KR20000061215A - The Manufacturing Method of the Steamed Rehmannia Root increasing the Indicator Ingredient - Google Patents

Abstract

PURPOSE: A process for preparing Rehmanniae Radix Preparata with index components of over 0.5% is provided, which is inhibited in a side effect and has high index component content. CONSTITUTION: The process for preparing Rehmanniae Radix Preparata comprises the steps of: (1) drying Rehmanniae Radix and soaking it in a medicinal wine, which contains living yeast; (2) steaming at a temperature of 100±2°C with 320-450g/cm¬2 pressure for 7-10 hours; (3) drying at a temperature of 50-55°C for 1 hour and at 55-60°C for over 2 hours; (4) repeating 5 times of steaming and drying process; (5) after fifth steaming process, drying at a temperature of 52-58°C for 2-3 hours, at 58-63°C for 2-3 hours and at 65-75°C for 10 hours and drying and aging in wind for 3-4 hours; and (6) repeating (5) process 2-3 times.

Description

The manufacturing method of the Steamed Rehmannia Root increasing the Indicator Ingredient}

The present invention relates to a method for producing sulfur, and more particularly, to a method for producing sulfur with significantly increased content of the indicator component.

Sukjihwang is manufactured by drying and steaming the roots of the yellow, that is, the live, and because it has a blood-reducing effect, it is prescribed for the treatment of anemia, menstrual irregularities, and other bleeding syndromes due to blood loss. It is prescribed when the body is weak or anxious because of its efficacy.

In the conventional method of manufacturing the sulfur, the dried sulfur, which is dried to produce the sulfur, then put the dried sulfur in a common container, such as a cauldron, marinated with makgeolli or other spirits, and steamed and dried 1 to 3 times will be.

The makgeolli, such as makgeolli, serves to remove the harmful ingredients contained in the ripened sulfur, which does not penetrate deep into the meat when the alcohol is poured into a container and is steamed once or three times. There was this impossible problem.

The reason is that there is a serious variation in the concentration and temperature of the liquor during steaming, and for this reason, there is a lack of removal of harmful components, and there was a problem of decaying during the long-term storage of Sukji sulfur.

Existing Sukjihwang prepared by the above method is weak in stomach and poorly digested, so people without appetite, bloated stomach and constipation, and those who have a lot of gas or phlegm due to inadequate airway There is a problem that can not be, and also can cause diarrhea or abdominal pain, there is a problem that the prescription is limited.

As a technique for solving such a problem, Korean Patent Application No. 96-35980 may be mentioned. In order to solve the above problems, this technique uses yakju as a spirit, sprays alcohol to dry liquor every hour after steaming, and dries dry steam after drying. It consists of 9 repetitions. At this time, the internal temperature of the steamer is maintained at 100 ° C., the pressure is 400 to 500 g / cm 2, and the steaming time is at least 4 hours in the first stage and about 3 hours in the second to ninth stages.

Sulfur sulfur obtained by the above method has a content of 5-hydroxymethyl-2-furaldehyde (5-Hydroxymethyl-2-furaldehyde), which is 0.2 to 0.3%, exceeding 0.1% of the content standard of the Ministry of Health and Welfare. Compared with ripening sulfur obtained by the method, side effects are suppressed and the content of the indicator component is high.

However, this method has to repeat the process of immersion, steaming, drying for 9 times, there is a problem that the manufacturing cost increases and the content of the indicator component is also insufficient.

In order for Sukji sulfur to have sufficient effect, the content of indicator substance should be more than 0.5%.

The present invention is to solve the problems as described above, it is an object of the present invention to provide a method for producing the sulfur of the ripened sulfur.

It is still another object of the present invention to provide sucrose which contains a high indicator component, the content of which is at least 0.5%.

In the present invention, dried raw sulfur is dried to make dried sulfur, dried by steaming and recovering with steaming steam in steamer, and then dried to produce the sulfur of sulfur, in the manufacturing of the sterilized sulfur, using the alcohol not sterilized as a medicine, internal steam temperature Is maintained at 100 ± 2 ℃, steaming pressure is maintained at 320 ~ 450g / ㎠, steaming once with a steaming time of 7 to 10 hours, and then dried five times.

Hereinafter, the present invention will be described in detail.

Medicinal herbs used in the needle are not sterilized and must use yeast. Commercially available herbal medicines are sterilized and sterilized and yeast is dead. The alcohol content of the chemicals used is about 8-10%. The needle immersion method is to immerse for 40 to 50 hours at 35 to 40 ° C.

After steaming, steaming process is carried out. The temperature of steaming machine should be maintained at 100 ± 2 ℃ and the internal pressure is 320 ~ 450g / ㎠. If the temperature deviation and the pressure range is out of the above range, the content of the indicator component is lowered.

One steaming time ranges from 7 to 10 hours, and if it is below this range, the content of indicator component is insufficient, and even if it exceeds this range, the content of indicator component no longer increases.

After the steaming is completed, the drying process is carried out. The drying process is to put the raw materials in a drying container and put in a dryer. The drying temperature is dried at 50 to 55 ° C. for about 1 hour and at 55 to 60 ° C. for 2 hours or more.

The content of the indicator material of the ripened sulfur obtained by repeating this process five times is 0.6-0.8%, and even if it is repeated further, there is no increase in the content of the indicator component.

The raw material after the fifth steam has been commercialized through the following drying process.

After first drying at 52-58 ° C. for 2-3 hours, the temperature is increased to 2 to 3 hours at 58 to 63 ° C., and the temperature is increased again to dry at 65 to 75 ° C. for 10 hours. After that, turn off the dryer and let it dry for 3 to 4 hours using natural wind.

This final drying process is repeated three to four times. After the final drying process, the product is solid and black liquid does not get on the hands.

Embodiments of the present invention are as follows.

In the examples below, 5-hydroxymethyl-2-furaldehyde sigma (5-Hydroxymethyl-2-furaldehyde (sigma # H9877)) was used as an indicator, and the instruments and reagents used were as follows.

Rotary vacuum evaporator: Rotarvapor R110 (Buchi)

Water bath (Buchi)

Seperating funnel

Condensor

HPLC system: YOUNG-LIN HPLC 9600 System

M930 Solvent Delivery Pump

M720 UV-VIS Absorbance Detector

Autochro-WIN Data System

* For reagents and solvents, use a special or first class reagent. For solvents for HPLC, use HPLC grade.

* HPLC conditions

a) Detector: UV 280nm

b) Column: TSKgel ODS-120T (4.6mm × 15cm)

c) Column temperature: 25 ℃

d) Solvent: (water: acetonitrile = 95: 5)

e) Flow rate: 1ml / min

f) injection volume: 10㎛

g) The test was repeated three times for each sample under the above conditions, and the peak area was measured by HPLC three times for the same sample.

<Example>

The dried Guangjihwang, which had not been sterilized, was removed by putting dried guanyin into a steamer at 38 ° C for 48 hours, and then steamed for 8 hours in a steamer maintained at 100 ± 2 ° C and a pressure of 350g / cm 2. The raw material, once steamed, was placed in a drying container, put in a dryer, and dried at 52 ° C. for 1 hour and 58 ° C. for 3 hours.

This process was repeated five times, but the final drying process was first dried for 2 hours at 55 ℃, the temperature was increased to 2 hours at 60 ℃, and again the temperature was dried for 10 hours at 70 ℃.

After that, the dryer was turned off and aged for 4 hours using natural wind. After the final drying process, the product was solid and black liquid did not come out of the hand.

The content of the indicator substance in the obtained product was 0.667%.

<Comparative Example>

Samples in 6 to 15 were prepared according to the method described in Korean Patent Application No. 96-35980. The internal steam temperature was around 100 ℃, the pressure was 450g / ㎠ and the samples were steamed for 5 hours for the first steaming time and 3 hours for 2 to 15 hours. In 24 hours and in 2nd to 15th periods, they were rested for 3 hours.

Changes in the indicator substance content of the obtained product were shown in Table 1 below.

division content (%) 6 0.368 7 0.384 8 0.391 9 0.396 10 0.404 11 signs 0.387 12 0.373 13 0.381 14 0.377 15 0.380

As can be seen through the above embodiment, not only the manufacturing process is shortened by the present invention, but also sucrose sulfur having a high content of the indicator component can be obtained.

In addition, the side effects are suppressed even in the weak spleen can be prescribed.

Claims (3)

After making raw sulfur by drying, make dried sulfur by distillation, distilled with medicine, steamed in steamer, and dried, and then prepared by using dried alcohol by using alcohol which has not been sterilized by alcohol. Maintaining 2 ℃, steaming pressure is maintained at 320 ~ 450g / ㎠, steaming once for 7 to 10 hours steaming, and then dried at a temperature of 50 ~ 75 ℃ 5 times A method for producing Sukji sulfur with an increase in the content of the indicator component. The method of claim 1, wherein the main immersion method is immersed for 40 to 50 hours at a temperature of 35 to 40 ℃, the production method of sukji sulfur with increased content of the indicator component. According to claim 1, The alcohol content of Yakju used is 8 to 10%, the method of producing the sulfur content of the increased content of the indicator component.