KR20170055368A - A composition for alleviating or treating symptoms caused by liver function decreases comprising taraxacum coreanum root extract - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for alleviating or treating symptoms caused by degradation of liver function, comprising a Taraxacum coreanum root extract as an active ingredient, and to health functional food for alleviating or improving symptoms caused by degradation of liver function, and more specifically, to a pharmaceutical composition for alleviating or treating symptoms caused by degradation of liver function, comprising a Taraxacum coreanum root extract, which has activation of inhibiting GOT, GPT and -GTP, as an active ingredient, and to health functional food for alleviating or improving symptoms caused by degradation of liver function.

Description

TECHNICAL FIELD [0001] The present invention relates to a pharmaceutical composition for alleviating or treating a symptom of lowering the function of liver comprising an extract of Root Extract of White Dandelion as an active ingredient. BACKGROUND OF THE INVENTION 1. Field of the Invention < RTI ID =

The present invention relates to a pharmaceutical composition for alleviating or treating a symptom of lowering of liver function comprising white dandelion root extract as an active ingredient and a health functional food for alleviating or ameliorating symptoms of hepatic dysfunction. More specifically, the present invention relates to GOT, GPT and γ- The present invention relates to a pharmaceutical composition for alleviating or treating a symptom of lowering of hepatic function including an effective ingredient of a white dandelion root extract having inhibitory activity, and a health functional food for alleviating or ameliorating symptoms of hepatic dysfunction.

Modern people are suffering from irregular eating habits, stress, excessive drinking and smoking, pollution due to industrialization, and exposure to toxic chemicals. Symptoms of lowering liver function include systemic fatigue, loss of appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, decreased vision, limpiness, bad breath, red spot in skin, jaundice, frequent bleeding, And sexual dysfunction. In particular, excessive intake of fat or excessive alcohol consumption through food causes fat accumulation in the liver tissue, which increases serum glutamate-oxaloacetate transaminase (sGOT) and serum glutamatepyruvate transaminase (sGPT) in the serum.

In order to distinguish the various diseases related to the liver, it is necessary to comprehensively analyze several chemical tests. For this purpose, some test items are collectively referred to as liver function tests. GOT, GPT, and γ-GTP are the main tests. In addition, many items such as total protein, albumin, and ammonia are added.

GOT (glutamic oxaloacetic transaminase) is an enzyme that catalyzes the reversible reaction of producing oxaloacetic acid and L-glutamic acid by transferring the amino group of L-aspartic acid to? -Ketoglutaric acid. In the diagnosis of hepatitis and myocardial infarction, measurement of this enzyme activity in the blood is frequently used.

GPT (glutamic-pyruvic transaminase) is an enzyme that catalyzes pyruvic acid and glutamic acid production by transferring the amino group of alanine to α-keto glutaric acid. In order to diagnose liver and biliary system diseases, the activity of this enzyme in blood is frequently measured.

γ-GTP (gamma-glutamyl transpeptidase, gamma-glutamyl transpeptidase) is an enzyme that acts to transfer glutamine acid to an external peptide or amino acid. Measurement of this enzymatic activity in the blood is often used to determine the abnormality of the biliary system or whether the hepatocyte is impaired.

On the other hand, Taraxacum coreanum is a perennial plant belonging to the genus Chrysanthemum (compositae). It is used as a drug of Poeongyong which is used for the purpose of detoxification, inflammation and diuretic, Has come. In addition, there is a record that young leaves are used as herbs and roots are used as medicines (Lee, Changbok, Korea Botanical Illustrated, Fukmunsa, Seoul, Contains the young seeds, young leaves and roots of dandelion as the main ingredient of food.

In addition, the dandelion is recorded in the fresh water main herb, and it is recorded that it is excited when a small amount is used for the anti-inflammation, antibacterial, diuretic, milk secretion promotion,

There are hundreds of dandelions all over the world, but domesticated dandelions are the most vulnerable. It is said that white dandelion (white flower) is more effective than white dandelion which is common in the city.

However, it has not been reported that the root of white dandelion is effective in the symptom of liver dysfunction. Thus, the present inventors have completed the present invention by identifying the liver function improvement effect using the root of white dandelion which is a domestic native medicinal resource .

An object of the present invention is white dandelion (Taraxacum coreanum ) root extract as an active ingredient. The present invention also provides a pharmaceutical composition for alleviating or treating liver dysfunction symptoms.

Another object of the present invention is to provide a method for the treatment of taraxacum coreanum ) root extract as an active ingredient.

The present invention to solve the above problems, the white dandelion (Taraxacum coreanum ) root extract as an active ingredient. The present invention also provides a pharmaceutical composition for alleviating or treating liver dysfunction symptoms.

According to a preferred embodiment of the present invention, the white dandelion root extract may be extracted with at least one solvent selected from the group consisting of water, C ₁ -C ₄ lower alcohol, ethyl acetate, chloroform and hexane.

According to another preferred embodiment of the present invention, the symptom of depressed liver function is selected from the group consisting of systemic fatigue, decreased appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, decreased visual acuity, Redness, jaundice, frequent bleeding, decreased sexual desire due to hormonal imbalance, and sexual dysfunction.

According to another preferred embodiment of the present invention, the white dandelion root extract may inhibit the activity of GOT, GPT and gamma-GPT.

The present invention also relates to the use of the white dandelion ( Taraxacum coreanum ) root extract as an active ingredient.

According to a preferred embodiment of the present invention, the white dandelion root extract may be extracted with at least one solvent selected from the group consisting of water, C ₁ -C ₄ lower alcohol, ethyl acetate, chloroform and hexane.

According to another preferred embodiment of the present invention, the white dandelion root extract may inhibit the activity of GOT, GPT and gamma-GPT.

According to another preferred embodiment of the present invention, the symptom of depressed liver function is selected from the group consisting of systemic fatigue, decreased appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, decreased visual acuity, Redness, jaundice, frequent bleeding, decreased sexual desire due to hormonal imbalance, and sexual dysfunction.

The white dandelion of the present invention ( Taraxacum coreanum root extract as an active ingredient, and a health functional food for alleviating or improving liver function inhibits the activity of GOT, GPT and γ-GPT to alleviate the symptom of liver dysfunction , ≪ / RTI >

In addition, the white dandelion used in the pharmaceutical composition and the health functional food for alleviating or treating the symptoms of the liver dysfunction of the present invention is a material obtainable from natural materials and has a small side effect and can be safely used in the human body. In particular, white dandelion is expected to contribute to strengthening global competitiveness of domestic and domestic medicinal resources according to the Convention on Biological Diversity and profitability of raw material producing farms through the identification of the liver function improvement effect as domestic domestic medicinal resource.

FIG. 1 is a graph showing the effect of inhibiting the GOP value of white dandelion root extract in rats caused liver damage by CCl ₄ (carbon tetrachloride).
FIG. 2 is a graph showing the effect of inhibiting the GTP-inhibition of white dandelion root extracts in mice in which liver damage was caused by CCl ₄ .
FIG. 3 is a graph showing the inhibitory effect of the white dandelion root extract on γ-GTP inhibition in mice with liver damage caused by CCl ₄ .
FIG. 4 is a graph showing the change in BUN value after administration of the white dandelion root extract to the liver damaged with CCl _4. FIG.
FIG. 5 is a graph showing changes in creatinine levels after administration of white dandelion root extract to rats caused liver damage by CCl _4. FIG.

Hereinafter, the present invention will be described in more detail.

As described above, the effects of alleviating, improving or treating hepatic dysfunction symptoms of white dandelion root extract have not been reported yet. Accordingly, the present inventors confirmed the possibility of alleviating, ameliorating, or treating the hypoxia-induced symptom of the liver dandruff root extract, and using the same to produce a pharmaceutical composition for alleviating or treating symptoms of hepatic dysfunction and a health functional food To solve the problem of the present invention.

The terms used in the present invention are defined as follows.

The term " pharmaceutical composition " means a mixture of other chemical components, such as a diluent or carrier, in the white dandelion root extract of the present invention.

The term " carrier " is defined as a compound that facilitates the addition of a compound into a cell or tissue. For example, dimethylsulfoxide (DMSO) is a commonly used carrier that facilitates the introduction of many organic compounds into cells or tissues of an organism.

The term " diluent " is defined as a compound that not only stabilizes the biologically active form of the compound of interest, but also dilutes in water to which the compound is dissolved. Salts dissolved in buffer solutions are used as diluents in the art. A commonly used buffer solution is phosphate buffered saline, since it mimics the salt state of the human solution. Since buffer salts can control the pH of the solution at low concentrations, buffer diluents rarely modify the biological activity of the compounds.

The term " treatment " means an approach to obtaining beneficial or desired clinical results. For purposes of the present invention, beneficial or desired clinical results include, but are not limited to, alleviation of symptoms, reduction in the extent of disease, stabilization (i.e., not worsening) of the disease state, (Either partially or totally), detectable or undetected, whether or not an improvement or temporary relief or reduction Also, " treatment " may mean increasing the survival rate compared to the expected survival rate when not receiving treatment. &Quot; Treatment " refers to both therapeutic treatment and prophylactic or preventative measures. Such treatments include treatments required for disorders that have already occurred as well as disorders to be prevented. "Alleviating" a disease may result in a reduction in the extent of the disease state and / or undesirable clinical symptoms and / or a slower or longer time course of the progression, It means to lose.

All technical terms used in the present invention are used in the sense that they are generally understood by those of ordinary skill in the relevant field of the present invention unless otherwise defined. Also, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention.

The invention white dandelion (Taraxacum coreanum ) root extract as an active ingredient. The present invention also provides a pharmaceutical composition for alleviating or treating liver dysfunction symptoms.

The white dandelion root extract can be extracted with a solvent such as water, C ₁ -C ₄ lower alcohol, ethyl acetate, chloroform or hexane, more preferably a C ₁ -C ₄ lower alcohol Can be used. More preferably, it may be ethanol. The extract may be applied by a general solvent extraction method using the above-mentioned solvent, or it may be a fraction purified by using column chromatography. The method for producing the extract according to the present invention can be applied to any plant extraction method known to those of ordinary skill in the art. For example, extraction with water, alcohol or mixed solvent, extraction with hot water or room temperature But is not limited thereto.

The white dandelion root extract may inhibit the activity of GOT, GPT and gamma-GTP.

The white dandelion root extract can alleviate or treat the symptoms caused by liver dysfunction. Specifically, the symptoms of decreased liver function include systemic fatigue, loss of appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, decreased vision, limping, bad breath, reddening of skin, jaundice, frequent bleeding , Sexual desire due to hormonal imbalance, sexual dysfunction, and the like.

As shown in 1 to 3, compared to the results, CCl control _40,000 administered one administration to mice caused liver damage the white dandelion root extract of the invention in every six weeks 200mg / kg by CCl ₄ GOP, GPT, and γ -GTP levels were all reduced. In particular, the values of GOP and γ-GTP were markedly decreased, and the γ-GTP levels decreased to the same level as that of the normal group in which the general dietary group was provided, indicating that the white dandelion root extract had an excellent effect for improving liver function I could confirm.

Furthermore, as shown in FIGS. 4 and 5, when the white dandelion root extract of the present invention was administered at a dose of 200 mg / kg per day for 6 weeks to rats suffering liver damage by CCl ₄ , the BUN level and the creatinine level were measured, And it was confirmed that the white dandelion root extract of the present invention improves the liver function without imposing a strain on the kidney.

The pharmaceutical compositions of the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions.

The pharmaceutical composition according to the present invention may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterilized injection solutions according to a conventional method .

Examples of carriers, excipients and diluents that may be contained in the composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin , Calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used.

Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose , Gelatin, and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included .

Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.

The amount of the composition of the present invention to be used may vary depending on the age, sex, and body weight of the patient and may vary depending on the condition of the subject to be treated, the specific category or type of the subject disease, Lt; RTI ID = 0.0 > a < / RTI >

The pharmaceutical composition of the present invention can be administered individually as a prophylactic or therapeutic agent or in combination with other therapeutic agents, and can be administered sequentially or simultaneously with conventional therapeutic agents.

The pharmaceutical composition may be administered to mammals such as rats, mice, livestock, humans, and the like in a variety of routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine dural or intracerebral injection.

In particular, it can be administered by any medically appropriate method, for example by injection into normal cerebrospinal fluid, such as normal intravenous or intraarterial administration. In some cases, intradermal administration, intracavity administration, intrathecal administration, tumor or direct administration to the arteries supplying the tumor is advantageous. When the tumor or a portion thereof has previously been removed by surgical operation, the therapeutic agent can be delivered directly to the tumor site (and, in particular, the enclosed cavity or "ablation "Quot; resection cavity ").

The composition of the present invention is appropriately selected depending on the degree of absorption of the active ingredient in the body, the excretion rate, the age and weight of the patient, the sex and condition of the patient, the severity of the disease to be treated and the like, but is generally 10 to 2,000 mg / And preferably 50 to 200 mg / kg. The unit dosage formulations thus formulated may be administered several times at predetermined time intervals as necessary.

The present invention also relates to the use of the white dandelion ( Taraxacum coreanum ) root extract as an active ingredient.

The white dandelion root extract may be extracted in the same manner as the white dandelion root extract extract contained in the pharmaceutical composition for alleviating or treating liver dysfunction symptoms of the present invention. Usually, Although it is not particularly limited, it can be preferably extracted with at least one solvent selected from the group consisting of water, C ₁ -C ₄ lower alcohol, ethyl acetate, chloroform and hexane.

Furthermore, the white dandelion extract may inhibit the activity of GOT, GPT and gamma-GPT.

The white dandelion root extract may alleviate or ameliorate the symptoms caused by liver dysfunction. Specific symptoms include systemic fatigue, poor appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, But are not limited to, drowsiness, bad breath, skin redness, jaundice, frequent bleeding, decreased sexual desire due to hormonal imbalance, and sexual dysfunction.

As shown in 1 to 3, compared to the results, CCl control _40,000 administered one administration to mice caused liver damage the white dandelion root extract of the invention in every six weeks 200mg / kg by CCl ₄ GOP, GPT, and γ -GTP levels were all reduced. In particular, the levels of GOP and γ-GTP were markedly decreased, and the γ-GTP level decreased to the same level as that of the normal diet group, and thus the white dandelion root extract was useful for the relief and treatment of symptoms .

Furthermore, as shown in FIGS. 4 and 5, when the white dandelion root extract of the present invention was administered at a dose of 200 mg / kg per day for 6 weeks to rats suffering liver damage by CCl ₄ , the BUN level and the creatinine level were measured, And it was confirmed that the white dandelion root extract of the present invention improves the liver function without imposing a strain on the kidney.

BUN (Blood Urea Nitrogen) measures the blood component of the blood, which can be used as an index of kidney function. The normal range is 10 to 26 mg / dL and may be increased due to renal dysfunction, shock, dehydration, stress, gastrointestinal bleeding, etc. and may be reduced for reasons such as liver disease, low protein diet, malnutrition and the like.

Creatinine is produced from creatine in muscle, and unlike urea, it has little effect other than kidney function, so it is useful to evaluate the renal function. Because the measurement method is slightly different depending on the laboratory, the value is different according to sex, age It is different. The causes of the decline are muscle mass loss and muscle loss, lack of protein intake, liver disease, and pregnancy.

The health functional food may contain flavoring agents such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, coloring agents and thickening agents (cheese, chocolate etc.), pectic acid and its salts, alginic acid and its salts, Organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. It can also contain natural fruit juices and pulp for the production of fruit juices and vegetable drinks. These components may be used independently or in combination. The health functional food may be any one of meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, gum, ice cream, soup, beverage, tea, functional water, drink, alcohol and vitamin .

The health beverage composition of the present invention is not particularly limited to a liquid ingredient except that it contains a white dandelion root extract and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages.

In addition, the health functional food may further include food additives, and the suitability of the food functional food as a " food additive " is not limited to the corresponding items in general rules and general test methods approved by the Food and Drug Administration Shall be determined according to the relevant standards and standards.

Examples of the products that have been used in the above-mentioned "food additives" include natural products such as ketones, chemical products such as glycine, potassium citrate, nicotinic acid and cinnamic acid, sensory coloring matter, licorice extract, crystalline cellulose, high- - Mixed preparations such as a sodium glutamate preparation, a noodle-added alkaline agent, a preservative preparation, a tar coloring agent and the like.

At this time, the white dandelion root extract according to the present invention, which is added to the food during the process of manufacturing the health functional food, can appropriately increase or decrease the content of the white dandelion root extract according to need, and the effective dose of the white dandelion root extract It can be used in accordance with the effective dose of the pharmaceutical composition, and the amount of the active ingredient to be mixed can be suitably determined according to the purpose of use such as prevention or therapeutic treatment. In the case of long-term consumption intended for health and hygiene purposes or for health control purposes, it may be below the above range.

The present invention will now be described more specifically with reference to the following examples. However, the following examples should not be construed as limiting the scope of the present invention, but should be construed to facilitate understanding of the present invention.

White dandelion  Preparation of Root Extract

The harvested white dandelion ( Taraxacum coreanum ) was washed with water and sonicated (Branson, USA), and the washed samples were lyophilized with a freeze dryer (Martin Chirst, Osterode, Germany). The lyophilized sample is pulverized and then subjected to repeated extraction three times with 99% ethanol (EtOH) at room temperature for 24 hours.

The extract obtained through the above-mentioned extraction is filtered using a filter paper (No. 4) and concentrated under reduced pressure at 45 ° C with a rotary evaporator (Heidolph, Germany). The resulting concentrate was taken as a powder after lyophilization.

White dandelion  Effect of Root Extract on Liver Function

The present inventors conducted the following experiment to examine the effect of improving the liver function of the white dandelion root extract.

Preparation of experimental animals

Five-week-old Sprague Dawley male white rats were purchased from Sam Taco Co., Ltd. (Osan, Korea) and adapted for one week in a basic diet at ambient temperature of 20 ° C, 50% .

Experimental group  Setting and sample administration

Each group 3 rats, fed a normal diet group normal group, divided by the CCl ₄ treated with a white dandelion root extract in rats caused liver damage by handling the control and CCl ₄ caused liver damage in handling white dandelion military experiments During the experiment, diets and water were freely supplied.

GOT, GPT, and γ-actin, which are hepatic damage markers, were extracted after 24 hours after the last oral administration and after harvesting under the ether anesthesia. GTP levels and renal damage markers BUN and creatinine levels were observed.

As shown in FIGS. 1 to 3, it was confirmed that the white dandelion group had reduced GOP, GPT and γ-GTP levels as compared with the control group administered with only CCl ₄ . In particular, the levels of GOP and γ-GTP were markedly decreased, and the γ-GTP level decreased to the same level as that of the normal diet group, and thus the white dandelion root extract was useful for the relief and treatment of symptoms .

Further, as shown in FIGS. 4 and 5, the BUN value and the creatinine level of the white dandelion group were measured to be within the normal range. As a result, the white dandelion root extract of the present invention showed no significant effect on the kidney function .

Formulation example

< Formulation example  1 > A pharmaceutical composition for alleviating or treating a symptom of lowering hepatic function Powder  Produce

 200 mg of white dandelion root extract was mixed with 100 mg of lactose and 10 mg of talc and filled in airtight bags to prepare powders.

< Formulation example  2> Preparation of tablets of pharmaceutical compositions for relieving or treating hepatic insufficiency symptoms

100 mg of white dandelion root extract was mixed with 100 mg of corn starch, 100 mg of lactose, and 2 mg of magnesium stearate, followed by tableting according to a conventional preparation method.

< Formulation example  3> Preparation of Capsules of Pharmaceutical Compositions for Mitigating or Treating Lowered Liver Function Symptoms

100 mg of white dandelion root extract was mixed with 100 mg of corn starch, 100 mg of lactose and 2 mg of magnesium stearate according to a conventional capsule preparation method, and filled in gelatin capsules to prepare capsules.

< Formulation example  4) Preparation of Injection of Pharmaceutical Composition for Mitigating or Treating Lowering Function of Liver Dysfunction

Was prepared containing 200 mg of white dandelion root extract per 1 ampoule (2 ml) according to the usual injection preparation method, containing sterilized distilled water suitable amount and pH adjuster proper amount.

< Formulation example  5 > A pharmaceutical composition for alleviating or treating a symptom of lowering hepatic function Liquid  Produce

200 mg of white dandelion root extract, 10 g of isomerized sugar, and 5 g of mannitol were dissolved in an appropriate amount of purified water and mixed with an appropriate amount of lemon flavor. Then, the mixture was adjusted to 100 ml with purified water, The solution was packed in a bottle and sterilized to prepare a liquid preparation.

Hereinafter, a preparation example of a health functional food containing the white dandelion root extract of the present invention as an active ingredient will be described, but the present invention is not intended to be limited thereto but is specifically explained.

< Formulation example  6> Preparation of health functional food for alleviating or improving liver dysfunction symptom

Vitamin A acetate 70mg, vitamin E 1.0mg, vitamin B1 0.13mg, vitamin B2 0.15mg, vitamin B6 0.5mg, vitamin B12 0.2g, vitamin C 10mg, biotin 10g, nicotinamide 1.7 &lt; RTI ID = 0.0 &gt; (50 mg of folic acid, 0.5 mg of calcium pantothenate) and an appropriate amount of inorganic mixture (1.75 mg of ferrous sulfate, 0.82 mg of zinc oxide, 25.3 mg of magnesium carbonate, 15 mg of monopotassium phosphate, 55 mg of calcium phosphate, 90 mg of potassium citrate, 100 mg, and magnesium chloride 24.8 mg) were mixed to prepare granules, and a health food was prepared according to a conventional method.

Claims (8)

White dandelion ( Taraxacum coreanum ) root extract as an active ingredient. The method according to claim 1, wherein the white dandelion root extract is extracted with at least one solvent selected from the group consisting of water, C ₁ -C ₄ lower alcohol, ethyl acetate, chloroform and hexane. A pharmaceutical composition for therapeutic use. The method according to claim 1, wherein the symptom of decreased liver function is selected from the group consisting of general fatigue, poor appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, decreased vision, limp, Wherein the symptom is at least one symptom selected from the group consisting of depression, anorexia, hemorrhage, decreased sexual desire due to hormone imbalance, and sexual dysfunction. The pharmaceutical composition according to claim 1, wherein the white dandelion root extract inhibits the activities of GOT, GPT and? -GTP. White dandelion ( Taraxacum coreanum ) Root Extract as an Active Ingredient. 6. The method according to claim 5, wherein the white dandelion root extract is extracted with at least one solvent selected from the group consisting of water, C ₁ -C ₄ lower alcohol, ethyl acetate, chloroform and hexane. Health functional foods for improvement. 6. The health food according to claim 5, wherein the white dandelion root extract inhibits the activities of GOT, GPT and? -GPT. 6. The method according to claim 5, wherein the symptom of decreased liver function is selected from the group consisting of systemic fatigue, loss of appetite, nausea, diarrhea, constipation, indigestion, abdominal bloating, eye fatigue, decreased visual acuity, Wherein the symptom is at least one symptom selected from the group consisting of depression, anorexia, hemorrhage, decreased sexual desire due to hormone imbalance, and sexual dysfunction.

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