KR20220099189A - Composition for preventing alopecia and activating growth of hair comprising distilled extract of rare earth complexbiomineral - Google Patents

Abstract

The present invention provides a composition for preventing hair loss and promoting hair growth containing a distilled extract of rare earth element complex bio-mineral matters as an active ingredient, and the composition of the present invention shortens the cycle of transition from telogen phase to anagen phase of the hair growth cycle, thereby having an excellent effect of allowing new hair grow faster.

Description

A composition for preventing hair loss and promoting hair growth comprising a distillate extract of rare earth complex bio-mineral as an active ingredient

The present invention relates to a hair loss prevention and hair growth promoter composition, and more specifically, as an active ingredient, a rare earth complex bio-mineral excellent in the effect of shortening the transition from the resting to the growing phase among the hair growth cycle, thereby making new hair grow faster. It relates to a hair loss prevention and hair growth promoter composition containing a distillate extract as an active ingredient.

There are about 100,000 to 150,000 hairs in the human body, and each hair has a different cycle and grows and falls out through anagen, catagen, and telogen. This cycle is repeated over 3-6 years, resulting in an average of 50 to 100 hairs falling out normally per day. In general, alopecia refers to an increase in the number of abnormal hair loss due to the shortening of the proportion of hair in the growth phase and more hair in the degenerative phase or telogen phase among these cycles.

Causes of hair loss include excessive secretion of male hormones, seborrheic scalp, stress, obesity, peroxide, and decreased scalp function due to bacteria, etc. have been discussed. However, the clear cause of hair loss is not known so far, and in recent years, the number of people suffering from hair loss due to changes in diet and increase in stress caused by social environment, etc., is increasing, and the age is also decreasing, and the hair loss population of women is also increasing.

From recent studies, dihydrotestosterone, a reduced form of androgens, a male hormone, is attracting attention as a major factor in hair loss. Testosterone, a male hormone, is converted to dihydrotestosterone by the action of 5α-reductase (5α-reductase).

In order to cure such a cause of hair loss, Merck Corporation has developed and marketed finasteride as a drug for inhibiting the production of dihydrotestosterone by inhibiting the action of 5α-reductase, but various side effects have been reported.

The present invention has been proposed to solve the problems of the prior art as described above, and the purpose of the present invention is to shorten the transition period from the resting period to the anagen phase among the hair growth cycle, thereby providing an excellent effect of rapidly growing new hair. It is to provide a composition for preventing hair loss and promoting hair growth containing a mineral as an active ingredient.

The technical problem of the present invention as described above is achieved by the following means.

(1) A composition for preventing hair loss and promoting hair growth containing a distillate extract of rare earth complex bio-mineral as an active ingredient.

(2) in (1) above,

The rare earth composite bio-mineral material is F 0.1 to 0.2 wt%, Na ₂ O 0.1 to 0.2 wt%, MgO 0.08 to 0.09 wt%, Al ₂ O ₃ 34.0 to 35.0 wt%, SiO ₂ 58.0 to 59.0 wt%, P ₂ O ₅ 0.04~0.05 wt%, SO ₃ 0.01~0.02 wt%, Cl 0.003~0.004 wt%, K ₂ O 2.8~2.9 wt%, CaO 0.008~0.009 wt%, TiO ₂ 1.5~1.6 wt%, Cr ₂ O ₃ 0.01 to 0.02 wt%, MnO 0.01 to 0.02 wt%, Fe ₂ O ₃ 1.0 to 2.0 wt%, NiO 0.005 to 0.006 wt%, CuO 0.002 to 0.003 wt%, Ga ₂ O ₅ 0.006 to 0.007 wt%, SrO 0.02 to 0.03 wt%, Y ₂ O ₃ 0.005 to 0.006 wt%, ZrO ₂ 0.02 to 0.03 wt%, BaO 0.05 to 0.06 wt%, ReO ₂ 0.006 to 0.007 wt%, PbO 0.004 to 0.005 wt%, TbO ₂ 0.002 to 0.003 wt% %, Pa 0.02 to 0.03% by weight of hair loss prevention and hair growth promoter composition, characterized in that it comprises.

(3) In the above (1), the distillate extract,

The composition for preventing hair loss and promoting hair growth, characterized in that it is obtained by distilling the rare earth complex biomineral material together with water in a distiller, heating it at a temperature of 110 to 130° C. for 1 to 10 hours, and then distilling.

(4) in (1) above,

Hair loss prevention and hair growth promoter composition, characterized in that it further comprises a distillate extract of eoseongcho, chrysanthemum leaf, morya powder, eugeunpi, baekseonpi, and lichen together with the distillate extract.

(5) in (4) above,

10 to 70% by weight of the distillation extract, 1 to 20% by weight of Eoseongcho, 1 to 20% by weight of green tea leaves, 1 to 20% by weight of squash leaves, 1 to 20% by weight of arborvitae leaf, and 1 to 20% by weight of leaflets in a distillation A composition for preventing hair loss and promoting hair growth, characterized in that it contains a skin improvement extract obtained by distillation.

According to the present invention, it has been shown that the effect of shortening the transition period from the resting period to the growth period among the hair growth period is excellent, so that new hair grows faster.

The composition for preventing hair loss and promoting hair growth according to the present invention includes a distillate extract of rare earth complex bio-mineral as an active ingredient.

The rare earth composite biomineral of the present invention is preferably F 0.1 to 0.2 wt%, Na ₂ O 0.1 to 0.2 wt%, MgO 0.08 to 0.09 wt%, Al ₂ O ₃ 34.0 to 35.0 wt%, SiO ₂ 58.0 to 59.0 wt%, P ₂ O ₅ 0.04 to 0.05 wt%, SO ₃ 0.01 to 0.02 wt%, Cl 0.003 to 0.004 wt%, K ₂ O 2.8 to 2.9 wt%, CaO 0.008 to 0.009 wt%, TiO ₂ 1.5 to 1.6 wt% %, Cr ₂ O ₃ 0.01~0.02 wt%, MnO 0.01~0.02 wt%, Fe ₂ O ₃ 1.0~2.0 wt%, NiO 0.005~0.006 wt%, CuO 0.002~0.003 wt%, Ga ₂ O ₅ 0.006~0.007 wt%, SrO 0.02~0.03 wt%, Y ₂ O ₃ 0.005~0.006 wt%, ZrO ₂ 0.02~0.03 wt%, BaO 0.05~0.06 wt%, ReO ₂ 0.006~0.007 wt%, PbO 0.004~0.005 wt%, TbO ₂ 0.002 to 0.003% by weight, including 0.02 to 0.03% by weight of Pa.

The rare earth composite bio-mineral material of the present invention more preferably has the composition distribution in Table 1 below taken from the Yenang Mine in Taebaek.

ingredient weight% F 0.1358 Na ₂ O 0.1194 MgO 0.0820 Al ₂ O ₃ 34.7739 SiO ₂ 58.5576 P ₂ O ₅ 0.0427 SO ₃ 0.0105 Cl 0.0034 K ₂ O 2.8695 CaO 0.0080 TiO ₂ 1.5024 Cr ₂ O ₃ 0.0153 MnO 0.0146 Fe ₂ O ₃ 1.7034 NiO 0.0055 CuO 0.0025 Ga ₂ O ₅ 0.0065 SrO 0.0255 Y ₂ O ₃ 0.0053 ZrO ₂ 0.0265 BaO 0.0566 ReO ₂ 0.0065 PbO 0.0040 TbO ₂ 0.0023 Pa 0.0203 total 100

The distillate extract of the rare-earth complex bio-mineral material according to the present invention is obtained by pulverizing the ore composed of the components of Table 1, and then distilling and cooling the ore by adding water. More specifically, it is obtained by putting the rare earth complex biomineral together with water in a distiller and heating it at a temperature of 110 to 130° C. for 1 to 10 hours, followed by distillation.

The distillation extract of the rare earth complex bio-mineral according to the present invention (hereinafter referred to as "EF 21") is excellent in the effect of shortening the transition period from the resting phase to the growth phase among the hair growth cycle, thereby making new hair grow faster.

The composition according to the present invention, together with 40 to 70% by weight of the EF 21, preferably at least 1 selected from eosincho, green tea leaves, chrysanthemum leaves, chrysanthemum leaves, and leaflets in order to prevent hair loss and promote hair growth. Each of the species enhancer or its extract is 10 to 30% by weight, more preferably 1 to 20% by weight of Eosongcho, 1 to 20% by weight of green tea leaves, 1 to 20% by weight of Bakhwasoo leaves, 1 to 20% by weight of chrysanthemum leaves, and It contains 0.1 to 99.9 wt% of an extract for preventing hair loss and hair growth including an enhancer obtained by distilling 1 to 20% by weight of the leaflets into a distiller and heating at a temperature of 110 to 130° C. for 1 to 10 hours.

The composition according to the present invention may include commonly used components, for example, conventional adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances, and carriers.

The composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, It may be formulated as oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty esters, fatty acid esters of polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Adult cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.

When the formulation of the present invention is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide as carrier components Ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester and the like can be used.

The composition according to the present invention may include a carrier that can be conventionally used in the formulation of the composition in addition to each of the above active ingredients. Examples of such carriers include alcohols, oils, surfactants, fatty acids, silicone oils, humectants, humectants, viscosity modifiers, emulsifiers, preservatives, stabilizers, sunscreens, coloring agents, fragrances, and the like. The carrier may be included in an amount of about 0.5% to about 99.99% by weight based on the total weight of the composition of the present invention, preferably about 80% by weight to about 99.99% by weight of the weight of the composition.

In addition, the composition having the effect of preventing hair loss and hair growth according to the present invention can be used according to a conventional method of use, and the number of times of use can be varied according to the user's condition or taste.

Hereinafter, the contents of the present invention will be described in more detail by way of examples. However, it should be noted that these Examples and Experimental Examples are merely illustrative for the understanding of the present invention and do not limit the scope of the present invention.

[Example] Preparation of extract for hair loss prevention and hair growth

5 kg of the powder of the rare earth complex bio-mineral having the composition of Table 1 was put in a distiller together with 20 liters of water and distilled at a temperature of 130° C. for 5 hours to obtain an extract EF 21.

Then, along with the EF 21 60% by weight, 20% by weight of eoseongcho, 10% by weight of green tea leaves, 10% by weight of sagebrush leaves, 5% by weight of arborvitae leaf, and 5% by weight of leaflets were added to the still, and the temperature was 130° C. for 6 hours. It was heated and distilled to obtain the extract for preventing hair loss and hair growth of the present invention.

[Experimental Example] Evaluation of hair growth phase induction promoting action

For the hair growth phase induction promoting effect experiment, a 7-week-old mouse (C57BL/6, female), which is widely used to evaluate the hair growth phase induction effect, was used. First, the hairs on the back of the mice were removed using an electric razor, and each mouse was weighed and divided into 10 mice so that the weight was evenly distributed. The excipient, the control drug, and the extract of Examples of the present invention were applied to the hair removal site, and at this time, 95% ethanol as the excipient, 2% minoxidil as the control drug, and 95% ethanol as the test drug, respectively, the extract of Example was diluted Thus, a final concentration of 0.5% was prepared and used. It was sufficiently applied with a brush once a day to the back area per mouse individual.

The overall treatment effect was judged into 4 stages: very improved (++), improved (+), slightly improved (±), and non-response (-) compared to the condition before administration of the hair and hair growth 20 days after the start of the experiment. judged.

Results of evaluation of hair growth phase induction promoting action sample Marisu ++ + ± - excipient - - 2 8 reference drug One 2 3 4 Example 3 3 2 2

As shown in Table 2 above, it can be seen that the mice coated with the extract of the present invention experienced rapid hair growth in the hair removal site.

Claims (5)

A composition for preventing hair loss and promoting hair growth, comprising a distillate extract of rare earth complex biominerals as an active ingredient. The method of claim 1,
The rare earth composite bio-mineral material is F 0.1 to 0.2 wt%, Na ₂ O 0.1 to 0.2 wt%, MgO 0.08 to 0.09 wt%, Al ₂ O ₃ 34.0 to 35.0 wt%, SiO ₂ 58.0 to 59.0 wt%, P ₂ O ₅ 0.04~0.05 wt%, SO ₃ 0.01~0.02 wt%, Cl 0.003~0.004 wt%, K ₂ O 2.8~2.9 wt%, CaO 0.008~0.009 wt%, TiO ₂ 1.5~1.6 wt%, Cr ₂ O ₃ 0.01 to 0.02 wt%, MnO 0.01 to 0.02 wt%, Fe ₂ O ₃ 1.0 to 2.0 wt%, NiO 0.005 to 0.006 wt%, CuO 0.002 to 0.003 wt%, Ga ₂ O ₅ 0.006 to 0.007 wt%, SrO 0.02 to 0.03 wt%, Y ₂ O ₃ 0.005 to 0.006 wt%, ZrO ₂ 0.02 to 0.03 wt%, BaO 0.05 to 0.06 wt%, ReO ₂ 0.006 to 0.007 wt%, PbO 0.004 to 0.005 wt%, TbO ₂ 0.002 to 0.003 wt% %, Pa 0.02 to 0.03% by weight of hair loss prevention and hair growth promoter composition, characterized in that it comprises. According to claim 1, wherein the distillate extract,
The composition for preventing hair loss and promoting hair growth, characterized in that the rare earth complex biomineral is put in a distiller together with water and heated at a temperature of 110 to 130° C. for 1 to 10 hours, followed by distillation. The method of claim 1,
Anti-hair loss and hair growth promoter composition, characterized in that it further comprises a distillate extract of eoseongcho, chrysanthemum leaf, morya powder, eugeunpi, baekseonpi, and lichen together with the distillate extract. 5. The method of claim 4,
10 to 70% by weight of the distillation extract, 1 to 20% by weight of Eoseongcho, 1 to 20% by weight of green tea leaves, 1 to 20% by weight of squash leaves, 1 to 20% by weight of arborvitae leaf, and 1 to 20% by weight of leaflets in a distillation A composition for preventing hair loss and promoting hair growth, characterized in that it contains a skin improvement extract obtained by distillation by input.