KR102432526B1 - 디시클로플라틴의 제조방법 - Google Patents

디시클로플라틴의 제조방법 Download PDF

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Publication number
KR102432526B1
KR102432526B1 KR1020177032550A KR20177032550A KR102432526B1 KR 102432526 B1 KR102432526 B1 KR 102432526B1 KR 1020177032550 A KR1020177032550 A KR 1020177032550A KR 20177032550 A KR20177032550 A KR 20177032550A KR 102432526 B1 KR102432526 B1 KR 102432526B1
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South Korea
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dicycloplatin
carboplatin
mixing step
dicarboxylic acid
solvent
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Korean (ko)
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KR20170134737A (ko
Inventor
샤오종 리우
지루이 시
예 자오
리앙 장
Original Assignee
신-낫 프로덕츠 엔터프라이즈 엘엘씨
메돈케어 파마수티컬 씨오., 엘티디
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Publication of KR20170134737A publication Critical patent/KR20170134737A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020177032550A 2015-04-10 2015-04-10 디시클로플라틴의 제조방법 Active KR102432526B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2015/025334 WO2016164040A1 (en) 2015-04-10 2015-04-10 Process for the preparation of dicycloplatin

Publications (2)

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KR20170134737A KR20170134737A (ko) 2017-12-06
KR102432526B1 true KR102432526B1 (ko) 2022-08-12

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KR1020177032550A Active KR102432526B1 (ko) 2015-04-10 2015-04-10 디시클로플라틴의 제조방법

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US (1) US9447130B1 (OSRAM)
EP (1) EP3280408B1 (OSRAM)
JP (1) JP6925318B2 (OSRAM)
KR (1) KR102432526B1 (OSRAM)
CN (1) CN106132408B (OSRAM)
AU (1) AU2015390714B2 (OSRAM)
CA (1) CA2981158C (OSRAM)
DK (1) DK3280408T3 (OSRAM)
ES (1) ES2765648T3 (OSRAM)
IL (1) IL254894B (OSRAM)
MX (1) MX2017012985A (OSRAM)
RU (1) RU2676269C1 (OSRAM)
WO (1) WO2016164040A1 (OSRAM)
ZA (1) ZA201706795B (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016205782A1 (en) 2015-06-19 2016-12-22 Syn-Nat Products Enterprise LLC Composition containing carboplatin and use
BR112017027285A2 (pt) 2015-06-19 2018-09-11 Syn Nat Products Entpr Llc ?cocristal, composição farmacêutica e método para o tratamento de uma doença?
CA2989001A1 (en) * 2015-06-25 2016-12-29 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
CN106995467B (zh) * 2017-05-03 2019-06-21 江苏大红鹰恒顺药业有限公司 一种微波催化合成双环铂的方法
CN109053808B (zh) * 2017-06-21 2020-12-29 宋勤华 一种高纯度双环铂针状晶体的工业化制备方法
AU2018372753B2 (en) * 2017-11-21 2024-03-21 Medoncare Pharmaceutical Co., Ltd Combination product comprising dicycloplatin and preparation method and use thereof
CN108780053A (zh) * 2018-02-09 2018-11-09 北京索普兴大医药研究有限公司 双环铂药物检测方法
WO2018171371A2 (zh) * 2018-02-22 2018-09-27 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的制备方法
CN108521780B (zh) * 2018-02-22 2024-08-02 昆明贵研药业有限公司 一锅法制备双二羧酸二氨络铂(ii)衍生物的方法
WO2020056582A1 (zh) * 2018-09-18 2020-03-26 昆明贵研药业有限公司 一种双二羧酸二氨络铂(ii)衍生物的纯化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69130261T2 (de) * 1991-03-23 1999-05-20 Sunkyong Industries Ltd., Suwon, Kyonggi Platinkomplexe und verfahren zu deren herstellung
US5455270A (en) * 1993-08-11 1995-10-03 Bristol-Myers Squibb Co. Stabilized solutions of platinum(II) antitumor agents
CN1121380C (zh) * 2000-03-03 2003-09-17 北京兴大豪斯科技有限公司 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物
EP1473298B1 (en) * 2001-11-30 2009-05-13 Jingzun Wang Supermolecular carboplatinum derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions
EP1867673B1 (en) * 2005-03-18 2011-11-16 The University of Tokyo Coordination compound composed of diaminocyclohexane platinum (ii) and block copolymer and anti-cancer agent comprising the same
EP1879568B1 (en) * 2005-03-28 2009-05-06 Dabur Pharma Limited Stable pharmaceutical compositions of platinum (ii) antitumour agents
AU2007209099A1 (en) 2006-01-30 2007-08-02 Platco Technologies (Proprietary) Limited Preparation of platinum (ll) complexes
JP2010530411A (ja) * 2007-06-18 2010-09-09 プラットコー テクノロジーズ （プロプライエタリー） リミテッド 白金（ｉｖ）錯体

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Publication number Publication date
AU2015390714A1 (en) 2017-10-26
EP3280408A4 (en) 2018-10-17
JP2018510914A (ja) 2018-04-19
IL254894B (en) 2021-02-28
BR112017021590A2 (pt) 2018-07-03
US9447130B1 (en) 2016-09-20
MX2017012985A (es) 2018-05-22
CN106132408B (zh) 2018-02-13
CA2981158C (en) 2022-05-24
CA2981158A1 (en) 2016-10-13
EP3280408A1 (en) 2018-02-14
ES2765648T3 (es) 2020-06-10
AU2015390714B2 (en) 2021-02-04
ZA201706795B (en) 2019-02-27
DK3280408T3 (da) 2020-02-03
US20160297842A1 (en) 2016-10-13
KR20170134737A (ko) 2017-12-06
CN106132408A (zh) 2016-11-16
EP3280408B1 (en) 2019-10-23
WO2016164040A1 (en) 2016-10-13
JP6925318B2 (ja) 2021-08-25
IL254894A0 (en) 2017-12-31
RU2676269C1 (ru) 2018-12-27

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