KR102449136B1 - Compositions containing Taraxacum coreanum extract - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a white dandelion flower extract as an active ingredient, and by including white dandelion flower as an active ingredient, it has excellent antioxidant effect and is effective in skin whitening and skin wrinkle relief.

Description

Composition containing a white dandelion flower extract as an active ingredient {Compositions containing Taraxacum coreanum extract}

The present invention relates to a cosmetic composition and health functional food containing a white dandelion flower extract as an active ingredient.

In recent years, according to the eco-friendly and nature-oriented consumption trend, active ingredients in functional cosmetics are formulated in various forms in functional cosmetics based on their usefulness based on natural products and chemical substances derived from plants or animals.

In particular, the development of functional cosmetics using various natural materials, such as vegetable and marine raw materials, has led to the rise of natural functional cosmetics and oriental medicinal functional cosmetics.

Functional cosmetics are cosmetics according to the Cosmetics Act, which clean and beautify the human body to maintain and promote the health of skin and hair, and to brighten the appearance by adding attractiveness. It refers to a product that has a slight effect on the human body.

The ideal condition for such functional cosmetics is that there should be no harm to the human body, prevent the deposition of melanin pigment on the wrinkle-improving skin, suppress the formation of freckles and blemishes, etc. The point is that the action on the human body should be mild.

Due to the side effects of chemical substances included in functional cosmetics, consumers' reluctance to use chemical substances or additives in functional cosmetics has recently increased, and accordingly, interest in functional cosmetics using natural products with few side effects and functional effects has increased. is increasing rapidly.

On the other hand, white dandelion, which grows wild in the sun in Korea, is a native species and is known to strengthen bones and muscles, remove toxins, and reduce fever. The silymarin component contained in the leaves and stems of white dandelion helps the action of enzymes and strengthens the cell membrane to promote hepatocyte regeneration and is widely used as a material for improving liver function.

In the case of white dandelion root, it contains a large amount of polyphenol compounds with excellent antioxidant activity such as caffeic acid, chicoric acid, and chlorogenic acid.

Therefore, there is a need for a composition using white dandelion, which is a natural material, which has excellent antioxidant effect and is effective for skin whitening and skin wrinkles.

Republic of Korea Patent Publication No. 2017-0055368 Republic of Korea Patent Publication No. 2017-0055366

It is an object of the present invention to provide a cosmetic composition for skin whitening and wrinkle improvement containing a white dandelion flower extract as an active ingredient.

In addition, another object of the present invention is to provide a health functional food for skin whitening and wrinkle relief containing a white dandelion flower extract as an active ingredient.

The cosmetic composition for skin whitening and wrinkle improvement of the present invention for achieving the above object may contain a white dandelion flower extract as an active ingredient.

The white dandelion flower extract may be extracted with water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, preferably a hot water extract.

As another example, the white dandelion flower extract may be a fermented product obtained by fermenting the white dandelion flower hot water extract as a strain.

The strain is at least one selected from the group consisting of Lactobacillus plantarum, Lactobacillus sakei, Leuconostoc mesenteroides and Lactobacillus buchneri. can be heard

In addition, the health functional food for skin whitening and wrinkle relief of the present invention for achieving the above other object may contain a white dandelion flower extract as an active ingredient.

The cosmetic composition containing the white dandelion flower extract of the present invention as an active ingredient is non-toxic, has excellent antioxidant effect, and is effective for skin whitening and skin wrinkle relief.

The present invention relates to a cosmetic composition and health functional food containing a white dandelion flower extract as an active ingredient.

Hereinafter, the present invention will be described in detail.

The cosmetic composition of the present invention contains a white dandelion flower extract as an active ingredient.

The white dandelion ( Taraxacum coreanum ) does not have a main stem, and leaves come out in a pile from a thick root and spread obliquely. Forked fragments are 5-6 pairs, and the edges have serrations. The young leaves of white dandelion are eaten raw or lightly blanched and seasoned with herbs, the roots are fried, and the flowers are dried in the shade and drunk as tea.

In the present invention, white dandelion flowers are used. If you use leaves, roots, etc. instead of flowers of white dandelion, the desired effect cannot be obtained.

The white dandelion flower extract may be a solvent extract extracted with a solvent or a fermented product.

For example, the white dandelion flower solvent extract is extracted through sonication under an extraction solvent, and specifically, the white dandelion flower and the extraction solvent are mixed in a weight ratio of 1: 5 to 25, preferably 1: 10 to 20, and 20 to 50 kHz, preferably 30 to 40 kHz, and 50 to 700 W, preferably 150 to 400 W power ultrasonicator at 50 to 90 ° C, preferably 70 to 80 ° C for 5 to 60 minutes, preferably Treated for 15 to 30 minutes.

When extracting white dandelion flowers, in the case of solvent extraction rather than ultrasonic extraction, not only a small amount of active ingredients are extracted, but also antioxidant, skin whitening and skin regeneration effects may be low.

When the weight ratio of the white dandelion flower to the extraction solvent is out of the above range, the active ingredient of the white dandelion flower may be extracted in a small amount in the extract.

In addition, when the frequency and power of the ultrasonicator are less than the lower limit, the active ingredient of the white dandelion flower may be extracted in a small amount, and if it exceeds the upper limit, other substances in addition to the active ingredient are also extracted in a large amount, thereby reducing the effect.

In addition, when the extraction temperature and extraction time are less than the lower limit, the active ingredient of the white dandelion flower can be extracted in a small amount. have.

The extraction solvent for extracting the extract is water, a lower alcohol having 1 to 4 carbon atoms, ethylene glycol, ethyl ether, or a mixed solvent thereof. The lower alcohol may include 20 to 99% by volume of methanol, ethanol, butanol or propanol aqueous solution, and preferably water for excellent antioxidant, skin whitening and skin wrinkle relief.

As another example, the white dandelion flower fermented product is the white dandelion flower ultrasonic solvent extract, preferably, after inoculating the strain in the white dandelion flower ultrasonic hot water extract, it is fermented for 10 to 30 days at 25 to 50 ° C. at 100 to 300 rpm. .

The strain is at least one selected from the group consisting of Lactobacillus plantarum, Lactobacillus sakei, Leuconostoc mesenteroides and Lactobacillus buchneri. For example, when using a strain other than the strain known to produce beta-glucosidase, the antioxidant, skin whitening and skin wrinkle alleviation effects may be low or absent.

When the temperature, mixing speed, and time during fermentation are less than the lower limit, the active ingredient of white dandelion flower may be extracted in a small amount, and if it exceeds the upper limit, the desired effect may not be exhibited at all due to the decomposition of physiologically active substances. have.

The white dandelion flower extract of the present invention may be used in health functional foods in addition to cosmetic compositions.

The term 'extract' used while referring to the white dandelion flower in this specification includes not only the crude extract obtained by treating the extraction solvent but also the processed product of the white dandelion flower extract. For example, the white dandelion flower extract may be prepared in a powder state by an additional process such as distillation under reduced pressure and freeze drying or spray drying.

Meanwhile, in the present specification, the term 'contained as an active ingredient' means including an amount sufficient to achieve the efficacy or activity of the white dandelion flower extract. For example, the white dandelion flower extract is used at a concentration of 10 to 1500 μg/ml, preferably 100 to 1000 μg/ml. Since the white dandelion flower extract is a natural product and there is no side effect on the human body even when used in excess, the quantitative upper limit of the white dandelion flower extract contained in the composition of the present invention can be selected and implemented by those skilled in the art within an appropriate range.

In the cosmetic composition of the present invention, in addition to the above cosmetic composition, other ingredients commonly formulated in cosmetics may be blended as needed. Examples of such blending ingredients include oil and fat ingredients, humectants, emollients, surfactants, organic and inorganic pigments, Organic powder, UV absorber, preservative, disinfectant, antioxidant, pH adjuster, alcohol, colorant, fragrance, blood circulation promoter, cooling agent, limiting agent, purified water, water-soluble vitamin, fat-soluble vitamin, polymer peptide, polymer polysaccharide, sphingolipid and seaweed an extract, etc. are mentioned.

The cosmetic composition of the present invention may be prepared in the form of emulsified formulations and solubilized formulations commonly used in the art.

In addition, the components included in the cosmetic composition of the present invention may include components commonly used in cosmetic compositions in addition to the above components as active ingredients, for example, conventional adjuvants such as stabilizers, pigments and natural fragrances; It may further include a carrier.

Products to which the composition of the present invention can be added include, for example, mist, skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nourishing lotion, massage cream, nourishing cream, sunscreen cream , moisture cream, hand cream, foundation, essence, nourishing essence, mask pack, press powder, loose powder, eye shadow, etc., and soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.

When the formulation of the present invention is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. can

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, propane , butane or propellants such as dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty esters, fatty acid esters of polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, as a carrier component, water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.

In addition, the present invention provides a health functional food composition comprising a white dandelion flower extract as an active ingredient.

Health functional food is a food prepared by adding white dandelion flower extract to food materials such as beverages, tea, spices, gum, and confectionery, or by encapsulating, powdering, or suspension, etc. However, unlike general drugs, it has the advantage of not having side effects that may occur when taking the drug for a long period of time by using food as a raw material. The health functional food of the present invention obtained in this way is very useful because it can be ingested on a daily basis. The amount of white dandelion flower extract added in such a health functional food cannot be uniformly defined as it varies depending on the type of health functional food, but it can be added within a range that does not impair the original taste of the food. It is usually in the range of 0.01 to 50% by weight, preferably 0.1 to 20% by weight. In addition, in the case of a health functional food in the form of pills, granules, tablets or capsules, it is usually added in an amount of 0.1 to 100% by weight, preferably 0.5 to 80% by weight. In one embodiment, the health functional food of the present invention may be in the form of a pill, tablet, capsule or beverage.

Hereinafter, preferred examples are presented to help the understanding of the present invention, but the following examples are merely illustrative of the present invention, and it will be apparent to those skilled in the art that various changes and modifications are possible within the scope and spirit of the present invention, It goes without saying that such variations and modifications fall within the scope of the appended claims.

Example 1. Ultrasonic hot water extract

White dandelion flower and water were mixed in a weight ratio of 1:20, put in an ultrasonicator (JAC Ultrasinic, Hwaseng, Korea), and extracted for 30 minutes using ultrasonic waves (40 kHz, 200 W) at 80 ° C. Then, the extract was extracted at 1000 rpm. The supernatant was recovered by centrifugation for 5 minutes to obtain an ultrasonic hot water extract of white dandelion flower.

Example 2. Fermented product

culture medium

Leukonostok mecenteroides was inoculated with 1% MRS broth and cultured for 24 hours at 37° C. to be used as a culture medium.

fermented product

The ultrasonic hot water extract prepared in Example 1 and Leukonostok mecenteroides were mixed in a weight ratio of 1: 2 to adjust the pH to 6.95 to 7.05, and then 1 part by weight per 100 parts by weight of the mixture was added and at 37 ° C. After fermenting for 48 hours, crushed using a Homogenizer (HG-15A, DAIHAN, Korea), adjusted to pH 4.78w0.05, fermented at 45° C. for 48 hours, and then centrifuged to recover the supernatant to obtain a fermented white dandelion flower. .

Comparative Example 1. Ultrasonic Ethanol Extract

It was carried out in the same manner as in Example 1, except that an 80% by volume aqueous ethanol solution was used instead of water to obtain an ethanol extract of white dandelion.

Comparative Example 2. Ultrasonic Methanol Extract

It was carried out in the same manner as in Example 1, except that an 80% by volume aqueous methanol solution was used instead of water to obtain a methanol extract of white dandelion.

Comparative Example 3. Ethanol Fermented Product

By fermenting the ethanol extract prepared in Comparative Example 1 using Leukonostok mecenteroides as in Example 2, an ethanol fermented product of white dandelion flower was obtained.

<Test Example>

Test Example 1. Measurement of total polyphenol content, total flavonoid content and DPPH scavenging ability

1-1. Total polyphenol content (mg GAE/g DW): Measured by modifying the Folin-Denis method, folin-ciocalteu's phenol solution (Folin &Ciocalteu'sphenol; Sigma-Aldrich, USA) was added to the sample and reduced by a polyphenol compound The molybdenum blue color reaction generated by the process was based on the principle. After adding 0.2 N FC solution to 0.14 ml of the sample and leaving it for 10 minutes, 0.56 ml of 7.5% Na ₂ CO ₃ was added and reacted for 1 hour, and the absorbance value was measured at 756 nm. Gallic acid (Sigma-Aldrich, USA) was used as a standard material, and the unit was expressed as mg gallic acid equivalent (GAE)/g dry weight (DW) compared with the prepared gallic acid calibration curve.

1-2. Total flavonoid content (TFC): The TFC content was used by modifying the method of Zhishen et al. [21]. TFC concentration was measured by measuring absorbance based on the principle that yellow color develops when alkali is applied to flavonoids. To 0.5 mL of each sample, 2.5 mL of distilled water and 1.5 mL of 99.5% (v/v) ethanol were added, then 0.1 mL of 1 M potassium acetate and 0.1 mL of 10% aluminum chloride were added, stirred, and left at room temperature for 30 min. Absorbance was measured at 415 nm, and a calibration curve was obtained by diluting quercetin (Sigma-Aldrich, Minneapolis, USA) to 25, 50, 100, 200 g/mL to determine the flavonoid content in mg quercetin equivalent (QE)/g dry matter (DM ) is shown.

1-3. DPPH scavenging ability (%): The electron donating ability was measured by modifying the method of Blois, and DPPH (2,2-Diphenyl-1-picrylhydrazyl, Sigma -Aldrich) The reducing power of the sample was measured through free radical scavenging activity. After adding 1.25 ml of DPPH solution to 0.25 ml of sample and reacting for 20 minutes in the dark, absorbance was measured at 517 nm. Based on the absorbance of the control group not adding the sample, the percentage of DPPH radical scavenging activity according to the following [Equation 1] indicated as

[Equation 1]

DPPH radical scavenging activity (%)={1-(Abs(test)-Abs(color))/Abs(control)}X100

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 total polyphenols
(mg GAE/g DW) 31.9 40.62 16.2 12.4 11.1 total flavonoids
(mg QE/g DM) 5.02 5.54 2.82 2.55 2.30 DPPH scavenging ability (%) 45.42 62.65 15.12 10.91 9.88

As shown in Table 1 above, the ultrasonic hot water extract and fermented product of white dandelion flower prepared according to Examples 1 and 2 of the present invention had higher total polyphenol content and total flavonoid content than Comparative Examples 1 to 3, and had higher DPPH scavenging ability. It was confirmed that it was excellent.

In particular, it was confirmed that the fermented product of Example 2 had higher total polyphenol content and total flavonoid content and excellent DPPH scavenging ability compared to the ultrasonic hot water extract of Example 1. Contrary to Examples 1 and 2, where the fermented product showed excellent results It was confirmed that the ethanol fermentation product of Comparative Example 3 had lower total polyphenol content, total flavonoid content and DPPH scavenging ability than the ultrasonic ethanol extract of Comparative Example 1.

Since polyphenols and flavonoids have excellent antioxidant effects, it can be seen that the ultrasonic extracts and fermented products of white dandelion flowers prepared according to Examples 1 and 2 have excellent antioxidant effects compared to Comparative Examples 1 to 3.

In addition, as a result of measuring the DPPH radical scavenging ability, which is an index of antioxidant activity, a proportional relationship with the total polyphenol and total flavonoid content was confirmed.

Test Example 2. Tyrosinase (Tyrosinase) and collagenase (Collagenase) activity inhibition

2-1. Measurement of inhibition of tyrosinase activity: The inhibitory activity of tyrosinase was tested by modifying Flurkey's method. A buffer was prepared by dissolving 0.8039 g of sodium phosphate monobasic anhydrous and 0.9511 g of sodium phosphate dibasic anhydrous in 100 mL of distilled water, respectively, and adjusting the pH to 6.8. As the prepared buffer, the substrate 10 mM 3,4-dihydroxy phenylanin (I-dopa) (20 mg/mL) and the enzyme 1250 unit tyrosinase were prepared, and 1250 unit tyrosinase was diluted 10-fold in distilled water and used. As a positive control, kojic acid (2 mg/mL) was prepared. In a 2 mL microtube, 0.4 g of buffer, 0.2 g of substrate, 0.2 g of sample, and 0.2 g of enzyme were sequentially added and stirred, followed by reaction at 25° C. for 30 minutes. After the reaction, absorbance was measured at 475 nm.

[Equation 2]

Tyrosinase inhibition rate (inhibitory activity, %) = [1-sample OD / control OD] * 100

2-2. Measurement of Collagenase Inhibitory Effect: The collagenase inhibitory effect was measured by modifying the method of Wㆌsch and Heidrich. The pH of the buffer was adjusted to 7.5 by adding 1 M Hcl to a mixture of 0.1 M tris and 4 mM cacl2. The substrate 4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-D-Arg (1.2 mg/mL) and the enzyme collagenase (0.4 mg/mL) were prepared in the prepared buffer, and the positive control L-ascorbic acid was added to the high-liquid ratio of the extraction sample. was prepared according to Distilled water and L-ascorbid acid were added to the microtube for each condition, respectively, distilled water and L-ascorbid acid were added instead of the sample to 0.05 g, negative control and positive control. Then, 0.075 g of enzyme and 0.125 g of substrate were added in order, stirred, and reacted at 37°C for 30 minutes. did it After the reaction, 0.25 mL of 20% citric acid was added to stop the reaction, and 1.2 mL of ethyl acetate was added, followed by stirring at RPM 120 for 10 minutes. After centrifugation, only the supernatant was separated and absorbance was measured at 320 nm.

[Equation 3]

Collagenase inhibition rate (inhibitory activity, %) = [1-sample OD / control OD] * 100

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Tyrosinase inhibition rate (%) 66.78 87.72 36.72 30.65 31.69 Collagenase inhibition rate (%) 54.68 66.03 30.15 25.48 23.17

As shown in Table 2 above, it was confirmed that the ultrasonic hot water extract and fermented product of white dandelion flower prepared according to Examples 1 and 2 of the present invention had higher tyrosinase inhibition and collagenase inhibition than Comparative Examples 1-3. did.

In particular, it was confirmed that the fermented product of Example 2 had higher tyrosinase inhibition and collagenase inhibition than the ultrasonic hot water extract of Example 1, and Comparative Example 3 as opposed to Examples 1 and 2, where the fermented product showed excellent results. It was confirmed that the ethanol fermented product of Comparative Example 1 had a lower tyrosinase inhibition rate and a lower collagenase inhibition rate than the ultrasonic ethanol extract of Comparative Example 1.

Hereinafter, formulation examples of the composition containing the powder of the present invention will be described, but the present invention is not intended to limit the present invention, but merely to describe it in detail.

Preparation Example 1. Preparation of granules

1,000 mg of fermented product powder obtained in Example 2

appropriate amount of vitamin mixture

70 μg vitamin A acetate

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

0.5 mg of vitamin B6

0.2 μg of vitamin B12

Vitamin C 10 mg

Biotin 10 μg

Nicotinamide 1.7 mg

50 μg folic acid

Calcium pantothenate 0.5 mg

Appropriate amount of inorganic mixture

ferrous sulfate 1.75 mg

Zinc Oxide 0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dibasic calcium phosphate 55 mg

Potassium citrate 90 mg

100 mg calcium carbonate

Magnesium chloride 24.8 mg

The composition ratio of the vitamin and mineral mixture is relatively suitable for granules in a preferred embodiment, but the mixing ratio may be arbitrarily modified. It can be prepared and used in the preparation of a health functional food composition according to a conventional method.

Preparation Example 2. Preparation of functional beverage

1,000 mg of fermented product powder obtained in Example 2

1,000 mg citric acid

100 g of oligosaccharides

2 g of plum concentrate

1 g taurine

Add purified water to total 900 mL

After mixing the above ingredients according to the usual health drink manufacturing method, after stirring and heating at 85 ° C for about 1 hour, the resulting solution is filtered and acquired in a sterilized 2 L container, sealed and sterilized, then refrigerated. It is used to prepare the functional beverage composition of the present invention.

Although the composition ratio is prepared by mixing ingredients suitable for relatively favorite beverages in a preferred embodiment, the mixing ratio may be arbitrarily modified according to regional and national preferences such as demand class, demanding country, and use.

A preparation example of a cosmetic composition suitable for applying the present invention will be presented.

Preparation example 3: lotion

Preparation examples of the lotion in the cosmetic including the fermented product of Example 2 are shown in Table 3 below.

ingredient Content (wt%) Fermented product of Example 2 5.0 glycerin 6.0 1,3-butylene glycol 3.0 PG 1500 1.0 allantoin 0.1 DL-Panthenol 0.3 EDTA-2Na 0.02 Benzophenone-9 0.04 Sodium Hyaluronate 5.0 ethanol 10.0 Polysorbate 20 0.2 preservatives, fragrances, colors a very small amount Distilled water remaining amount Sum 100

Preparation Example 4: Lotion

Preparation examples of lotions in the cosmetic containing the degreasing microalgae enzyme decomposition product of Example 1 are shown in Table 4 below.

ingredient Content (wt%) Fermented product of Example 2 3.0 propylene glycol 6.0 glycerin 4.0 triethanolamine 1.2 Tocopheryl Acetate 3.0 liquid paraffin 5.0 squalane 3.0 Macadamina Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxyvinyl Polymer 1.0 preservatives, fragrances, colors a very small amount Distilled water remaining amount Sum 100

Preparation Example 5: Nourishing Cream

A preparation example of a nutritional cream in a cosmetic comprising the fermented product of Example 2 is shown in Table 5 below.

ingredient Content (wt%) Fermented product of Example 2 1.0 lipophilic monostearate glycerin 1.5 cetearyl alcohol 1.5 stearic acid 1.0 Polysorbate 60 1.5 Sorbitan Stearate 0.6 Isostearylisostearate 5.0 squalane 5.0 mineral oil 35.0 dimethicone 0.5 Hydroxyethyl Cellulose 0.12 glycerin 6.0 triethanolamine 0.7 preservatives, fragrances, colors a very small amount Distilled water remaining amount Sum 100

Preparation 6: Essence

Preparation examples of the essence in the cosmetic including the fermented product of Example 2 are shown in Table 6 below.

ingredient Content (wt%) Fermented product of Example 2 1.5 glycerin 10.0 betaine 5.0 PEG 1500 2.0 allantoin 0.1 DL-Panthenol 0.3 EDTA-2Na 0.02 Benzophenone-9 0.04 Hydroxyethyl Cellulose 0.1 Sodium Hyaluronate 8.0 Carboxyvinyl Polymer 0.2 triethanolamine 0.18 Octyldodecanol 0.3 Octyldodeces-16 0.4 ethanol 6.0 preservatives, fragrances, colors a very small amount Distilled water remaining amount Sum 100

Preparation Example 7: Emulsion for mask pack

Preparation examples of the emulsion for a mask pack among the cosmetics containing the fermented product of Example 2 are shown in Table 7 below.

ingredient Content (wt%) Fermented product of Example 2 1.0 polyvinyl alcohol 15.0 Cellulose Gum 0.15 glycerin 3.0 PEG 1500 2.0 cyclodextrin 0.15 DL-Panthenol 0.4 allantoin 0.1 Monoammonium glycyrrhizinate 0.3 nicotinamide 0.5 ethanol 6.0 PEG 40 hydrogenated castor oil 0.3 preservatives, fragrances, colors a very small amount Distilled water remaining amount Sum 100

Claims (8)

A cosmetic composition for skin whitening and wrinkle improvement comprising an ultrasonic extract of white dandelion flower as an active ingredient,
The ultrasonic extract of white dandelion flower is a mixture of white dandelion flower and water in a weight ratio of 1: 5 to 25 with an ultrasonicator of a frequency of 20 to 50 kHz and a power of 50 to 700 W under 50 to 90 ° C. for 5 to 60 minutes. A cosmetic composition for skin whitening and wrinkle improvement, characterized in that obtained by treatment during delete delete delete delete The cosmetic composition according to claim 1, wherein the white dandelion flower extract is a fermented product obtained by fermenting the white dandelion flower hot water extract with a strain. 7. The group of claim 6, wherein the strain is Lactobacillus plantarum, Lactobacillus sakei, Leuconostoc mesenteroides, and Lactobacillus buchneri). A cosmetic composition, characterized in that at least one selected from As a health functional food for skin whitening and wrinkle relief, comprising an ultrasonic extract of white dandelion flower as an active ingredient,
The ultrasonic extract of white dandelion flower is a mixture of white dandelion flower and water in a weight ratio of 1: 5 to 25 with an ultrasonicator of a frequency of 20 to 50 kHz and a power of 50 to 700 W under 50 to 90 ° C. for 5 to 60 minutes. Health functional food for skin whitening and wrinkle relief, characterized in that obtained by treatment during