KR20130103199A - Composition for preventing sleeping drive - Google Patents

Abstract

PURPOSE: A composition for preventing drowsy driving is provided to effectively prevent drowsy driving by being applied on skin (especially on palm) using aroma perfume and skin penetrating ingredients. CONSTITUTION: A composition for preventing drowsy driving contains 100 parts by weight of a Glycyrrhiza extract, 5-15 parts by weight of saccharin, 2-8 parts by weight of hyaluronic acid, 1-5 parts by weight of ceramide, 1-5 parts by weight of cypress essential oil, 1-5 parts by weight of lavender essential oil, 1-5 parts by weight of peppermint essential oil, 1-5 parts by weight of lipidure, and 1-5 parts by weight of epidermal growth factor (EGF). The composition is a cosmetic composition.

Description

Composition for preventing drowsiness driving {Composition for Preventing Sleeping Drive}

The present invention relates to a composition for preventing drowsiness, comprising licorice extract, saccharin, hyaluronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, repeater and epidermal growth factor (EGF).

In general, the driver requires a great deal of concentration while the vehicle is being driven, and accidents that cause damage to the vehicle and human life occur due to a brief distraction while driving. Even in such careless driving, drowsy driving causes not only one's own damage but also a large accident that damages others.

Various methods are used to prevent drowsy driving. The driver opens the window to let him breathe, or chews chewing gum to try to get rid of his drowsiness. In addition, a method of forming irregularities on the road surface to generate unique sounds and vibrations while driving is also used to prevent drowsy driving.

In addition, as a means for preventing an accident that may be caused by the driver's drowsiness, the driver's body state is judged while the vehicle is being driven by using an EEG monitor, and when the driver's drowsy driving is determined, the driver's drowsiness is prevented. There is also a technique for performing various operations. That is, the driver's drowsiness may be prevented by automatically opening the window of the vehicle or increasing the volume of the car audio.

In addition, Korean Patent Laid-Open Publication No. 10-2004-0074202 discloses a technique for preventing drowsy operation by injecting natural acacia extract and carbon dioxide gas to generate instantaneous cold air.

Accordingly, in consideration of the risk of drowsy driving, the present inventors have recognized the necessity of developing a technology that can be applied to the skin to prevent drowsy driving.

Republic of Korea Patent Publication No. 10-2004-0074202

The present inventors have tried to develop a composition that can be applied to the skin to prevent drowsiness operation. As a result, a composition comprising licorice extract, saccharin, hyaluronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, repeater and epidermal growth factor (EGF) is applied to the skin to prevent drowsiness driving. As a result of testing the effect, it showed an excellent anti-drowsy driving effect, and by confirming the safety to the human skin, the present invention was completed.

Accordingly, it is an object of the present invention to provide a composition for preventing drowsy driving.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

According to an aspect of the present invention, the present invention is for preventing drowsiness, including licorice extract, saccharin, hyuronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, lipidus and epidermal growth factor (EGF) To provide a composition.

The present inventors have tried to develop a composition that can be applied to the skin to prevent drowsiness operation. As a result, a composition comprising licorice extract, saccharin, hyaluronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, repeater and epidermal growth factor (EGF) is applied to the skin to prevent drowsiness driving. As a result of the test, it showed an excellent effect of preventing drowsiness driving and showed safety for human skin.

In the present specification, "Liquorice (甘草, Glycyrrhiza uralensis FISCH.) is a perennial herb, which is used as an oral or external medicine to relieve all kinds of pain and urgency as well as to increase efficacy while harmonizing with all herbs in oriental medicine. It is known to have a weakening effect such as neutralization of the poison.

The licorice extract can be obtained using various extraction methods known in the art, and preferably, (a) water, (b) anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol) Etc.), (c) the mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform or (g) 1,3-butylene glycol can be obtained as an extraction solvent. have.

If necessary, after the extraction solvent treatment may be obtained through an additional purification process. Licorice through various additional purification methods, such as separation using ultrafiltration membranes with constant molecular weight cut-off values, separation by various chromatography (designed for separation according to size, charge, hydrophobicity or affinity). Extracts can be obtained.

As used herein, the term "essential oil" refers to a volatile organic compound having aromaticity, which is obtained from plants, mainly obtained from leaves (eucalypse, peppermint) and from flowers (lavenders), depending on the area to be collected. , Roses), those obtained from branches (Junifer), those obtained from stems (sandwood), those obtained from roots (Bettybert, Calmouth) and the like.

Meanwhile, essential oils are composed of organic compounds including alcohols, aldehydes, esters, catones, oxides, and the like, and these components have anti-infective action, antihistamine action and anti-allergic action, respectively, It will have a unique therapeutic effect. For example, a large amount of ketones are effective in healing wounds, and a high amount of alcohol has a superior antibacterial effect.

There are many ways to apply these essential oils to the body, such as applying directly to the skin, spraying, and inhalation through the nose, but the most commonly used method is through the skin. The essential oils that pass through the skin are absorbed by the capillaries and reach the systemic circulation.

"Peppermint oil" included in the composition of the present invention is menthol (menthol) and menhone (menthone) as the main constituents, and has an anti-septic, anti-spasmodic and expectorant effect It is known.

The "cypress oil" extracted from the cypress used in the composition of the present invention is known to be effective in sterilization, deodorization, skin care, blood circulation, cold, etc., promote blood circulation and metabolism, and produce efficacy such as forest bath. It is known to have a mysterious effect on fatigue and healthy longevity, and does not cause side effects from long-term use.

The "lavender" used in the composition of the present invention is used so much that it has a nickname of mild and soft, the queen of herbs, lavender essential oil is generally used as a fragrance ingredient in soaps, cosmetics, perfumes, ice cream, candy, bread It is also used in foods such as and gum, and is known to have effects such as antibacterial, antifungal, and antiseptic properties.

Essential oils used in the present invention were purchased commercially.

The "saccharin" included in the composition of the present invention contains phenylalanine as a main component, and the phenylalanine penetrates the skin and exhibits an effect of preventing drowsiness as a component of the composition of the present invention.

In addition, hyaluronic acid and ceramide included in the composition of the present invention exhibits an anti-drowsy driving effect and a skin moisturizing effect.

"Epidermal Growth Factor (EGF)" included in the composition of the present invention is a protein formed in the body by binding to receptors on the surface of the skin to promote the production of new cells. It is known to have the effects of cell turnover, skin turnover, elasticity, and moisturizing.

According to a preferred embodiment of the present invention, the composition of the present invention is based on 100 parts by weight of licorice extract 5-15 parts by weight saccharin, 2-8 parts by weight of hyaluronic acid, 1-5 parts by weight of ceramide, 1-5 parts by weight of one-pack essential oil Parts, 1-5 parts by weight of aromatic lavender essential oil, 1-5 parts by weight of peppermint essential oil, 1-5 parts by weight of repeater and 1-5 parts by weight of epidermal growth factor (EGF), more preferably licorice extract 100 parts by weight of saccharin 7-12 parts by weight, hyaluronic acid 3-6 parts by weight, ceramide 1.5-3.5 parts by weight, cypress essential oil 1.5-3.5 parts by weight, aromatic lavender essential oil 1.5-3.5 parts by weight, peppermint essential oil 1.5 -3.5 parts by weight, Repeater 1.5-3.5 parts and Epithelial Growth Factor (EGF) 1.5-3.5 parts by weight.

When the above components are included in the content of the composition of the present invention exhibits drowsy driving prevention effect.

According to another preferred embodiment of the present invention, the composition of the present invention may further comprise a natural herbal preservative.

The composition of the present invention can be prepared with a cosmetic composition.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to the above components, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers. It includes. In addition, the cosmetic composition may further include a skin absorption promoting substance to improve its effect.

Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations, sprays and cosmetic packs, etc., but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, beauty pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, Fatty acid esters of 1,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

On the other hand, in a specific embodiment of the present invention, the cumulative skin irritation test results for the composition of the present invention was found to be harmless to the human body. Therefore, the composition of the present invention can be used safely in long-term use because there is little toxicity and side effects, in particular can be safely applied to the cosmetic composition as described above.

The features and advantages of the present invention are summarized as follows:

(Iii) The present invention relates to a composition for preventing drowsiness driving, comprising licorice extract, saccharin, hyaluronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, lipidus and epidermal growth factor (EGF).

(Ii) The composition of the present invention is applied to the skin (especially palms) to exhibit an excellent anti-drowsy driving effect by the aroma and skin penetrating components.

(Iii) The composition of the present invention can be safely applied to the cosmetic composition because there is no cytotoxicity and skin side effects.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, and it is to be understood by those skilled in the art that the present invention is not limited thereto It will be obvious.

Example

Throughout this specification,% used to refer to the concentration of a particular substance is (weight / weight)% solids / solid, (weight / volume)%, and liquid / Liquid is (volume / volume)%.

Preparation Example 1: Preparation of Drowsy Driving Prevention Composition

To prepare a composition of the present invention with the composition shown in Table 1.

material Content (g) Weight portion Licorice extract 80 g 100 saccharin 7 g 8.75 Hydrulonic acid 4 g 5 Ceramide 2 g 2.5 Cypress Essential Oil 2 g 2.5 Aromatherapy Lavender Essential Oil 2 g 2.5 Peppermint Essential Oil 2 g 2.5 Repeater 2 g 2 g Epidermal growth factor (EGF) 2 g 2 g

Specifically, homogeneously mix licorice extract, saccharin, hyaluronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, lipidus (soy lysorecithin) and epidermal growth factor (EGF) in purified water The mixture was heated and dissolved until it was stirred for 10 minutes with a disperser. Then, after emulsifying at 2,500 rpm for 5 minutes with a homogenizer, 100 ml of the composition was prepared by rotating at 1,000 atmospheres using a high pressure homogenizer for 10 minutes.

Experimental Example  1: Effect of preventing drowsy driving of the composition of the present invention

Five people of average age 30 years (average weight: 65 kg, driving experience: average 3 years) were tested for the anti-drowsy driving effect of the composition of the present invention. Specifically, after 30 minutes of lunch, the composition of the present invention was applied to the palm of the Gyeongbu Expressway Cheonan-Nonsan at an average speed of 100 km / h at the speed of 100 km / h with no application of the present invention to the palms, and after 30 minutes of lunch the following day. The same section was run at the same speed while the invention composition was applied to the palm to test the effect of drowsy driving. And, this process was carried out five times, once, the driver's sleep time was set to an average of seven and a half hours to set the test conditions only for drowsy driving due to food intake. The drowsy driving prevention effect was shown by the + +, ++ and + in order of the greatest effect, the results are summarized in Table 2 below. The case where the composition of this invention was not apply | coated was carried out using the comparative example and the case where 10 ml of this invention composition was apply | coated to the palm as Example 1. The results below represent the average of five patients.

- 1 time Episode 2 3rd time 4 times 5 times Example ++ +++ +++ ++ +++ Comparative example - - - - -

As can be seen in Table 2, the composition of the present invention was found to have excellent drowsy driving prevention effect. It is not only the effect of aroma scent by the components included in the composition of the present invention, but also the composition of the present invention in the emulsified state penetrates into the epidermis, dermis and subcutaneous layer, is absorbed into the lymphatic system through the body fluid and eventually reaches the blood, resulting in drowsiness. It is judged to exhibit an prevention effect. And, drowsy driving prevention effect was confirmed to last for about 4-5 hours.

Experimental Example  2: safety testing on human skin

Treatment of the composition prepared in Preparation Example 1 (Example 1) was scored using the following Equation 1 to the degree of the reaction on the skin every time, the results are shown in Table 3 below:

At this time, ± 1 point in the reaction, + 2 points, + + gives a grade of 4 points, was determined as a safe composition when the average reactivity is less than 3.

Test substance Number of subjects who responded Average reactivity 1 week 2 weeks 3 weeks Primary Secondary Third Fourth 5th 6th Seventh 8th car 9th ± + ++ ± + ++ ± + ++ ± + ++ ± + ++ ± + ++ ± + ++ ± + ++ ± + ++ Untreated group --- --- --- --- --- --- --- --- --- - Example 1 2 - - --- --- --- --- --- --- --- --- 0.18 Inspector 30 30 30 30 30 30 30 30 30 -

As shown in Table 3, in Example 1, the number of people corresponding to ±, + and ++ was 2, 0 and 0, respectively, and the rest did not appear. When calculated according to the above-described formula, the average reactivity was 0.18, which was less than 3, which was judged to be a safe composition. Therefore, the composition of the present invention did not show a distinct cumulative stimulation pattern, and was determined to be a material safe for human skin.

Manufacturing example  2: Preparation of Various Formulations

(1): Nutrition Cream

Ingredients and Contents of Nutrition Cream ingredient Content (% by weight) Example 1 One Jojoba oil 5.0 Liquid paraffin 7.0 Cetylaryl alcohol 2.0 Polyglyceryl-3 Methyl Glucose Disteare 2.0 Glyceryl stearate 0.5 Squalane 3.0 Propylene glycol 4.0 glycerin 5.0 Triethanolamine 0.3 Carboxyvinyl polymer 0.3 Tocopheryl acetate 0.2 Preservative, incense a very small amount Purified water Balance Sum 100

(2): massage cream

Ingredients and Contents of Massage Cream ingredient Content (% by weight) Example 1 One Wax 10.00 Polysorbate 60 1.5 Sorbitan sesquioleate 0.8 Liquid paraffin 40.0 Squalane 5.00 Caprylic / Captic Triglycerides 4.00 glycerin 5.00 Butylene glycol 3.00 Propylene glycol 3.00 Triethanolamine 0.2 Preservatives, micronutrients, trace fragrances and trace water Balance Sum 100

(3): flexible lotion

Components and Contents of Flexible Lotion ingredient Content (% by weight) Example 1 One EDTA 0.05 PIZZY 1500 4.00 Carbomer 0.16 1,3 Butylene Glycol 3.00 Polyoxyethylene Hydrogenated Castor Oil 0.45 Triethanolamine 0.12 Preservative, fragrance, pigment a very small amount Purified water Balance Sum 100

(4): astringent lotion

Components and Contents of Converging Lotion ingredient Content (% by weight) Example 1 One glycerin 2.00 1,3 butylene glycol 3.00 EDTA 0.05 ethanol 7.00 Polyoxyethylene Hydrogenated Castor Oil 0.40 Preservative, fragrance, pigment a very small amount Purified water Balance Sum 100

(5): nutrition lotion

Ingredients and content of nutritional lotion ingredient Content (% by weight) Example 1 One Wax 4.00 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 Liquid paraffin 5.00 Squalane 5.00 Caprylic / Captic Triglycerides 5.00 glycerin 3.00 Butylene glycol 3.00 Propylene glycol 3.00 Carboxyvinyl polymer 0.1 Triethanolamine 0.2 Preservatives, micronutrients, trace fragrances and trace water Balance Sum 100

(6): lotion

Ingredients and Contents of Lotions ingredient Content (% by weight) Example 1 One glycerin 3.00 Carbomer 0.10 Xanthan gum 0.05 1,3 Butylene Glycol 3.00 Polyglycerin-3 Methylglucose Distearate 1.50 Glycerin Stearate 0.50 Cetearyl alcohol 0.30 Jojoba oil 3.00 Liquid paraffin 2.00 Squalane 3.00 Dimethicone 0.50 Tocopheryl acetate 0.20 Triethanolamine 0.10 Preservative, fragrance, pigment a very small amount Purified water Balance Sum 100

(7): gel

Gel composition and composition ingredient Content (% by weight) Example 1 One EDTA 0.02 1,3 Butylene Glycol 4.00 Carbomer 0.60 glycerin 5.00 Hydroxyethylcellulose 0.15 Triethanolamine 0.50 Triclosan 0.20 ethanol 5.00 Polyoxy Ethylene Hydrogenated Castor Oil 4.00 Preservative, fragrance, pigment a very small amount Purified water a very small amount Sum 100

(8): essence

Ingredients and Contents of Essence ingredient Content (% by weight) Example 1 One EDTA 0.05 Potassium-cetylphosphate 0.30 glycerin 5.00 1,3 Butylene Glycol 4.00 Glyceryl stearate / phage-100 stearate 0.50 Sorbitan stearate 0.30 Jojoba oil 0.50 Macadamia Nut Oil 0.50 Tocopheryl acetate 0.50 Butylated hydroxy toluene 0.05 Dimethicone 3.00 Polyacrylamide / C13-14 Isoparaffin / Laureth-7 1.50 Glyceryl Polymethacrylate / Propylene Glycol 5.00 ethanol 3.00 Preservative, fragrance, pigment a very small amount Purified water Balance Sum 100

(9): Beauty Pack

Ingredients and Contents of Cosmetic Pack ingredient Content (% by weight) Example 1 One Polyvinyl alcohol 13.0 Sodium carboxymethylcellulose 0.2 Allantoin 0.1 ethanol 5.00 Nonyl phenyl ether 0.3 Preservatives, micronutrients, trace fragrances and trace water Balance Sum 100

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (4)

Licorice extract, saccharin, hyaluronic acid, ceramide, cypress essential oil, aromatic lavender essential oil, peppermint essential oil, lipidur and epidermal growth factor (EGF) composition for preventing drowsiness driving.
According to claim 1, wherein the composition is based on 100 parts by weight of licorice extract 5-15 parts of saccharin, 2-8 parts by weight of hyaluronic acid, 1-5 parts by weight of ceramide, 1-5 parts by weight of essential oil, aroma lavender essential 1-5 parts by weight of oil, 1-5 parts by weight of peppermint essential oil, 1-5 parts by weight of repeater and 1-5 parts by weight of epidermal growth factor (EGF).
The composition of claim 1, wherein the composition is a cosmetic composition.
The composition of claim 3 wherein the composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray and cosmetic pack. A composition characterized by having a formulation selected from the group consisting of.