KR102490852B1 - Manufacturing method for rehmannia radix - Google Patents

Abstract

The present invention relates to a preparation method of Rehmanniae radix preparata. According to a conventional method for preparing Rehmanniae radix preparata, the Rehmanniae radix preparata itself is dried and then liquor immersion, steaming, and drying steps are repeated so that there is a disadvantage that eating the same can easily cause indigestion and a preparation period is long. In order to address the disadvantage, the preparation method of Rehmanniae radix preparata according to the present invention comprises: a raw Rehmannia glutinosa crushing step (S100); a crushed Rehmannia glutinosa drying step (S200); a dried Rehmannia glutinosa liquor immersion step (S300); a steaming step (S400); and a powder type drying step (S500). In the meantime, the raw Rehmannia glutinosa may be crushed after dried first. In addition, the completed Rehmanniae radix preparata can be present in both a powder form and a lump form and is very convenient to use in an oriental medicine and food. In the preparation method of Rehmanniae radix preparata according to the present invention, the raw Rehmannia glutinosa is crushed before steamed to allow 5-HMF, an indicator substance to remain a lot in the resulting product, thereby enabling the Rehmanniae radix preparata to be digested well when the Rehmanniae radix preparata is used as oriental medicine or food. In addition, the step of preparing dried Rehmannia glutinosa will take less time, soaking the dried Rehmannia glutinosa with yellow wine (or white wine) can be facilitated, and the steaming time can be shortened.

Description

Rehmannia radix manufacturing method {Manufacturing method for rehmannia radix}

The present invention relates to a method for producing rehmannia glutinosa, and more particularly, to a method for producing rehmannia glutinosa in which raw rehmannia is crushed and dried, or dried and then crushed, followed by a main needle step.

Rehmannia glutinosa Libosch. var. purpurea Makino or the root of a plant belonging to the same genus) is a perennial herb belonging to the Scrophulariaceae family. Rehmannia glutinosa leaves and fine roots are removed and the soil is washed clean. Saengjihwang is widely recognized for its efficacy in blood, tonic, sedation, anemia, hematemesis, hemorrhage, uterine bleeding, and tuberculous weakness.

Dried saengjihwang is called geonhwang, and geonhwang is sweet and bitter in taste and cold in nature. Representative medicinal effects are applied to cow's thirst, hematemesis, urinary hemorrhage, and menstrual irregularity.

Drying after being steamed and dried by adding dry yellow wine to yellow wine or baekju is classified as Rehmanniae Radix Preparata, and each is used with different pharmacology. Sukjihwang is sweet in taste and slightly hot in nature.

Sukjihwang has the efficacy of blood and consonant sound, and is used for menstrual irregularity, weak constitution, poor growth of children, dementia, premature ejaculation, and impotence. In addition, the effect of improving the peripheral microcirculation of various chronic diseases by improving the recent blood circulation, the increase of superoxide dismutase and glutathione peroxidase and the inhibition of lipid peroxidation, the effect of increasing immunity, anticancer action, Increased fibrinolytic system activity, decreased polybrene-induced erythrocyte aggregation, increased erythrocyte deformability and ATP content have been reported. The difference in the pharmacological action of Rehmannia Root and Rehmannia Root is due to the fact that substances beneficial to the human body are newly created in the process of steaming Rehmannia Root and drying it. The more times the steaming and drying process is repeated, the higher the quality of sukjihwang is evaluated. During the steaming process of rehmannia glutinosa, sugars, the main component of rehmannia glutinosa, are converted into 5-hydroxymethyl-2-furaldehyde (5-HMF), which is used as an indicator to evaluate the quality of processed foods with high sugar content. 5-HMF is also used as an indicator substance when evaluating the quality of sukjihwang, and the higher the content of 5-HMF, the higher the quality of sukjihwang.

However, sukjihwang by the traditional manufacturing method of sukjihwang has the following problems.

First, when used as a herbal medicine or food raw material, there are many side effects of indigestion, so digestive agents are added or pills are used.

Second, when drying fresh Rehmannia Root, the skin must be properly removed and dried so that the main needle works well. Therefore, the performance of the sukjihwang is degraded.

Third, it takes a long time to dry because the lump-shaped raw Rehmannia Root is dried in the drying step.

Publication No. 1990-0012623

The present invention is intended to solve the above-mentioned problems, and indigestion, prolonged working process, decrease in work efficiency, and main needle of the conventional manufacturing method of rehmannia glutinosa in which raw rehmannia glutinosa is dried to make dried rehmannia root and the dried rehmannia root is repeated several times. It is easy to digest by solving the inefficiency, minimizes the decrease in the content of active ingredients during the manufacturing process, and can contain various types of active ingredients in high content. aim for what you want to do

In order to achieve the object of the present invention as described above, the manufacturing method according to the present invention comprises the steps of crushing raw Rehmannia glutinosa; Drying the crushed Saeng Rehmannia Root; Steeping the dried dry sulfuric acid; steaming and drying; It is characterized in that it comprises; sizing step and drying step.

The method for manufacturing sukjihwang according to the present invention is characterized in that the suljihwang is crushed into powder having a particle size of 0.1mm to 1mm.

The method for preparing sukjihwang according to the present invention is characterized in that it is steamed for 2 to 4 hours at a temperature of 80 to 120 ° C.

The method for manufacturing sukjihwang according to the present invention is characterized in that it is aged for 3 to 5 hours.

The method for producing sukjihwang according to the present invention is characterized in that sukjihwang contains 0.15% or more of 5-hydroxymethyl-2-furaldehyde (5-HMF).

The method for manufacturing sukjihwang according to the present invention is characterized in that the steamed and aged rehmannia tuber is made into a size of 10 to 15mm in diameter and 10 to 20cm in length and dried.

According to the method for manufacturing sukjihwang according to the present invention, it is digested well when taken, drying is fast in the process of manufacturing dried rehmannia after pulverizing raw rehmannia, good for sufficiently soaking hwangju in dried rehmannia, the time for steaming can be shortened, and the steaming is well The number of times of steaming can be reduced, and after completion of steaming, a model of the finished product can be produced according to the purpose, and extraction is easy even without alcohol extraction. There is an effect that the indicator substance (5-HMF) is more detected.

1 is a flow chart showing a method for manufacturing sukjihwang according to a first embodiment of the present invention.
Figure 2 is a flow chart showing a method for manufacturing sukjihwang according to a second embodiment of the present invention.
Figure 3 (a) is a diagram showing the process of crushing saengjihwang,
(b) is a diagram showing the saengjihwang after the crushing is completed.
Figure 4 is a diagram showing dried geonhwang geonhwang the crushing is completed.
Figure 5 is a diagram showing the process of injecting Geonjihwang.
Figure 6 (a) is a diagram showing the process of steaming and maturing the main-chilled Rehmannia Root,
(b) is a diagram showing dried Rehmannia after steaming and maturation.
Figure 7 (a), (b) is a diagram showing the steps for preparing Rehmannia Root in the form of powder form Rehmannia Root in lump form.
8 is a diagram showing the finally obtained sukjihwang.
9 is a diagram showing a 5-HMF test report of Sookjihwang by a conventional method.
Figure 10 is a diagram showing the 5-HMF test report of Sookjihwang (3 symptoms) according to the present invention.
Figure 11 is a diagram showing the 5-HMF test report of Sookjihwang (4 symptoms) according to the present invention.

A general method for manufacturing sukjihwang of the present invention will be described with reference to Figure 1 as follows,

Crushing saengjihwang (S100);

Drying the crushed Saeng Rehmannia Root (S200);

Steeping dried dry sulfuric acid (S300);

Steaming (S400);

Drying in powder form (S500);

By repeating S300 ~ S500 at least once to complete the manufacturing of sukjihwang,

S300 ~ S500 are repeated at least once, but in the last time, the drying step (S500) is not executed, and after the steaming step (S400), the lump form manufacturing step (S600); Step 700 of drying in the form of lumps; can be executed.

On the other hand, another manufacturing method of the present invention includes a method of producing sukjihwang by crushing dried rehmannia instead of crushing raw rehmannia.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[Example 1] Method for producing sukjihwang by crushing saengreh

First, the harvested raw material of Rehmannia Root is washed about three times. And remove moisture from the surface. And proceed to the next step in turn.

1. Crushing saengjihwang (S100);

Saengjihwang is crushed into powder having a particle size of 1.5 mm or less. In general, but crushed into powder having a particle diameter of 0.1 ~ 1.5mm, it can be preferably crushed into powder having a particle diameter of 0.5 ~ 1mm.

Figure 3 (a) is a diagram showing the process of crushing saengjihwang using a crusher,

Figure 3 (b) is a diagram showing the completion of crushing saengjihwang.

When crushed into a powder having a particle diameter of less than 0.1 mm, the efficacy as a herbal medicine or food is reduced, and when crushed into a powder having a particle diameter exceeding 1.5 mm, the efficacy of the main needle in the next main acupuncture step is reduced. More preferably, it is possible to crush saenghwangji in consideration of the decrease in particle size due to drying so that the powder having a particle size of 710 to 1000 μm based on the dried powder is 85% by weight or more of the total dried powder, and through this, the main needle described later It is possible to minimize the extraction of active ingredients in Saeng Rehmannia Root, for example, actioside, generated in the step by ethanol in the main needle solution during injection. In addition, as will be described later, the main needle serves to increase sweetness by removing the astringent taste of Rehmannia glutinosa and adding sugars in the main needle solution to Rehmannia glutinosa. Loss of sweet ingredients such as sucrose can be minimized. If the powder with a particle size of 710 ~ 1000㎛ based on the dried powder is crushed to less than 85% by weight of the total dried powder, the expression of the effect according to the control of the particle size distribution of the above-mentioned crushed powder is insignificant, and the active ingredient and The loss of sweetness can be difficult to prevent. In addition, if the particle size of the dried powder exceeds 1000 μm, decomposition of indigestible components may not be sufficient in the aging process performed after steaming, which will be described later.

On the other hand, it is possible to adjust the crushing level only in the crushing step to have a desired particle size, but is not limited thereto, and it is revealed that the powder can be classified to have a desired particle size using a standard sieve after crushing.

2. Drying the saengjihwang (S200);

The crushed Saeng Rehmannia Root is dried before browning. The drying process may be performed under the conditions used in the conventional manufacturing method of sukjihwang, that is, it may be dried at room temperature or hot air dried at a temperature of 60 ° C or less using a hot air dryer. The shredded saengrehwang is placed in a sieve and dried. The sieve used is generally stainless steel.

4 is a diagram showing dried dry sulfur.

In the conventional method, since the raw material is dried as it is, it takes a long time to dry, but in the present invention, since the raw material is in the form of a powder, the surface area of the raw material is increased and the drying time is shortened.

On the other hand, dried Rehmannia glutinosa powder having a desired particle size distribution can be obtained by drying the crushed Rehmannia glutinosa powder and then crushing it again. That is, it may be difficult to grind Saeng Rehmannia into powder with a small particle size due to the contained moisture. In this case, the crushing performed before drying is crushed to have an appropriate size, for example, a particle size of 1.5 mm or less to facilitate drying, , It may be advantageous to obtain Rehmannia glutinosa powder having a desired particle size distribution through further crushing to have a desired appropriate particle size distribution after drying.

3. Acupuncture (S300);

5 is a diagram showing a main needle step;

Put the dried geonhwang in a sieve and immerse it in the hwangju so that it is sufficiently moistened. The main acupuncture is to immerse Rehmannia glutinosa in a main acupuncture solution, which is alcohol. As the main acupuncture solution, yellow wine or baekju can be used. Both Hwangju and Baekju are grain wines made with barley, wheat, and rice as the main ingredients. In the brewing process, the astringent taste of Rehmannia Root is removed, and the sugar content of Rehmannia Root increases due to the sugars contained in the grain wine, Hwangju or Baekju.

Since most of the moisture is removed from dry ginseng compared to raw sage, hull (or baekju) is permeated by the main needle, but in the conventional method, when turmeric is in the form of a lump rather than a powder form, it is lumpy and shell On the other hand, in the present invention, since the dry sulfur is crushed and powdered, the surface area of the dried yellow is increased so that the yellow wine (or white wine) sufficiently penetrates into the dried yellow The performance of the sukjihwang is improved.

However, as described in the crushing step described above, the active ingredient and sweetening ingredient originally contained in Rehmannia Root may be lost by the main needle, and even when the particle size of the Rehmannia Root powder to be main needled is adjusted to a desired size, the active ingredient and sweetening ingredient may be insufficient to reduce the loss of Therefore, preferably, the main needle may be performed at a low temperature of 4 to 8 ° C. for 4 to 6 hours. If the temperature during infusion exceeds 8℃, active ingredients such as actioside and catalpinoside and sweetness components such as sugars may be greatly lost. My sugars are slow to permeate the Rehmannia Root, which may not be enough to bring out the sweetness. In addition, even in the case of infusion at a desirable low temperature condition, it may be difficult to express the effect of the infusion if the infusion time is less than 4 hours, and loss of active ingredients may increase even if infusion is incubated at a low temperature in excess of 6 hours.

4. Steaming step (S400);

Drying in powder form (S500);

After the main needle is completed, Rehmannia Root is steamed in a pressure cooker at a temperature of 80 ~ 120 ℃ for 2 ~ 4 hours. Preferably it can be steamed at a temperature of 90 ~ 120 ℃. If the temperature is less than 80 ° C, the steaming process does not work properly, and if the temperature exceeds 120 ° C, the ingredients contained in the herbal medicine are destroyed, and there is a concern that the content of harmful ingredients to the human body such as benzopyrene may increase.

On the other hand, after the steaming is completed, aging of the steamed Rehmannia Root may be performed. After the steaming is completed, the aging may be performed in a pressure vessel in which the steaming is performed, and at this time, the temperature switch of the pressure vessel may be turned off and the residual heat in the pressure vessel may be used for 3 to 5 hours. At this time, it is more preferable to age by adjusting the relative humidity in the pressure vessel to be 20% or less during aging, and through this, indigestible polysaccharides that may cause indigestion, such as stachyose and / or raffino Oz content can be greatly reduced. If the relative humidity in the pressurizer is adjusted to exceed 20% during aging, the decomposition of indigestible polysaccharides is insignificant, and reducing sugars such as sucrose and galactose, which increase active ingredients and sweetness, are reduced by high humidity conditions during aging. There is a risk of loss to the outside of the powder.

After steaming (including aging) is completed, it is dried in powder form.

Figure 6 (a) is a diagram showing that the main needle is put into a pressure machine and steamed, (b) is a diagram showing that the steamed rehmannia is dried.

Steaming may be carried out in a cylindrical vessel made of stainless steel.

In the conventional method, it takes a lot of time to steam because the spiced dry yellow is in the form of a lump, but in the present invention, since it is in the form of powder, the steaming time is shortened.

In addition to shortening the steaming time, the steaming effect is also high, so the number of times of steaming can be reduced. For example, sukjihwang, which requires steaming five times in the conventional method, can obtain the same effect if it is steamed three times in the present invention.

In the method of manufacturing sukjihwang, the steps of cooking, steaming, and drying are repeated. Repeat 3 times in case of symptom 3, and repeat 9 times in case of symptom 9. The more times the steaming and drying process is repeated, the higher the quality of the Sujih Rehmannia Root is evaluated.

In the conventional method, after steaming and drying, it remains in the form of lump-shaped sukjihwang. However, in the present invention, after the steaming and drying process, it remains in the form of crushed sukjihwang. In this way, the Sukkot Rehmannia Root of the present invention can be used accurately and conveniently in the required amount when used in herbal medicines and foods by obtaining powdered Sukkot Rehmannia Root, unlike conventional lump-shaped Sukkot Rehmannia Root.

5. A lump form manufacturing step (S600);

Lump type drying step (S700);

In addition, in the present invention, the main preparation, steaming, and drying are repeated, but in the last round, the powder drying step (S500) may be performed, and the lump manufacturing step and the lump drying step may be performed. That is, in the case of 3 proofs, the first time is the main needle, steaming, and powder form drying step, the second time is the main needle, steaming, and powder form drying step, and the third time (i.e., the last time) is main needle, steaming, and size After going through the conditioning step, it is dried.

Referring to FIG. 1, in the case of three symptoms, the steps S100 -> S200 -> S300 -> S400 -> S500 -> S300 -> S400 -> S500 -> S300 -> S400 -> S600 -> S700 are executed. do. That is, in the last time (third time), it can be dried through the lump form manufacturing step (S600).

In the case of five symptoms, S100 -> S200 -> S300 -> S400 -> S500 -> S300 -> S400 -> S500 -> S300 -> S400 -> S500 -> S300 -> S400 -> S500 -> S300 -> Steps S400 -> S600 -> S700 are executed. That is, in the last time (the fifth time), drying may be performed through the lump form manufacturing step (S600).

In the conventional manufacturing method, Rehmannia glutinosa was used as herbal medicine or food directly in a state where it was not crushed, steamed, and dried, but in the present invention, it was steamed in a state where it was crushed. You can resize it to the shape you want. In addition, by properly adjusting the particle size of the powder during crushing, the loss of active ingredients and sweetness ingredients originally contained in Rehmannia Root due to the main needle is minimized, so that it has high active ingredients, has no pungent taste, and improves the sensory sensation due to sweetness. You can get a sukjihwang.

Figure 7 (a), (b) is a diagram showing how to make a model of an appropriate thickness of the steamed Rehmannia tuber in powder form, which is a similar process to pulling bar rice cake at a rice cake shop. When 7 (b) is completed, cut into appropriate sizes (not shown) and dry.

In the above process, the size of Rehmannia Root is suitable for a diameter of 10 to 15 mm and a length of 10 to 20 cm, preferably a size of 10 to 15 mm in diameter and 10 to 15 cm in length.

In this way, in the conventional method, the size of the sukjihwang is fixed and cannot be used in various ways, but the sukjihwang according to the present invention can be produced by adjusting the size to suit the purpose.

Figure 8 is a diagram showing the finished sukjihwang through the lump shape manufacturing step (S600); and the lump shape drying step (S700).

[Example 2] Method for producing sukjihwang by crushing geonhwang

Example 2 is a method for producing sukjihwang by crushing geonhwangji instead of crushing saenghwangji, that is, the case in which the order of S100 and S200 in Example 1 is reversed, and the specific method according to each step is the same as in Example 1 Do. On the other hand, in order to reduce the particle size of the crushed powder obtained during crushing in the crushing step or to facilitate crushing, lyophilization, for example, freeze-drying at a temperature condition of -40 ° C or less, more preferably - 60 ° C or less, crushing There are cases, but in this case, it is undesirable because the active ingredients in Rehmannia glutinosa can be destroyed through the freeze-drying process. Therefore, the crushing process is carried out at a temperature of -20 ° C or higher even during freeze-drying, or at room temperature, for example, 20 ~ 25 ° C. It is desirable to do

In Example 2, first, the harvested raw material of Rehmannia Root is washed about three times. And remove moisture from the surface. Then, as shown in FIG. 2, the following steps are sequentially performed.

1. Step of drying saengjihwang (T100);

2. Crushing dried dry sulfur (T200);

3. Acupuncture (T300);

4. Steaming (T400);

5. Drying in powder form (T500);

6. Steps T300 to T500 are repeated at least once to complete the preparation of sukjihwang, or steps T300 to T500 are repeated at least once, but step T500 is not performed at the last time, and lump form manufacturing step (T600); Drying in the form of lumps (T700); to complete the preparation of sukjihwang.

[Sukjihwang Efficacy Index Substance]

The indicators showing the efficacy of Sukjihwang are as follows.

1. 5-HMF (5-hydroxymethyl-2-furaldehyde: C ₆ H ₆ O ₃ )

5-HMF (5-hydroxymethyl-2-furaldehyde) is an indicator substance for the efficacy of Sukjihwang used in Korea. During the steaming process of rehmannia glutinosa, polysaccharide, the main component of rehmannia glutinosa, is decomposed, increasing the concentration of monosaccharides and generating 5-HMF (5-hydroxymethyl-2-furaldehyde), a degradation product. It is used as an indicator material to evaluate quality. 5-HMF is also used as an indicator substance when evaluating the quality of sukjihwang, and the higher the content of 5-HMF, the higher the quality of sukjihwang.

In the manufacturing process of rehmannia glutinosa as a medicinal material, repeated steaming and subsequent drying process reduce the concentration of stachyose present in dried rehmannia, and the glycoside is completely decomposed or significantly reduced in content. It is known that 5-hydroxymethyl-2-furaldehyde (5-HMF), which is a degradation product, is produced. In the past, catalpol, d-mannitol, and rehmanniosides a-d were mainly used as indicators for quality control of rehmannia glutinosa. There are problems such as decomposition during the heat treatment process during the manufacturing process of Rehmannia Root. Recently, an analysis method for quality control of Rehmannia Root using 5-HMF, which is a unique component that exists only in the cooking process and is produced as a breakdown product of monosaccharide during the steaming process, has been reported. . In this regard, the Korean Pharmacopoeia issued by the Food and Drug Administration stipulates that rehmannia glutinosa contains 0.1% or more of 5-HMF as an index substance.

The following test report was obtained by requesting the Applicant to the Oriental Medicine Analysis Center of Dongeuihak Co., Ltd., which has been officially approved by the Ministry of Food and Drug Safety. For details, see FIGS. 9 to 11.

* Test item: 5-hydroxymethyl-2furaldehyde

* Test standard: 0.1% or more

* Inspection completion date: 2022.02.10

The above test report is summarized in the following table.

do (a) (b) (c) test subject (A) Company - Conventional method Invention (certificate 3) Invention (Certificate 4) shame 0.1% 0.2% 0.2%

Even if the conventional method passes the test standard (0.1%), it is generally about 0.12%. However, as shown in the test report above, the sokjihwang according to the present invention (cases 3 and 4) was found to contain 0.2% or more of 5-HMF, which is much higher than 0.12%.

2. Acteoside (C ₂₉ H ₃₆ O ₁₅ )

Actioside is an indicator substance used in China, and the Chinese Pharmacopoeia is based on the content of 0.02% or more. Actioside is a non-toxic natural extract that can strongly scavenge reactive oxygen species. In particular, Rehmannia glutinosa extract exhibits not only strong antioxidant power, but also immune activity, UV absorption, collagenase activity inhibitory effect, and melanin production inhibitory effect, so it can be used for preventing and treating various diseases mediated by reactive oxygen species, as well as skin It can also be usefully used as a cosmetic raw material for anti-aging, anti-wrinkle, anti-UV skin damage.

As a result of the experiment, Sukjihwang according to the present invention contained 0.02% or more of actioside.

3. Catalpinoside (C ₁₅ H ₂₂ O ₁₀ )

Catalpinoside is an indicator substance used in China, and the Chinese Pharmacopoeia is based on its content of 0.2% or more. Catalpinoside is an iridoid glucoside widely distributed in many plant families, mainly obtained from the root of Rehmannia Root. Catalpinoside has antidiabetic, cardiovascular, neuroprotective, anticancer, hepatoprotective, anti-inflammatory, and antioxidant activities in experimental studies.

Sukjihwang according to the present invention contains 0.2% or more of catalpinoside as a result of experiments.

<Example 3>

After washing the commercially-purchased saengrehwang, the water on the outside was completely removed, and a step of crushing to a size of 1.5 mm or less was performed. Thereafter, the crushed raw Rehmannia glutinosa powder was dried using a hot air dryer at a temperature of 50 ° C to obtain dried Rehmannia glutinosa powder. Then, the dried Rehmannia glutinosa powder was put back into the crusher, and the ratio of powder with a particle size of 710 to 1000㎛ among the dried powder was adjusted to be as high as possible. Thereafter, dried Rehmannia glutinosa powder was put into an electric sieving tester equipped with standard sieve designation numbers 18, 20, and 25 to obtain dried Rehmannia glutinosa powder having a particle size distribution consisting of particles having a particle size of 710 to 1000 μm.

Thereafter, the main soaking step is performed in which the dried Rehmannia glutinosa powder whose particle size is adjusted is impregnated in Hwangju at a temperature of 5℃ for 5 hours, and then it is put into a pressure machine commonly used for steaming Rehmannia glutinosa at a temperature of 95℃ and a relative humidity of 85RH%. It was first steamed for an hour, and aged for 4 hours using internal residual heat with the temperature switch of the compressor turned off. Afterwards, the primary steaming-aged powder was dried using a 50° C. hot air dryer.

Thereafter, the dried primary steaming-aged powder was again subjected to the main needle step under the same conditions, followed by secondary steaming under the same conditions as the primary steaming, and aging and drying under the same conditions to obtain secondary steaming-aged powder. . This process was repeated twice more to obtain 4-strength sukjihwang powder shown in Table 2 below.

<Examples 4 to 6>

It was prepared in the same manner as in Example 3, but the fine powder (particle diameter less than 710 μm) that passed through the standard sieve after classification through the electric sieve tester was again put into the electric sieve tester equipped with standard sieve designation numbers 14, 16, 30, and 45 After obtaining a fine powder having a particle size of 355 to 600 μm and a coarse powder having a particle size of 1180 to 1400 μm, the particle size of Example 3 was adjusted so that the fine powder was 14% by weight and 25% by weight, respectively, of the total weight of the dried Rehmannia glutinosa powder. It was mixed with dried Rehmannia glutinosa powder or the obtained crude powder was subjected to the same main needle and steaming process to obtain 4-strength Rehmannia glutinosa powder as shown in Table 2 below.

<Examples 7 to 8>

It was carried out in the same manner as in Example 3, but the temperature conditions during main needles or the relative humidity during aging after steaming were changed as shown in Table 2 below to obtain 4-strength Suk Rehmannia powder as shown in Table 2 below.

<Example 9>

It was carried out in the same manner as in Example 3, but the aging step after steaming was omitted and main needles and steaming were repeated to obtain 4-strength sukjihwang powder as shown in Table 2 below.

<Experimental example>

The following physical properties were evaluated for the sukjihwang according to Examples 3 to 9, and the results are shown in Table 2 below.

1. Component Analysis

The contents of actioside and catalpinoside as active ingredients, reducing sugar that enhances sweetness, and raffinose, which is an indigestible polysaccharide, were evaluated by the following evaluation methods. The content obtained as a result of the evaluation was calculated as the content (mg / g) based on the weight of added sukjihwang, and the result values of Examples 4 to 9 were calculated as relative percentages based on the result values of Example 3 based on 100. converted into

* Actioside

About 10 g of Suk Rehmannia Root powder sample was put into a concentration flask, ethanol was added to make 100 ml, and then filtered with 0.45 μm Millipore filter paper, and this was repeated 5 times, and the extracted sample was analyzed by HPLC. At this time, the analysis conditions were a detector using a differential refractometer, a column mBondapak C18 (3.9 mm × 30 cm), a column temperature of 40 ° C, and a mixed solution of acetonitrile and 0.1% trifluoracetic acid aqueous solution at a weight ratio of 20:80 as the mobile phase. was used and analyzed at a flow rate of 1.0 ml/min, a column temperature of 30 °C, and a detection wavelength of 332.6 nm. The measured amount of actioside obtained a result value (mg / g) based on the weight of the added sukjihwang.

* Catalpinoside

After putting about 10 g of Sukjihwang powder sample into a concentration flask, 200 mL of distilled water was added, ultrasonic extraction was performed for 1 hour, and the supernatant was centrifuged at 13,500 rpm for 10 minutes, and the supernatant was filtered through a 0.45 μm syringe filter and used as a test sample. The analysis was performed using HPLC, and the analysis conditions were analyzed using a YMC-pack ODS-AM (250 × 4.6 mm, 5 μm, YMC Co. Ltd., Kyoto, Japan) column. The detector used an ultraviolet diode array detector (UV-DAD), the detection wavelength was set to 210 nm, the column temperature was 30 °C, and the injection amount was set to 10 μL. The mobile phase conditions were set to ACN:H2O:HCOOH (3:97:0.1) isocratic conditions at a flow rate of 1 mL/min.

* Reducing sugar content

The contents of sucrose, fructose, and galactose were measured according to the Qualitative and Quantitative Methods of Sugars in the Korean Food Codex. Specifically, after putting about 10 g of Suk Rehmannia powder sample into a concentration flask, distilled water was added to make 100 ml, and then the sample solution was filtered with 0.45 μm Millipore filter paper and analyzed by HPLC. At this time, as for the analysis conditions, a differential refractometer was used as a detector, Zobrax NH2 (4.6 mm × 25 cm) as a column, a column temperature of 40 ° C, a mixed solution of water and acetonitrile in a weight ratio of 25:75 was used as the mobile phase, and the flow rate was Analyzed at 1.0 ml/min. The measured input sucrose, fructose, and galactose contents were all added to obtain a resultant value (mg / g) based on the weight of the added sucrose.

2. Sensory evaluation

Sensory evaluation was conducted for taste and digestibility.

First, in relation to the taste, three experts took the extract of the Sujih Rehmannia powder extracted under the same conditions using hot water at 80 ° C as the extraction solvent for the Sujih Rehmannia powder, and comprehensively examined the overall taste such as flavor, sweetness, and bitter taste. , were rated as moderate and poor.

Next, with respect to digestibility, a total of 20 people, 10 adult men and women each, bloated after consuming the same amount of extract of Rehmannia glutinosa powder and 80 ℃ hot water as an extraction solvent once a day for 5 days, Gas generation and diarrhea are comprehensively reviewed, 5 points good, 3 points average, 2 points uncomfortable, 1 point very uncomfortable, and the average is calculated by adding the results, and when the average value exceeds 4 points, it is good, More than 3 points to less than 4 points were marked as moderate, more than 2 points and less than 3 points as uncomfortable, and less than 2 points as very uncomfortable.

Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Dried Rehmannia glutinosa powder particle size (㎛) /
Corresponding particle size powder ratio (% by weight) 710 to 1000
/100 710 to 1000
/86 710 to 1000
/75 1180 to 1400
/100 710 to 1000
/100 710 to 1000
/100 710 to 1000
/100 Temperature at main hand (℃) 5 5 5 5 13 5 5 Aging after steaming / Relative humidity (%) ○/
10-20% ○/
10-20% ○/
10-20% ○/
10-20% ○/
10-20% ○/
30-40% Not done/- Actioside (%) 100 89.4 74.1 102.2 70.5 89 100.2 Catalpinoside (%) 100 95 86.5 100 85.4 98.4 100 Reducing sugar content (%) 100 94.5 84.7 101.6 86.5 87.3 109.6 sensory evaluation taste Great Great Good Great Good Good Great digestion Good Good Good Inconvenience Good Inconvenience very uncomfortable

As can be seen from Table 2,

In the case of Examples 3 to 4 in which the particle size of the dried Rehmannia glutinosa powder was appropriately adjusted, the loss of the content of active ingredients, especially actioside, was greatly prevented compared to Example 5, and the digestion was good compared to Example 6, making it indigestible. It can be seen that the polysaccharide was well digested.

In addition, in the case of Example 7, which was performed at a temperature higher than the preferred range according to the present invention at 13 ° C. during the main needle, it can be seen that the loss of active ingredients is greater than that of Example 1, and the sweetness is also reduced.

In addition, in the case of Example 8, in which the humidity condition during aging was more than 20% relative humidity, the loss of active ingredients increased compared to Example 1, and it could be seen that the digestibility was not good.

In addition, in the case of Example 9 in which aging itself was not performed, it was found to be very inconvenient due to poor digestion.

[Other effects]

As mentioned above, the sukjihwang prepared according to the present invention has various advantages for each step of the manufacturing method, and has the following additional advantages.

As mentioned above, sukjihwang has various effects, but sukjihwang is oily, so it can cause indigestion or diarrhea in people with poor digestive health. However, the sukjihwang according to the present invention does not cause indigestion or diarrhea by injecting saengjihwang in the form of crushed door powder.

In addition, it is easy to extract when extracting using the completed sukjihwang. For example, using 1 kg of Rehmannia Root, 500 g is obtained when extracted with water in the conventional method, and 750 g is obtained when using alcohol. When used, it is possible to obtain an extract close to 1 kg. In this way, extraction is not only easy, but also 30% or more of the extract can be obtained compared to conventional methods.

The method for manufacturing sukjihwang according to the present invention described above is not limited to the above embodiment, and anyone having ordinary knowledge in the field to which the present invention belongs without departing from the gist of the present invention claimed in the claims below There is a technical spirit to the extent that it can be implemented with various changes.

Claims (11)

Crushing saenghwangji so that the powder having a particle size of 710 to 1000 μm based on the dried powder is 85% by weight or more of the total dried powder;
Drying the crushed Saeng Rehmannia Root;
Steeping dried dry sulfur at a temperature of 4 to 8 ° C. for 4 to 6 hours;
At a temperature of 80 to 120 ° C., steaming for 2 to 4 hours and then aging for 3 to 5 hours at a relative humidity of 10 to 20% for the steamed Rehmannia glutinosa; and
Steamed-ripened Rehmannia glutinosa; manufacturing method characterized in that it comprises a. Drying saengjihwang;
crushing the dried dry sulfur powder so that the powder having a particle size of 710 to 1000 μm is 85% by weight or more of the total dried powder;
Steeping the crushed dry sulfur at a temperature of 4 to 8 ° C. for 4 to 6 hours;
At a temperature of 80 to 120 ° C., steaming for 2 to 4 hours and then aging for 3 to 5 hours at a relative humidity of 10 to 20% for the steamed Rehmannia glutinosa; and
Steamed-ripened Rehmannia glutinosa; manufacturing method characterized in that it comprises a. delete delete delete delete delete According to claim 1 or 2,
Sookjihwang is 5-hydroxymethyl-2-furaldehyde (5-hydroxymethyl-2-furaldehyde,
5-HMF) manufacturing method characterized in that it contains 0.15% or more. According to claim 1 or 2,
By repeating the step of brewing, the step of aging after steaming, and the step of drying at least once to complete the preparation of sukjihwang in powder form,
It is repeated at least once, but the drying step at the last time is performed by preparing the steamed-aged Rehmannia glutinosa in the form of a lump and then drying the lump form to produce a lump form of Rehmannia glutinosa. delete According to claim 9,
The method of manufacturing the steamed-aged Rehmannia glutinosa in a lump form is to make the steamed-aged Rehmannia glutinosa into a size of 10 to 20 cm in length.

Images