170003556A (ko) 2017-01-09
US20170266270A1 (en) 2017-09-21
CA2946418A1 (en) 2015-11-19

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