KR102489107B1 - Composition for preventing alopecia and activating growth of hair comprising distilled extract of rare earth complexbiomineral - Google Patents

Abstract

The present invention provides a composition for preventing hair loss and stimulating hair growth containing distilled extracts of rare earth composite bio-minerals as an active ingredient, and the composition of the present invention shortens the cycle of transition from the telogen phase to the anagen phase of the hair growth cycle to create new hair. This fast-growing effect is excellent.

Description

Composition for preventing hair loss and promoting hair growth containing distilled extracts of rare earth composite bio-minerals as an active ingredient

The present invention relates to a composition for preventing hair loss and promoting hair growth, and more specifically, as an active ingredient, a rare earth composite bio-mineral material having an excellent effect of rapidly growing new hair by shortening a cycle transitioning from a resting phase to a growing phase among hair growth cycles. It relates to a hair loss prevention and hair growth promoter composition containing a distillation extract as an active ingredient.

There are about 100,000 to 150,000 hairs in the human body, and each hair has a different cycle and grows and falls out through anagen, catagen, and telogen. This cycle is repeated over 3-6 years, and as a result, an average of 50 to 100 hairs per day are normally lost. In general, alopecia refers to an increase in the number of hairs that fall out abnormally because the hair ratio in the growth phase is shortened and the hair in the catagen or telogen phase increases during this cycle.

As the cause of hair loss, excessive secretion of male hormones, seborrheic scalp, stress, obesity, deterioration of scalp function due to peroxides, bacteria, etc. have been discussed. However, no clear cause of hair loss has been identified so far, and in recent years, the number of people suffering from hair loss is increasing due to changes in diet, increased stress caused by social environments, etc., and the age is also decreasing, and the female hair loss population is also on the rise.

From recent studies, attention has been paid to dihydrotestosterone, a reduced form of androgen, a male hormone, as a major factor in hair loss. Testosterone, a male hormone, is converted into dihydrotestosterone by the action of 5α-reductase (5α-reductase), and it is known that the activity of 5α-reductase is high in the hair follicles of hair loss patients, thereby causing hair loss.

In order to cure the cause of such hair loss, Merck has developed and marketed finasteride as a drug that inhibits the action of 5α-reductase to suppress the production of dihydrotestosterone, but various side effects have been reported.

The present invention has been proposed to solve the problems of the prior art as described above, and its purpose is to shorten the cycle from the telogen to the anagen phase of the hair growth cycle, so that new hair grows quickly. It is to provide a hair loss prevention and hair growth promoter composition containing a mineral as an active ingredient.

The technical problem of the present invention as described above is achieved by the following means.

(1) An anti-hair loss and hair growth promoter composition containing a distillation extract of a rare earth complex bio-mineral material as an active ingredient.

(2) In the above (1),

The rare earth composite bio-mineral material contains 0.1 to 0.2% by weight of F, 0.1 to 0.2% by weight of Na ₂ O, 0.08 to 0.09% by weight of MgO, 34.0 to 35.0% by weight of Al ₂ O ₃ , 58.0 to 59.0% by weight of SiO ₂ , and P ₂ O ₅ 0.04 ~ 0.05 wt%, SO ₃ 0.01 ~ 0.02 wt%, Cl 0.003 ~ 0.004 wt%, K ₂ O 2.8 ~ 2.9 wt%, CaO 0.008 ~ 0.009 wt%, TiO ₂ 1.5 ~ 1.6 wt%, Cr ₂ O ₃ 0.01 to 0.02 wt%, MnO 0.01 to 0.02 wt%, Fe ₂ O ₃ 1.0 to 2.0 wt%, NiO 0.005 to 0.006 wt%, CuO 0.002 to 0.003 wt%, Ga ₂ O ₅ 0.006 to 0.007 wt%, SrO 0.02 to 0.03 wt%, Y ₂ O ₃ 0.005 to 0.006 wt%, ZrO ₂ 0.02 to 0.03 wt%, BaO 0.05 to 0.06 wt%, ReO ₂ 0.006 to 0.007 wt%, PbO 0.004 to 0.005 wt%, TbO ₂ 0.002 to 0.003 wt% %, Pa 0.02 ~ 0.03% by weight of the hair loss prevention and hair growth promoter composition characterized in that it comprises.

(3) In the above (1), the distillation extract is,

An anti-hair loss and hair growth promoter composition, characterized in that obtained by putting the rare earth composite bio-mineral material together with water in a distiller, heating it at a temperature of 110-130 ° C. for 1-10 hours, and then distilling it.

(4) In the above (1),

The anti-hair loss and hair growth promoter composition, characterized in that it further comprises distilled extracts of houttuynia cordata, arborvitae leaves, hair meal, radishes root bark, ringworm skin, and eggplant together with the distilled extract.

(5) In the above (4),

10 to 70% by weight of the distilled extract, 1 to 20% by weight of Houttuynia cordata, 1 to 20% by weight of green tea leaves, 1 to 20% by weight of bakhwasu leaves, 1 to 20% by weight of Arborvitae leaves, and 1 to 20% by weight of leaflets An anti-hair loss and hair growth promoter composition comprising a skin improvement extract obtained by distillation by adding.

According to the present invention, it was found that the effect of rapidly growing new hair by shortening the cycle of transition from the telogen to the anagen phase among the hair growth cycles was found to be excellent.

The composition for preventing hair loss and promoting hair growth according to the present invention includes a distilled extract of a mineral as an active ingredient.

The mineral of the present invention preferably contains F 0.1 ~ 0.2% by weight, Na ₂ O 0.1 ~ 0.2% by weight, MgO 0.08 ~ 0.09% by weight, Al ₂ O ₃ 34.0 ~ 35.0% by weight, SiO ₂ 58.0 ~ 59.0% by weight, P ₂ O ₅ 0.04 ~ 0.05 wt%, SO ₃ 0.01 ~ 0.02 wt%, Cl 0.003 ~ 0.004 wt%, K ₂ O 2.8 ~ 2.9 wt%, CaO 0.008 ~ 0.009 wt%, TiO ₂ 1.5 ~ 1.6 wt%, Cr ₂ O ₃ 0.01 to 0.02 wt%, MnO 0.01 to 0.02 wt%, Fe ₂ O ₃ 1.0 to 2.0 wt%, NiO 0.005 to 0.006 wt%, CuO 0.002 to 0.003 wt%, Ga ₂ O ₅ 0.006 to 0.007 wt%, SrO 0.02 ~ 0.03 wt%, Y ₂ O ₃ 0.005 ~ 0.006 wt%, ZrO ₂ 0.02 ~ 0.03 wt%, BaO 0.05 ~ 0.06 wt%, ReO ₂ 0.006 ~ 0.007 wt%, PbO 0.004 ~ 0.005 wt%, TbO ₂ 0.002 ~ 0.003% by weight, Pa 0.02 ~ 0.03% by weight.

The mineral of the present invention is more preferably to have a component composition distribution in Table 1 collected from Taebaek Yenang Mine.

ingredient weight% F 0.1358 Na ₂ O 0.1194 MgO 0.0820 Al ₂ O ₃ 34.7739 SiO ₂ 58.5576 P ₂ O ₅ 0.0427 SO ₃ 0.0105 Cl 0.0034 _K2O 2.8695 CaO 0.0080 TiO ₂ 1.5024 Cr ₂ O ₃ 0.0153 MnO 0.0146 Fe ₂ O ₃ 1.7034 NiO 0.0055 CuO 0.0025 Ga ₂ O ₅ 0.0065 SrO 0.0255 Y ₂ O ₃ 0.0053 ZrO ₂ 0.0265 BaO 0.0566 ReO ₂ 0.0065 PbO 0.0040 TbO ₂ 0.0023 Pa 0.0203 total 100

The distillation extract of the mineral according to the present invention is obtained by pulverizing the ore composed of the components in Table 1, then adding water and cooling by distillation. More specifically, it is obtained by putting the mineral material together with water in a distiller, heating it at a temperature of 110 to 130 ° C. for 1 to 10 hours, and then distilling it.

The distillation extract of the mineral according to the present invention (hereinafter referred to as "EF 21") has an excellent effect of rapidly growing new hair by shortening the cycle of transition from the telogen phase to the anagen phase among the hair growth cycles.

The composition according to the present invention, together with 40 to 70% by weight of the EF 21, preferably at least one selected from Houttuynia cordata, green tea leaves, water chestnut leaves, arborvitae leaves, and lobules to prevent hair loss and promote hair growth. 10 to 30% by weight of a species enhancer or extract thereof, more preferably 1 to 20% by weight of Houttuynia cordata, 1 to 20% by weight of green tea leaves, 1 to 20% by weight of Pakhwasu leaves, 1 to 20% by weight of Arborvitae leaves, and 1 to 20% by weight of leaflets is put into a distiller, heated at a temperature of 110 to 130 ° C. for 1 to 10 hours, and contains 0.1 to 99.9% by weight of an extract for preventing hair loss and growing hair containing an enhancer obtained by distillation.

The composition according to the present invention may include commonly used ingredients, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavoring agents, and carriers.

The composition of the present invention can be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, It may be formulated as an oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be formulated into a softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane / May contain a propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butyl glycol oil, fatty acid esters of glycerol, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Star cellulose, aluminum metahydroxide, bentonite, agar or tracanth and the like may be used.

When the formulation of the present invention is a surfactant-containing cleanser, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The composition according to the present invention may include a carrier that can be commonly used in the formulation of the composition in addition to each of the above active ingredients. Examples of such carriers include alcohols, oils, surfactants, fatty acids, silicone oils, humectants, humectants, viscosity modifiers, emulsions, preservatives, stabilizers, sunscreens, coloring agents, fragrances, and the like. The carrier may be included in about 0.5% to about 99.99% by weight, preferably about 80% to about 99.99% by weight, based on the total weight of the composition of the present invention.

In addition, the composition having an anti-hair loss and hair growth effect according to the present invention can be used according to a conventional method of use, and the number of times of use can be varied according to the user's condition or taste.

Hereinafter, the contents of the present invention will be described in more detail by examples. However, it should be noted that these Examples and Experimental Examples are only exemplified for understanding of the present invention and do not limit the scope of the present invention.

[Example] Preparation of extract for hair loss prevention and hair growth

5 kg of mineral powder having the composition of Table 1 was put in a still with 20 liters of water and distilled at 130 ° C. for 5 hours to obtain an extract EF 21.

Then, together with 60% by weight of the EF 21, 20% by weight of Houttuynia cordata, 10% by weight of green tea leaves, 10% by weight of bakhwasu leaves, 5% by weight of Arborvitae leaves, and 5% by weight of leaflets were put into a distiller for 6 hours at a temperature of 130 ° C. heated while distilled to obtain an extract for preventing hair loss and for hair growth according to the present invention.

[Experimental Example] Test for evaluating hair growth phase induction promotion action

For the hair anagen induction promoting effect experiment, 7-week-old mice (C57BL/6, female), which are widely used for the evaluation of hair anagen induction, were used. First, the hair on the back of the mouse was removed using an electric shaver, and each mouse was weighed and divided into 10 mice so that the weight was evenly distributed. Excipients, control agents, and extracts of the examples of the present invention were applied to the hair removal site. At this time, 95% ethanol was used as the vehicle, 2% minoxidil was used as the control agent, and the extracts of the examples were diluted with 95% ethanol as the test agent. It was prepared and used at a final concentration of 0.5%. It was sufficiently applied with a brush once a day to the back of each mouse.

In order to determine the overall treatment effect, hair growth and hair growth 20 days after the start of the experiment were compared with those before administration and classified into 4 stages: very good (++), good (+), little good (±), and no response (-). judged.

Results of evaluation of hair growth phase induction promotion action sample number of horses ++ + ± - excipient - - 2 8 reference drug One 2 3 4 Example 3 3 2 2

As shown in Table 2, it can be seen that the mouse applied with the extract of the present invention example rapidly grew hair in the hair removal area.

Claims (5)

F 0.1 ~ 0.2 wt%, Na ₂ O 0.1 ~ 0.2 wt%, MgO 0.08 ~ 0.09 wt%, Al ₂ O ₃ 34.0 ~ 35.0 wt%, SiO ₂ 58.0 ~ 59.0 wt%, P ₂ O ₅ 0.04 ~ 0.05 wt% , SO ₃ 0.01 ~ 0.02 wt%, Cl 0.003 ~ 0.004 wt%, K ₂ O 2.8 ~ 2.9 wt%, CaO 0.008 ~ 0.009 wt%, TiO ₂ 1.5 ~ 1.6 wt%, Cr ₂ O ₃ 0.01 ~ 0.02 wt%, MnO 0.01 to 0.02% by weight, Fe ₂ O ₃ 1.0 to 2.0% by weight, NiO 0.005 to 0.006% by weight, CuO 0.002 to 0.003% by weight, Ga ₂ O ₅ 0.006 to 0.007% by weight, SrO 0.02 to 0.03% by weight, Y ₂ O ₃ 0.005 ~ 0.006 wt%, ZrO ₂ 0.02 ~ 0.03 wt%, BaO 0.05 ~ 0.06 wt%, ReO ₂ 0.006 ~ 0.007 wt%, PbO 0.004 ~ 0.005 wt%, TbO ₂ 0.002 ~ 0.003 wt%, Pa 0.02 ~ 0.03 Containing a distillation extract of a mineral containing weight% as an active ingredient, the distillation extract,
A cosmetic composition for hair, characterized in that obtained by distilling the mineral material into a distiller with water and heating at a temperature of 110 to 130 ° C. for 1 to 10 hours. delete delete According to claim 1,
A cosmetic composition for hair, characterized in that it further comprises distilled extracts of houttuynia cordata, arborvitae leaves, hair meal, radishes root bark, ringworm skin, and distilled extracts of eggplant together with the distilled extract. According to claim 4,
10 to 70% by weight of the distilled extract, 1 to 20% by weight of Houttuynia cordata, 1 to 20% by weight of green tea leaves, 1 to 20% by weight of bakhwasu leaves, 1 to 20% by weight of Arborvitae leaves, and 1 to 20% by weight of leaflets A cosmetic composition for hair, characterized in that it comprises an extract obtained by injecting and distilling.