KR102498515B1 - 마이크로니들 어레이 및 사용 방법 - Google Patents

마이크로니들 어레이 및 사용 방법 Download PDF

Info

Publication number
KR102498515B1
KR102498515B1 KR1020177022921A KR20177022921A KR102498515B1 KR 102498515 B1 KR102498515 B1 KR 102498515B1 KR 1020177022921 A KR1020177022921 A KR 1020177022921A KR 20177022921 A KR20177022921 A KR 20177022921A KR 102498515 B1 KR102498515 B1 KR 102498515B1
Authority
KR
South Korea
Prior art keywords
article
microneedle
microneedles
tip
hollow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020177022921A
Other languages
English (en)
Korean (ko)
Other versions
KR20170108049A (ko
Inventor
마이클 제이. 프릿츠
크레이그 에스. 모클리
다니엘 에이치. 버그
제롬 이. 기스버즈
라이언 패트릭 시머즈
Original Assignee
쓰리엠 이노베이티브 프로퍼티즈 컴파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쓰리엠 이노베이티브 프로퍼티즈 컴파니 filed Critical 쓰리엠 이노베이티브 프로퍼티즈 컴파니
Publication of KR20170108049A publication Critical patent/KR20170108049A/ko
Application granted granted Critical
Publication of KR102498515B1 publication Critical patent/KR102498515B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150404—Specific design of proximal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
KR1020177022921A 2015-01-21 2016-01-19 마이크로니들 어레이 및 사용 방법 Active KR102498515B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562105987P 2015-01-21 2015-01-21
US62/105,987 2015-01-21
PCT/US2016/013820 WO2016118459A1 (en) 2015-01-21 2016-01-19 Microneedle array and method of use

Publications (2)

Publication Number Publication Date
KR20170108049A KR20170108049A (ko) 2017-09-26
KR102498515B1 true KR102498515B1 (ko) 2023-02-09

Family

ID=55353292

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177022921A Active KR102498515B1 (ko) 2015-01-21 2016-01-19 마이크로니들 어레이 및 사용 방법

Country Status (9)

Country Link
US (1) US10398885B2 (https=)
EP (1) EP3247449B1 (https=)
JP (1) JP6909366B2 (https=)
KR (1) KR102498515B1 (https=)
CN (1) CN107206221B (https=)
AU (1) AU2016209496B2 (https=)
ES (1) ES2885923T3 (https=)
SG (2) SG10201809690VA (https=)
WO (1) WO2016118459A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201809690VA (en) * 2015-01-21 2018-12-28 3M Innovative Properties Co Microneedle array and method of use
CN107126620A (zh) * 2017-06-27 2017-09-05 傅书华 一种隐形注射针
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
KR102188397B1 (ko) * 2018-07-04 2020-12-08 주식회사 지엘캄퍼니 마이크로 니들
KR102186163B1 (ko) * 2018-10-08 2020-12-04 연세대학교 산학협력단 다기능 마이크로구조체 패치
JP7689708B2 (ja) * 2019-06-25 2025-06-09 コスメディ製薬株式会社 針密度が不均一なマイクロニードルアレイ
US20220249821A1 (en) * 2019-07-22 2022-08-11 The Trustees Of Indiana University Technologies for needles with microchannels
KR102290268B1 (ko) 2019-10-11 2021-08-13 부산대학교 산학협력단 이식형 물질 전달체, 및 이의 제조방법
WO2021102369A1 (en) 2019-11-22 2021-05-27 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
BR112022022039A2 (pt) 2020-04-28 2022-12-13 Ticona Llc Conjunto de microagulhas
KR102742895B1 (ko) * 2020-11-06 2024-12-16 연세대학교 산학협력단 생체 정보 획득 장치 및 이를 이용한 생체 정보 처리 장치
US11389632B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Intradermal drug delivery device
CN112915378B (zh) * 2021-03-29 2022-07-22 飞诊医疗科技(南通)有限公司 一种智能微针给药器和与智能微针给药器连接的软件
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
CN114129889B (zh) * 2021-11-30 2023-12-19 温州医科大学 一种眼科用环形微针
FR3130167A1 (fr) * 2021-12-10 2023-06-16 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositif d'injection/prélèvement d'un fluide à travers la peau d'un être vivant
CN118203752B (zh) * 2023-05-26 2025-10-24 重庆金赛星医疗科技有限公司 空心微针及微针阵列芯片
CN117547725A (zh) * 2023-08-14 2024-02-13 重庆金赛星医疗科技有限公司 可溶性空心微针、微针阵列芯片及经皮给药贴片

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012196426A (ja) * 2010-09-29 2012-10-18 Fujifilm Corp 針状アレイ経皮吸収シート及び針状アレイ経皮吸収シートの製造方法
JP2013516280A (ja) * 2010-01-08 2013-05-13 ラティオ， インコーポレイテッド 薬剤注入装置
WO2014193725A1 (en) * 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection and infusion apparatus and method of using same

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
TW480759B (en) 1999-03-18 2002-03-21 Seiko Epson Corp Electronic machine, charged electronic machine and control method of electronic machine
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
KR20120087197A (ko) 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
WO2006062974A2 (en) 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
JP2007190112A (ja) 2006-01-18 2007-08-02 Toray Ind Inc マイクロニードル
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
JP2010502267A (ja) * 2006-08-28 2010-01-28 エージェンシー・フォー・サイエンス・テクノロジー・アンド・リサーチ マイクロニードルおよびマイクロニードルの製造方法
KR100911488B1 (ko) * 2007-09-07 2009-08-11 호남석유화학 주식회사 미세 바늘 및 미세 바늘 어레이
DE102008052749B4 (de) * 2008-10-22 2012-01-12 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Nadel, Nadelanordnung, Spritzgussform und Verfahren zum Herstellen
JP2012509106A (ja) 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー 中空のマイクロニードルアレイ及び方法
CN102458559B (zh) 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
CA2769102C (en) * 2009-07-31 2017-09-19 3M Innovative Properties Company Hollow microneedle arrays
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
BR112012014965B1 (pt) 2009-12-18 2020-03-17 3M Innovative Properties Company Método de moldagem de polímeros de cristal líquido termotrópico e artigos moldados
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
MX344881B (es) 2010-12-02 2017-01-11 3M Innovative Properties Co Microagujas de polimero cristalino liquido.
CN103402496B (zh) 2011-03-07 2016-01-20 3M创新有限公司 微针装置及方法
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
KR102236575B1 (ko) 2012-12-21 2021-04-05 쓰리엠 이노베이티브 프로퍼티즈 컴파니 접착제 조립체 및 이를 포함하는 마이크로니들 주사 장치
KR102219636B1 (ko) 2012-12-27 2021-02-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 중공형 마이크로니들을 갖는 물품 및 제조 방법
EP3021930B1 (en) 2013-07-16 2020-10-07 3M Innovative Properties Company Hollow microneedle with beveled tip
JP6430501B2 (ja) 2013-07-16 2018-11-28 スリーエム イノベイティブ プロパティズ カンパニー 斜角開口部を有する中空マイクロニードル
WO2015138206A1 (en) * 2014-03-10 2015-09-17 3M Innovative Properties Company Micro-needle device
SG10201809690VA (en) * 2015-01-21 2018-12-28 3M Innovative Properties Co Microneedle array and method of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516280A (ja) * 2010-01-08 2013-05-13 ラティオ， インコーポレイテッド 薬剤注入装置
JP2012196426A (ja) * 2010-09-29 2012-10-18 Fujifilm Corp 針状アレイ経皮吸収シート及び針状アレイ経皮吸収シートの製造方法
WO2014193725A1 (en) * 2013-05-31 2014-12-04 3M Innovative Properties Company Microneedle injection and infusion apparatus and method of using same

Also Published As

Publication number Publication date
SG11201705981RA (en) 2017-08-30
AU2016209496B2 (en) 2018-06-28
US20180008807A1 (en) 2018-01-11
SG10201809690VA (en) 2018-12-28
CN107206221B (zh) 2021-02-09
KR20170108049A (ko) 2017-09-26
CN107206221A (zh) 2017-09-26
JP6909366B2 (ja) 2021-07-28
JP2018506339A (ja) 2018-03-08
EP3247449A1 (en) 2017-11-29
WO2016118459A1 (en) 2016-07-28
ES2885923T3 (es) 2021-12-15
AU2016209496A1 (en) 2017-08-03
US10398885B2 (en) 2019-09-03
EP3247449B1 (en) 2021-01-06

Similar Documents

Publication Publication Date Title
KR102498515B1 (ko) 마이크로니들 어레이 및 사용 방법
US10576257B2 (en) Article comprising a microneedle and methods of use
JP6928735B2 (ja) 斜角開口部を有する中空マイクロニードル
US10099043B2 (en) Hollow microneedle array article
US10232157B2 (en) Hollow microneedle with beveled tip
US20160271380A1 (en) Microneedle applicator comprising a counter assembly
Kaushik et al. Microneedles–minimally invasive transdermal delivery technology

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 4