KR102476640B1 - 종양세포 치사활성 및 항균성 조성물 및 방법 - Google Patents

종양세포 치사활성 및 항균성 조성물 및 방법 Download PDF

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KR102476640B1
KR102476640B1 KR1020217037585A KR20217037585A KR102476640B1 KR 102476640 B1 KR102476640 B1 KR 102476640B1 KR 1020217037585 A KR1020217037585 A KR 1020217037585A KR 20217037585 A KR20217037585 A KR 20217037585A KR 102476640 B1 KR102476640 B1 KR 102476640B1
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cells
pharmaceutical composition
exosomes
composition
microvesicles
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KR20210144920A (ko
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한스 쥐. 클링거만
배리 제이. 시몬
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이뮤너티바이오, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/44—Fungal antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020217037585A 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법 Active KR102476640B1 (ko)

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KR1020227036373A KR20220147705A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

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US201361899066P 2013-11-01 2013-11-01
US61/899,066 2013-11-01
PCT/US2014/062695 WO2015066054A1 (en) 2013-11-01 2014-10-28 Tumoricidal and antimicrobial compositions and methods
KR1020167014198A KR102329796B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

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KR1020227036373A Division KR20220147705A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

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KR20210144920A KR20210144920A (ko) 2021-11-30
KR102476640B1 true KR102476640B1 (ko) 2022-12-09

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KR1020257021166A Pending KR20250099421A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020167014198A Active KR102329796B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020237018562A Ceased KR20230085215A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020217037585A Active KR102476640B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020227036373A Ceased KR20220147705A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

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KR1020257021166A Pending KR20250099421A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020167014198A Active KR102329796B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020237018562A Ceased KR20230085215A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

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US (10) US10258649B2 (enExample)
EP (3) EP3701957B1 (enExample)
JP (2) JP6603216B2 (enExample)
KR (5) KR20250099421A (enExample)
CN (2) CN120501764A (enExample)
AU (1) AU2014342477B2 (enExample)
CA (1) CA2927977C (enExample)
ES (1) ES2935906T3 (enExample)
WO (1) WO2015066054A1 (enExample)

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KR20250099421A (ko) 2013-11-01 2025-07-01 이뮤너티바이오, 인크. 종양세포 치사활성 및 항균성 조성물 및 방법
JP2018517415A (ja) 2015-06-10 2018-07-05 ナントクエスト インコーポレイテッド がんを処置するための改変ｎｋ−９２細胞
AU2016366677A1 (en) * 2015-12-09 2018-07-26 Nantcell, Inc. Compositions and methods for treatment of HER2 positive metastatic breast cancer
CN109476710B (zh) * 2016-07-19 2021-11-23 国立植物基因组研究所 抗真菌病原体的新蛋白质
CN109804064A (zh) * 2016-09-29 2019-05-24 南克维斯特公司 具有降低的免疫原性的hla i类缺陷的nk-92细胞
CN108324735B (zh) * 2017-01-20 2024-02-09 李莉 用于疾病治疗的胞外体制剂及其应用
WO2018208702A1 (en) * 2017-05-09 2018-11-15 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes
US20210040451A1 (en) * 2018-01-31 2021-02-11 Nantkwest, Inc. Use of 5% human albumin in wash and harvest media
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
EP4013782A4 (en) * 2019-08-12 2023-12-27 Advaccine (Suzhou) Biopharmaceuticals Co. Ltd. IMMUNE COMPOSITION COMPRISING A RESPIRATORY SYNZYTIAL VIRUS (RSV) G POLYPEPTIDE
WO2025221993A1 (en) 2024-04-18 2025-10-23 Immunitybio, Inc. Compositions and methods for producing il-16

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ES2363978T3 (es) 2004-02-13 2011-08-22 Cognis France, S.A.S. Uso de composiciones cosméticas que comprenden un extracto de las hojas de castanea sativa.
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WO2006023148A2 (en) 2004-07-10 2006-03-02 Fox Chase Cancer Center Genetically modified human natural killer cell lines
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KR101298012B1 (ko) 2011-02-08 2013-08-26 (주)차바이오앤디오스텍 암세포로의 표적지향을 위한 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물
US20150212064A1 (en) * 2011-08-12 2015-07-30 The Childrens's Hospital Of Philadelphia Degranulation indicator and methods of use thereof
KR20250099421A (ko) 2013-11-01 2025-07-01 이뮤너티바이오, 인크. 종양세포 치사활성 및 항균성 조성물 및 방법
WO2018236887A1 (en) 2017-06-20 2018-12-27 Nantkwest, Inc. Methods for treating merkel cell carcinoma (mcc) using nk-92 cells
AU2018311096A1 (en) 2017-08-04 2020-01-30 Nantkwest, Inc. Treating and inhibiting leukemia with NK-92 cells

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US11304977B2 (en) 2022-04-19
KR20230085215A (ko) 2023-06-13
US20250170181A1 (en) 2025-05-29
AU2014342477B2 (en) 2019-08-01
KR20210144920A (ko) 2021-11-30
US20190192568A1 (en) 2019-06-27
US20220160768A1 (en) 2022-05-26
EP3701957A1 (en) 2020-09-02
US10258649B2 (en) 2019-04-16
US20160250256A1 (en) 2016-09-01
WO2015066054A1 (en) 2015-05-07
AU2014342477A1 (en) 2016-05-26
EP3062800B1 (en) 2020-04-08
KR20160068976A (ko) 2016-06-15
JP2016539105A (ja) 2016-12-15
JP2020073478A (ja) 2020-05-14
US10517895B2 (en) 2019-12-31
US11975027B2 (en) 2024-05-07
CN105848662A (zh) 2016-08-10
US20240366674A1 (en) 2024-11-07
CA2927977C (en) 2024-03-05
EP4134085A1 (en) 2023-02-15
US20200038445A1 (en) 2020-02-06
ES2935906T3 (es) 2023-03-13
EP3062800A4 (en) 2017-04-19
JP6870053B2 (ja) 2021-05-12
US11213547B2 (en) 2022-01-04
US20190125801A1 (en) 2019-05-02
US20190192570A1 (en) 2019-06-27
US20190192569A1 (en) 2019-06-27
CN120501764A (zh) 2025-08-19
EP3701957B1 (en) 2022-12-28
US10646516B2 (en) 2020-05-12
KR20250099421A (ko) 2025-07-01
EP3062800A1 (en) 2016-09-07
US12064450B2 (en) 2024-08-20
JP6603216B2 (ja) 2019-11-06
CA2927977A1 (en) 2015-05-07
KR20220147705A (ko) 2022-11-03
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US10772912B2 (en) 2020-09-15
US20220175838A1 (en) 2022-06-09

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