KR20220098938A - Skin external composition comprising distilled extract of rare earth complexbiomineral for alleviating skin allergy - Google Patents

Abstract

The present invention provides a composition for skin external application comprising, as an active component, the composition for skin external application containing a distilled extract of a rare earth composite bio-mineral material as an active component, wherein the composition for skin external application according to the above configuration has a skin condition improving activity, particularly has an excellent improvement effect on allergies and atopy, which are the causes of skin troubles.

Description

Composition for external application for skin containing a distillate extract of rare earth complex bio-mineral as an active ingredient

The present invention relates to a composition for external application for skin, and more particularly, to an external preparation for skin containing, as an active ingredient, a distillate extract of rare earth complex bio-mineral, which has excellent skin condition improvement activity, in particular, an improvement effect on allergies and atopy, which are the causes of skin troubles. to the composition.

Atopic dermatitis is a chronic recurrent eczema disease that repeats improvement and exacerbation, and it is on the rise in recent years. . In addition, it is emerging as a major public health problem, with a prevalence of 8.5% even at the age of 18.

Infantile atopic dermatitis, which can be called the first stage of atopic dermatitis, starts with itchy erythema on both cheeks between 3 months and 2 years of age, and when it worsens, symptoms such as microvesicles, exudation, wet scab, and pustule formation occur. In particular, the affected area mainly occurs on the cheeks, head, neck, forehead, wrist, side of arms and legs, buttocks, etc. In addition, it has three aspects: wet type, seborrheic type, and dry type. The wet type is the most common in atopic dermatitis in infancy, and the seborrheic type is accompanied by seborrheic tendency and systemic exfoliative erythroderma occurs. The dry type is accompanied by severe dry skin.

Childhood atopic dermatitis, which can be called the second stage of atopic dermatitis, occurs mainly between the ages of 2 and 10 years, and acute lesions (less oozing and dry lesions, scabs) that are slightly milder than those of infancy eczema occur. The main affected areas are the anterior periphery, the popliteal region, the flexor part, the wrist, the eyelids, the face, and the neck. The basic lesion of the childhood atopic dermatitis is dry, slightly raised squamous papules, which fuse to form lichenification, mostly epidermal excoriation.

Atopic dermatitis stage 3 Atopic dermatitis in adolescents and adults occurs mainly in those aged 10 years or older, and is characterized by the formation of localized erythema, scales, papules, or bullous plaques or as hyperpigmented lichenoid patches. The main affected areas are the anterior periphery, the popliteal region, the flexor part, the neck, forehead, around the eyes, hands, and wrists.

Currently, materials such as antipruritic agents, antibacterial agents, immunomodulators and steroids are generally used for these atopic dermatitis symptoms. However, these atopic materials have problems such as generation of resistance due to long-term administration, repetition of symptom relief and recurrence, and side effects of some therapeutic agents.

The present invention has been proposed to solve the problems of the prior art as described above, and its object is to provide a composition for external application for skin excellent in skin condition improvement activity, in particular, an improvement effect on allergies and atopic dermatitis that cause skin troubles. have.

The technical problem of the present invention as described above is achieved by the following means.

(1) A composition for external application for skin containing a distillate extract of rare earth complex bio-minerals as an active ingredient.

(2) in (1) above,

The rare earth composite bio-mineral material is F 0.1 to 0.2 wt%, Na ₂ O 0.1 to 0.2 wt%, MgO 0.08 to 0.09 wt%, Al ₂ O ₃ 34.0 to 35.0 wt%, SiO ₂ 58.0 to 59.0 wt%, P ₂ O ₅ 0.04~0.05 wt%, SO ₃ 0.01~0.02 wt%, Cl 0.003~0.004 wt%, K ₂ O 2.8~2.9 wt%, CaO 0.008~0.009 wt%, TiO ₂ 1.5~1.6 wt%, Cr ₂ O ₃ 0.01 to 0.02 wt%, MnO 0.01 to 0.02 wt%, Fe ₂ O ₃ 1.0 to 2.0 wt%, NiO 0.005 to 0.006 wt%, CuO 0.002 to 0.003 wt%, Ga ₂ O ₅ 0.006 to 0.007 wt%, SrO 0.02 to 0.03 wt%, Y ₂ O ₃ 0.005 to 0.006 wt%, ZrO ₂ 0.02 to 0.03 wt%, BaO 0.05 to 0.06 wt%, ReO ₂ 0.006 to 0.007 wt%, PbO 0.004 to 0.005 wt%, TbO ₂ 0.002 to 0.003 wt% %, Pa composition for external application for skin, characterized in that it comprises 0.02 to 0.03% by weight.

(3) In the above (1), the distillate extract,

The composition for external application for skin, characterized in that it is obtained by putting the rare earth complex biomineral together with water in a distiller, heating it at a temperature of 110 to 130° C. for 1 to 10 hours, and then distilling it.

(4) in (1) above,

The composition for external application for skin, characterized in that it further comprises a distillate extract of eoseongcho, chrysanthemum leaves, moryu powder, eugeunpi, baekseonpi, and lichen together with the distillate extract.

(5) in (4) above,

10 to 70% by weight of the distillation extract, 1 to 30% by weight of Eoseongcho, 1 to 20% by weight of chrysanthemum leaves, 1 to 10% by weight of mulberry flour, 1 to 10% by weight of Yugeun skin, 1 to 10% by weight of white sagebrush, and 1 A composition for external application for skin, characterized in that it contains a skin improvement extract obtained by distilling by distilling ~10% by weight.

(6) in any one selected from (1) to (4),

The composition for external application for skin is a composition for the treatment of atopic dermatitis.

The composition for external application for skin according to the present invention is excellent in skin condition improvement activity, in particular, the improvement effect on allergies and atopy that cause skin troubles.

The external preparation for skin according to the present invention contains the distillate extract of rare earth complex bio-minerals as an active ingredient.

The rare earth composite biomineral of the present invention is preferably F 0.1 to 0.2 wt%, Na ₂ O 0.1 to 0.2 wt%, MgO 0.08 to 0.09 wt%, Al ₂ O ₃ 34.0 to 35.0 wt%, SiO ₂ 58.0 to 59.0 wt%, P ₂ O ₅ 0.04 to 0.05 wt%, SO ₃ 0.01 to 0.02 wt%, Cl 0.003 to 0.004 wt%, K ₂ O 2.8 to 2.9 wt%, CaO 0.008 to 0.009 wt%, TiO ₂ 1.5 to 1.6 wt% %, Cr ₂ O ₃ 0.01~0.02 wt%, MnO 0.01~0.02 wt%, Fe ₂ O ₃ 1.0~2.0 wt%, NiO 0.005~0.006 wt%, CuO 0.002~0.003 wt%, Ga ₂ O ₅ 0.006~0.007 wt%, SrO 0.02~0.03 wt%, Y ₂ O ₃ 0.005~0.006 wt%, ZrO ₂ 0.02~0.03 wt%, BaO 0.05~0.06 wt%, ReO ₂ 0.006~0.007 wt%, PbO 0.004~0.005 wt%, TbO ₂ 0.002 to 0.003% by weight, including 0.02 to 0.03% by weight of Pa.

The rare earth composite bio-mineral material of the present invention more preferably has the composition distribution in Table 1 below taken from the Yenang Mine in Taebaek.

ingredient weight% F 0.1358 Na ₂ O 0.1194 MgO 0.0820 Al ₂ O ₃ 34.7739 SiO ₂ 58.5576 P ₂ O ₅ 0.0427 SO ₃ 0.0105 Cl 0.0034 K ₂ O 2.8695 CaO 0.0080 TiO ₂ 1.5024 Cr ₂ O ₃ 0.0153 MnO 0.0146 Fe ₂ O ₃ 1.7034 NiO 0.0055 CuO 0.0025 Ga ₂ O ₅ 0.0065 SrO 0.0255 Y ₂ O ₃ 0.0053 ZrO ₂ 0.0265 BaO 0.0566 ReO ₂ 0.0065 PbO 0.0040 TbO ₂ 0.0023 Pa 0.0203 total 100

The distillate extract of the rare-earth complex bio-mineral material according to the present invention is obtained by pulverizing the ore composed of the components of Table 1, and then distilling and cooling the ore by adding water. More specifically, it is obtained by putting the rare earth complex biomineral together with water in a distiller and heating it at a temperature of 110 to 130° C. for 1 to 10 hours, followed by distillation.

The distillation extract of the rare earth complex bio-mineral according to the present invention (hereinafter referred to as "EF 21") promotes blood circulation and helps to excrete toxins and sleep well, especially skin condition improvement activity, for example, a cause of skin troubles It is excellent in improving the allergy, especially atopy.

The external preparation for skin according to the present invention, together with 10 to 70% by weight of the EF 21, preferably, to promote the improvement effect on allergies and atopic dermatitis, which are the cause of skin troubles, preferably H. 1 to 30% by weight of each of at least one enhancer or an extract thereof selected from , white sagebrush, and oilseed oil, more preferably 1 to 30% by weight of Eoseongcho, 1 to 20% by weight of arborvitae leaf, 1 to 10% by weight of mulberry powder %, 1 to 10% by weight of Yugeun skin, 1 to 10% by weight of white sagebrush, and 1 to 10% by weight of oilseed oil are put in a distiller and heated at a temperature of 110 to 130° C. for 1 to 10 hours, containing an enhancer obtained by distillation Contains 0.1 to 99.9% by weight of the skin improvement extract.

The external preparation for skin according to the present invention may include components commonly used, for example, conventional auxiliary agents such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances, and carriers.

The external preparation for skin of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , oil, powder foundation, emulsion foundation, wax foundation, spray, etc., but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty esters, fatty acid esters of polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Adult cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.

When the formulation of the present invention is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide as carrier components Ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester and the like can be used.

The external preparation for skin according to the present invention may include, in addition to each of the above active ingredients, a carrier that can be commonly used in the formulation of external preparations for skin. Examples of such carriers include alcohols, oils, surfactants, fatty acids, silicone oils, humectants, humectants, viscosity modifiers, emulsifiers, preservatives, stabilizers, sunscreens, coloring agents, fragrances, and the like. The carrier may be included in an amount of from about 0.5% to about 99.99% by weight, preferably from about 80% to about 99.99% by weight of the weight of the composition, based on the total weight of the external preparation for skin of the present invention.

In addition, the external preparation for skin having an allergy-improving effect according to the present invention can be used according to a conventional method of use, and the number of times of use can be varied according to the skin condition or taste of the user.

Hereinafter, the contents of the present invention will be described in more detail by way of examples. However, it should be noted that these Examples and Experimental Examples are only illustrative for the understanding of the present invention and do not limit the scope of the present invention.

[Example] Preparation of skin improvement extract

5 kg of the powder of the rare earth complex bio-mineral having the composition of Table 1 was put in a distiller together with 20 liters of water and distilled at a temperature of 130° C. for 5 hours to obtain an extract EF 21.

Then, along with 50% by weight of the EF 21, 15% by weight of eoseongcho, 10% by weight of arborvitae leaf, 8% by weight of mulberry flour, 7% by weight of Yugeun skin, 5% by weight of white sagebrush, and 5% by weight of oilseed oil were added to the distiller, and the temperature It was heated to 130° C. for 6 hours and distilled to obtain the skin improvement extract of the present invention.

[Example 1] Preparation of ointment

An ointment for external use on the skin was prepared by a known method according to the prescription in Table 2 below.

composition weight% skin improvement extract 40 diethyl sebacate 8 brazing 5 Polyoxyethylene oleyl ether phosphate 6 sodium benzoate 5 vaseline to 100

[Example 2] Preparation of cream

Creams were prepared by a known method according to the prescription in Table 3 below.

composition weight% stearic acid 15 cetanol One potassium hydroxide 0.7 glycerin 5 propylene glycol 3 antiseptic One incense One skin improvement extract to 100

[Example 3] Preparation of lotion (mist)

A skin lotion for external use was prepared by a known method according to the prescription in Table 4 below.

Composition (wt%) weight% Polyoxyethylene hydrogenated castor oil 1.0 methyl paraoxybenzoate 0.2 glycerin 6.0 1,3-butylene glycol 5.0 Carbomer 0.2 triethanolamine 0.3 propylene glycol 5.0 ethanol 3.2 Carboxyvinyl Polymer 0.1 incense appropriate amount skin improvement extract to 100

[Experimental Example 1] Confirmation of skin irritation and protective effect of ointment and cream

A certain amount (10m/5cm2) of the external preparations prepared in Examples 1 and 2 above were applied to the forearms of 20 healthy adult males and females (10 males, 10 females), and the other areas were covered with aluminum foil. After 30 minutes of shielding, long-wavelength ultraviolet rays were irradiated with a dose of 10.2J/cm 2 using an ultraviolet irradiator, and skin conditions (erythema, edema, papules, etc.) were observed after 24 hours. As a result of observation, side effects such as erythema did not occur on the skin, so it was confirmed that each of the external preparations had no phototoxicity and had a skin protection effect.

[Experimental Example 2] Confirmation of skin irritation and protective effect of lotion

Apply a certain amount (10m/5cm2) of the lotion prepared in Example 3 to the forearms of 20 healthy adult males and females (10 males, 10 females), and cover other areas with aluminum foil after 30 minutes , using a UV irradiator, long-wavelength UV light was irradiated at a dose of 10.2J/cm 2 , and skin conditions (erythema, edema, papule, etc.) were observed after 24 hours. As a result of observation, side effects such as erythema did not occur on the skin, so it was confirmed that the lotion had no phototoxicity and had a skin protection effect.

[Experimental Example 3] Skin stability test for cream and lotion

A human patch test was performed using the external preparations prepared in Examples 1 and 3 above on the forearms of 20 healthy adult males and females (10 males and 10 females). After wiping the forearm of the test subject well with 70% ethanol, a pin chamber containing 20 μl of the external preparations prepared in each example above in a conventional cosmetic base was closed and attached to the site for 24 hours using an adhesive tape. After 24 hours, the adhesive tape and the pin chamber were removed, and the sample remaining on the skin was lightly wiped off with gauze to observe the skin condition, and then again after 24 hours. As a result of the experiment, there was no positive reaction in the human patch test for confirming the skin irritation of the external preparation according to the present invention, so it was confirmed that there is no irritation to the human skin.

[Experimental Example 4] Skin allergy improvement test

The skin allergy improvement test confirmed the itch suppression effect of each example using a 6-week-old NC/Nga female mouse according to a known method. For this, after hair removal of the back of NC/Nga mice that have undergone a one-week acclimatization period, 100 μl of 1-chloro-2,4-dinitrobenzene (DNCB, allergen) (1%, solvent is acetone:olive) Oil = 3:1) was applied for 5 days to induce an allergic reaction. Thereafter, 0.4% DNCB and the external preparations of Examples 1 to 3 were treated once a day for 4 weeks. As a negative control, 100 μl of a solvent (acetone:olive oil=3:1) was applied, and as a positive control, a glucocorticosteroid was used. In addition, the number of animals per group was set to 5 animals. In the evaluation of itch suppression, immediately after DNCB treatment at the end of 4 weeks of sample treatment, the number of times of scratching with the hind paw in an unattended state was recorded with a video camera for 1 hour, and the degree of inhibition of the number of times was evaluated.

Table 5 below shows the itch inhibitory effect (%) by the external preparation of each Example (n = 5).

ingredient Inhibitory effect (%) Example 1 84 Example 2 87 Example 3 90 glucocorticosteroids 86 control -

[Experimental Example 5] Atopic symptom relief experiment

As a test subject, 70 patients with atopic disease were applied to the skin using the bases prepared according to Examples 1 to 3 and Comparative Example 1 twice a day for 1 week. For each, Examples and Comparative Examples were visually judged, and the degree of symptom relieving effect of the Example compared to the Comparative Example was evaluated in two stages: effective and no difference, and the results are shown in Table 6.

test substance Effective (persons) No difference (persons) Example 1 7 3 Example 2 7 3 Example 3 8 2 Comparative Example 1 0 10

As can be seen from the results of Table 5, the external skin preparations of Examples 1 to 3 showed an atopic symptom relief effect for at least 7 of 10 test subjects per each Example, and no side effects were observed in the skin. appear.

As described above, although described with reference to preferred embodiments of the present invention, those skilled in the art can variously modify and change the present invention within the scope without departing from the spirit and scope of the present invention described in the claims below. You will understand that it can be done.

Claims (6)

A composition for external application for skin containing a distillate extract of rare earth complex bio-minerals as an active ingredient. The method of claim 1,
The rare earth composite bio-mineral material is F 0.1 to 0.2 wt%, Na ₂ O 0.1 to 0.2 wt%, MgO 0.08 to 0.09 wt%, Al ₂ O ₃ 34.0 to 35.0 wt%, SiO ₂ 58.0 to 59.0 wt%, P ₂ O ₅ 0.04~0.05 wt%, SO ₃ 0.01~0.02 wt%, Cl 0.003~0.004 wt%, K ₂ O 2.8~2.9 wt%, CaO 0.008~0.009 wt%, TiO ₂ 1.5~1.6 wt%, Cr ₂ O ₃ 0.01 to 0.02 wt%, MnO 0.01 to 0.02 wt%, Fe ₂ O ₃ 1.0 to 2.0 wt%, NiO 0.005 to 0.006 wt%, CuO 0.002 to 0.003 wt%, Ga ₂ O ₅ 0.006 to 0.007 wt%, SrO 0.02 to 0.03 wt%, Y ₂ O ₃ 0.005 to 0.006 wt%, ZrO ₂ 0.02 to 0.03 wt%, BaO 0.05 to 0.06 wt%, ReO ₂ 0.006 to 0.007 wt%, PbO 0.004 to 0.005 wt%, TbO ₂ 0.002 to 0.003 wt% %, Pa composition for external application for skin, characterized in that it comprises 0.02 to 0.03% by weight. According to claim 1, wherein the distillate extract,
The composition for external application for skin, characterized in that it is obtained by putting the rare earth complex bio-mineral together with water in a distiller, heating it at a temperature of 110 to 130° C. for 1 to 10 hours, and then distilling it. The method of claim 1,
The composition for external application for skin, characterized in that it further comprises a distillate extract of eoseongcho, chrysanthemum leaves, moryu powder, eugeunpi, baekseonpi, and lichen together with the distillate extract. 5. The method of claim 4,
20 to 70% by weight of the distillation extract, 1 to 30% by weight of Eoseongcho, 1 to 20% by weight of chrysanthemum leaves, 1 to 10% by weight of mulberry flour, 1 to 10% by weight of Yugeun skin, 1 to 10% by weight of white sagebrush, and 1 A composition for external application for skin, comprising a skin improvement extract obtained by distilling ~10% by weight in a distiller. 5. The method according to any one of claims 1 to 4,
The composition for external application for skin is a composition for the treatment of atopic dermatitis.