KR102142228B1 - Composition for hair loss prevention and hair growth promoting containing colostrum, biotin and guarana extract and preparation method therof - Google Patents

Abstract

The present invention relates to a composition for hair loss prevention and hair growth promoting effects, containing natural substances such as colostrum, biotin and a guarana extract, and to a method for preparing the same. The composition according to the present invention exhibits an excellent effect of preventing hair loss when periodically and directly applied to a scalp, and causes little concern about side effects such as skin problems, as a composition prepared by using the natural substances. Also, the composition has an excellent effect of promoting hair growth by supplying nutrients to hair roots to prevent hair loss and make the hair roots healthy.

Description

Composition for hair loss prevention and hair growth promotion containing colostrum, biotin, and guarana extract and method for producing same {Composition for hair loss prevention and hair growth promoting containing colostrum, biotin and guarana extract and preparation method therof}

The present invention relates to a composition having a natural hair colostrum, biotin and guarana extract and having hair loss prevention and hair growth promoting efficacy, and a method for manufacturing the same.

In general, the causes of human hair loss include genetic factors, progression of aging, drug use, radiation therapy, and post-severe stress. From a biochemical and physiological point of view, hair loss is known to be attributed to three main causes: hyperactivity, scalp blood circulation problems, and lack of nutrients essential for hair metabolism. The above three factors alone can cause hair loss, but when the hair loss factors are combined to cause synergy, alopecia is accelerated and symptoms become severe. In particular, if the generation, change, recognition, and signaling processes of male hormones become excessive due to genetic factors or acquired special conditions, hair follicle tissue tends to age prematurely, so it is more likely to become bald earlier than the general population. . In addition, due to genetic factors, aging, western high-fat lifestyle, and other external factors, the tension of the scalp is easily increased, or if there are symptoms such as arteriosclerosis, blood circulation disorders easily occur and thus disorders in smooth hair metabolism occur. Recently, as well as male hair loss, there is a trend that the hair loss in young people, including obese hair loss among women, is gradually spreading, and many types of hair loss treatments, hair growth agents, etc. are commercially available to improve the hair loss phenomenon.

Minoxidil, a typical hair loss treatment on the market, was originally a hypertension treatment developed to lower blood pressure, but it is a drug that has become more popular as a hair growth agent due to hair growth as a side effect of use. However, minoxidil formulations are known to cause side effects such as scalp pruritus, erythema, keratin, and contact dermatitis or hirsutism (J Korean Med Assoc 2013 January; 56(1): 45-54).

Another representative hair loss treatment agent, Propesia, blocks 5-alpha-reductase type 2 enzyme, which plays an important role in the development of androgenetic alopecia, thereby inhibiting testosterone from being converted into dihydrotestosterone (DHT), resulting in hair loss. It is known to inhibit progression. Propecia is known to have an excellent anti-hair loss effect, but the reagent used to manufacture it is expensive and has toxic problems, and because it acts in a way that artificially blocks the production of steroid hormones, it can cause various side effects. There is danger. Accordingly, there is a need to develop a safe therapeutic agent that has excellent efficacy in preventing hair loss and promoting hair growth and has no side effects.

Although previously disclosed for a hair loss prevention composition comprising a guarana extract (Patent Publication No. 10-2012-0069407), a colostrum, biotin, and guarana extract are mixed and applied in an appropriate ratio to apply to a natural hair loss prevention composition having an improved function. There is no commercialization.

Korean Patent Publication No. 10-2012-0069407

Accordingly, the present inventor has completed a composition having an effect of preventing hair loss and promoting hair growth by mixing colostrum, biotin, and guarana extract in an appropriate ratio.

An object of the present invention is to provide a composition having the efficacy of preventing hair loss and promoting hair growth, which contains colostrum, biotin and guarana extract.

In addition, it is an object to provide a method for producing the composition.

In order to solve the above problems, the present invention provides a quasi-drug composition having the effect of preventing hair loss and promoting hair growth, which includes colostrum, biotin, and guarana extract.

The colostrum is milk that is secreted between the end of pregnancy of a mammal and a few days after delivery, and unlike normal milk, it contains more nutrients and antibodies necessary for survival and growth. The mammals include, but are not limited to, sheep, cows, goats, goats, horses, camels or donkeys. The colostrum includes immunoglobulins (Immuno globulin), lysozyme, Cytokines, Lympohokines, Lactoferrin, Priline-Rich-Poltpeptides, and promotes brain and body development. It has components such as Sphingmyelin, Phosphatidylcholine, and DHA, which are factors such as fiber growth and cell tissue formation and regeneration, hair tissue formation and regeneration, bone, muscle and nerve tissue cell growth and differentiation. It has been found by research that it contains various growth-promoting factors such as EGF (Epidermal growth factor), TGF, IGF-1, IGF-2, FGF, and GH.

Among these ingredients, EGF, in particular, greatly contributes to the regeneration of damaged hair roots and the growth of hair, and thus has an excellent effect on preventing hair loss and promoting hair growth. It prevents hair loss due to maintenance of growth and deterioration of human immunity.

The biotin is a vitamin containing sulfur and is involved in fat and carbohydrate metabolism. Biotin acts as an essential cofactor of four decarboxylase enzymes, three of which are involved in calorie and amino acid metabolism, and one acts to make fatty acids. Biotin is referred to as'vitamin H'because it has a good effect on skin and hair. In addition, biotin is involved in the production of blood cells and the secretion of testosterone, and along with other vitamin B groups, it smoothes the functions of the nervous system and bone marrow.

The guarana (Guarana, Paullinia cupana ) is a vine plant of the genus Aptaceae, native to the Brazilian Amazon basin. Guarana is well known for its size similar to that of coffee beans. Guarana seeds are an effective stimulant as a dietary supplement due to the high concentration of caffeine. The guarana has a very high caffeine content, so it has an excellent arousal effect and is used as a raw material for soft drinks, energy drinks, hangover relieving drinks, and tonics.

The guarana extract used in the present invention is characterized by using a guarana seed extract powder form.

The colostrum, biotin and guarana extracts are characterized by extracting colostrum, biotin and guarana by mixing in a ratio of 1:1:1 by weight, but are not limited thereto.

When extracting colostrum, biotin and guarana, ethanol, ethyl acetate or diethyl ether may be used as an extraction solvent, and ethanol is preferred, but is not limited thereto. The extraction solvent is characterized by using a concentration of 30% to 50% and ethanol of 40% is preferred, but is not limited thereto.

The composition may be a quasi-drug composition or a cosmetic composition, and the composition may include components that can be generally included in the quasi-drug composition.

As used in the present invention, the term "quasi-drug" refers to articles that are used for the purpose of diagnosing, treating, improving, alleviating, treating or preventing a disease of a person or animal, and which have less action than pharmaceutical products, for example, the pharmacist method. According to the article, quasi-drug products exclude products used for pharmaceutical use, and include products used to treat or prevent disease in humans and animals, and products that have little or no direct action on the human body.

When the composition of the present invention is used as a quasi-drug additive, it may be added as it is or used with other quasi-drugs or quasi-drug components, and may be suitably used according to conventional methods. The mixing ratio with other components used together may be appropriately determined according to the purpose of use (eg, prevention, improvement or therapeutic treatment).

Examples of the quasi-drug composition include, but are not limited to, scalp hair care compositions such as shampoo, conditioner, hair conditioner, ointment, cream, lotion, essence, spray, and the like.

The composition may be used as a form applied directly or sprayed on the scalp, but is not limited thereto.

The composition may be included in about 0.001 to 50% by weight relative to the total weight of the quasi-drug composition.

The present invention provides a cosmetic composition for preventing hair loss or promoting hair growth.

The formulation of the cosmetic composition of the present invention may include, for example, a solution, shampoo, rinse, ointment, cream, foam, essence, suspension, emulsion, gel, lotion, powder, oil, spray, etc. Does not work.

The cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be blended with general cosmetic products, and for example, oil, water, surfactant, moisturizer, lower alcohol, thickener, etc. Chelating agents, pigments, preservatives, fragrances, etc. may be appropriately blended, but are not limited thereto.

The cosmetically acceptable carrier included in the cosmetic composition of the present invention may vary depending on the formulation of the cosmetic composition.

When the formulation of the present invention is an ointment, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc. It can be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. may be used as a carrier component, and in particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane /Propellant such as butane or dimethyl ether, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier may be used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil, and the like can be used, and in particular, cottonseed oil, peanut oil, corn seed oil, olive oil, castor oil and sesame oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, suspensions such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth may be used, but is not limited thereto. These may be used alone or in combination of two or more.

The cosmetic composition of the present invention may preferably be a cosmetic composition for scalp hair care. Specifically, for example, hair tonic, hair cream, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow hair growth agent, eyelash hair growth agent, eyelash nutritional supplement, etc. However, it is not limited thereto.

The composition is not limited in its content, but may be included in an amount of about 0.001 to 50% by weight based on the total weight of the cosmetic composition.

In addition, the present invention is a step of immersing 70 to 100 wt g of colostrum powder, 70 to 100 wt g of biotin powder, and 70 to 100 wt g of guarana seed extract powder in 1 L of ethanol; Preparing the mixed extract for 18 to 30 hours at a temperature of 10 to 25°C after immersion; Provides a method for preparing a hair loss prevention quasi-drug composition containing colostrum and guarana extract, comprising the step of obtaining a 80-90% solution of the upper portion of the mixed extract.

The composition for preventing hair loss and promoting hair growth according to the present invention exhibits an excellent effect in preventing hair loss when used as a method of periodically applying directly to the scalp, and is a composition prepared using natural materials, and has less fear of side effects such as skin troubles and hair roots. It has the excellent effect of supplying nutrients to prevent hair loss as well as making hair follicles healthy.

Hereinafter, a preferred embodiment according to the present invention will be described in more detail with reference to the accompanying drawings.

Example 1. Preparation of natural hair loss prevention extract

Pure colostrum powder, biotin, guarana seed extract (containing Guarana 22%) of sheep, cow, goat, goat, horse, camel or donkey was prepared. Thereafter, 1 L of 40% ethanol was placed in a container, and then 85 g of colostrum powder, 85 g of biotin powder, and 85 g of guarana seed extract powder were immersed in the ethanol. After 24 hours at room temperature in the immersed state, 850 ml of a superior supernatant was obtained to prepare a composition liquid that can be applied directly to the skin.

Example 2. Prevention of hair loss and validation of hair growth promotion

The composition coating agent according to the present invention and the composition coating agent consisting of different composition ratios are divided into 5 groups for 30 men (20 to 60 years old) suffering from male pattern hair loss disease randomly landed in the country. The experiment was conducted in a manner of applying twice a day in the morning, once in the evening, and twice, and evaluation was performed after 7 days, 14 days, and 30 days and 60 days, and the hair growth state was observed and the results are shown in Table 1.

Group A: control group, no coating agent applied

Group B: Apply a coating agent containing guarana extract

C group: Colostrum, biotin, guarana extract composed of a weight ratio of 1:1:0.5 to apply the extracted composition coating agent

Group D: Colostrum, biotin, and guarana extracts are formulated in a weight ratio of 1:1:1 to apply the extracted composition coating agent.

Group E: Colostrum, biotin, and guarana extracts in a weight ratio of 1:1:2 to apply the extracted composition coating agent

division 7 days elapsed 14 days elapsed 30 days elapsed 60 days elapsed Group A - - - - Group B - - + + Group C - + + ++ Group D - + +++ ++++ Group E - + ++ ++

(-: no hair loss and no hair growth effect, +: hair loss stop, ++: some fine hair growth, +++: some fine hair and normal hair formation, ++++: normal hair formation)

As shown in the above results, in the case of the composition coating agent extracted by constituting colostrum, biotin, and guarana extracts in a weight ratio of 1:1: 1, the hair loss prevention effect was the fastest, as well as fine hairs on the hair loss site over 30 days. The hair growth phenomenon was clearly observed as it started to go out, and it was observed that hair growth occurred at the level of normal hair when applied steadily for more than 60 days. Although hair growth promoting effect was also shown in group C and group E, the composition of colostrum, biotin, and guarana was composed of a weight ratio of 1:1:1, and the hair growth effect was less than that of the extracted composition.

The invention made by the present inventors has been described in detail according to the above embodiment. However, the above embodiments are merely illustrative of the contents of the present invention, and the scope of the invention is not limited to the above embodiments, and the scope of the present invention is not departed by a person having ordinary knowledge in the art. It should be understood as changeable in.

Claims (6)

Colostrum, biotin and guarana seed extract as a composition mixed in a ratio of 1:1:1 by weight, and then mixed and extracted using 40% by weight of ethanol, characterized in that the composition is applied directly to the scalp, preventing hair loss And hair growth promoting quasi-drug composition. delete delete delete Colostrum, biotin and guarana seed extract as a composition in a ratio of 1:1:1 by weight ratio, after mixing and extracting using 40% by weight ethanol, the composition is characterized in that applied directly to the scalp, hair loss prevention And a hair growth promoting cosmetic composition.
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